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1. 发明授权

US5571708A Thrombin-activatable plasminogen activator 失效
标题翻译：凝血酶激活性纤溶酶原激活物
公开(公告)号：US5571708A
公开(公告)日：1996-11-05
申请号：US49195
申请日：1993-04-19
申请人： Wen-Pin Yang , Gary R. Matsueda , Shyh-Yu Shaw
发明人： Wen-Pin Yang , Gary R. Matsueda , Shyh-Yu Shaw
IPC分类号： A61K38/00 , C07K16/18 , C12N9/72 , C12P21/08 , A61K38/48 , C07H19/00 , C07K16/00
CPC分类号： C12N9/6462 , C07K16/18 , C12Y304/21073 , A61K38/00 , C07K2319/00
摘要： A new chimeric plasminogen activator with high fibrin affinity was designed to bind to a fibrin clot and initiate clot destruction in the presence of thrombin, but not plasmin. The chimeric molecule has an antibody variable region having a fibrin-specific antigen binding site and a single chain urokinase region having a thrombin activation site but not a plasmin activation site. The preferred embodiment, 59D8-ScuPA-T, has an N-terminal fragment of an anti-fibrin antibody (59DB) and a C-terminal thrombin-activatable low molecular weight single-chain urokinase plasminogen activator (scuPA-T). The scuPA-T portion was obtained by deletion of two amino acids (Phe157 and Lys 158) that make up the plasmin activation site from low molecular weight single chain urokinase-type plasminogen activator (scuPA).
摘要翻译：设计具有高纤维蛋白亲和力的新的嵌合纤溶酶原激活物结合纤维蛋白凝块，并在凝血酶存在下引发凝块破坏，而不是纤溶酶。嵌合分子具有具有纤维蛋白特异性抗原结合位点的抗体可变区和具有凝血酶活化位点而不是纤溶酶活化位点的单链尿激酶区。优选的实施方案59D8-ScuPA-T具有抗纤维蛋白抗体（59DB）和C末端凝血酶激活的低分子量单链尿激酶纤溶酶原激活物（scuPA-T）的N-末端片段。通过从低分子量单链尿激酶型纤溶酶原激活物（scuPA）中缺失构成纤溶酶活化位点的两个氨基酸（Phe157和Lys158）获得scuPA-T部分。

2. 发明授权

US07557437B2 Fan out type wafer level package structure and method of the same 有权
标题翻译：扇出式晶圆级封装结构及其方法
公开(公告)号：US07557437B2
公开(公告)日：2009-07-07
申请号：US11946424
申请日：2007-11-28
申请人： Wen-Kun Yang , Wen-Pin Yang , Shih-Li Chen
发明人： Wen-Kun Yang , Wen-Pin Yang , Shih-Li Chen
IPC分类号： H01L23/02
CPC分类号： H01L21/561 , H01L23/3128 , H01L23/5389 , H01L24/19 , H01L24/20 , H01L24/97 , H01L25/0655 , H01L25/0657 , H01L2224/0401 , H01L2224/04105 , H01L2224/12105 , H01L2224/20 , H01L2224/211 , H01L2224/24137 , H01L2224/24195 , H01L2224/32225 , H01L2224/73267 , H01L2224/92244 , H01L2224/97 , H01L2225/06524 , H01L2225/06541 , H01L2225/06551 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01015 , H01L2924/01019 , H01L2924/01027 , H01L2924/01029 , H01L2924/01033 , H01L2924/01068 , H01L2924/01074 , H01L2924/01075 , H01L2924/01076 , H01L2924/01077 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/09701 , H01L2924/14 , H01L2924/15173 , H01L2924/15311 , H01L2924/15788 , H01L2924/19041 , H01L2224/82 , H01L2924/00
摘要： To pick and place standard dice on a new base for obtaining an appropriate and wider distance between dice than the original distance of dice on a wafer. The package structure has a larger size of balls array than the size of the die by fan out type package. Moreover, the die may be packaged with passive components or other dice with a side by side structure or a stacking structure.
摘要翻译：在新的基础上选择和放置标准骰子，以获得骰子之间适当和更宽的距离，而不是晶片上骰子的原始距离。包装结构具有比通过扇出型包装的模具尺寸更大的球阵列尺寸。此外，管芯可以与被动部件或其他具有并排结构或堆叠结构的管芯封装。

3. 发明授权

US07482431B2 KCNQ2 potassium channels 有权
标题翻译： KCNQ2钾通道
公开(公告)号：US07482431B2
公开(公告)日：2009-01-27
申请号：US11707363
申请日：2007-02-16
申请人： Michael A. Blanar , Paul C. Levesque , Wayne A. Little , Michael G. Neubauer , Wen-Pin Yang
发明人： Michael A. Blanar , Paul C. Levesque , Wayne A. Little , Michael G. Neubauer , Wen-Pin Yang
IPC分类号： C07K14/705
CPC分类号： C07K14/705 , A61K48/00
摘要： The present invention relates to KCNQ proteins defining potassium channels. In particular, the invention concerns the human KCNQ2, human KCNQ3, murine KCNQ2, and rat KCNQ2 proteins reported herein. KCNQ2 and KCNQ3 proteins are nervous system-selective and may be involved in neurotransmission and neuroprotection. The KCNQ2 and KCNQ3 of the present invention can be used to assay for modulators of the proteins, which would be useful in treatment of such disorders as ataxia, myokymia, seizures, Alzheimer's disease, Parkinson's disease, age-associated memory loss, learning deficiencies, motor neuron diseases, epilepsy, stroke, and the like.
摘要翻译：本发明涉及定义钾通道的KCNQ蛋白。特别地，本发明涉及本文报道的人KCNQ2，人类KCNQ3，鼠KCNQ2和大鼠KCNQ2蛋白。 KCNQ2和KCNQ3蛋白是神经系统选择性的，可能参与神经传递和神经保护。本发明的KCNQ2和KCNQ3可用于测定蛋白质的调节剂，其可用于治疗诸如共济失调，myokymia，癫痫发作，阿尔茨海默氏病，帕金森病，年龄相关记忆丧失，学习缺陷，运动神经元疾病，癫痫，中风等。

4. 发明授权

US07262289B2 KCNQ potassium channels and methods of modulating same 有权
标题翻译： KCNQ钾通道及其调节方法
公开(公告)号：US07262289B2
公开(公告)日：2007-08-28
申请号：US10131685
申请日：2002-04-24
申请人： Michael A. Blanar , Wen-Pin Yang , Paul C. Levesque , Michael G. Neubauer , Wayne A. Little
发明人： Michael A. Blanar , Wen-Pin Yang , Paul C. Levesque , Michael G. Neubauer , Wayne A. Little
IPC分类号： C12N14/705
CPC分类号： C07K14/705 , A61K48/00
摘要： The present invention relates to KCNQ proteins defining potassium channels. In particular, the invention concerns the human KCNQ2, human KCNQ3, murine KCNQ2, and rat KCNQ2 proteins reported herein. KCNQ2 and KCNQ3 proteins are nervous system-selective and may be involved in neurotransmission and neuroprotection. The KCNQ2 and KCNQ3 of the present invention can be used to assay for modulators of the proteins, which would be useful in treatment of such disorders as ataxia, myokymia, seizures, Alzheimer's disease, Parkinson's disease, age-associated memory loss, learning deficiencies, motor neuron diseases, epilepsy, stroke, and the like.
摘要翻译：本发明涉及定义钾通道的KCNQ蛋白。特别地，本发明涉及本文报道的人KCNQ2，人类KCNQ3，鼠KCNQ2和大鼠KCNQ2蛋白。 KCNQ2和KCNQ3蛋白是神经系统选择性的，可能参与神经传递和神经保护。本发明的KCNQ2和KCNQ3可用于测定蛋白质的调节剂，其可用于治疗诸如共济失调，myokymia，癫痫发作，阿尔茨海默氏病，帕金森病，年龄相关记忆丧失，学习缺陷，运动神经元疾病，癫痫，中风等。

5. 发明授权

US07196408B2 Fan out type wafer level package structure and method of the same 有权
标题翻译：扇出式晶圆级封装结构及其方法
公开(公告)号：US07196408B2
公开(公告)日：2007-03-27
申请号：US11301303
申请日：2005-12-12
申请人： Wen-Kun Yang , Wen-Pin Yang , Shih-Li Chen
发明人： Wen-Kun Yang , Wen-Pin Yang , Shih-Li Chen
IPC分类号： H01L23/02
CPC分类号： H01L21/561 , H01L23/3128 , H01L23/5389 , H01L24/19 , H01L24/20 , H01L24/97 , H01L25/0655 , H01L25/0657 , H01L2224/0401 , H01L2224/04105 , H01L2224/12105 , H01L2224/20 , H01L2224/211 , H01L2224/24137 , H01L2224/24195 , H01L2224/32225 , H01L2224/73267 , H01L2224/92244 , H01L2224/97 , H01L2225/06524 , H01L2225/06541 , H01L2225/06551 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01015 , H01L2924/01019 , H01L2924/01027 , H01L2924/01029 , H01L2924/01033 , H01L2924/01068 , H01L2924/01074 , H01L2924/01075 , H01L2924/01076 , H01L2924/01077 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/09701 , H01L2924/14 , H01L2924/15173 , H01L2924/15311 , H01L2924/15788 , H01L2924/19041 , H01L2224/82 , H01L2924/00
摘要： To pick and place standard dies on a new base for obtaining an appropriate and wider distance between dies than the original distance of dies on a wafer. The package structure has a larger size of balls array than the size of the die by fan out type package. Moreover, the die may be packaged with passive components or other dies with a side by side structure or a stacking structure.
摘要翻译：在新的基座上选择和放置标准模具，以获得模具之间适当和更宽的距离，而不是晶片上的模具的原始距离。包装结构具有比通过扇出型包装的模具尺寸更大的球阵列尺寸。此外，模具可以与被动部件或具有并排结构或堆叠结构的其它模具一起封装。

6. 发明授权

US07041496B2 DNA encoding rodent KCNQ2 potassium channel 有权
标题翻译：编码啮齿动物KCNQ2钾通道的DNA
公开(公告)号：US07041496B2
公开(公告)日：2006-05-09
申请号：US10128870
申请日：2002-04-24
申请人： Michael A. Blanar , Steven Dworetzky , Wen-Pin Yang , Paul C. Levesque , Valentin K. Gribkoff , Michael G. Neubauer , Wayne A. Little
发明人： Michael A. Blanar , Steven Dworetzky , Wen-Pin Yang , Paul C. Levesque , Valentin K. Gribkoff , Michael G. Neubauer , Wayne A. Little
IPC分类号： C12N15/11 , C12N5/10 , C12N15/63
CPC分类号： C07K14/705 , A61K48/00
摘要： The present invention relates to KCNQ proteins defining potassium channels. In particular, the invention concerns the human KCNQ2, human KCNQ3, murine KCNQ2, and rat KCNQ2 proteins reported herein. KCNQ2 and KCNQ3 proteins are nervous system-selective and may be involved in neurotransmission and neuroprotection. The KCNQ2 and KCNQ3 of the present invention can be used to assay for modulators of the proteins, which would be useful in treatment of such disorders as ataxia, myokymia, seizures, Alzheimer's disease, Parkinson's disease, age-associated memory loss, learning deficiencies, motor neuron diseases, epilepsy, stroke, and the like.
摘要翻译：本发明涉及定义钾通道的KCNQ蛋白。特别地，本发明涉及本文报道的人KCNQ2，人类KCNQ3，鼠KCNQ2和大鼠KCNQ2蛋白。 KCNQ2和KCNQ3蛋白是神经系统选择性的，可能参与神经传递和神经保护。本发明的KCNQ2和KCNQ3可用于测定蛋白质的调节剂，其可用于治疗诸如共济失调，myokymia，癫痫发作，阿尔茨海默氏病，帕金森病，年龄相关记忆丧失，学习缺陷，运动神经元疾病，癫痫，中风等。

7. 发明授权

US09110215B2 Display device 有权
标题翻译：显示设备
公开(公告)号：US09110215B2
公开(公告)日：2015-08-18
申请号：US13902858
申请日：2013-05-27
申请人： Wen-Pin Yang
发明人： Wen-Pin Yang
IPC分类号： G02F1/13357 , F21V8/00 , G02F1/1333
CPC分类号： G02B6/0088 , G02B6/009 , G02F2001/133317
摘要： A display device includes a display panel having an active display area, an optical film set, a light source module, and a frame. The light source module includes a light guide plate (LGP) and a light source adjacent to a side surface of the LGP. The optical film set is located between the display panel and the LGP. The frame disposed between the LGP and the optical film set extends to the LGP and covers a portion of the LGP. The frame has a first surface carrying the optical film set, a second surface facing to the light emitting surface, and a chamfered inclined surface. The chamfered inclined surface is within the active display area and connects the first and second surfaces. An extending distance of the first surface in the active display area is smaller than an extending distance of the second surface in the active display area.
摘要翻译：显示装置包括具有有源显示区域的显示面板，光学膜组件，光源模块和框架。光源模块包括导光板（LGP）和与LGP的侧表面相邻的光源。光学胶片组位于显示面板和LGP之间。设置在LGP和光学膜组之间的框架延伸到LGP并覆盖LGP的一部分。框架具有承载光学膜组的第一表面，面向发光表面的第二表面和倒角倾斜表面。倒角的倾斜表面在活动显示区域内，并连接第一和第二表面。活动显示区域中的第一表面的延伸距离小于活动显示区域中的第二表面的延伸距离。

8. 发明申请

US20130322121A1 BACKLIGHT MODULE 审中-公开
标题翻译：背光模组
公开(公告)号：US20130322121A1
公开(公告)日：2013-12-05
申请号：US13902859
申请日：2013-05-27
申请人： Wen-Pin Yang
发明人： Wen-Pin Yang
IPC分类号： F21V8/00
CPC分类号： G02B6/0085 , G02B6/0088 , G02B6/0091
摘要： A backlight module includes an outer cover, a heat dissipation plate, a frame, a light guide plate, a back plate, and a light source. The outer cover includes a side wall. The heat dissipation plate is disposed within the outer cover and has a flat plate-shaped first end. The frame is disposed within the outer cover. The light guide plate is disposed between the heat dissipation plate and the frame. The back plate is disposed within the outer cover and has a flat plate-shaped second end parallel to the first end of the heat dissipation plate. The light source is disposed on the first end of the heat dissipation plate and has a substrate and a light emitting diode element. The substrate is perpendicular to the first end of the heat dissipation plate. The first end of the heat dissipation plate and the substrate are adjacent to the side wall.
摘要翻译：背光模块包括外盖，散热板，框架，导光板，背板和光源。外盖包括侧壁。散热板设置在外盖内并具有平板状的第一端。框架设置在外盖内。导光板配置在散热板和框架之间。背板设置在外盖内并具有与散热板的第一端平行的平板状的第二端。光源设置在散热板的第一端上并具有基板和发光二极管元件。基板垂直于散热板的第一端。散热板和基板的第一端与侧壁相邻。

9. 发明申请

US20090042226A1 Identification and cloning of a full-length human CLNK-related gene, MIST (MAST cell immunoreceptor signal transducer) 有权
标题翻译：鉴定和克隆全长人类CLNK相关基因MIST（MAST细胞免疫受体信号转导子）
公开(公告)号：US20090042226A1
公开(公告)日：2009-02-12
申请号：US12231623
申请日：2008-09-04
申请人： Juan J. Perez-Villar , Han Chang , Steven B. Kanner , Gena S. Whitney , Yuli Wu , Wen-Pin Yang
发明人： Juan J. Perez-Villar , Han Chang , Steven B. Kanner , Gena S. Whitney , Yuli Wu , Wen-Pin Yang
IPC分类号： G01N33/53 , C07K16/18 , C12N5/06 , C12N9/00
CPC分类号： C07K14/47 , A01K2217/05 , Y10S435/81
摘要： The present invention describes a newly discovered full-length polynucleotide encoding an SH2 domain-containing adapter protein, called human MIST, cloned, isolated and identified from a human spleen cDNA library. Also described are the MIST polypeptide sequence, expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies related to the polynucleotide and/or polypeptide of the present invention. Novel splice variant forms of human MIST are provided. Methods for screening for modulators, particularly inhibitors, of the MIST protein and use of the human MIST polynucleotide and polypeptide for therapeutics and diagnostics are described.
摘要翻译：本发明描述了一种新发现的全长多核苷酸，其编码含有SH2结构域的衔接蛋白，称为人MIST，从人脾cDNA文库克隆，分离和鉴定。还描述了与本发明的多核苷酸和/或多肽相关的MIST多肽序列，表达载体，宿主细胞，激动剂，拮抗剂，反义分子和抗体。提供人类MIST的新型剪接变体形式。描述了用于筛选MIST蛋白的调节剂，特别是抑制剂的方法以及人MIST多核苷酸和多肽用于治疗和诊断的用途。

10. 发明授权

US07442770B2 Human clnk-related polypeptide, MIST (Mast Cell Immunoreceptor Signal Transducer) 有权
标题翻译：人类相关多肽MIST（Mast Cell Immunoreceptor Signal Transducer）
公开(公告)号：US07442770B2
公开(公告)日：2008-10-28
申请号：US11640775
申请日：2006-12-18
申请人： Juan J. Perez-Villar , Han Chang , Wen-Pin Yang , Yuli Wu , Gena S. Whitney , Steven B. Kanner
发明人： Juan J. Perez-Villar , Han Chang , Wen-Pin Yang , Yuli Wu , Gena S. Whitney , Steven B. Kanner
IPC分类号： C07K14/435 , C12N15/12 , C12N15/63
CPC分类号： C07K14/47 , A01K2217/05 , Y10S435/81
摘要： The present invention describes a newly discovered full-length polynucleotide encoding an SH2 domain-containing adapter protein, called human MIST, cloned, isolated and identified from a human spleen cDNA library. Also described are the MIST polypeptide sequence, expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies related to the polynucleotide and/or polypeptide of the present invention. Novel splice variant forms of human MIST are provided. Methods for screening for modulators, particularly inhibitors, of the MIST protein and use of the human MIST polynucleotide and polypeptide for therapeutics and diagnostics are described.
摘要翻译：本发明描述了一种新发现的全长多核苷酸，其编码含有SH2结构域的衔接蛋白，称为人MIST，从人脾cDNA文库克隆，分离和鉴定。还描述了与本发明的多核苷酸和/或多肽相关的MIST多肽序列，表达载体，宿主细胞，激动剂，拮抗剂，反义分子和抗体。提供人类MIST的新型剪接变体形式。描述了用于筛选MIST蛋白的调节剂，特别是抑制剂的方法以及人MIST多核苷酸和多肽用于治疗和诊断的用途。

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