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1. 发明申请

US20100324319A1 Tame based chelators and uses thereof 失效
公开(公告)号：US20100324319A1
公开(公告)日：2010-12-23
申请号：US12803835
申请日：2010-07-07
申请人： Enver ARSLANTAS , Richard R. SCHMIDT , Peter M. SMITH-JONES , Gerd RITTER
发明人： Enver ARSLANTAS , Richard R. SCHMIDT , Peter M. SMITH-JONES , Gerd RITTER
IPC分类号： C07F5/00 , C07C229/36
CPC分类号： C07C229/16 , A61K51/0478 , C07C331/28
摘要： New bifunctional chelation complexes are described. These are based on the structure of the so-called “TAME-HexA” molecule. The compounds are especially useful for forming chelation complexes with metal ions, including radioisotopes.

2. 发明授权

US07780947B2 Tame based chelators and uses thereof 有权
标题翻译：温驯的螯合剂及其用途
公开(公告)号：US07780947B2
公开(公告)日：2010-08-24
申请号：US10582195
申请日：2004-12-03
申请人： Enver Arslantas , Richard R. Schmidt , Peter M. Smith-Jones , Gerd Ritter
发明人： Enver Arslantas , Richard R. Schmidt , Peter M. Smith-Jones , Gerd Ritter
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： C07C229/16 , A61K51/0478 , C07C331/28
摘要： New bifunctional chelation complexes are described. These are based on the structure of the so-called “TAME-HexA” molecule. The compounds are especially useful for forming chelation complexes with metal ions, including radioisotopes.
摘要翻译：描述了新的双功能螯合配合物。这些基于所谓的“TAME-HexA”分子的结构。该化合物特别可用于形成与金属离子的螯合络合物，包括放射性同位素。

3. 发明授权

US06692931B1 Recombinant glycoproteins, method for the production thereof, medicaments containing said glycoproteins and use thereof 失效
标题翻译：重组糖蛋白，其生产方法，含有所述糖蛋白的药物及其用途
公开(公告)号：US06692931B1
公开(公告)日：2004-02-17
申请号：US09831868
申请日：2001-12-13
申请人： Werner Reutter , Rudolf Tauber , Rüdiger Horstkorte , Sabine Nöhring , Martin Gohlke , Rolf Nuck , Richard R. Schmidt , Charlotte Hauser
发明人： Werner Reutter , Rudolf Tauber , Rüdiger Horstkorte , Sabine Nöhring , Martin Gohlke , Rolf Nuck , Richard R. Schmidt , Charlotte Hauser
IPC分类号： C12Q156
CPC分类号： C07K14/47 , A61K38/00 , C07K14/505
摘要： The invention relates to novel recombinant glycoproteins that act as messenger substances, signaling substances, promoters, stimulators and initiators in a multitude of ways in the animal, especially human, circulation system. The invention also relates to a method for the production thereof, pharmaceutical agents containing said glycoproteins and the use thereof The invention more particularly relates to novel recombinant human glycoproteins (rh glycoproteins), preferably novel rh differentiation factors, especially rh erythropoietin; novel rh growth factors, especially rh CSF (colony stimulating factor), rh GMCSF (granulocytes monocytes stimulation factor); novel rh thrombolytic agents, especially rh tPA (tissue plasminogen activator) and rh urokinase; novel rh thromboprophylactic agents, especially rh antithrombin III; novel rh coagulation factors, especially rh factor VIII and rh factor IX; novel rh interferons, especially rh &agr;, &bgr; and &ggr; interferons; and novel rh interleukins, especially rh IL-2, IL-15, IL-16 and IL-17. The invention further relates to a method for the production of said substances, pharmaceutical agents containing them and to the use thereof.
摘要翻译：本发明涉及在动物，特别是人类循环系统中以多种方式用作信使物质，信号物质，促进剂，刺激剂和引发剂的新型重组糖蛋白。本发明还涉及其生产方法，含有所述糖蛋白的药物及其用途。本发明更具体涉及新型重组人糖蛋白（rh糖蛋白），优选新颖的rh分化因子，特别是促红细胞生成素; rh细胞生长因子，特别是rh CSF（集落刺激因子），rhGMCSF（粒细胞单核细胞刺激因子）; 新型rh溶栓剂，特别是rh tPA（组织纤溶酶原激活物）和rh尿激酶; 新型rh血栓预防剂，特别是rh抗凝血酶III; 新型rh凝血因子，特别是rh因子VIII和rh因子IX; 新型rh干扰素，特别是rhα，β和γ干扰素; 和新型rh白介素，特别是rh IL-2，IL-15，IL-16和IL-17。本发明还涉及生产所述物质的方法，含有它们的药剂及其用途。

4. 发明授权

US4952683A Process for the preparation of sphingosine derivatives 失效
标题翻译：鞘氨醇衍生物的制备方法
公开(公告)号：US4952683A
公开(公告)日：1990-08-28
申请号：US137957
申请日：1987-12-24
申请人： Roland Tschannen , Wolfgang Fraefel , Richard R. Schmidt , Rudolf Klager , Peter Zimmermann
发明人： Roland Tschannen , Wolfgang Fraefel , Richard R. Schmidt , Rudolf Klager , Peter Zimmermann
IPC分类号： A61K31/70 , C07H15/10
CPC分类号： C07H15/10 , Y02P20/55
摘要： New compounds of the formula (I)-D and (I)-L as shown in the sheet of formulae are described, for example D- and L-erythro-1-(.beta.-D-glycopyranosyloxy)-3-hydroxy-2-palmitoylamino-4-trans-octadecene, which exert actions promoting wound healing and cell and tissue regeneration, and can be used therapeutically for the treatment of wounds of any cause. They are prepared in good yield and in a stereochemically homogeneous form from ceramides of the formula (II)-D and/or (II)-L. The process comprises the protection of the 1-hydroxyl group, esterification of the 3-hydroxyl group, elimination of the 1-hydroxyl protective group, reaction with the trifluoroacetimidate or trichloroacetimidate of a 2,3,4,6-tetraacylated D-glucose and elimination of the O-acyl groups. When a D,L-ceramide (II) is used, the esterification of the 3-hydroxyl group is carried out by an optically active acid followed by separation into the diastereomers, or separation into the diastereomers is carried out after the reaction with the D-glucose derivative.
摘要翻译：描述了式（I）-D和（I）-L的新化合物，如式中所示，例如D-和L-赤式-1-（β-D-糖吡喃糖基氧基）-3-羟基-2 - 棕榈酰氨基-4-反式十八碳烯，其发挥促进伤口愈合和细胞和组织再生的作用，并且可以用于治疗任何原因的伤口。它们以良好的收率和立体化学均匀的形式由式（II）-D和/或（II）-L的神经酰胺制备。该方法包括1-羟基的保护，3-羟基的酯化，1-羟基保护基的消除，与3,4,4,6-四酰化D-葡萄糖的三氟乙酰亚胺酸酯或三氯乙酰亚胺酸酯的反应，以及消除O-酰基。当使用D，L-神经酰胺（II）时，3-羟基的酯化通过光学活性酸进行，然后分离成非对映异构体，或者在与D反应后进行非对映异构体的分离 - 葡萄糖衍生物。

5. 发明授权

US06242583B1 Carbohydrate derivatives and their solid-phase synthesis 失效
标题翻译：碳水化合物衍生物及其固相合成
公开(公告)号：US06242583B1
公开(公告)日：2001-06-05
申请号：US09171566
申请日：1998-10-21
申请人： Richard R. Schmidt , Jörg Rademann
发明人： Richard R. Schmidt , Jörg Rademann
IPC分类号： C07H100
CPC分类号： C07H5/10 , C07H3/06
摘要： The invention relates to carbohydrate derivatives, to a process for their preparation and to their use.
摘要翻译：本发明涉及碳水化合物衍生物，其制备方法及其应用。

6. 发明授权

US5498704A Preparation of alkyl glycosides 失效
标题翻译：烷基糖苷的制备
公开(公告)号：US5498704A
公开(公告)日：1996-03-12
申请号：US302779
申请日：1994-09-21
申请人： Gerhard Wolf , Alfred Oftring , Guenter Oetter , Richard R. Schmidt , Wolfgang Klotz
发明人： Gerhard Wolf , Alfred Oftring , Guenter Oetter , Richard R. Schmidt , Wolfgang Klotz
IPC分类号： C07H1/00 , C07H15/04 , C11D1/14 , C11D1/66 , C11D1/68 , C11D1/83 , C07H17/00
CPC分类号： C07H15/04 , C11D1/662 , C11D1/83 , C11D1/146
摘要： A process is described for preparing alkyl glycosides by reacting reducing saccharides with dialkyl sulfate whose alkyl groups contain at least 6 carbon atoms, in a molar ratio of saccharides to dialkyl sulfate of 1:1 to 1:5, the reaction mixtures, which contain alkyl monoglycosides and alcohol sulfates as essential constituents, being used as surfactants, preferably in detergents and cleaning agents.
摘要翻译： PCT No.PCT / EP93 / 00875 Sec。 371日期1994年9月21日 102（e）1994年9月21日PCT PCT 1993年4月8日PCT公布。公开号WO93 / 21197 日本专利日：1993年10月28日。描述了一种制备烷基糖苷的方法，其中还原糖与烷基含有至少6个碳原子的二烷基硫酸盐以糖与二烷基硫酸盐的摩尔比为1:1至1:5，含有烷基单糖苷和醇硫酸盐作为必需组分的反应混合物用作表面活性剂，优选用于洗涤剂和清洁剂。

7. 发明授权

US5371203A Process for the stereoselective preparation of .beta.-fucopyranosyl phosphates and very pure GDP-fucose 失效
标题翻译：用于立体选择性制备β-吡喃半乳糖基磷酸酯和非常纯的GDP-岩藻糖的方法
公开(公告)号：US5371203A
公开(公告)日：1994-12-06
申请号：US828617
申请日：1992-01-31
申请人： Richard R. Schmidt , Karl-Heinz Jung , Barbara Spahngehl , Willy Kinzy , Jurgen Hemberger
发明人： Richard R. Schmidt , Karl-Heinz Jung , Barbara Spahngehl , Willy Kinzy , Jurgen Hemberger
IPC分类号： C07H11/04 , C07H15/18 , C07H19/207 , C07H1/00
CPC分类号： C07H19/207 , C07H11/04
摘要： The invention relates to a process for the stereoselective preparation of .beta.-L-fucopyranosyl phosphates via the trichloroacetimidates of protected L-fucose and the synthesis and purification of very pure GDP-fucose from the .beta.-L-fucopyranosyl phosphates.
摘要翻译：本发明涉及通过受保护的L-岩藻糖的三氯乙酰亚胺酯立体选择性制备β-L-吡喃葡萄糖基磷酸酯的方法，以及从β-L-吡喃葡萄糖基磷酸酯合成和纯化非常纯的GDP-岩藻糖。

8. 发明授权

US4777273A Preparation of alkyl (6R,7S,8R)-6,9-dihydroxy-7,8-isopropylidenedioxy-2,4-nonadienoates and their use for the preparation of D-biotin 失效
标题翻译：（6R，7S，8R）-6,9-二羟基-7,8-异亚丙基二氧基-2,4-非二烯酸的制备及其用于制备D-生物素
公开(公告)号：US4777273A
公开(公告)日：1988-10-11
申请号：US899792
申请日：1986-08-25
申请人： Richard R. Schmidt , Martin Maier
发明人： Richard R. Schmidt , Martin Maier
IPC分类号： C07D317/30
CPC分类号： C07D317/30
摘要： Alkyl (6R,7S,8R)-6,9-dihydroxy-7,8-isopropylidenedioxy-2,4-nonadienoates of the formula I ##STR1## where R is alkyl of 1 to 4 carbon atoms are prepared by reacting 3,5-O-isopropylidene-D-arabinose of the formula II ##STR2## with a 3-carboalkoxyprop-2-en-1-ylidene triphenylphosphorane of the formula III ##STR3## in a solvent at elevated temperatures, by a process wherein the reaction is carried out in, as the solvent, a suitable aliphatic or aromatic hydrocarbon, a halogen derivative thereof or a cycloaliphatic ether, preferably an aromatic hydrocarbon of 6 to 8 carbon atoms, at from 65 to 130.degree. C., preferably from 80 to 115.degree. C.Using this process, the basic skeleton of d-biotin can be synthesized from D-arabinose in substantially better yields than obtainable hitherto.
摘要翻译：通式I（I）的烷基（6R，7S，8R）-6,9-二羟基-7,8-异亚丙基二氧基-2,4-非二烯酸酯其中R是1至4个碳原子的烷基是通过使式（II）的3,5-二异丙基-D-阿拉伯糖与式III的3-碳烷氧基-2-丙烯-1-基三苯基正膦（III）在升高的溶剂中反应温度，其中反应在溶剂中进行，其中反应在65-130℃下作为溶剂进行合适的脂族或芳族烃，其卤素衍生物或脂环族醚，优选6至8个碳原子的芳族烃。优选为80-115℃。使用该方法，可以从D-阿拉伯糖合成D-生物素的基本骨架，其产率远高于迄今所得的产率。

9. 发明授权

US08173102B2 Tame based chelators and uses thereof 失效
标题翻译：温驯的螯合剂及其用途
公开(公告)号：US08173102B2
公开(公告)日：2012-05-08
申请号：US12803835
申请日：2010-07-07
申请人： Enver Arslantas , Richard R. Schmidt , Peter M. Smith-Jones , Gerd Ritter
发明人： Enver Arslantas , Richard R. Schmidt , Peter M. Smith-Jones , Gerd Ritter
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： C07C229/16 , A61K51/0478 , C07C331/28
摘要： New bifunctional chelation complexes are described. These are based on the structure of the so-called “TAME-HexA” molecule. The compounds are especially useful for forming chelation complexes with metal ions, including radioisotopes.
摘要翻译：描述了新的双功能螯合配合物。这些基于所谓的“TAME-HexA”分子的结构。该化合物特别可用于形成与金属离子的螯合络合物，包括放射性同位素。

10. 发明授权

US5126441A Bisglycosides 失效
标题翻译： BISGLYCOSIDES
公开(公告)号：US5126441A
公开(公告)日：1992-06-30
申请号：US655776
申请日：1991-02-15
申请人： Gerhard Wolf , Richard R. Schmidt , Karin Jankowski , Andreas Terjung
发明人： Gerhard Wolf , Richard R. Schmidt , Karin Jankowski , Andreas Terjung
IPC分类号： C07C31/20 , C07C215/12 , C07H15/04 , C07H15/10 , C11D1/66 , C11D3/22
CPC分类号： A61K8/602 , A61Q19/00 , C07C215/12 , C07C31/20 , C07H15/04 , C07H15/10 , C11D1/662
摘要： Bisglycosides IGly--O--CHR.sup.2 --(CH.sub.2).sub.p --(XR.sup.1).sub.n --(CH.sub.2).sub.q --(CHR.sup.3).sub.m --O--Gly IwhereX is C--R.sup.4 or N,R.sup.1 is C.sub.1 -C.sub.30 -alkyl, C.sub.2 -C.sub.30 -alkenyl, O--C.sub.1 -C.sub.30 -alkyl or O--C.sub.2 -C.sub.30 -alkenyl when X is C--R.sup.4, and is CO--C.sub.1 -C.sub.30 -alkyl or CO--C.sub.2 -C.sub.30 -alkenyl when X is N,R.sup.2 to R.sup.4 are each hydrogen, C.sub.1 -C.sub.30 -alkyl or C.sub.2 -C.sub.30 -alkenyl,n is from 1 to 3,m is 0 or 1,p and q are each from 0 to 2 andGly is a mono- or disaccharide composed of aldopentoses,aldohexoses and/or ketohexoses,are used as surfactants or emulsifiers in detergents, cleaning agents and toiletries.
摘要翻译：双甘草苷I Gly-O-CHR2-（CH2）p-（XR1）n-（CH2）q-（CHR3）mO-Gly1其中X是C-R4或N，R1是C1-C30-烷基，C2-C30 当X为C-R 4时为O-C 1 -C 30 - 烷基或O-C 2 -C 30 - 烯基，并且当X为N时为CO-C 1 -C 30 - 烷基或CO-C 2 -C 30烯基各自为氢，C 1 -C 30 - 烷基或C 2 -C 30 - 烯基，n为1至3，m为0或1，p和q各自为0至2，Gly为由戊糖醛酸组成的单糖或二糖，己糖和/或酮己糖作为表面活性剂或乳化剂用于洗涤剂，清洁剂和洗浴用品。

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