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1. 发明申请

US20130189793A1 Stable Colloidal Suspensions Of Gold Nanoconjugates And The Method For Preparing The Same 审中-公开
标题翻译：金纳米结晶的稳定胶体悬浮液及其制备方法
公开(公告)号：US20130189793A1
公开(公告)日：2013-07-25
申请号：US13744633
申请日：2013-01-18
申请人： Wei Qian , Yong Che
发明人： Wei Qian , Yong Che
IPC分类号： G01N21/64
CPC分类号： G01N21/64 , A61K47/6923 , B01J13/0034 , B01J13/0043 , B82Y30/00 , G01N21/554
摘要： In the present invention, a method for determining the stability threshold amount of a stabilizer component for gold nanoparticles to prevent their aggregation in any electrolyte solution, is disclosed. The method permits for very low levels of stabilizer components to be used while still permitting conjugation with other functional ligands. The method comprises preparation of stable gold nanoparticles conjugated with different amount of stabilizing agents in deionized water first and then testing the stability of colloidal suspension of these gold nanoparticles in the presence of the electrolyte solution by monitoring the absorbance at 520 nm. The invention also comprises a method for fabrication of nanoconjugates comprising gold nanoparticles and only the stabilizer components or comprising gold nanoparticles, stabilizer components and functional ligands, which are stable in the presence of electrolytes.
摘要翻译：在本发明中，公开了一种用于确定金纳米颗粒的稳定剂组分以防止其在任何电解质溶液中聚集的稳定剂阈值量的方法。该方法允许使用非常低水平的稳定剂组分，同时仍允许与其它官能配体缀合。该方法首先制备在去离子水中与不同量的稳定剂缀合的稳定金纳米颗粒，然后通过监测520nm处的吸光度，测定这些金纳米粒子在电解质溶液存在下的胶体悬浮液的稳定性。本发明还包括一种制造纳米缀合物的方法，其包括金纳米颗粒并且仅包含稳定剂组分或包含在电解质存在下稳定的金纳米颗粒，稳定剂组分和官能配体。

2. 发明授权

US08697129B2 Stable colloidal gold nanoparticles with controllable surface modification and functionalization 有权
标题翻译：稳定的胶体金纳米粒子具有可控的表面改性和功能化
公开(公告)号：US08697129B2
公开(公告)日：2014-04-15
申请号：US13038788
申请日：2011-03-02
申请人： Wei Qian , Makoto Murakami , Yuki Ichikawa , Yong Che
发明人： Wei Qian , Makoto Murakami , Yuki Ichikawa , Yong Che
IPC分类号： A61K9/14 , A61K33/24
CPC分类号： A61K49/0002 , A61K9/0019 , A61K9/1688 , A61K41/0057 , A61K47/10 , B01J13/0034 , B01J13/0043 , B82Y5/00 , B82Y30/00 , B82Y40/00 , G01N21/64 , G01N21/658 , G01N33/531 , G01N33/54346 , G01N2021/3595
摘要： In the present invention, a method of producing stable bare colloidal gold nanoparticles is disclosed. The nanoparticles can subsequently be subjected to partial or full surface modification. The method comprises preparation of colloidal gold nanoparticles in a liquid by employing a top-down nanofabrication method using bulk gold as a source material. The surface modification of these nanoparticles is carried out by adding one or multiple types of ligands each containing functional groups which exhibit affinity for gold nanoparticle surfaces to produce the conjugates. Because of the high efficiency and excellent stability of the nanoparticles produced by this method, the fabricated gold nanoparticle conjugates can have surface coverage with functional ligands which can be tuned to be any percent value between 0 and 100%.
摘要翻译：在本发明中，公开了一种制备稳定的裸胶体金纳米颗粒的方法。随后可以对纳米颗粒进行部分或全面修饰。该方法包括使用以大块金为原料的自顶向下纳米制造方法在液体中制备胶体金纳米颗粒。这些纳米颗粒的表面改性是通过添加一种或多种类型的配体，每个配体包含对金纳米颗粒表面具有亲和性以产生共轭物的官能团。由于通过该方法制备的纳米颗粒的高效率和优异的稳定性，所制备的金纳米颗粒共轭物可以具有表面覆盖的功能性配体，其可被调整为0至100％之间的任何百分比值。

3. 发明申请

US20140170070A1 STABLE COLLOIDAL GOLD NANOPARTICLES WITH CONTROLLABLE SURFACE MODIFICATION AND FUNCTIONALIZATION 审中-公开
标题翻译：具有可控表面改性和功能化的稳定的胶体金纳米颗粒
公开(公告)号：US20140170070A1
公开(公告)日：2014-06-19
申请号：US14187416
申请日：2014-02-24
申请人： Wei Qian , Makoto Murakami , Yuki Ichikawa , Yong Che
发明人： Wei Qian , Makoto Murakami , Yuki Ichikawa , Yong Che
IPC分类号： A61K49/00 , A61K47/10 , A61K41/00 , G01N21/65
CPC分类号： A61K49/0002 , A61K9/0019 , A61K9/1688 , A61K41/0057 , A61K47/10 , B01J13/0034 , B01J13/0043 , B82Y5/00 , B82Y30/00 , B82Y40/00 , G01N21/64 , G01N21/658 , G01N33/531 , G01N33/54346 , G01N2021/3595
摘要： In the present invention, a method of producing stable bare colloidal gold nanoparticles is disclosed. The nanoparticles can subsequently be subjected to partial or full surface modification. The method comprises preparation of colloidal gold nanoparticles in a liquid by employing a top-down nanofabrication method using bulk gold as a source material. The surface modification of these nanoparticles is carried out by adding one or multiple types of ligands each containing functional groups which exhibit affinity for gold nanoparticle surfaces to produce the conjugates. Because of the high efficiency and excellent stability of the nanoparticles produced by this method, the fabricated gold nanoparticle conjugates can have surface coverage with functional ligands which can be tuned to be any percent value between 0 and 100%.
摘要翻译：在本发明中，公开了一种制备稳定的裸胶体金纳米颗粒的方法。随后可以对纳米颗粒进行部分或全面修饰。该方法包括使用以大块金为原料的自顶向下纳米制造方法在液体中制备胶体金纳米颗粒。这些纳米颗粒的表面改性是通过添加一种或多种类型的配体，每个配体包含对金纳米颗粒表面具有亲和性以产生共轭物的官能团。由于通过该方法制备的纳米颗粒的高效率和优异的稳定性，所制备的金纳米颗粒共轭物可以具有表面覆盖的功能性配体，其可被调整为0至100％之间的任何百分比值。

4. 发明授权

US08992815B2 Production of organic compound nanoparticles with high repetition rate ultrafast pulsed laser ablation in liquids 有权
标题翻译：在液体中生产具有高重复率超快速脉冲激光烧蚀的有机复合纳米粒子
公开(公告)号：US08992815B2
公开(公告)日：2015-03-31
申请号：US12951496
申请日：2010-11-22
申请人： Zhendong Hu , Yong Che
发明人： Zhendong Hu , Yong Che
IPC分类号： B01J13/00 , B82Y40/00 , A61K9/14 , B23K26/06
CPC分类号： A61K9/10 , A61K9/14 , A61K31/12 , B01J13/0086 , B23K26/0624 , B23K26/144 , B23K26/146 , B82Y40/00 , Y10S977/889 , Y10S977/901
摘要： Disclosed is a method of producing a chemically pure and stably dispersed organic nanoparticle colloidal suspension using an ultrafast pulsed laser ablation process. The method comprises irradiating a target of an organic compound material in contact with a poor solvent with ultrashort laser pulses at a high repetition rate and collecting the nanoparticles of the organic compound produced. The method may be implemented with a high repetition rate ultrafast pulsed laser source, an optical system for focusing and moving the pulsed laser beam, an organic compound target in contact with a poor solvent, and a solvent circulating system to cool the laser focal volume and collect the produced nanoparticle products. By controlling various laser parameters, and with optional poor solvent flow movement, the method provides stable colloids of dispersed organic nanoparticles in the poor solvent in the absence of any stabilizing agents.
摘要翻译：公开了使用超快脉冲激光烧蚀工艺制备化学纯的和稳定分散的有机纳米颗粒胶体悬浮液的方法。该方法包括用高重复率的超短激光脉冲对与有害化合物接触的有机化合物材料进行照射，并收集生成的有机化合物的纳米颗粒。该方法可以用高重复率超快脉冲激光源，用于聚焦和移动脉冲激光束的光学系统，与不良溶剂接触的有机化合物靶和溶剂循环系统来实现，以冷却激光焦点体积和收集生产的纳米颗粒产品。通过控制各种激光参数，并且具有可选的不良溶剂流动运动，该方法在不存在任何稳定剂的情况下在不良溶剂中提供分散的有机纳米颗粒的稳定胶体。

5. 发明授权

US08540173B2 Production of fine particles of functional ceramic by using pulsed laser 有权
标题翻译：使用脉冲激光生产功能性陶瓷微粒
公开(公告)号：US08540173B2
公开(公告)日：2013-09-24
申请号：US12951557
申请日：2010-11-22
申请人： Yuki Ichikawa , Zhengong Hu , Bing Liu , Yong Che
发明人： Yuki Ichikawa , Zhengong Hu , Bing Liu , Yong Che
IPC分类号： B02C19/18
CPC分类号： C09K11/025 , C09K11/08 , Y10T428/2982
摘要： A method of forming nanometer sized fine particles of functional ceramic from a bulk functional ceramic, particularly fine particles of phosphorous ceramics from a bulk phosphor material is disclosed. The method relies on irradiation of a bulk phosphorous ceramic in a liquid with an ultrashort-pulsed-laser-fragmentation beam to thereby form nanometer sized particles of the phosphorous ceramic. The method is unique in that the generated particles retain the chemical and crystalline properties of the bulk phosphorous ceramic. The generated solutions are stable colloids from which the particles can be isolated or used as is.
摘要翻译：公开了一种从体积功能陶瓷形成纳米尺寸的功能性陶瓷微粒的方法，特别是来自块状磷光体材料的磷陶瓷的细颗粒的方法。该方法依赖于用超短脉冲激光破碎光束在液体中照射大块磷陶瓷，从而形成纳米尺寸的磷陶瓷颗粒。该方法的独特之处在于所产生的颗粒保留了大块磷陶瓷的化学和结晶性质。产生的溶液是稳定的胶体，颗粒可从其中分离或原样使用。

6. 发明申请

US20110192714A1 NANOPARTICLE PRODUCTION IN LIQUID WITH MULTIPLE-PULSE ULTRAFAST LASER ABLATION 有权
标题翻译：用多脉冲超声波激光吸收的液体中的纳米生物
公开(公告)号：US20110192714A1
公开(公告)日：2011-08-11
申请号：US12951423
申请日：2010-11-22
申请人： Bing LIU , Zhendong Hu , Yong Che
发明人： Bing LIU , Zhendong Hu , Yong Che
IPC分类号： B01J19/08
CPC分类号： B01J19/121 , B22F1/0018 , B22F9/04 , B22F2999/00 , Y10S977/889 , B22F2202/11
摘要： A method for generating nanoparticles in a liquid comprises generating groups of ultrafast laser pulses, each pulse in a group having a pulse duration of from 10 femtoseconds to 200 picoseconds, and each group containing a plurality of pulses with a pulse separation of 1 to 100 nanoseconds and directing the groups of pulses at a target material in a liquid to ablate it. The multiple pulse group ablation produces nanoparticles with a reduced average size, a narrow size distribution, and improved production efficiency compared to prior pulsed ablation systems.
摘要翻译：用于在液体中产生纳米颗粒的方法包括产生超快激光脉冲组，组中的每个脉冲具有10飞秒至200皮秒的脉冲持续时间，并且每组包含脉冲间隔为1至100纳秒的多个脉冲并将脉冲组定向在液体中的目标材料以烧蚀它。与先前的脉冲消融系统相比，多脉冲组消融产生具有降低的平均尺寸，窄尺寸分布和提高的生产效率的纳米颗粒。

7. 发明申请

US20110192450A1 METHOD FOR PRODUCING NANOPARTICLE SOLUTIONS BASED ON PULSED LASER ABLATION FOR FABRICATION OF THIN FILM SOLAR CELLS 审中-公开
标题翻译：用于制造薄膜太阳能电池的脉冲激光雷射的纳米级解决方案
公开(公告)号：US20110192450A1
公开(公告)日：2011-08-11
申请号：US12951585
申请日：2010-11-22
申请人： Bing LIU , Yong Che
发明人： Bing LIU , Yong Che
IPC分类号： H01L31/0256 , B01J19/12 , B82Y40/00
CPC分类号： H01L31/035281 , B22F1/0022 , B22F9/04 , B22F2998/00 , B22F2999/00 , B23K26/361 , B82B1/001 , B82Y40/00 , H01L31/0296 , H01L31/0322 , H01L31/03923 , H01L31/03925 , H01L31/1828 , Y02E10/541 , Y02E10/543 , Y02P70/521 , B22F1/0018 , B22F2202/11
摘要： A method of producing nanoparticles of solar light absorbing compound materials based on pulsed laser ablation is disclosed. The method uses irradiation of a target material of solar light absorbing compound material with a pulsed laser beam having a pulse duration of from 10 femtoseconds to 500 picoseconds to ablate the target thereby producing nanoparticles of the target. The nanoparticles are collected and a solution of the nanoparticles is applied to a substrate to produce a thin film solar cell. The method preserves the composition and structural crystalline phase of the starting target. The method is a much lower cost fabrication method for thin film solar cells.
摘要翻译：公开了一种基于脉冲激光烧蚀制备太阳光吸收复合材料的纳米颗粒的方法。该方法使用具有10飞秒至500皮秒的脉冲持续时间的脉冲激光束照射太阳光吸收复合材料的目标材料以烧蚀靶，从而产生靶的纳米颗粒。收集纳米颗粒，并将纳米颗粒的溶液施加到基底以产生薄膜太阳能电池。该方法保留起始靶的组成和结构结晶相。该方法是薄膜太阳能电池成本低廉的制造方法。

8. 发明申请

US20100227133A1 PULSED LASER MICRO-DEPOSITION PATTERN FORMATION 有权
标题翻译：脉冲激光微沉积图形成
公开(公告)号：US20100227133A1
公开(公告)日：2010-09-09
申请号：US12400438
申请日：2009-03-09
申请人： Bing Liu , Zhendong Hu , Makoto Murakami , Jingzhou Xu , Yong Che
发明人： Bing Liu , Zhendong Hu , Makoto Murakami , Jingzhou Xu , Yong Che
IPC分类号： B32B3/00 , C23C14/34 , C23C14/00
CPC分类号： C23C20/04 , B41M5/262 , B41M5/267 , B44F1/10 , C23C14/28 , C23C14/3435 , G02B26/101 , Y10T428/24802 , Y10T428/24917
摘要： A method of forming patterns on transparent substrates using a pulsed laser is disclosed. Various embodiments include an ultrashort pulsed laser, a substrate that is transparent to the laser wavelength, and a target plate. The laser beam is guided through the transparent substrate and focused on the target surface. The target material is ablated by the laser and is deposited on the opposite substrate surface. A pattern, for example a gray scale image, is formed by scanning the laser beam relative to the target. Variations of the laser beam scan speed and scan line density control the material deposition and change the optical properties of the deposited patterns, creating a visual effect of gray scale. In some embodiments patterns may be formed on a portion of a microelectronic device during a fabrication process. In some embodiments high repetition rate picoseconds and nanosecond sources are configured to produce the patterns.
摘要翻译：公开了使用脉冲激光在透明基板上形成图案的方法。各种实施例包括超短脉冲激光器，对激光波长透明的衬底和靶板。激光束被引导通过透明基板并聚焦在目标表面上。目标材料被激光烧蚀并沉积在相对的基板表面上。通过相对于目标扫描激光束来形成例如灰度图像的图案。激光束扫描速度和扫描线密度的变化控制材料沉积并改变沉积图案的光学性质，产生灰度的视觉效果。在一些实施例中，可以在制造过程期间在微电子器件的一部分上形成图案。在一些实施例中，高重复率皮秒和纳秒源被配置为产生图案。

9. 发明授权

US06558846B1 Secondary power source 有权
标题翻译：二次电源
公开(公告)号：US06558846B1
公开(公告)日：2003-05-06
申请号：US09266871
申请日：1999-03-12
申请人： Manabu Tsushima , Takeshi Morimoto , Yong Che
发明人： Manabu Tsushima , Takeshi Morimoto , Yong Che
IPC分类号： H01M448
CPC分类号： H01M10/0525 , H01M4/131 , H01M4/505 , H01M4/525 , H01M4/625
摘要： A secondary power source, which comprises a positive electrode containing activated carbon and a lithium-containing transition metal oxide, a negative electrode containing a carbon material capable of doping and undoping lithium ions, and an organic electrolyte containing a lithium salt.
摘要翻译：二次电源，其包含含有活性炭的正极和含锂过渡金属氧化物，含有能够掺杂和去掺杂锂离子的碳材料的负极和含有锂盐的有机电解质。

10. 发明授权

US08836941B2 Method and apparatus to prepare a substrate for molecular detection 有权
标题翻译：制备用于分子检测的底物的方法和装置
公开(公告)号：US08836941B2
公开(公告)日：2014-09-16
申请号：US12951524
申请日：2010-11-22
申请人： Makoto Murakami , Yong Che , Bing Liu , Yuki Ichikawa
发明人： Makoto Murakami , Yong Che , Bing Liu , Yuki Ichikawa
IPC分类号： G01J3/44 , C23C14/08 , B82Y30/00 , C23C14/34 , G01N21/65 , B82Y40/00
CPC分类号： G01N21/658 , B82Y30/00 , B82Y40/00 , C23C14/083 , C23C14/3435
摘要： An device for Raman spectroscopy such as surface enhanced Raman spectroscopy (SERS) is disclosed herein. Various embodiments may be utilized to prepare a SERS substrate using several deposition techniques such as pulsed laser deposition. Some embodiments optimize coverage, volume, or elements of SERS active metals. The method is a single step inexpensive method for preparing a SERS active substrate. In some embodiments a coating layer underneath the SERS active metals is utilized for additional enhancements.
摘要翻译：本文公开了一种用于拉曼光谱的装置，例如表面增强拉曼光谱（SERS）。可以使用多种沉积技术例如脉冲激光沉积来制备SERS衬底的各种实施例。一些实施例优化SERS活性金属的覆盖，体积或元素。该方法是用于制备SERS活性基底的单步廉价方法。在一些实施方案中，SERS活性金属下面的涂层用于额外的增强。

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