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1. 发明授权

US08475808B2 Immunogenic reagents from west nile virus 有权
标题翻译：西尼罗病毒的免疫原性试剂
公开(公告)号：US08475808B2
公开(公告)日：2013-07-02
申请号：US10557427
申请日：2004-05-21
申请人： William Andrews , David Chien , Qui-Lim Choo , Stephen Coates , Doris Coit , Charles Harrington , Susan Hilt , Michael Houghton , Angelica Medina-Selby , Sergio Pichuantes , Yiu-Lian Fong
发明人： William Andrews , David Chien , Qui-Lim Choo , Stephen Coates , Doris Coit , Charles Harrington , Susan Hilt , Michael Houghton , Angelica Medina-Selby , Sergio Pichuantes , Yiu-Lian Fong
IPC分类号： A61K39/12 , C12Q1/70 , C12N15/86
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/545 , A61K2039/55566 , C07K2319/02 , C12N2770/24122 , C12N2770/24134 , G01N33/56983 , G01N33/6854 , G01N2333/18 , G01N2469/20 , Y02A50/394
摘要： Recombinant production of immunogenic West Nile Virus (WNV) proteins is described. These proteins, heterodimers comprising the proteins, fusions thereof, polynucleotides encoding the proteins, and combinations thereof, as well as antibodies produced therefrom, can be used in immunogenic compositions for preventing, treating and diagnosing WNV infection. Also described are highly sensitive ELISA and strip immunoassay methods for detecting the presence of WNV in biological samples.
摘要翻译：描述了免疫原性西尼罗病毒（WNV）蛋白的重组产生。包含蛋白质的这些蛋白质，其融合物，编码蛋白质的多核苷酸及其组合以及由其产生的抗体可用于预防，治疗和诊断WNV感染的免疫原性组合物中。还描述了用于检测生物样品中WNV存在的高灵敏度ELISA和条带免疫测定方法。

2. 发明申请

US20070092538A1 Immunogenic reagents from west nile virus 有权
标题翻译：西尼罗病毒的免疫原性试剂
公开(公告)号：US20070092538A1
公开(公告)日：2007-04-26
申请号：US10557427
申请日：2004-05-21
申请人： William Andrews , David Chien , Qui-Lim Choo , Stephen Coates , Doris Coit , Charles Harrington , Susan Hilt , Michael Houghton , Angelica Medina-Selby , Sergio Pichuantes
发明人： William Andrews , David Chien , Qui-Lim Choo , Stephen Coates , Doris Coit , Charles Harrington , Susan Hilt , Michael Houghton , Angelica Medina-Selby , Sergio Pichuantes
IPC分类号： A61K39/12 , C12Q1/70 , C12N15/86 , C07K14/18 , C12N5/08 , C12N5/06
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/545 , A61K2039/55566 , C07K2319/02 , C12N2770/24122 , C12N2770/24134 , G01N33/56983 , G01N33/6854 , G01N2333/18 , G01N2469/20 , Y02A50/394
摘要： Recombinant production of immunogenic West Nile Virus (WNV) proteins is described. These proteins, heterodimers comprising the proteins, fusions thereof, polynucleotides encoding the proteins, and combinations thereof, as well as antibodies produced therefrom, can be used in immunogenic compositions for preventing, treating and diagnosing WNV infection. Also described are highly sensitive ELISA and strip immunoassay methods for detecting the presence of WNV in biological samples.
摘要翻译：描述了免疫原性西尼罗病毒（WNV）蛋白的重组产生。包含蛋白质的这些蛋白质，其融合物，编码蛋白质的多核苷酸及其组合以及由其产生的抗体可用于预防，治疗和诊断WNV感染的免疫原性组合物中。还描述了用于检测生物样品中WNV存在的高灵敏度ELISA和条带免疫测定方法。

3. 发明申请

US20050255124A1 HCV E1E2 vaccine compositions 审中-公开
标题翻译： HCV E1E2疫苗组合物
公开(公告)号：US20050255124A1
公开(公告)日：2005-11-17
申请号：US11154324
申请日：2005-06-16
申请人： Michael Hougton , Stephen Coates , Derek O'Hagan , Yiu-Lian Fong
发明人： Michael Hougton , Stephen Coates , Derek O'Hagan , Yiu-Lian Fong
IPC分类号： A61K39/29 , A01N43/04 , A61K9/107 , A61K31/70 , A61K39/12 , A61K39/39 , A61K45/00 , A61K47/00 , A61K47/06 , A61K47/22 , A61K47/34 , A61K48/00 , A61P1/16 , A61P31/12 , A61P31/14 , A61P37/04 , C07K14/18 , C12N15/09 , C12Q1/68 , C12Q1/70
CPC分类号： C07K14/005 , A61K39/12 , A61K39/29 , A61K2039/5555 , A61K2039/55561 , A61K2039/55566 , A61K2039/57 , C12N2770/24222 , C12N2770/24234
摘要： HCV E1E2 compositions comprising E1E2 antigens, submicron oil-in-water emulsions and/or immunostimulatory nucleic acid sequences are described. The compositions can be used in methods of stimulating an immune response in a vertebrate subject.
摘要翻译：描述了包含E1E2抗原的HCV E1E2组合物，亚微米水包油乳剂和/或免疫刺激性核酸序列。该组合物可用于刺激脊椎动物受试者的免疫应答的方法。

4. 发明授权

US08693518B2 High temperature industrial furnace roof system 有权
标题翻译：高温工业炉顶系统
公开(公告)号：US08693518B2
公开(公告)日：2014-04-08
申请号：US12556448
申请日：2009-09-09
申请人： Fred Lindeman , Stephen Coates , William R. Materna , Timothy Park
发明人： Fred Lindeman , Stephen Coates , William R. Materna , Timothy Park
IPC分类号： F27D1/02 , F27D1/00 , F23M5/06 , F23M5/02
CPC分类号： F27D1/025 , C03B18/16 , F27D11/02 , F27D99/0006
摘要： A high temperature industrial furnace roof system having first and second spaced apart hanger brick rows with a filler row disposed therebetween and a cable system including a plurality of electrical cables. The filler row includes a plurality of filler elements having at least one removable heating module with a heat source. The cable system operatively connects the heat source with a power source and permits the removable heating module to be removed from the respective filler element while the respective heat source remains operatively connected with the power source.
摘要翻译：一种高温工业炉顶系统，具有第一和第二间隔开的衣架砖排，其间设置有填料排，以及包括多根电缆的电缆系统。填料行包括多个填充元件，其具有至少一个具有热源的可移除加热模块。电缆系统可操作地将热源与电源连接，并允许可拆卸加热模块从相应的填充元件移除，同时相应的热源保持与电源的操作性连接。

5. 发明授权

US06427610B1 High temperature industrial furnace roof structure 有权
标题翻译：高温工业炉顶结构
公开(公告)号：US06427610B1
公开(公告)日：2002-08-06
申请号：US09685996
申请日：2000-10-11
申请人： Stephen Coates , Barry R. James
发明人： Stephen Coates , Barry R. James
IPC分类号： F23M502
CPC分类号： F27D1/021 , F27D1/04
摘要： A refractory hanger brick for high temperature industrial furnace roof construction having an elongated upwardly extending refractory portion having a generally rectangular cross section and a lower refractory base portion having a generally rectangular lower face, each side of the base portion having a base length greater than a corresponding side of the elongated upwardly extending refractory portion so as to provide support for insulating material and/or adjacent filler bricks. The upper end of the elongated upwardly extending refractory portion distal from the lower refractory base portion forms a hanger recess along opposite sides of the upper end. At least one generally laterally extending lug is disposed above each of the hanger recesses to retain the hanger in a fixed position and to provide at least one hanger position along the upper end opposite sides.
摘要翻译：一种用于高温工业炉屋顶结构的耐火衣架砖，具有具有大致矩形横截面的细长向上延伸的耐火部分和具有大致矩形下表面的下耐火基座部分，基部部分的每一侧具有大于延伸的向上延伸的耐火部分的相应侧面，以便为绝缘材料和/或相邻填料砖提供支撑。远离下部耐火材料基部的细长向上延伸的耐火材料部分的上端沿着上端的相对侧形成一个衣架凹槽。至少一个大致横向延伸的凸耳设置在每个悬挂器凹部上方，以将衣架保持在固定位置，并且沿着上端相对侧提供至少一个悬挂器位置。

6. 发明申请

US20110058589A1 HIGH TEMPERATURE INDUSTRIAL FURNACE ROOF SYSTEM 有权
标题翻译：高温工业炉室系统
公开(公告)号：US20110058589A1
公开(公告)日：2011-03-10
申请号：US12556448
申请日：2009-09-09
申请人： Fred LINDEMAN , Stephen Coates , William R. Materna , Timothy Park
发明人： Fred LINDEMAN , Stephen Coates , William R. Materna , Timothy Park
IPC分类号： C03B5/42 , F23M5/02 , C03B5/027
CPC分类号： F27D1/025 , C03B18/16 , F27D11/02 , F27D99/0006
摘要： A high temperature industrial furnace roof system having first and second spaced apart hanger brick rows with a filler row disposed therebetween and a cable system including a plurality of electrical cables. The filler row includes a plurality of filler elements having at least one removable heating module with a heat source. The cable system operatively connects the heat source with a power source and permits the removable heating module to be removed from the respective filler element while the respective heat source remains operatively connected with the power source.
摘要翻译：一种高温工业炉顶系统，具有第一和第二间隔开的衣架砖排，其间设置有填料排，以及包括多根电缆的电缆系统。填料行包括多个填充元件，其具有至少一个具有热源的可移除加热模块。电缆系统可操作地将热源与电源连接，并允许可拆卸加热模块从相应的填充元件移除，同时相应的热源保持与电源的操作性连接。

7. 发明申请

US20090027822A1 Transient blocking unit having a fab-adjustable threshold current 审中-公开
标题翻译：具有晶圆厂可调阈值电流的瞬态阻断单元
公开(公告)号：US20090027822A1
公开(公告)日：2009-01-29
申请号：US12220798
申请日：2008-07-25
申请人： Mohamed N. Darwish , Tao Wei , Stephen Coates , Richard A. Harris , Andrew J. Morrish
发明人： Mohamed N. Darwish , Tao Wei , Stephen Coates , Richard A. Harris , Andrew J. Morrish
IPC分类号： H02H3/22 , H01L21/8234
CPC分类号： H02H9/025 , H01L27/0266 , H01L2224/49113 , H01L2924/13062 , H01L2924/13091 , H01L2924/3011 , H02H3/006 , H01L2924/00
摘要： A transient blocking unit (TBU) is a transistor circuit that is normally on, but rapidly and automatically switches to a high-resistance current blocking state when a current threshold is exceeded, thereby protecting a series connected load from over-voltage or over-current conditions. Process variation of transistor threshold voltage and on-resistance can cause undesirable variation of the TBU threshold current and/or of TBU resistance. Control of TBU threshold current and/or resistance is improved by providing for trimming the TBU during its fabrication to provide a one-time adjustment of the threshold current or resistance. Such trimming can be done with a resistive trimming circuit placed in series with the on-resistance of the relevant TBU transistor. Alternatively, a segmented TBU transistor having an on-resistance that is adjustable by way of wire bonding during fabrication can be employed.
摘要翻译：瞬态阻断单元（TBU）是通常导通的晶体管电路，但当超过电流阈值时，会迅速自动切换到高电阻电流阻断状态，从而保护串联负载免受过电压或过流条件。晶体管阈值电压和导通电阻的工艺变化可能导致TBU阈值电流和/或TBU电阻的不良变化。通过在其制造期间提供修整TBU以提供阈值电流或电阻的一次调整来改善对TBU阈值电流和/或电阻的控制。这种修整可以通过与相关TBU晶体管的导通电阻串联放置的电阻微调电路来完成。或者，可以使用具有在制造期间通过引线键合调节的导通电阻的分段TBU晶体管。

8. 发明授权

US07369387B2 Apparatus and method for temperature-dependent transient blocking 有权
标题翻译：温度依赖性瞬态阻塞的装置和方法
公开(公告)号：US07369387B2
公开(公告)日：2008-05-06
申请号：US11270874
申请日：2005-11-08
申请人： Richard A. Harris , Stephen Coates , Francois Hebert
发明人： Richard A. Harris , Stephen Coates , Francois Hebert
IPC分类号： H02H5/04
CPC分类号： H02H9/025 , H02H5/042 , H02H5/044
摘要： An apparatus and method for temperature-dependent transient blocking employing a transient blocking unit (TBU) that uses at least one depletion mode n-channel device interconnected with at least one depletion mode p-channel device. The interconnection is performed such that a transient alters a bias voltage Vp of the p-channel device and a bias voltage Vn of the n-channel device in concert to effectuate their mutual switch off to block the transient. The apparatus has a temperature control unit that is in communication with the TBU and adjusts at least one of the bias voltages Vp, Vn in response to a sensed temperature Ts, thereby enabling the apparatus to also respond to over-temperature. In some embodiments the p-channel device is replaced with a positive temperature coefficient thermistor (PTC). The temperature control unit can use any suitable circuit element, including, among other a PTC, resistor, negative temperature coefficient element, positive temperature coefficient element, transistor, diode.
摘要翻译：一种采用使用与至少一个耗尽型p沟道器件互连的至少一个耗尽型n沟道器件的瞬态阻塞单元（TBU）的温度依赖性瞬态阻塞的装置和方法。执行互连，使得瞬态改变p沟道器件的偏置电压V SUB p N和N沟道器件的偏置电压V N n N一致地实现他们的相互关闭来阻止瞬态。该装置具有与TBU通信的温度控制单元，并响应于感测到的温度T 1调整至少一个偏置电压V SUB，V SUB，从而使得设备也能够响应过温。在一些实施例中，用正温度系数热敏电阻（PTC）代替p沟道器件。温度控制单元可以使用任何合适的电路元件，包括PTC，电阻器，负温度系数元件，正温度系数元件，晶体管，二极管等。

9. 发明申请

US20080271656A1 Removable filler module 有权
标题翻译：可拆卸的填充模块
公开(公告)号：US20080271656A1
公开(公告)日：2008-11-06
申请号：US11799673
申请日：2007-05-01
申请人： Fred Lindeman , Stephen Coates , William R. Materna , Timothy Park
发明人： Fred Lindeman , Stephen Coates , William R. Materna , Timothy Park
IPC分类号： F23M5/04
CPC分类号： F27D1/021 , C03B18/16 , C03B18/22 , F27D1/04 , F27D1/1621 , F27D99/0001 , F27D2099/0008
摘要： This invention relates to an industrial furnace roof filler element to allow replacement of a failed heat source during operation. The filler element can include a lower portion, a module, an aperture, a protuberance, a bore and/or a heat source. This invention also relates to a method of operation for an industrial furnace wherein a failed heat source is replaced during operation of the industrial furnace.
摘要翻译：本发明涉及一种工业炉顶填料元件，用于在操作期间更换失效的热源。填充元件可以包括下部，模块，孔，突起，孔和/或热源。本发明还涉及一种工业炉的操作方法，其中在工业炉的操作期间更换了失效的热源。

10. 发明申请

US20060176638A1 Minimized wire bonds in transient blocking unit packaging 审中-公开
标题翻译：在瞬态阻塞单元包装中最小化引线键
公开(公告)号：US20060176638A1
公开(公告)日：2006-08-10
申请号：US11249165
申请日：2005-10-12
申请人： Stephen Coates
发明人： Stephen Coates
IPC分类号： H02H9/06
CPC分类号： H01L23/49575 , H01L24/48 , H01L24/49 , H01L25/18 , H01L2224/05554 , H01L2224/48137 , H01L2224/49175 , H01L2224/73265 , H01L2924/00014 , H01L2924/1301 , H01L2924/13055 , H01L2924/13062 , H01L2924/13091 , H01L2924/14 , H01L2924/3011 , H02H9/025 , H01L2924/00 , H01L2224/45099 , H01L2224/45015 , H01L2924/207
摘要： A transient blocking unit (TBU) module which includes a control circuit, for detecting overcurrents, packaged together with integrated over-current protection and discrete over-voltage protection integrated into a single package. In one example embodiment, the present innovations are embodied as a unit for protecting a circuit from high voltage and high current, comprising a transient blocking unit component with at least one high voltage device wherein the transient blocking unit is integrated with the high voltage device.
摘要翻译：瞬态阻塞单元（TBU）模块，其包括用于检测过电流的控制电路，其中集成了过流保护和集成到单个封装中的离散过电压保护。在一个示例实施例中，本发明被实施为用于保护电路免受高电压和高电流的单元，其包括具有至少一个高压器件的瞬态阻塞单元部件，其中瞬态阻断单元与高压器件集成。

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