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1. 发明授权

US10059733B2 Gemcitabine analogs 有权
公开(公告)号：US10059733B2
公开(公告)日：2018-08-28
申请号：US15122506
申请日：2015-02-27
申请人： NUCORION PHARMACEUTICALS, INC.
发明人： Zucai Suo , David J. Taggart , Sheng Cao
IPC分类号： A01N43/04 , A61K31/70 , C07H19/06 , C07H19/10 , C07H19/11 , A61K45/06 , A61K31/7068 , A61K31/7064 , A61K31/706
CPC分类号： C07H19/06 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K45/06 , C07H19/10 , C07H19/11 , Y02A50/385 , Y02A50/387 , Y02A50/463
摘要： Gemcitabine analogs, including monophosphorylated analogs, are described herein and are suitable for use in pharmaceutical compositions, kits and treatment methods. The treatment methods include treatment of viral infections, including, but not limited to, treatment of Hepatitis C Virus, and uncontrolled cellular proliferation, including cancer, such as, but not limited to, non-small cell lung cancer, pancreatic cancer, bladder cancer, breast cancer, liver cancer, esophageal cancer and lymphoma.

2. 发明授权

US10000522B2 Derivatives of uridine 5′-cyclophosphate useful to treat hepatitis C viral infections 有权
公开(公告)号：US10000522B2
公开(公告)日：2018-06-19
申请号：US15590813
申请日：2017-05-09
申请人： Ligand Pharmaceuticals Incorporated
发明人： Lin Zhi
IPC分类号： C07H19/10 , C07H19/11
CPC分类号： C07H19/10 , C07H19/11
摘要： Some embodiments of the present invention include nucleoside 5′-monophosphate derivative compounds, their preparation and their uses. In some embodiments, such compounds are useful to treat hepatitis C viral infections.

3. 发明授权

US09809616B2 Pyrimidine nucleosides and their monophosphate prodrugs for the treatment of viral infections and cancer 有权
公开(公告)号：US09809616B2
公开(公告)日：2017-11-07
申请号：US14066461
申请日：2013-10-29
申请人： Cocrystal Pharma, Inc. , Emory University
发明人： Franck Amblard , Steven J. Coats , Raymond F. Schinazi
IPC分类号： A01N43/04 , A61K31/07 , C07H19/048 , C07H19/00 , C07H19/06 , C07H19/10 , C07H19/067 , C07H19/11 , A61K45/06 , A61K31/7068
CPC分类号： C07H19/06 , A61K31/7068 , A61K45/06 , C07H19/067 , C07H19/10 , C07H19/11
摘要： The compounds are of the class of N4-hydroxycytidine nucleosides, modified monophosphate and phosphonates prodrugs analogs, and pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof, useful in treating HCV or Norovirus infections.

4. 发明申请

US20170165287A1 CRYSTAL FORM OF A NUCLEOSIDE INHIBITOR OF HCV 审中-公开
公开(公告)号：US20170165287A1
公开(公告)日：2017-06-15
申请号：US15039388
申请日：2013-11-28
申请人： JANSSEN SCIENCES IRELAND UC
发明人： Jennifer ALBANEZE-WALKER , Xianglu ZENG , Yuanyuan YUAN
IPC分类号： A61K31/7072 , C07H19/11
CPC分类号： A61K31/7072 , C07H19/11
摘要： Provided are crystalline forms of the compound of formula (I), which is a nucleoside inhibitor of HCV, processes for the preparation thereof, and pharmaceutical compositions comprising these crystalline forms.

5. 发明授权

US09587275B2 Single molecule sequencing with two distinct chemistry steps 有权
标题翻译：具有两个不同化学步骤的单分子测序
公开(公告)号：US09587275B2
公开(公告)日：2017-03-07
申请号：US14848136
申请日：2015-09-08
申请人： Pacific Biosciences of California, Inc.
发明人： Robin Emig , Lei Jia , Jeremiah Hanes , Lubomir Sebo
IPC分类号： C12Q1/68 , C07H19/10 , C07H19/11 , C07H19/20 , C07H19/213
CPC分类号： C12Q1/6869 , C07H19/10 , C07H19/11 , C07H19/20 , C07H19/213 , C12Q1/6874 , C12Q2521/301 , C12Q2525/186 , C12Q2563/107 , C12Q2537/157 , C12Q2521/319 , C12Q2521/525
摘要： Methods, Compositions, and Systems are provided for nucleic acid sequencing where the sequential incorporation of nucleotides uses two distinct chemical steps. A plurality of nucleotide analogs, each having a labeled leaving group at its 3′ hydroxyl can be sequentially added to a growing strand in the presence of a selective cleaving activity that cleaves the 3′ hydroxyl leaving group preferentially after it has been incorporated. The selective cleaving agent can comprise an exonuclease activity, and the exonuclease activity can be a polymerase-associated exonuclease activity. Nucleotide analogs having labels on both a cleavable polyphosphate portion and on a 3′ hydroxyl leaving group can provide signals characteristic of nucleotide analog incorporation. Systems having illumination optics, collection optics, and substrates observe signals from the labels as they are being incorporated into a growing nucleic acid strand, allowing for the sequencing of template nucleic acids.
摘要翻译：提供了用于核酸测序的方法，组合物和系统，其中连续掺入核苷酸使用两个不同的化学步骤。在选择性切割活性的存在下，可以将多个在其3'羟基上具有标记的离去基团的核苷酸类似物依次加入到生长链中，该选择性裂解活性优选在其引入后优先切割3'羟基离去基团。选择性切割剂可以包含核酸外切酶活性，并且核酸外切酶活性可以是聚合酶相关的外切核酸酶活性。在可切割聚磷酸酯部分和3'羟基离去基团上具有标记的核苷酸类似物可以提供核苷酸类似物掺入特征的信号。具有照明光学器件，收集光学元件和底物的系统在标记被并入生长的核酸链中观察信号，允许对模板核酸进行测序。

6. 发明申请

US20170044205A1 3'-SUBSTITUTED METHYL OR ALKYNYL NUCLEOSIDES NUCLEOTIDES FOR THE TREATMENT OF HCV 审中-公开
标题翻译： 3'-取代的甲基或亚烷基核苷酸用于治疗HCV的核酸
公开(公告)号：US20170044205A1
公开(公告)日：2017-02-16
申请号：US15304506
申请日：2015-04-16
申请人： IDENIX PHARMACEUTICALS LLC
发明人： David DUKHAN , Cyril B. DOUSSON , Gilles GOSSELIN , Jean-Laurent PAPARIN , Guillaume BRANDT , Rachid RAHALI , Aurelien SALANSON , François-René ALEXANDRE
IPC分类号： C07H19/20 , A61K31/7068 , C07H19/10 , A61K31/7072 , A61K45/06 , A61K31/7076
CPC分类号： C07H19/20 , A61K31/7052 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K45/06 , C07H19/10 , C07H19/11
摘要： Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 3′-substituted methyl or alkynyl nucleosides of Formula I: (I); or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form or polymorphic form thereof, wherein Base, PD, RA, RB1, RB2, RC and Z are as defined herein.
摘要翻译：本文提供了用于治疗黄病毒科感染（包括HCV感染）的化合物，组合物和方法。在某些实施方案中，公开了核苷衍生物的化合物和组合物，其可以单独施用或与其它抗病毒剂组合施用。在某些实施方案中，化合物是式I的3'-取代的甲基或炔基核苷：（I）; 或其药学上可接受的盐，溶剂化物，立体异构形式，互变异构形式或其多晶型形式，其中碱，PD，RA，RB1，RB2，RC和Z如本文所定义。

7. 发明授权

US09540411B2 HCV polymerase inhibitors 有权
标题翻译： HCV聚合酶抑制剂
公开(公告)号：US09540411B2
公开(公告)日：2017-01-10
申请号：US15210500
申请日：2016-07-14
申请人： MEDIVIR AB
发明人： Genadiy Kalayanov , Staffan Torssell , Horst Wahling
IPC分类号： C07H19/213 , C07H19/11 , C07H19/073 , C07H19/173
CPC分类号： C07H19/06 , A61K31/7072 , A61K45/06 , C07H19/073 , C07H19/10 , C07H19/11 , C07H19/16 , C07H19/173 , C07H19/20 , C07H19/213 , C07H23/00
摘要： The invention provides compounds of the formula: wherein B is a nucleobase selected from the groups (a) to (d): and the other variables are as defined in the claims, which are of use in the treatment or prophylaxis of hepatitis C virus infection, and related aspects.
摘要翻译：本发明提供下式的化合物：其中B是选自（a） - （d）组的核碱基，其他变量如权利要求中所定义，其用于治疗或预防丙型肝炎病毒感染，及相关方面。

8. 发明申请

US20170002037A1 CYCLIC NUCLEOTIDE ANALOGS 审中-公开
标题翻译：循环核素类似物
公开(公告)号：US20170002037A1
公开(公告)日：2017-01-05
申请号：US15180999
申请日：2016-06-13
申请人： ALIOS BIOPHARMA, INC.
发明人： Leonid Beigelman , David Bernard Smith , Jerome Deval , Vivek Kumar Rajwanshi
IPC分类号： C07H19/20 , A61K45/06 , A61K31/7072 , A61K31/685 , C07H19/10 , A61K31/7076 , C07F9/6574
CPC分类号： C07H19/20 , A61K31/14 , A61K31/513 , A61K31/52 , A61K31/685 , A61K31/7072 , A61K31/7076 , A61K45/06 , C07F9/65744 , C07H17/02 , C07H19/10 , C07H19/11 , C07H19/213 , Y02A50/414 , Y02A50/465 , A61K2300/00
摘要： Disclosed herein are cyclic nucleotide analogs, methods of synthesizing cyclic nucleotide analogs and methods of treating diseases and/or conditions such as viral infections, cancer, and/or parasitic diseases with cyclic nucleotide analogs.
摘要翻译：本文公开了环状核苷酸类似物，合成环状核苷酸类似物的方法和用环状核苷酸类似物治疗疾病和/或病症如病毒感染，癌症和/或寄生虫病的方法。

9. 发明申请

US20160176911A1 SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF 有权
公开(公告)号：US20160176911A1
公开(公告)日：2016-06-23
申请号：US14970896
申请日：2015-12-16
申请人： ALIOS BIOPHARMA, INC.
发明人： Leonid Beigelman , David Bernard Smith , Guangyi Wang , Natalia Dyatkina
IPC分类号： C07H19/10 , A61K45/06 , C12N7/00 , A61K31/708 , C12N9/12 , A61K31/7072 , C07H19/20
CPC分类号： C07H19/10 , A61K31/706 , A61K31/7064 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K45/06 , A61P31/14 , C07H19/06 , C07H19/11 , C07H19/16 , C07H19/20 , C07H19/213 , C12N7/00 , C12N9/127 , C12N2770/24261 , C12Y207/07048 , A61K2300/00
摘要： Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a HCV infection with one or more nucleotide analogs.

10. 发明授权

US09296778B2 3′,5′-cyclic phosphate prodrugs for HCV infection 有权
标题翻译： 3'，5'-环磷酸酯前药用于HCV感染
公开(公告)号：US09296778B2
公开(公告)日：2016-03-29
申请号：US13899487
申请日：2013-05-21
申请人： Idenix Pharmaceuticals, Inc. , Centre National De La Recherche Scientifique , Universite Montpellier 2 Sciences Et Techniques
发明人： Christophe Claude Parsy , Francois-Rene Alexandre , Cyril B. Dousson , David Dukhan , Gilles Gosselin , Houcine Rahali , Dominique Surleraux
IPC分类号： A61K31/7068 , A61K31/7076 , A61K45/06 , C07H19/10 , C07H19/20 , C07H19/213 , C07H19/11
CPC分类号： C07H19/20 , A61K31/7068 , A61K31/7076 , A61K45/06 , C07H19/10 , C07H19/11 , C07H19/213
摘要： Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.
摘要翻译：本文提供了用于治疗黄病毒科感染（包括HCV感染）的化合物，组合物和方法。在某些实施方案中，公开了核苷衍生物的化合物和组合物，其可以单独施用或与其它抗病毒剂组合施用。

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