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1. 发明授权

US06471645B1 Communications system for an implantable device and a drug dispenser 失效
标题翻译：用于可植入装置和药物分配器的通信系统
公开(公告)号：US06471645B1
公开(公告)日：2002-10-29
申请号：US09475709
申请日：1999-12-30
申请人： Dwight H. Warkentin , Bozidar Ferek-Petric
发明人： Dwight H. Warkentin , Bozidar Ferek-Petric
IPC分类号： A61B500
CPC分类号： A61N1/37282 , A61N1/08 , Y10S128/903 , Y10S128/904 , Y10S128/92
摘要： A closed loop system for monitoring drug dose, intake and effectiveness includes a pill dispenser in data communications with at least one implantable medical device. The system is preferably implemented in a web-enabled environment in which a remote data center communicates with the implantable devices (IMDs) in a patient via a programmer or the pill dispenser. Th data center includes high speed computers and databases relating to patient history and device information. A physician or clinician may access the remote data center to review and monitor the IMDs remotely. More specifically, the IMDs are adapted to chronically monitor the pill dispenser to thereby log and document drug dose, patient compliance with prescriptive regimens and as well to monitor drug efficacy in the patient. The system further provides a dynamic drug management system, compatible with a web-enabled interactive data communication environment, that accurately monitors dose and specific drug effectiveness in a patient to enhance patient care.
摘要翻译：用于监测药物剂量，摄入量和有效性的闭环系统包括与至少一个可植入医疗装置的数据通信中的药丸分配器。该系统优选地在web启用的环境中实现，其中远程数据中心通过编程器或药丸分配器与患者中的可植入装置（IMD）通信。数据中心包括与病历和设备信息相关的高速计算机和数据库。医生或临床医生可以访问远程数据中心以远程审查和监视IMD。更具体地，IMD适于长期监测药丸分配器，从而记录和记录药物剂量，患者对规定方案的依从性以及监测患者的药物功效。该系统进一步提供了一种动态药物管理系统，与能够准确地监测患者剂量和特异性药物效力的网络互动数据通信环境兼容以增强患者护理。

2. 发明授权

US08002700B2 Communications system for an implantable medical device and a delivery device 失效
标题翻译：用于可植入医疗装置和递送装置的通信系统
公开(公告)号：US08002700B2
公开(公告)日：2011-08-23
申请号：US10631953
申请日：2003-07-31
申请人： Bozidar Ferek-Petric , Dwight H. Warkentin
发明人： Bozidar Ferek-Petric , Dwight H. Warkentin
IPC分类号： A61B5/00
CPC分类号： A61N1/37264 , A61M5/14 , A61M5/142 , A61M5/1684 , A61M5/1723 , A61M2005/14208 , A61M2205/3523 , A61M2205/3561 , A61M2205/3576 , A61M2205/3584 , A61M2230/00 , A61N1/08 , A61N1/32 , A61N1/36071 , A61N1/37282 , G06F19/00 , G06F19/3418 , G06F19/3462 , G06F19/3468 , G16H50/20 , A61M2230/005
摘要： A closed loop system for monitoring drug dose, intake and effectiveness includes a drug delivery device in data communications with at least one implantable medical device. The system is preferably implemented in a web-enabled environment in which a remote data center communicates with the implantable devices (IMDs) in a patient via a programmer or the pill dispenser. A physician, clinician, or other user may access the remote data center to review and monitor the IMDs or the drug delivery regime remotely. The system further provides a dynamic drug management system, compatible with a web-enabled interactive data communication environment that accurately monitors dose and specific drug effectiveness in a patient to enhance patient care.
摘要翻译：用于监测药物剂量，摄取量和有效性的闭环系统包括与至少一个可植入医疗装置进行数据通信的药物递送装置。该系统优选地在web启用的环境中实现，其中远程数据中心通过编程器或药丸分配器与患者中的可植入装置（IMD）通信。医生，临床医师或其他用户可以访问远程数据中心，以便远程审查和监控IMD或药物传递机制。该系统进一步提供动态药物管理系统，与能够准确地监测患者中的剂量和特异性药物有效性以增强患者护理的网络互动数据通信环境兼容。

3. 发明授权

US06824512B2 Communications system for an implantable device and a drug dispenser 有权
标题翻译：用于可植入装置和药物分配器的通信系统
公开(公告)号：US06824512B2
公开(公告)日：2004-11-30
申请号：US10123958
申请日：2002-04-17
申请人： Dwight H. Warkentin , Bozidar Ferek-Petric
发明人： Dwight H. Warkentin , Bozidar Ferek-Petric
IPC分类号： A61B500
CPC分类号： A61N1/37282 , A61N1/08 , Y10S128/903 , Y10S128/904 , Y10S128/92
摘要： A closed loop system for monitoring drug dose, intake and effectiveness includes a pill dispenser in data communications with at least one implantable medical device. The system is preferably implemented in a web-enabled environment in which a remote data center communicates with the implantable devices (IMDs) in a patient via a programmer or the pill dispenser. Th data center includes high speed computers and databases relating to patient history and device information. A physician or clinician may access the remote data center to review and monitor the IMDs remotely. More specifically, the IMDs are adapted to chronically monitor the pill dispenser to thereby log and document drug dose, patient compliance with prescriptive regimens and as well to monitor drug efficacy in the patient. The system further provides a dynamic drug management system, compatible with a web-enabled interactive data communication environment, that accurately monitors dose and specific drug effectiveness in a patient to enhance patient care.
摘要翻译：用于监测药物剂量，摄入量和有效性的闭环系统包括与至少一个可植入医疗装置的数据通信中的药丸分配器。该系统优选地在web启用的环境中实现，其中远程数据中心通过编程器或药丸分配器与患者中的可植入装置（IMD）通信。数据中心包括与病历和设备信息相关的高速计算机和数据库。医生或临床医生可以访问远程数据中心以远程审查和监视IMD。更具体地，IMD适于长期监测药丸分配器，从而记录和记录药物剂量，患者对规定方案的依从性以及监测患者的药物功效。该系统进一步提供了一种动态药物管理系统，与能够准确地监测患者剂量和特异性药物效力的网络互动数据通信环境兼容以增强患者护理。

4. 发明授权

US07369892B2 Ischemic heart disease detection 有权
标题翻译：缺血性心脏病检测
公开(公告)号：US07369892B2
公开(公告)日：2008-05-06
申请号：US10085072
申请日：2002-03-01
申请人： Bozidar Ferek-Petric
发明人： Bozidar Ferek-Petric
IPC分类号： A61N1/368
CPC分类号： A61N1/36585 , A61N1/3962
摘要： An implantable medical device system for detecting cardiac conditions such the long-term ischemic heart disease, an occlusion of a coronary artery by a thrombus or an impending as a myocardial infarction. The implantable medical device (IMD) system includes a sensor that outputs a blood flow rate signal representing a rate of blood flow through a coronary sinus of a patient's heart. An implantable medical device (IMD) includes a microcomputer circuit configured to analyze the blood flow rate signal and detect a cardiac condition as a function of the blood flow rate signal. The system can also includes an implantable lead that senses electrical activity from the patient's heart. The microcomputer circuit monitors an ST segment of the electrical activity signal and detects a cardiac condition as a function of blood flow rate signal in conjunction with the electrical activity signal.
摘要翻译：一种用于检测心脏状况如长期缺血性心脏病，血栓阻塞冠状动脉或即将作为心肌梗塞的可植入医疗装置系统。可植入医疗装置（IMD）系统包括传感器，该传感器输出表示通过患者心脏的冠状窦的血流量的血流速度信号。可植入医疗装置（IMD）包括：微型计算机电路，被配置为分析血液流量信号并根据血液流量信号检测心脏状态。该系统还可以包括感测来自患者心脏的电活动的可植入引线。微电脑电路监视电活动信号的ST段，并结合电活动信号检测作为血流量信号的函数的心脏状况。

5. 发明授权

US06442430B1 Implantable medical device programmers having headset video and methods of using same 有权
标题翻译：具有耳机视频的植入式医疗设备编程器和使用其的方法
公开(公告)号：US06442430B1
公开(公告)日：2002-08-27
申请号：US09727463
申请日：2000-12-04
申请人： Bozidar Ferek-Petric
发明人： Bozidar Ferek-Petric
IPC分类号： A61N137
CPC分类号： A61N1/37247
摘要： Programmers, systems and methods utilizing body-wearable components, such as a head-mounted video display apparatus, are provided to program implantable medical devices (IMDs). The head-mounted video display apparatus provides information regarding programming parameters as well as information regarding the patient and/or the IMD. By being worn on the body, programmers of the present invention are highly portable. Further, by providing a head-mounted video display apparatus, programmers of the present invention provide a display that remains viewable even in crowded environments.
摘要翻译：提供使用身体穿戴性部件（例如头戴式视频显示装置）的编程器，系统和方法来编程可植入医疗装置（IMD）。头戴式视频显示装置提供关于编程参数的信息以及关于患者和/或IMD的信息。通过佩戴在身体上，本发明的程序员是高度便携的。此外，通过提供头戴式视频显示装置，本发明的编程器提供即使在拥挤的环境中仍然可视的显示器。

6. 发明授权

US5318595A Pacing method and system for blood flow velocity measurement and regulation of heart stimulating signals based on blood flow velocity 失效
标题翻译：基于血流速度的血流速度测量和心脏刺激信号调节的起搏方法和系统
公开(公告)号：US5318595A
公开(公告)日：1994-06-07
申请号：US880552
申请日：1992-05-08
申请人： Bozidar Ferek-Petric , Branko Breyer
发明人： Bozidar Ferek-Petric , Branko Breyer
IPC分类号： A61N1/362
CPC分类号： A61N1/362
摘要： A system and method for regulation of pacing signals, and more particularly for regulation of an atrioventricular interval in a cardiac electrotherapy system based on measurement of blood flow velocity profiles. More particularly, a diastolic blood flow filling wave and an atrial blood flow filling wave are determined and a time delay between peaks of the two waves and/or a superimposition velocity of the two waves relative to one another are utilized for the regulation. The regulation preferably occurs by comparing the measured time delay to a desired time delay or desired superimposition velocity, and the result of the comparison is then employed for regulating the pacing, or regulating the atrio-ventricular interval.
摘要翻译：一种用于调节起搏信号的系统和方法，更具体地涉及基于血流速度分布的测量来调节心脏电疗系统中的房室间隔。更具体地，确定舒张血流充填波和心房血流充盈波，并且将这两个波的峰值之间的时间延迟和/或两个波相对于彼此的叠加速度用于调节。该调节优选通过将测量的时间延迟与期望的时间延迟或期望的叠加速度进行比较而发生，然后将比较结果用于调节起搏或调节心室间隔。

7. 发明授权

US5316001A Cardiac measurement system for measuring blood flow velocity by use of a sensor implanted inside the heart 失效
标题翻译：心脏测量系统，用于通过使用植入心脏内部的传感器测量血流速度
公开(公告)号：US5316001A
公开(公告)日：1994-05-31
申请号：US20684
申请日：1993-02-22
申请人： Bozidar Ferek-Petric , Branko Breyer
发明人： Bozidar Ferek-Petric , Branko Breyer
IPC分类号： A61B8/06 , A61N1/365 , A61B5/026
CPC分类号： A61B8/06 , A61B8/12 , A61B8/445 , A61N1/36528 , A61N1/36571
摘要： A cardiac electrotherapy system has flow velocity measurement capability for measuring a velocity of blood flow at a region of a tricuspid valve of a heart. A pacing system is provided which outputs a pacing electrical signal to the heart. A control unit which is responsive to a measured flow velocity from the flow velocity measurement unit detects heart irregularities and controls electrical pacing signals to the heart. In detecting heart irregularities, peak flow velocity waveforms are detected and analyzed. The flow velocity measurement employs a Doppler ultrasonic transducer which is mounted on a cardiac pacing lead in spaced relation to a pacing electrode at a distal end of the lead. When the pacing lead is inserted in the heart, the pacing electrode is placed at an apex of the right ventricle and the piezoelectric Doppler transducer is positioned at or near the tricuspid valve. The flow velocity transducer is preferably formed as an annular piezo body having associated electrodes. An ultrasonic lens directs ultrasonic rays from the transducer and an ultrasonic wave inhibitor structure prevents transmission of ultrasonic waves in an undesired direction. With the cardiac electrotherapy system, improved and more reliable monitoring of cardiac activity is achieved and a corresponding improved pacing results.
摘要翻译：心脏电疗系统具有用于测量心脏三尖瓣区域的血流速度的流速测量能力。提供一种起搏系统，其向心脏输出起搏电信号。响应于来自流速测量单元的测量流速的控制单元检测心脏不规则并且控制到心脏的起搏信号。在检测心脏不规则时，检测并分析峰值流速波形。流速测量采用多普勒超声换能器，其安装在心脏起搏引线上，与引线远端的起搏电极间隔开。当起搏引线插入心脏时，起搏电极放置在右心室的顶点，压电多普勒换能器位于三尖瓣或其附近。流速传感器优选地形成为具有相关电极的环形压电体。超声波透镜引导来自换能器的超声波射线，并且超声波抑制器结构防止超声波在不希望的方向上传播。通过心脏电疗系统，可以实现对心脏活动的改善和更可靠的监测，并产生相应的改善的起搏结果。

8. 发明授权

US5271392A Method and apparatus for administering cardiac electrotherapy dependent on mechanical and electrical cardiac activity 失效
标题翻译：用于根据机械和电学心脏活动进行心脏电疗的方法和装置
公开(公告)号：US5271392A
公开(公告)日：1993-12-21
申请号：US827055
申请日：1992-01-27
申请人： Bozidar Ferek-Petric
发明人： Bozidar Ferek-Petric
IPC分类号： A61N1/05 , A61N1/365 , A61N1/362
CPC分类号： A61N1/056 , A61N1/36514
摘要： A method for administering cardiac electrotherapy and an implantable electrotherapy apparatus employ myocardial tensiometry to measure contractions of the heart muscle. The system includes a tensiometric element disposed at a location subject to bending due to cardiac contractions, the tensiometric element consisting either of piezoelectric material or variable resistivity material, the mechanical stresses to which the tensiometric element is subjected causing the element to produce a voltage or a resistivity variation comparable in frequency and amplitude to the contractions. The tensiometric element may be in the form of a strip disposed on a surface of a patch electrode, of the type suitable for use in an implantable defibrillator, or may be a strip or a tube located at the bend of a J-shaped pacing lead, of the type implantable in the atrium or in the ventricle in a cardiac pacemaker system. Electrical cardiac activity due to repolarization of the cardiac tissue is also sensed, and the frequency of the electrical activity, the frequency of the mechanical activity due to the cardiac contractions, and the amplitude of the voltage signal produced by the tensiometric element are used to control the administration of electrotherapy to the cardiac tissue.
摘要翻译：一种用于心脏电疗的方法和一种可植入式电疗装置，其使用心肌张力测量法来测量心肌的收缩。该系统包括设置在由于心脏收缩而受弯曲的位置的张力元件，张力元件由压电材料或可变电阻率材料组成，张力元件受到的机械应力使元件产生电压或电阻率变化在频率和幅度上与收缩相当。所述张力元件可以是设置在贴片电极的表面上的条形的形式，适用于可植入除颤器的类型，或者可以是位于J形起搏引线的弯曲处的带或管，在心脏起搏器系统中可植入在心房或心室中的类型。还感测到由于心脏组织的复极化引起的电心脏活动，并且使用电活动频率，由心脏收缩引起的机械活动的频率以及由张力测量元件产生的电压信号的振幅来控制向心脏组织施用电疗。

9. 发明授权

US07850610B2 Electrode location mapping system and method 有权
标题翻译：电极定位系统及方法
公开(公告)号：US07850610B2
公开(公告)日：2010-12-14
申请号：US10878780
申请日：2004-06-28
申请人： Bozidar Ferek-Petric
发明人： Bozidar Ferek-Petric
IPC分类号： A61B8/00
CPC分类号： A61B8/0841 , A61B5/0422 , A61B5/062 , A61B5/743 , A61B8/0833 , A61B8/0883 , A61B8/4245 , A61B8/5238 , A61B2034/2053
摘要： A mapped location of one or more electrodes within an electrical mapping volume is superimposed onto an ultrasound image corresponding to the electrical mapping volume.
摘要翻译：电对映体积内的一个或多个电极的映射位置被叠加到对应于电映射体积的超声图像上。

10. 发明授权

US07526335B2 Communications system for an implantable device and a drug dispenser 有权
标题翻译：用于可植入装置和药物分配器的通信系统
公开(公告)号：US07526335B2
公开(公告)日：2009-04-28
申请号：US11077269
申请日：2005-03-10
申请人： Bozidar Ferek-Petric
发明人： Bozidar Ferek-Petric
IPC分类号： A61N1/36
CPC分类号： A61M5/14276 , A61M2205/3523 , A61M2205/52 , A61N1/3702 , A61N1/37247 , A61N1/37252
摘要： A system for monitoring drug dispensation and drug effects on physiological signals or implantable medical device (IMD) performance is provided. The system includes a drug dispenser adapted for telemetric communication with an IMD, an IMD capable of acquiring time-based physiological or device performance data, and a programmer/monitor for receiving and displaying IMD-acquired data and drug dispensation data. The system may further include a patient activator for transmitting signals indicative of symptoms experienced by a patient associated with a side-effect caused by a drug or a condition for which the drug has been prescribed to treat. In an associated method, a drug dispensation signal is generated upon activation of the drug dispenser. IMD-acquired data, drug dispensation data, and patient symptom data are retrieved by a programmer/monitor. IMD-acquired data is combined with or grouped according to drug dispensation data and displayed.
摘要翻译：提供了一种用于监测药物分配和对生理信号或植入式医疗装置（IMD）性能的药物作用的系统。该系统包括适于与IMD进行遥测通信的药物分配器，能够获取基于时间的生理或设备性能数据的IMD，以及用于接收和显示IMD获取的数据和药物分配数据的编程器/监视器。该系统可以进一步包括患者激活器，用于传输指示患者经历的与由药物引起的副作用相关的症状的信号或药物已被规定治疗的状况。在相关联的方法中，在药物分配器激活时产生药物分配信号。 IMD获取的数据，药物分配数据和患者症状数据由程序员/监视器检索。 IMD获取的数据与药物分配数据组合或分组并显示。

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