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1. 发明授权

US06322966B1 Viral specific requirements for self-priming RNA replication of hepatitis C virus replicase 失效
标题翻译：丙型肝炎病毒复制酶自我启动RNA复制的病毒特异性要求
公开(公告)号：US06322966B1
公开(公告)日：2001-11-27
申请号：US09309670
申请日：1999-05-11
申请人： Weidong Zhong , Zhi Hong , Johnson Y. N. Lau
发明人： Weidong Zhong , Zhi Hong , Johnson Y. N. Lau
IPC分类号： C12Q170
CPC分类号： C12Q1/6867
摘要： The present invention relates to identification of the features of an RNA template that provide for efficient “copy-back” self-priming activity of hepatitis C virus replicase. This activity can be used to screen for anti-HCV replicase compounds, or to characterize the biological relevance of lead compounds that have already been identified. The specific features of the optimal RNA templates can be used for developing a system to characterize HCV NS5B polymerase mechanistically and kinetically, and for designing small RNA molecules to co-crystallize with HCV NS5B polymerase.
摘要翻译：本发明涉及确定提供丙型肝炎病毒复制酶的有效“复制”自吸活性的RNA模板的特征。该活性可用于筛选抗HCV复制酶化合物，或表征已鉴定的铅化合物的生物相关性。最佳RNA模板的具体特征可用于开发系统，以机械和动力学表征HCV NS5B聚合体，并设计小RNA分子与HCV NS5B聚合酶共结晶。

2. 发明授权

US06297005B1 De novo priming activity of hepatitis C virus replicase 失效
标题翻译：丙型肝炎病毒复制酶的初始启动活性
公开(公告)号：US06297005B1
公开(公告)日：2001-10-02
申请号：US09305185
申请日：1999-05-04
申请人： Weidong Zhong , Zhi Hong , Annette Schettino Uss , Johnson Y. N. Lau
发明人： Weidong Zhong , Zhi Hong , Annette Schettino Uss , Johnson Y. N. Lau
IPC分类号： C12Q168
CPC分类号： C12Q1/6867 , C12N9/127 , C12Q1/707 , C12Q2525/186 , C12Q2531/149
摘要： The present invention relates to identification of a novel, de novo priming activity of hepatitis C virus replicase. This activity can be used to screen for anti-HCV replicase compounds, or to characterize the biological relevance of lead compounds that have already been identified.
摘要翻译：本发明涉及鉴定丙型肝炎病毒复制酶的新型引发活性。该活性可用于筛选抗HCV复制酶化合物，或表征已鉴定的铅化合物的生物相关性。

3. 发明授权

US06967075B2 HCV replicase complexes 失效
标题翻译： HCV复制酶复合物
公开(公告)号：US06967075B2
公开(公告)日：2005-11-22
申请号：US09828034
申请日：2001-04-06
申请人： Weidong Zhong , Zhi Hong , Eric Ferrari
发明人： Weidong Zhong , Zhi Hong , Eric Ferrari
IPC分类号： C12N9/12 , C12Q1/70
CPC分类号： C12N9/127 , C12Q1/707
摘要： This invention provides efficient HCV replicase complexes comprising novel RNA template and primer pair. Assay systems are also provided, which use such complexes, for detecting replicase activity, quantitatively studying the kinetics and mechanism of HCV NS5B-catalyzed nucleotide incorporation, and identifying inhibitors of HCV replicase. The assay systems use small and well-defined synthetic RNAs which allow efficient assembly of all catalytic components in the quaternary complex for HCV NS5B-directed RNA replication. Specific template-primer requirements for efficient RNA synthesis by HCV NS5B replicase are provided for use in assay systems.
摘要翻译：本发明提供了包含新型RNA模板和引物对的有效的HCV复制酶复合物。还提供了使用这种复合物的检测系统，用于检测复制酶活性，定量研究HCV NS5B催化的核苷酸掺入的动力学和机制，以及鉴定HCV复制酶的抑制剂。测定系统使用小而且明确定义的合成RNA，其允许有效组装用于HCV NS5B定向RNA复制的季复合物中的所有催化组分。提供HCV NS5B复制酶高效RNA合成的具体模板引物要求，用于测定系统。

4. 发明申请

US20070032448A1 Sugar modified nucleosides as viral replication inhibitors 审中-公开
标题翻译：糖改性核苷作为病毒复制抑制剂
公开(公告)号：US20070032448A1
公开(公告)日：2007-02-08
申请号：US10535742
申请日：2002-10-02
申请人： Zhi Hong , Hadylin An , Yili Ding , Jean-Luc Girardet , Weidong Zhong
发明人： Zhi Hong , Hadylin An , Yili Ding , Jean-Luc Girardet , Weidong Zhong
IPC分类号： A61K31/7076
CPC分类号： C07H19/16 , A61K31/7076 , C07H19/044 , C07H19/067 , C07H19/10 , C07H19/11 , C07H19/167 , C07H19/20 , C07H19/213
摘要： Various 2′-modified nucleoside analogs and corresponding prodrugs are provided, and particularly contemplated methods of use include use as antiviral agents, and especially as antiviral agents against HCV.
摘要翻译：提供了各种2'-修饰的核苷类似物和相应的前药，并且特别预期的使用方法包括用作抗病毒剂，特别是作为抗HCV的抗病毒剂。

5. 发明申请

US20060074035A1 Dinucleotide inhibitors of de novo RNA polymerases for treatment or prevention of viral infections 审中-公开
标题翻译：用于治疗或预防病毒感染的从头RNA聚合酶的二核苷酸抑制剂
公开(公告)号：US20060074035A1
公开(公告)日：2006-04-06
申请号：US10418662
申请日：2003-04-17
申请人： Zhi Hong , Weidong Zhong , Haoyun An , Dinesh Barawkar
发明人： Zhi Hong , Weidong Zhong , Haoyun An , Dinesh Barawkar
IPC分类号： A61K31/7076 , C07H19/04
CPC分类号： C07H19/04
摘要： Contemplated dinucleotide compounds have a general structure of A-B and inhibit synthesis of an RNA-dependent polymerase that initiates RNA replication de novo. In preferred dinucleotides, A comprises a purine or modified purine heterocyclic base and B comprises a pyrimidine or modified pyrimidine heterocyclic base.
摘要翻译：考虑的二核苷酸化合物具有A-B的一般结构，并抑制从头开始RNA复制的RNA依赖性聚合酶的合成。在优选的二核苷酸中，A包含嘌呤或修饰的嘌呤杂环碱基，B包含嘧啶或修饰的嘧啶杂环碱基。

6. 发明授权

US08553694B2 Pseudo wire label reflector, an edge equipment, and a two-layer virtual network 有权
标题翻译：伪线标签反射器，边缘设备和双层虚拟网络
公开(公告)号：US08553694B2
公开(公告)日：2013-10-08
申请号：US12854584
申请日：2010-08-11
申请人： Ke Du , Mingyi Wang , Chunhong Huang , Jun Feng , Weidong Zhong
发明人： Ke Du , Mingyi Wang , Chunhong Huang , Jun Feng , Weidong Zhong
IPC分类号： H04L12/56
CPC分类号： H04L12/4641 , H04L45/507
摘要： A pseudo wire label reflector, based on a existing label distribution router, further includes: a mode management unit, for determining the mode for switching and transferring a pseudo wire label message; a first session management unit, for saving the support information that LDP signaling session connection supports the pseudo wire label reflecting capacity; a first pseudo wire label receiving unit, for receiving a pseudo wire label message; a first pseudo wire management unit, for saving the switched pseudo wire state and deciding whether to modify the pseudo wire label message according to the switch and transfer mode determined by the mode management unit; a first pseudo wire label sending unit, for sending the pseudo wire label message. The invention also provides an edge apparatus and a L2 VPN. The present invention makes PE equipments participating pseudo wire service to set up PSN tunnel and LDP signaling session connection with the pseudo wire label reflector by introducing the pseudo wire label reflector and extending the capacity that the current edge apparatus supports the pseudo wire label reflector.
摘要翻译：基于现有标签分发路由器的伪线标签反射器还包括：模式管理单元，用于确定用于切换和传送伪线标签消息的模式; 第一会话管理单元，用于保存LDP信令会话连接支持伪线标签反映能力的支持信息; 第一伪线标签接收单元，用于接收伪线标签消息; 第一伪线管理单元，用于保存切换伪线状态，并根据由模式管理单元确定的切换和传送模式来决定是否修改伪线标签消息; 第一伪线标签发送单元，用于发送伪线标签消息。本发明还提供边缘设备和L2 VPN。本发明使PE设备参与伪线业务，通过引入伪线标签反射器并扩展当前边缘设备支持伪线标签反射器的容量，建立伪线标签反射器的PSN隧道和LDP信令会话连接。

7. 发明申请

US20100323989A1 PHARMACEUTICAL COMBINATIONS USEFUL FOR TREATING HCV 审中-公开
标题翻译：用于治疗HCV的药物组合
公开(公告)号：US20100323989A1
公开(公告)日：2010-12-23
申请号：US12817392
申请日：2010-06-17
申请人： William E. Delaney , Hongmei Mo , Weidong Zhong
发明人： William E. Delaney , Hongmei Mo , Weidong Zhong
IPC分类号： A61K31/675 , A61P31/14
CPC分类号： A61K9/2004 , A61K9/0019 , A61K9/08 , A61K31/4709 , A61K31/501 , A61K45/06 , A61K2300/00
摘要： This invention relates to combinations of Compound 1 and Compound 2 which are useful for treating hepatitis C virus infection.
摘要翻译：本发明涉及可用于治疗丙型肝炎病毒感染的化合物1和化合物2的组合。

8. 发明申请

US20080291921A1 Pseudo Wire Label Reflector, an Edge Equipment, a Two-Layer Virtual Network and a Method of Providing Pseudo Wire Service 有权
标题翻译：伪线标签反射器，边缘设备，双层虚拟网络和提供伪线服务的方法
公开(公告)号：US20080291921A1
公开(公告)日：2008-11-27
申请号：US11632445
申请日：2005-01-04
申请人： Ke Du , Mingyi Wang , Chunhong Huang , Jun Feng , Weidong Zhong
发明人： Ke Du , Mingyi Wang , Chunhong Huang , Jun Feng , Weidong Zhong
IPC分类号： H04L12/56
CPC分类号： H04L12/4641 , H04L45/507
摘要： A pseudo wire label reflector, based on a existing label distribution router, further includes: a mode management unit, for determining the mode for switching and transferring a pseudo wire label message; a first session management unit, for saving the support information that LDP signaling session connection supports the pseudo wire label reflecting capacity; a first pseudo wire label receiving unit, for receiving a pseudo wire label message; a first pseudo wire management unit, for saving the switched pseudo wire state and deciding whether to modify the pseudo wire label message according to the switch and transfer mode determined by the mode management unit; a first pseudo wire label sending unit, for sending the pseudo wire label message. The invention also provides an edge apparatus, a L2 VPN and a method for providing pseudo wire service in PSN. The present invention makes PE equipments participating pseudo wire service to set up PSN tunnel and LDP signaling session connection with the pseudo wire label reflector by introducing the pseudo wire label reflector and extending the capacity that the current edge apparatus supports the pseudo wire label reflector.
摘要翻译：基于现有标签分发路由器的伪线标签反射器还包括：模式管理单元，用于确定用于切换和传送伪线标签消息的模式; 第一会话管理单元，用于保存LDP信令会话连接支持伪线标签反映能力的支持信息; 第一伪线标签接收单元，用于接收伪线标签消息; 第一伪线管理单元，用于保存切换伪线状态，并根据由模式管理单元确定的切换和传送模式来决定是否修改伪线标签消息; 第一伪线标签发送单元，用于发送伪线标签消息。本发明还提供一种边缘设备，L2 VPN和在PSN中提供伪线服务的方法。本发明使PE设备参与伪线业务，通过引入伪线标签反射器并扩展当前边缘设备支持伪线标签反射器的容量，建立伪线标签反射器的PSN隧道和LDP信令会话连接。

9. 发明授权

US09556216B2 2′-Ethynyl nucleoside derivatives for treatment of viral infections 有权
标题翻译：用于治疗病毒感染的2'-乙炔基核苷衍生物
公开(公告)号：US09556216B2
公开(公告)日：2017-01-31
申请号：US14421249
申请日：2013-08-27
申请人： Sampath-Kumar Anandan , Virender Singh Aulakh , Martijn Fenaux , Xiaodong Lin , Liang Mao , Oliver Saunders , Zachary Kevin Sweeney , Fumiaki Yokokawa , Weidong Zhong
发明人： Sampath-Kumar Anandan , Virender Singh Aulakh , Martijn Fenaux , Xiaodong Lin , Liang Mao , Oliver Saunders , Zachary Kevin Sweeney , Fumiaki Yokokawa , Weidong Zhong
IPC分类号： C07H19/10 , A61K31/7072 , A61K31/7068 , A61K45/06
CPC分类号： A61K31/7072 , A61K31/7068 , A61K45/06 , A61K47/22 , C07H19/06 , C07H19/067 , C07H19/10
摘要： The present invention provides a compound of formula A: or a pharmaceutically acceptable salt thereof, wherein B, Q, R1, R5, R6, R7, R8 and Z are as defined herein, which is a 2′-branched nucleoside useful for the treatment or prevention of viral infections, particularly dengue fever, yellow fever, West Nile virus, Japanese encephalitis virus, tick-borne encephalitis virus, Kunjin virus, Murray Valley encephalitis, St Louis encephalitis, Omsk hemorrhagic fever virus, bovine viral diarrhea virus, Zika virus and Hepatitis C virus.
摘要翻译：本发明提供式A化合物或其药学上可接受的盐，其中B，Q，R 1，R 5，R 6，R 7，R 8和Z如本文所定义，其为可用于治疗的2'-支链核苷或预防病毒感染，特别是登革热，黄热病，西尼罗病毒，日本脑炎病毒，蜱传脑炎病毒，昆金病毒，墨累谷脑炎，圣路易脑炎，鄂木斯克出血热病毒，牛病毒性腹泻病毒，Zika病毒和丙型肝炎病毒。

10. 发明申请

US20100324059A1 PHARMACEUTICAL COMPOSITIONS USEFUL FOR TREATING HCV 审中-公开
标题翻译：用于治疗HCV的药物组合物
公开(公告)号：US20100324059A1
公开(公告)日：2010-12-23
申请号：US12818407
申请日：2010-06-18
申请人： William E. Delaney , Hongmei Mo , Weidong Zhong
发明人： William E. Delaney , Hongmei Mo , Weidong Zhong
IPC分类号： A61K31/501 , A61P31/14
CPC分类号： A61K9/2004 , A61K9/08 , A61K31/497 , A61K31/501 , A61K45/06 , A61K2300/00
摘要： This invention relates to combinations of Compound 1 and Compound 2 which are useful for treating hepatitis C virus infection.
摘要翻译：本发明涉及可用于治疗丙型肝炎病毒感染的化合物1和化合物2的组合。

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