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1. 发明授权

US06692931B1 Recombinant glycoproteins, method for the production thereof, medicaments containing said glycoproteins and use thereof 失效
标题翻译：重组糖蛋白，其生产方法，含有所述糖蛋白的药物及其用途
公开(公告)号：US06692931B1
公开(公告)日：2004-02-17
申请号：US09831868
申请日：2001-12-13
申请人： Werner Reutter , Rudolf Tauber , Rüdiger Horstkorte , Sabine Nöhring , Martin Gohlke , Rolf Nuck , Richard R. Schmidt , Charlotte Hauser
发明人： Werner Reutter , Rudolf Tauber , Rüdiger Horstkorte , Sabine Nöhring , Martin Gohlke , Rolf Nuck , Richard R. Schmidt , Charlotte Hauser
IPC分类号： C12Q156
CPC分类号： C07K14/47 , A61K38/00 , C07K14/505
摘要： The invention relates to novel recombinant glycoproteins that act as messenger substances, signaling substances, promoters, stimulators and initiators in a multitude of ways in the animal, especially human, circulation system. The invention also relates to a method for the production thereof, pharmaceutical agents containing said glycoproteins and the use thereof The invention more particularly relates to novel recombinant human glycoproteins (rh glycoproteins), preferably novel rh differentiation factors, especially rh erythropoietin; novel rh growth factors, especially rh CSF (colony stimulating factor), rh GMCSF (granulocytes monocytes stimulation factor); novel rh thrombolytic agents, especially rh tPA (tissue plasminogen activator) and rh urokinase; novel rh thromboprophylactic agents, especially rh antithrombin III; novel rh coagulation factors, especially rh factor VIII and rh factor IX; novel rh interferons, especially rh &agr;, &bgr; and &ggr; interferons; and novel rh interleukins, especially rh IL-2, IL-15, IL-16 and IL-17. The invention further relates to a method for the production of said substances, pharmaceutical agents containing them and to the use thereof.
摘要翻译：本发明涉及在动物，特别是人类循环系统中以多种方式用作信使物质，信号物质，促进剂，刺激剂和引发剂的新型重组糖蛋白。本发明还涉及其生产方法，含有所述糖蛋白的药物及其用途。本发明更具体涉及新型重组人糖蛋白（rh糖蛋白），优选新颖的rh分化因子，特别是促红细胞生成素; rh细胞生长因子，特别是rh CSF（集落刺激因子），rhGMCSF（粒细胞单核细胞刺激因子）; 新型rh溶栓剂，特别是rh tPA（组织纤溶酶原激活物）和rh尿激酶; 新型rh血栓预防剂，特别是rh抗凝血酶III; 新型rh凝血因子，特别是rh因子VIII和rh因子IX; 新型rh干扰素，特别是rhα，β和γ干扰素; 和新型rh白介素，特别是rh IL-2，IL-15，IL-16和IL-17。本发明还涉及生产所述物质的方法，含有它们的药剂及其用途。

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