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1. 发明授权

US06512949B1 Implantable medical device for measuring time varying physiologic conditions especially edema and for responding thereto 有权
标题翻译：用于测量时变生理条件的植入式医疗装置，特别是水肿并对其进行响应
公开(公告)号：US06512949B1
公开(公告)日：2003-01-28
申请号：US09352179
申请日：1999-07-12
申请人： William J. Combs , Catherine R. Condie , Roy Martin , Dwight H. Warkentin , John D. Wahlstrand , David L. Thompson , Li Wang
发明人： William J. Combs , Catherine R. Condie , Roy Martin , Dwight H. Warkentin , John D. Wahlstrand , David L. Thompson , Li Wang
IPC分类号： A61B500
CPC分类号： A61N1/36521 , A61B5/0535 , A61B5/7207 , A61N1/3627
摘要： An impedance monitor for discerning edema through evaluation of respiratory rate. Preferred embodiment includes edema monitor and trigger to initiate diagnostic reporting or corrective action when activated. Recording of Long Term Average and Short Term Average values for secondary edema measure based on DC signal level are described as are methods and apparatus for removing unwanted recurring noise.
摘要翻译：通过评估呼吸频率来辨别水肿的阻抗监测仪。优选实施例包括水肿监测和触发以在被激活时启动诊断报告或纠正动作。长期平均和短期记录基于直流信号电平的次级水肿测量的平均值被描述为用于消除不期望的重复噪声的方法和装置。

2. 发明授权

US5957861A Impedance monitor for discerning edema through evaluation of respiratory rate 失效
标题翻译：阻抗监测仪通过评估呼吸频率进行辨认性水肿
公开(公告)号：US5957861A
公开(公告)日：1999-09-28
申请号：US791206
申请日：1997-01-31
申请人： William J. Combs , Catherine R. Condie , Roy Martin , Dwight H. Warkentin , John D. Wahlstrandl
发明人： William J. Combs , Catherine R. Condie , Roy Martin , Dwight H. Warkentin , John D. Wahlstrandl
IPC分类号： A61B5/053 , A61B5/08 , A61N1/362 , A61N1/37 , A61B5/00
CPC分类号： A61B5/4878 , A61B5/0535 , A61B5/0809 , A61N1/3702 , A61N1/3627
摘要： An impedance monitor for discerning edema through evaluation of respiratory rate. Preferred embodiment includes edema monitor and trigger to initiate diagnostic reporting or corrective action when activated. Recording of Long Term Average and Short Term Average values for secondary edema measure based on DC signal level are described as are methods and apparatus for removing unwanted recurring noise.
摘要翻译：通过评估呼吸频率来辨别水肿的阻抗监测仪。优选实施例包括水肿监测和触发以在被激活时启动诊断报告或纠正动作。长期平均和短期记录基于直流信号电平的次级水肿测量的平均值被描述为用于消除不期望的重复噪声的方法和装置。

3. 发明授权

US5871508A Apparatus for cardiac pacing in transplant 失效
标题翻译：移植心脏起搏装置
公开(公告)号：US5871508A
公开(公告)日：1999-02-16
申请号：US908142
申请日：1997-08-06
申请人： David L. Thompson , Dwight H. Warkentin
发明人： David L. Thompson , Dwight H. Warkentin
IPC分类号： A61N1/368 , A61N1/372
CPC分类号： A61N1/368
摘要： Pacemaker designed for support of both orthotopic and heterotopic transplants has three lead bore connector block assembly and dedicated or dedictable amplifiers for pacing and sensing configurations unique to transplant situations. The provision of definable amplifier assignments allows for enhanced sensing, capture detection and therapy.
摘要翻译：用于支持原位和异位移植的起搏器具有三个引导孔连接器块组件和用于移动情况独特的起搏和感测配置的专用或可放大放大器。提供可定义的放大器分配允许增强感测，捕获检测和治疗。

4. 发明授权

US06824512B2 Communications system for an implantable device and a drug dispenser 有权
标题翻译：用于可植入装置和药物分配器的通信系统
公开(公告)号：US06824512B2
公开(公告)日：2004-11-30
申请号：US10123958
申请日：2002-04-17
申请人： Dwight H. Warkentin , Bozidar Ferek-Petric
发明人： Dwight H. Warkentin , Bozidar Ferek-Petric
IPC分类号： A61B500
CPC分类号： A61N1/37282 , A61N1/08 , Y10S128/903 , Y10S128/904 , Y10S128/92
摘要： A closed loop system for monitoring drug dose, intake and effectiveness includes a pill dispenser in data communications with at least one implantable medical device. The system is preferably implemented in a web-enabled environment in which a remote data center communicates with the implantable devices (IMDs) in a patient via a programmer or the pill dispenser. Th data center includes high speed computers and databases relating to patient history and device information. A physician or clinician may access the remote data center to review and monitor the IMDs remotely. More specifically, the IMDs are adapted to chronically monitor the pill dispenser to thereby log and document drug dose, patient compliance with prescriptive regimens and as well to monitor drug efficacy in the patient. The system further provides a dynamic drug management system, compatible with a web-enabled interactive data communication environment, that accurately monitors dose and specific drug effectiveness in a patient to enhance patient care.
摘要翻译：用于监测药物剂量，摄入量和有效性的闭环系统包括与至少一个可植入医疗装置的数据通信中的药丸分配器。该系统优选地在web启用的环境中实现，其中远程数据中心通过编程器或药丸分配器与患者中的可植入装置（IMD）通信。数据中心包括与病历和设备信息相关的高速计算机和数据库。医生或临床医生可以访问远程数据中心以远程审查和监视IMD。更具体地，IMD适于长期监测药丸分配器，从而记录和记录药物剂量，患者对规定方案的依从性以及监测患者的药物功效。该系统进一步提供了一种动态药物管理系统，与能够准确地监测患者剂量和特异性药物效力的网络互动数据通信环境兼容以增强患者护理。

5. 发明授权

US06804555B2 Multi-site ventricular pacing system measuring QRS duration 有权
标题翻译：多站点心室起搏系统测量QRS持续时间
公开(公告)号：US06804555B2
公开(公告)日：2004-10-12
申请号：US09896281
申请日：2001-06-29
申请人： Dwight H. Warkentin
发明人： Dwight H. Warkentin
IPC分类号： A61N1368
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： Bi-Ventricular or AV synchronous cardiac pacing systems that pace and sense in at least one atrial heart chamber and deliver ventricular pacing pulses to right ventricular (RV) and left ventricular (LV) sites separated by a V—V delay for treatment of heart failure are disclosed that optimize one or more of the AV delay and V—V delay to enhance left ventricular filling and cardiac output as a function of QRS duration. A system and method for monitoring the QRS duration, processing such signals to provide data from which the onset or progression of heart failure is determined, and adjusting synchronous pacing delay parameters including SAV delay and/or PAV delay and/or V—V delay to enhance cardiac output as a function of QRS duration is provided. The SAV, PAV, and/or the V—V delays can be varied from the prevailing delays as a function of measured QRS duration so as to minimize the width of the QRS complex.
摘要翻译：公开了双心室或AV同步心脏起搏系统，其在至少一个心房室中起搏和感觉，并将心室起搏脉冲输送到通过VV延迟分离用于治疗心力衰竭的右心室（RV）和左心室（LV）部位。优化AV延迟和VV延迟中的一个或多个以增强作为QRS持续时间的函数的左心室充盈和心输出量的系统和方法。用于监测QRS持续时间的系统和方法，处理这些信号以提供来自其的起始或进展的数据确定了心力衰竭，并且提供了包括SAV延迟和/或PAV延迟和/或VV延迟的同步起搏延迟参数，以增强作为QRS持续时间的函数的心输出量。 SAV，PAV和/或V-V延迟可以从作为测量QRS持续时间的函数的主要延迟变化，以便使QRS复合体的宽度最小化。

6. 发明授权

US09399091B2 System and method to regulate ultrafiltration 有权
标题翻译：调节超滤的系统和方法
公开(公告)号：US09399091B2
公开(公告)日：2016-07-26
申请号：US12571127
申请日：2009-09-30
申请人： Daniel C. Sigg , Sarah Anne Audet , Tommy D. Bennett , Dwight H. Warkentin
发明人： Daniel C. Sigg , Sarah Anne Audet , Tommy D. Bennett , Dwight H. Warkentin
IPC分类号： A61M37/00 , A61M1/34 , A61M1/16 , A61M1/36
CPC分类号： A61M1/3403 , A61M1/16 , A61M1/34 , A61M1/3406 , A61M1/341 , A61M1/36 , A61M1/3669 , A61M2205/18 , A61M2205/33 , A61M2205/3334 , A61M2205/3344 , A61M2205/3523 , A61M2205/50 , A61M2205/502 , A61M2205/52 , A61M2230/005 , A61M2230/04 , A61M2230/20 , A61M2230/201 , A61M2230/30 , A61M2230/65
摘要： A medical device system including a physiological sensor and ultrafiltration unit senses a physiological signal in a patient and computes a fluid status measurement of the patient using the physiological signal. Ultrafiltration therapy is delivered to the patient according to a therapy delivery control parameter established in response to the fluid status measurement.
摘要翻译：包括生理传感器和超滤单元的医疗装置系统感测患者的生理信号，并使用生理信号计算患者的流体状况测量。根据响应于流体状态测量而建立的治疗递送控制参数将超滤治疗递送给患者。

7. 发明授权

US07027866B2 Mechanically-based interval optimization for a biventricular pacing engine 失效
标题翻译：用于双心室起搏引擎的基于机械的间隔优化
公开(公告)号：US07027866B2
公开(公告)日：2006-04-11
申请号：US10629075
申请日：2003-07-29
申请人： Dwight H. Warkentin
发明人： Dwight H. Warkentin
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36564 , A61N1/3682 , A61N1/3684
摘要： According to the present invention, discrete measurements of fluid pressure development (and derivatives thereof) are used in optimizing hemodynamics for cardiac resynchronization therapy (CRT) delivery and multiple chamber cardiac pacing, and in enhancing hemodynamics in the event of a sub-optimal left-side lead placement. For example, such diverse pressure measurements include: maximum positive or negative dP/dt values, ePAD, RV systolic, RV diastolic, pulse pressure, and the like. According to the present invention, on a periodic basis or upon demand one or more cardiac pacing intervals are iteratively cycled through a predetermined range and the resulting pressure measurements stored for comparison. The cardiac pacing intervals are then adjusted based at least in part upon the most appropriate, or desirable, measured hemodynamics of the patient. The present invention may be implemented as computer readable instructions executed by a microprocessor-based implantable medical device.
摘要翻译：根据本发明，流体压力发展（及其衍生物）的离散测量用于优化用于心脏再同步治疗（CRT）递送和多室心脏起搏的血液动力学，并且在用于增强血液动力学的情况下，侧排位置。例如，这种不同的压力测量包括：最大正或负dP / dt值，ePAD，RV收缩压，RV舒张压，脉压等。根据本发明，周期性地或根据需要，一个或多个心脏起搏间隔在预定范围内迭代循环，并且将所得到的压力测量值存储用于比较。然后至少部分地基于最合适的或期望的测量的患者的血液动力学来调整心脏起搏间隔。本发明可以被实现为由基于微处理器的可植入医疗装置执行的计算机可读指令。

8. 发明授权

US5527347A Dual chamber pacing system and method with automatic adjustment of the AV escape interval for treating cardiomyopathy 失效
标题翻译：双室起搏系统及方法，自动调整心肌病AV逃逸间隔
公开(公告)号：US5527347A
公开(公告)日：1996-06-18
申请号：US391884
申请日：1995-02-21
申请人： Michael B. Shelton , Dwight H. Warkentin
发明人： Michael B. Shelton , Dwight H. Warkentin
IPC分类号： A61N1/368 , A61N1/362
CPC分类号： A61N1/3627 , A61N1/3682
摘要： There is provided a dual chamber pacemaker system and method for ventricular pacing to provide therapy for a patient with cardiomyopathy, this system being characterized by automatically adjusting the AV escape interval so that ventricular pace pulses are delivered at an AV delay which is optimized for HOCM and/or dialated cardiomyopathy therapy. The pacemaker system continually obtains and stores representations of a QRS wave characteristic such as duration, derived either directly from the QRS signal or from an FFRS signal, and compares duration data from one or more cycles to prior stored duration data. The system then adjusts the AV interval as a function of the duration comparison, and the direction of the last adjustment of AV escape interval. By this means, the AV escape interval is maintained at or just short of the onset of fusion, thereby automatically providing for optimally lengthened AV escape intervals consistent with full capture by the delivered ventricular pace pulse.
摘要翻译：提供了一种用于心室起搏的双室心脏起搏器系统和方法，用于为患有心肌病的患者提供治疗，该系统的特征在于自动调节AV逃逸间隔，使得心室起搏脉冲在AV延迟下被传递，该AV延迟被优化用于HOCM， /或拨号心肌病治疗。起搏器系统连续地获得并存储QRS波特征的表示，例如持续时间，直接从QRS信号或从FFRS信号导出，并将来自一个或多个周期的持续时间数据与先前存储的持续时间数据进行比较。然后，系统根据持续时间比较调整AV间隔，并调整AV转义间隔的最后调整方向。通过这种方式，AV逃逸间隔保持在融合开始或短于融合开始，从而自动提供与被传递的心室起搏脉冲的完全捕获相一致的最佳延长的AV逃逸间隔。

9. 发明授权

US08126549B2 Cardiac protection system and method 有权
标题翻译：心脏保护系统及方法
公开(公告)号：US08126549B2
公开(公告)日：2012-02-28
申请号：US12173780
申请日：2008-07-15
申请人： Daniel C. Sigg , James A. Coles, Jr. , Dwight H. Warkentin , Deborah Ann Jaye
发明人： Daniel C. Sigg , James A. Coles, Jr. , Dwight H. Warkentin , Deborah Ann Jaye
IPC分类号： A61N1/362
CPC分类号： A61N1/365 , A61B5/0031 , A61N1/368 , A61N1/3702 , A61N1/37258 , A61N1/37282 , A61N1/37288
摘要： A cardiac ischemic protection system and method for conditioning a patient's heart is provided. The method can include detecting acute myocardial infarction, angina pectoris, silent ischemia, or stunning and providing closed-loop dyssynchronous pacing to the patient's heart to precondition and/or postcondition the patient's heart in order to reduce ischemic damage.
摘要翻译：提供了用于调节患者心脏的心脏缺血保护系统和方法。该方法可以包括检测急性心肌梗塞，心绞痛，静息缺血或惊恐，并向患者的心脏提供闭环异步起搏以预先和/或后置病人的心脏以减少缺血性损伤。

10. 发明授权

US08046064B2 Method of delivering PESP/ICC as well as adjusting the refractory period of the heart 有权
$Method of delivering PESP/ICC as well as adjusting the refractory period of the heart$
标题翻译：提供PESP / ICC的方法以及调整心脏的不应期
公开(公告)号：US08046064B2
公开(公告)日：2011-10-25
申请号：US11379892
申请日：2006-04-24
申请人： Dwight H. Warkentin , D. Curtis Deno
发明人： Dwight H. Warkentin , D. Curtis Deno
IPC分类号： A61N1/39
CPC分类号： A61N1/3627 , A61N1/36014 , A61N1/36114 , A61N1/36514 , A61N1/36585 , A61N1/368
摘要： Medical devices and methods are used to treat cardiac dysfunction conditions which involve delivery of stimulation pulses in cardiac refractory periods in order to modulate an effective refractory period (ERP). Such devices and methods may be used in conjunction with or in place of other therapies, including increased cardiac contractility (ICC) therapy, post extrasystolic potentiation (PESP) therapy, and other therapies to achieve increased heart contractility, provide a safer and more effective regimen for the corresponding stimulation therapies, and reduce the risk of inducing an arrhythmia.
摘要翻译：医疗器械和方法被用于治疗心脏功能障碍状况，其涉及在心脏不应期内输送刺激脉冲以调节有效的不应期（ERP）。这些装置和方法可以与其他疗法结合使用或替代其它疗法，包括增加心肌收缩力（ICC）治疗，收缩后增强疗法（PESP）疗法和其他疗法以达到增加的心脏收缩力，提供更安全和更有效的方案用于相应的刺激疗法，并降低引起心律失常的风险。

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