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1. 发明授权

US07217698B2 Use of mannosamine derivatives for the stimulation of neurite growth 失效
标题翻译：使用甘露糖胺衍生物刺激神经突生长
公开(公告)号：US07217698B2
公开(公告)日：2007-05-15
申请号：US10490934
申请日：2002-09-25
申请人： Werner Reutter , Rüdiger Horstkorte , Carolin Horstkorte
发明人： Werner Reutter , Rüdiger Horstkorte , Carolin Horstkorte
IPC分类号： A61K31/70 , A61K31/7028
CPC分类号： C07H13/04 , A61K31/7008
摘要： The present invention relates to the use of peracylated N-acyl-mannosamine derivatives for the preparation of a medicament for stimulating neurite growth.
摘要翻译：本发明涉及过酰基化N-酰基 - 甘露糖胺衍生物在制备用于刺激神经突生长的药物中的用途。

2. 发明申请

US20050107333A1 Use of mannosamine derivatives for the stimulation of neurite growth 失效
标题翻译：使用甘露糖胺衍生物刺激神经突生长
公开(公告)号：US20050107333A1
公开(公告)日：2005-05-19
申请号：US10490934
申请日：2002-09-25
申请人： Werner Reutter , Rudiger Horstkorte , Carolin Horstkorte
发明人： Werner Reutter , Rudiger Horstkorte , Carolin Horstkorte
IPC分类号： A61K31/7008 , A61P25/00 , C07H13/04
CPC分类号： C07H13/04 , A61K31/7008
摘要： The present invention relates to the use of peracylated N-acyl-mannosamine derivatives for the preparation of a medicament for stimulating neurite growth.
摘要翻译：本发明涉及过酰基化N-酰基 - 甘露糖胺衍生物在制备用于刺激神经突生长的药物中的用途。

3. 发明授权

US06692931B1 Recombinant glycoproteins, method for the production thereof, medicaments containing said glycoproteins and use thereof 失效
标题翻译：重组糖蛋白，其生产方法，含有所述糖蛋白的药物及其用途
公开(公告)号：US06692931B1
公开(公告)日：2004-02-17
申请号：US09831868
申请日：2001-12-13
申请人： Werner Reutter , Rudolf Tauber , Rüdiger Horstkorte , Sabine Nöhring , Martin Gohlke , Rolf Nuck , Richard R. Schmidt , Charlotte Hauser
发明人： Werner Reutter , Rudolf Tauber , Rüdiger Horstkorte , Sabine Nöhring , Martin Gohlke , Rolf Nuck , Richard R. Schmidt , Charlotte Hauser
IPC分类号： C12Q156
CPC分类号： C07K14/47 , A61K38/00 , C07K14/505
摘要： The invention relates to novel recombinant glycoproteins that act as messenger substances, signaling substances, promoters, stimulators and initiators in a multitude of ways in the animal, especially human, circulation system. The invention also relates to a method for the production thereof, pharmaceutical agents containing said glycoproteins and the use thereof The invention more particularly relates to novel recombinant human glycoproteins (rh glycoproteins), preferably novel rh differentiation factors, especially rh erythropoietin; novel rh growth factors, especially rh CSF (colony stimulating factor), rh GMCSF (granulocytes monocytes stimulation factor); novel rh thrombolytic agents, especially rh tPA (tissue plasminogen activator) and rh urokinase; novel rh thromboprophylactic agents, especially rh antithrombin III; novel rh coagulation factors, especially rh factor VIII and rh factor IX; novel rh interferons, especially rh &agr;, &bgr; and &ggr; interferons; and novel rh interleukins, especially rh IL-2, IL-15, IL-16 and IL-17. The invention further relates to a method for the production of said substances, pharmaceutical agents containing them and to the use thereof.
摘要翻译：本发明涉及在动物，特别是人类循环系统中以多种方式用作信使物质，信号物质，促进剂，刺激剂和引发剂的新型重组糖蛋白。本发明还涉及其生产方法，含有所述糖蛋白的药物及其用途。本发明更具体涉及新型重组人糖蛋白（rh糖蛋白），优选新颖的rh分化因子，特别是促红细胞生成素; rh细胞生长因子，特别是rh CSF（集落刺激因子），rhGMCSF（粒细胞单核细胞刺激因子）; 新型rh溶栓剂，特别是rh tPA（组织纤溶酶原激活物）和rh尿激酶; 新型rh血栓预防剂，特别是rh抗凝血酶III; 新型rh凝血因子，特别是rh因子VIII和rh因子IX; 新型rh干扰素，特别是rhα，β和γ干扰素; 和新型rh白介素，特别是rh IL-2，IL-15，IL-16和IL-17。本发明还涉及生产所述物质的方法，含有它们的药剂及其用途。

4. 发明授权

US07465817B2 Inositolized phospholipids 失效
标题翻译：肌醇磷脂
公开(公告)号：US07465817B2
公开(公告)日：2008-12-16
申请号：US10535834
申请日：2003-11-20
申请人： Kerstin Danker , Michael Mickeleit , Dieter Mueller , Werner Reutter
发明人： Kerstin Danker , Michael Mickeleit , Dieter Mueller , Werner Reutter
IPC分类号： C07F9/02
CPC分类号： C07F9/117 , C07F9/10 , C07H15/04
摘要： The present invention relates to a phospholipid dreivative having a substituted or unsubstituted polyhydroxylated aliphatic carbocycle attached to the sn-1 or sn-2 position of the glycerol backbone, a pharmaceutical composition comprising said phospholipid, a method for preparing said phospholipid and a medicament comprising said phospholipid.
摘要翻译：本发明涉及具有连接到甘油骨架的sn-1或sn-2位上的取代或未取代的多羟基化脂族碳环的磷脂衍生物，包含所述磷脂的药物组合物，制备所述磷脂的方法和包含所述磷脂的药物磷脂

5. 发明申请

US20050042714A1 Glycoconjugates of sialic acid derivates, methods for their production and use thereof 审中-公开
标题翻译：唾液酸衍生物的糖缀合物，其制备方法和用途
公开(公告)号：US20050042714A1
公开(公告)日：2005-02-24
申请号：US10487023
申请日：2002-08-17
申请人： Michael Pawlita , Cornelia Oetke , Oliver Keppler , Reinhard Brossmer , Stephan Hinderlich , Werner Reutter
发明人： Michael Pawlita , Cornelia Oetke , Oliver Keppler , Reinhard Brossmer , Stephan Hinderlich , Werner Reutter
IPC分类号： A61K38/00 , C07K14/47 , A61K38/16 , C07K9/00 , C12P21/06
CPC分类号： C07K14/4702 , A61K38/00
摘要： The present invention relates to glycoconjugates containing a sialic acid derivate of general formula (I) and wherein the sialic acid derivate of general formula (I) is conjugated to a mono-, di- or oligosaccharide with up to 40 glycosidically linked, optionally branched sugar residues representing furanose and/or pyranose rings, which are linked N- or O-glycosidically to the polypeptide. The sialic derivatives of general formula (I) are useful for producing pharmaceutical compositions for immunosuppression, cell protection, stimulation of hematopoesis regulation of hormonal secretion and hormonal activation.
摘要翻译：本发明涉及含有通式（I）的唾液酸衍生物的糖缀合物，其中通式（I）的唾液酸衍生物与单糖，二糖或寡糖与多达40个糖苷连接的任选支链糖表示呋喃糖和/或吡喃糖环的残基，其与多肽连接在N-或O-糖苷上。通式（I）的唾液酸衍生物可用于制备用于免疫抑制，细胞保护，刺激造血调节激素分泌和激素激活的药物组合物。

6. 发明授权

US5625037A Antibodies, method of preparing same, oligosaccharides and clones for providing said antibodies, and the use of said antibodies for tumor diagnosis and therapy 失效
标题翻译：抗体，其制备方法，用于提供所述抗体的寡糖和克隆，以及所述抗体用于肿瘤诊断和治疗的用途
公开(公告)号：US5625037A
公开(公告)日：1997-04-29
申请号：US128264
申请日：1993-09-28
申请人： Werner Reutter , Rolf Nuck , Martin Zimmermann
发明人： Werner Reutter , Rolf Nuck , Martin Zimmermann
IPC分类号： C07K16/30 , G01N33/574
CPC分类号： G01N33/57492 , C07K16/30 , C07K16/303 , Y10S436/813
摘要： Antibodies against N-glycan structures of cell membrane surfaces and showing in an ELISA test a positive reaction against antigenic oligosaccharides, said antibodies comprising chitobiose-mannose-trisaccharides.
摘要翻译：针对细胞膜表面的N-聚糖结构的抗体并且在ELISA测试中显示针对抗原寡糖的阳性反应，所述抗体包含壳寡糖 - 甘露糖 - 三糖。

7. 发明申请

US20060105996A1 Inositolized phospholipids 失效
标题翻译：肌醇磷脂
公开(公告)号：US20060105996A1
公开(公告)日：2006-05-18
申请号：US10535834
申请日：2003-11-20
申请人： Kerstin Danker , Michael Mickeleit , Dieter Mueller , Werner Reutter
发明人： Kerstin Danker , Michael Mickeleit , Dieter Mueller , Werner Reutter
IPC分类号： A61K31/685 , C07F9/10
CPC分类号： C07F9/117 , C07F9/10 , C07H15/04
摘要： The present invention relates to a phospholipid dreivative having a substituted or unsubstituted polyhydroxylated aliphatic carbocycle attached to the sn-1 or sn-2 position of the glycerol backbone, a pharmaceutical composition comprising said phospholipid, a method for preparing said phospholipid and a medicament comprising said phospholipid.
摘要翻译：本发明涉及具有连接到甘油骨架的sn-1或sn-2位上的取代或未取代的多羟基化脂族碳环的磷脂衍生物，包含所述磷脂的药物组合物，制备所述磷脂的方法和包含所述磷脂的药物磷脂

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