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1. 发明申请

US20050029308A1 System for dispensing a precise amount of fluid 失效
标题翻译：用于分配精确量的流体的系统
公开(公告)号：US20050029308A1
公开(公告)日：2005-02-10
申请号：US10621657
申请日：2003-07-16
申请人： William Benett , Peter Krulevitch , Steven Visuri , John Dzenitis , Kevin Ness
发明人： William Benett , Peter Krulevitch , Steven Visuri , John Dzenitis , Kevin Ness
IPC分类号： B01L3/02 , G01N1/00 , G01N35/10 , B67D5/42
CPC分类号： B01L3/0217 , B01L2400/0487 , G01N35/1016 , G01N35/1065 , G01N2035/1034
摘要： A dispensing system delivers a precise amount of fluid for biological or chemical processing and/or analysis. Dispensing means moves the fluid. The dispensing means is operated by a pneumatic force. Connection means delivers the fluid to the desired location. An actuator means provides the pneumatic force to the dispensing means. Valving means transmits the pneumatic force from the actuator means to the dispensing means.
摘要翻译：分配系统提供精确量的用于生物或化学处理和/或分析的流体。分液装置移动流体。分配装置通过气动力操作。连接装置将流体输送到所需位置。致动器装置向分配装置提供气动力。阀装置将气动力从致动器装置传递到分配装置。

2. 发明申请

US20120322058A1 Analysis of nucleic acids 有权
标题翻译：核酸分析
公开(公告)号：US20120322058A1
公开(公告)日：2012-12-20
申请号：US13385277
申请日：2012-02-09
申请人： John Frederick Regan , Serge Saxonov , Mike Lucero , Ben Hindson , Phil Belgrader , Simant Dube , Austin So , Jeffrey Clark Mellen , Nicholas Jack Heredia , Kevin Ness , Bill Colston
发明人： John Frederick Regan , Serge Saxonov , Mike Lucero , Ben Hindson , Phil Belgrader , Simant Dube , Austin So , Jeffrey Clark Mellen , Nicholas Jack Heredia , Kevin Ness , Bill Colston
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/683 , C12Q1/6858 , C12Q2600/158 , C12Q2600/172 , C12Q2537/16 , C12Q2563/159 , C12Q2537/165
摘要： Provided herein are improved methods, compositions, and kits for analysis of nucleic acids. The improved methods, compositions, and kits can enable copy number estimation of a nucleic acid in a sample. Also provided herein are methods, compositions, and kits for determining the linkage of two or more copies of a target nucleic acid in a sample (e.g., whether the two or more copies are on the same chromosome or different chromosomes) or for phasing alleles.
摘要翻译：本文提供了用于分析核酸的改进的方法，组合物和试剂盒。改进的方法，组合物和试剂盒可以使得样品中核酸的拷贝数估计可以进行。本文还提供了用于确定样品中靶核酸的两个或多个拷贝（例如，两个或多个拷贝是位于同一染色体或不同染色体上）或用于定相等位基因的连接的方法，组合物和试剂盒。

3. 发明授权

US07089917B1 Snowmobile fuel system sump tank 有权
标题翻译：雪车燃油系统油罐
公开(公告)号：US07089917B1
公开(公告)日：2006-08-15
申请号：US10869423
申请日：2004-06-16
申请人： Scott E. McKinster , John A. Crudden , Kevin Ness , Richard A. Frederickson
发明人： Scott E. McKinster , John A. Crudden , Kevin Ness , Richard A. Frederickson
IPC分类号： F02M37/10 , B62M27/02
CPC分类号： F02M37/106 , B62J37/00 , B62M27/02 , F02B61/00 , F02M37/0052
摘要： In some embodiments, a fuel sump system may include one or more of the following features: (a) a fuel tank, (b) a fuel sump tank in fluid communication with the fuel tank to receive fuel from the fuel tank, (c) a fuel pump having an intake positioned in the sump tank to pump fuel from the sump tank to an engine via a fuel supply line, (d) a fuel return line in fluid communication with the engine for returning fuel the fuel return line being in fluid communication with the sump tank to supply returned fuel to the sump tank, (e) a fuel pressure regulator operably coupled to the return line, and (f) a transfer pump operatively coupled to the fuel tank and the sump tank for transferring fuel from the fuel tank to the sump tank.
摘要翻译：在一些实施例中，燃料池系统可以包括以下特征中的一个或多个：（a）燃料箱，（b）与燃料箱流体连通以从燃料箱接收燃料的燃料箱罐，（c）燃料泵，其具有位于所述贮槽中的进气口，用于经由燃料供应管线将燃料从所述集油箱泵送到发动机;（d）与所述发动机流体连通的燃料返回管线，所述燃料返回管路用于使燃料返回管线处于流体与贮槽相通以将返回的燃料供应到贮槽，（e）可操作地连接到返回管线的燃料压力调节器，以及（f）可操作地联接到燃料箱和贮槽的输送泵，用于将燃料从燃油箱到油底壳。

4. 发明申请

US20110159499A1 METHODS AND COMPOSITIONS FOR DETECTING GENETIC MATERIAL 审中-公开
标题翻译：用于检测遗传材料的方法和组合物
公开(公告)号：US20110159499A1
公开(公告)日：2011-06-30
申请号：US12954634
申请日：2010-11-25
申请人： Benajamin HINDSON , Serge Saxonov , Phillip Belgrader , Kevin Ness , Michael Lucero , Billy Colston
发明人： Benajamin HINDSON , Serge Saxonov , Phillip Belgrader , Kevin Ness , Michael Lucero , Billy Colston
IPC分类号： C12Q1/68 , C07H21/00
CPC分类号： C12Q1/6806 , C12Q1/6827 , C12Q2537/157 , C12Q2563/161 , C12Q2533/107 , C12Q2521/319
摘要： This invention provides compositions and methods for detecting differences in copy number of a target polynucleotide. In some cases, the methods and compositions provided herein are useful for diagnosis of fetal genetic abnormalities, when the starting sample is maternal tissue (e.g., blood, plasma). The methods and materials described apply techniques for allowing detection of small, but statistically significant, differences in polynucleotide copy number.
摘要翻译：本发明提供了用于检测靶多核苷酸拷贝数差异的组合物和方法。在一些情况下，当起始样品是母体组织（例如血液，血浆）时，本文提供的方法和组合物可用于诊断胎儿遗传异常。描述的方法和材料适用于允许检测多核苷酸拷贝数的小但统计学上显着的差异的技术。

5. 发明申请

US20110036718A1 METHODS FOR SEPARATING PARTICLES AND/OR NUCLEIC ACIDS USING ISOTACHOPHORESIS 有权
标题翻译：使用异烟肼分离颗粒和/或核酸的方法
公开(公告)号：US20110036718A1
公开(公告)日：2011-02-17
申请号：US12542215
申请日：2009-08-17
申请人： Byoungsok Jung , Kevin Ness , Klint A. Rose
发明人： Byoungsok Jung , Kevin Ness , Klint A. Rose
IPC分类号： G01N27/447
CPC分类号： G01N27/44747 , G01N27/44773 , G01N2030/8827
摘要： According to one embodiment, a method includes co-feeding fluids comprising a leading electrolyte, a trailing electrolyte, and at least one of DNA and RNA to a channel, and applying an electric field to the fluids in a direction perpendicular to an axis of the channel for inducing transverse isotachophoresis. In another embodiment, a method includes co-feeding fluids to a channel. The fluids include a leading electrolyte, a trailing electrolyte, biological objects, at least one of DNA and RNA, and a spacer electrolyte having an electrophoretic mobility that is between an electrophoretic mobility of at least some of the biological objects and an electrophoretic mobility of the at least one of the DNA and the RNA. The method also includes applying an electric field to the fluids in a direction perpendicular to an axis of the channel for inducing transverse isotachophoresis. Other methods of isotachophoresis are disclosed in addition to these.
摘要翻译：根据一个实施方案，一种方法包括将包含前导电解质，尾电解质和至少一种DNA和RNA的流体的流体共同输送到通道，以及在垂直于诱导横向等电泳的通道。在另一个实施例中，一种方法包括将流体共同输送到通道。流体包括前导电解质，尾电解质，生物物体，DNA和RNA中的至少一种以及具有电泳迁移率的间隔电解质，所述间隔电解质位于至少一些生物体的电泳迁移率与电泳迁移率之间至少一个DNA和RNA。该方法还包括在垂直于通道的轴线的方向上向流体施加电场以诱导横向等速电泳。除此之外还公开了其他的等速电泳方法。

6. 发明授权

US09285340B2 Methods for separating particles and/or nucleic acids using isotachophoresis 有权
标题翻译：使用等速电泳法分离颗粒和/或核酸的方法
公开(公告)号：US09285340B2
公开(公告)日：2016-03-15
申请号：US12542215
申请日：2009-08-17
申请人： Byoungsok Jung , Kevin Ness , Klint A. Rose
发明人： Byoungsok Jung , Kevin Ness , Klint A. Rose
IPC分类号： G01N27/447
CPC分类号： G01N27/44747 , G01N27/44773 , G01N2030/8827
摘要： According to one embodiment, a method includes co-feeding fluids comprising a leading electrolyte, a trailing electrolyte, and at least one of DNA and RNA to a channel, and applying an electric field to the fluids in a direction perpendicular to an axis of the channel for inducing transverse isotachophoresis. In another embodiment, a method includes co-feeding fluids to a channel. The fluids include a leading electrolyte, a trailing electrolyte, biological objects, at least one of DNA and RNA, and a spacer electrolyte having an electrophoretic mobility that is between an electrophoretic mobility of at least some of the biological objects and an electrophoretic mobility of the at least one of the DNA and the RNA. The method also includes applying an electric field to the fluids in a direction perpendicular to an axis of the channel for inducing transverse isotachophoresis. Other methods of isotachophoresis are disclosed in addition to these.
摘要翻译：根据一个实施方案，一种方法包括将包含前导电解质，尾电解质和至少一种DNA和RNA的流体的流体共同输送到通道，以及在垂直于诱导横向等电泳的通道。在另一个实施例中，一种方法包括将流体共同供给到通道。流体包括前导电解质，尾电解质，生物物体，DNA和RNA中的至少一种以及具有电泳迁移率的间隔电解质，所述间隔电解质位于至少一些生物体的电泳迁移率和电泳迁移率之间至少一个DNA和RNA。该方法还包括在垂直于通道的轴线的方向上向流体施加电场以诱导横向等速电泳。除此之外还公开了其他的等速电泳法。

7. 发明授权

US09127312B2 Analysis of nucleic acids 有权
标题翻译：核酸分析
公开(公告)号：US09127312B2
公开(公告)日：2015-09-08
申请号：US13385277
申请日：2012-02-09
申请人： John Frederick Regan , Serge Saxonov , Mike Lucero , Ben Hindson , Phil Belgrader , Simant Dube , Austin So , Jeffrey Clark Mellen , Nicholas Jack Heredia , Kevin Ness , Bill Colston
发明人： John Frederick Regan , Serge Saxonov , Mike Lucero , Ben Hindson , Phil Belgrader , Simant Dube , Austin So , Jeffrey Clark Mellen , Nicholas Jack Heredia , Kevin Ness , Bill Colston
IPC分类号： C12Q1/68 , C07H21/00
CPC分类号： C12Q1/6883 , C12Q1/683 , C12Q1/6858 , C12Q2600/158 , C12Q2600/172 , C12Q2537/16 , C12Q2563/159 , C12Q2537/165
摘要： Provided herein are improved methods, compositions, and kits for analysis of nucleic acids. The improved methods, compositions, and kits can enable copy number estimation of a nucleic acid in a sample. Also provided herein are methods, compositions, and kits for determining the linkage of two or more copies of a target nucleic acid in a sample (e.g., whether the two or more copies are on the same chromosome or different chromosomes) or for phasing alleles.
摘要翻译：本文提供了用于分析核酸的改进的方法，组合物和试剂盒。改进的方法，组合物和试剂盒可以使得样品中核酸的拷贝数估计可以进行。本文还提供了用于确定样品中靶核酸的两个或多个拷贝（例如，两个或多个拷贝是位于同一染色体或不同染色体上）或用于定相等位基因的连接的方法，组合物和试剂盒。

8. 发明申请

US20120252015A1 METHODS AND COMPOSITIONS FOR DETECTING GENETIC MATERIAL 审中-公开
标题翻译：用于检测遗传材料的方法和组合物
公开(公告)号：US20120252015A1
公开(公告)日：2012-10-04
申请号：US13400030
申请日：2012-02-17
申请人： Benjamin Hindson , Serge Saxonov , Philip Belgrader , Kevin Ness , Michael Lucero , Billy Colston , Shawn Paul Hodges , Nicholas J. Heredia , Jeffrey Clark Mellen , Camille Bodley Troup , Paul Wyatt
发明人： Benjamin Hindson , Serge Saxonov , Philip Belgrader , Kevin Ness , Michael Lucero , Billy Colston , Shawn Paul Hodges , Nicholas J. Heredia , Jeffrey Clark Mellen , Camille Bodley Troup , Paul Wyatt
IPC分类号： C12Q1/68 , G01N21/64
CPC分类号： C12Q1/6883 , C12Q2521/331 , C12Q2523/125 , C12Q2600/154
摘要： The present disclosure provides methods and compositions for detecting polynucleotides in a sample and for quantifying polynucleotide load in a sample. The polynucleotides can be associated with a disease, disorder, or condition. In some applications, methylated DNA is quantified, e.g., in order to determine the load of polynucleotides in a sample. The present disclosure also provides methods and compositions for determining the load of fetal polynucleotides in a biological sample, e.g., the load of fetal polynucleotides (e.g., DNA, RNA) in maternal plasma. The present disclosure provides methods and compositions for detecting cellular processes such as cellular viability, growth rates, and infection rates. This disclosure also provides compositions and methods for detecting differences in copy number of a target polynucleotide. In some embodiments, the methods and compositions provided herein are useful for diagnosis of fetal genetic abnormalities, when the starting sample is maternal tissue (e.g., blood, plasma).
摘要翻译：本公开提供了用于检测样品中的多核苷酸并用于定量样品中的多核苷酸负载的方法和组合物。多核苷酸可以与疾病，病症或病症相关。在一些应用中，例如为了确定样品中多核苷酸的负载量化甲基化DNA。本公开还提供了用于确定生物样品中胎儿多核苷酸负荷的方法和组合物，例如母体血浆中胎儿多核苷酸（例如DNA，RNA）的负载。本公开提供了用于检测细胞过程如细胞活力，生长速率和感染率的方法和组合物。本公开还提供了用于检测靶多核苷酸的拷贝数差异的组合物和方法。在一些实施方案中，当起始样品是母体组织（例如血液，血浆）时，本文提供的方法和组合物可用于诊断胎儿遗传异常。

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