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1. 发明申请

US20140170070A1 STABLE COLLOIDAL GOLD NANOPARTICLES WITH CONTROLLABLE SURFACE MODIFICATION AND FUNCTIONALIZATION 审中-公开
标题翻译：具有可控表面改性和功能化的稳定的胶体金纳米颗粒
公开(公告)号：US20140170070A1
公开(公告)日：2014-06-19
申请号：US14187416
申请日：2014-02-24
申请人： Wei Qian , Makoto Murakami , Yuki Ichikawa , Yong Che
发明人： Wei Qian , Makoto Murakami , Yuki Ichikawa , Yong Che
IPC分类号： A61K49/00 , A61K47/10 , A61K41/00 , G01N21/65
CPC分类号： A61K49/0002 , A61K9/0019 , A61K9/1688 , A61K41/0057 , A61K47/10 , B01J13/0034 , B01J13/0043 , B82Y5/00 , B82Y30/00 , B82Y40/00 , G01N21/64 , G01N21/658 , G01N33/531 , G01N33/54346 , G01N2021/3595
摘要： In the present invention, a method of producing stable bare colloidal gold nanoparticles is disclosed. The nanoparticles can subsequently be subjected to partial or full surface modification. The method comprises preparation of colloidal gold nanoparticles in a liquid by employing a top-down nanofabrication method using bulk gold as a source material. The surface modification of these nanoparticles is carried out by adding one or multiple types of ligands each containing functional groups which exhibit affinity for gold nanoparticle surfaces to produce the conjugates. Because of the high efficiency and excellent stability of the nanoparticles produced by this method, the fabricated gold nanoparticle conjugates can have surface coverage with functional ligands which can be tuned to be any percent value between 0 and 100%.
摘要翻译：在本发明中，公开了一种制备稳定的裸胶体金纳米颗粒的方法。随后可以对纳米颗粒进行部分或全面修饰。该方法包括使用以大块金为原料的自顶向下纳米制造方法在液体中制备胶体金纳米颗粒。这些纳米颗粒的表面改性是通过添加一种或多种类型的配体，每个配体包含对金纳米颗粒表面具有亲和性以产生共轭物的官能团。由于通过该方法制备的纳米颗粒的高效率和优异的稳定性，所制备的金纳米颗粒共轭物可以具有表面覆盖的功能性配体，其可被调整为0至100％之间的任何百分比值。

2. 发明授权

US08697129B2 Stable colloidal gold nanoparticles with controllable surface modification and functionalization 有权
标题翻译：稳定的胶体金纳米粒子具有可控的表面改性和功能化
公开(公告)号：US08697129B2
公开(公告)日：2014-04-15
申请号：US13038788
申请日：2011-03-02
申请人： Wei Qian , Makoto Murakami , Yuki Ichikawa , Yong Che
发明人： Wei Qian , Makoto Murakami , Yuki Ichikawa , Yong Che
IPC分类号： A61K9/14 , A61K33/24
CPC分类号： A61K49/0002 , A61K9/0019 , A61K9/1688 , A61K41/0057 , A61K47/10 , B01J13/0034 , B01J13/0043 , B82Y5/00 , B82Y30/00 , B82Y40/00 , G01N21/64 , G01N21/658 , G01N33/531 , G01N33/54346 , G01N2021/3595
摘要： In the present invention, a method of producing stable bare colloidal gold nanoparticles is disclosed. The nanoparticles can subsequently be subjected to partial or full surface modification. The method comprises preparation of colloidal gold nanoparticles in a liquid by employing a top-down nanofabrication method using bulk gold as a source material. The surface modification of these nanoparticles is carried out by adding one or multiple types of ligands each containing functional groups which exhibit affinity for gold nanoparticle surfaces to produce the conjugates. Because of the high efficiency and excellent stability of the nanoparticles produced by this method, the fabricated gold nanoparticle conjugates can have surface coverage with functional ligands which can be tuned to be any percent value between 0 and 100%.
摘要翻译：在本发明中，公开了一种制备稳定的裸胶体金纳米颗粒的方法。随后可以对纳米颗粒进行部分或全面修饰。该方法包括使用以大块金为原料的自顶向下纳米制造方法在液体中制备胶体金纳米颗粒。这些纳米颗粒的表面改性是通过添加一种或多种类型的配体，每个配体包含对金纳米颗粒表面具有亲和性以产生共轭物的官能团。由于通过该方法制备的纳米颗粒的高效率和优异的稳定性，所制备的金纳米颗粒共轭物可以具有表面覆盖的功能性配体，其可被调整为0至100％之间的任何百分比值。

3. 发明申请

US20140213807A1 Methods For Preparing Aqueous Suspension Of Precious Metal Nanoparticles 审中-公开
标题翻译：制备贵金属纳米粒子水悬浮液的方法
公开(公告)号：US20140213807A1
公开(公告)日：2014-07-31
申请号：US14161773
申请日：2014-01-23
申请人： Yuki Ichikawa , Andrius Marcinkevicus , Masayuki Ito , Wei Qian
发明人： Yuki Ichikawa , Andrius Marcinkevicus , Masayuki Ito , Wei Qian
IPC分类号： C08G65/328 , B82Y30/00
CPC分类号： C08G65/328 , B01J13/0043 , B82Y30/00
摘要： The present disclosure is directed to methods of preparing stable suspensions of precious metal nanoparticles and methods for attaching bio-molecules to the nanoparticles. The formation of nanoparticles can be accomplished by either chemical synthesis or pulsed laser ablation in a liquid. The present disclosure reveals the importance of controlling the conductivity of the dispersion medium during pulsed laser ablation in a liquid to control the particle size of the nanoparticles. The present disclosure also reveals the importance of adjusting and maintaining the conductivity in a range of 25 μS/cm or less during storage of the nanoparticles and just prior to performing bioconjugation reactions. The control of conductivity is an important process for maintaining the nanoparticles as a stable non-aggregated colloidal suspension in a dispersion medium.
摘要翻译：本公开涉及制备贵金属纳米颗粒的稳定悬浮液的方法和将生物分子附着到纳米颗粒的方法。纳米颗粒的形成可以通过液体中的化学合成或脉冲激光烧蚀来实现。本公开揭示了在液体中的脉冲激光烧蚀期间控制分散介质的电导率以控制纳米颗粒的粒度的重要性。本公开还揭示了在纳米颗粒储存期间和刚好在进行生物共轭反应之前调节和保持电导率在25μS/ cm以下范围内的重要性。导电性的控制是将纳米颗粒保持在分散介质中作为稳定的非聚集胶体悬浮液的重要方法。

4. 发明申请

US20130189793A1 Stable Colloidal Suspensions Of Gold Nanoconjugates And The Method For Preparing The Same 审中-公开
标题翻译：金纳米结晶的稳定胶体悬浮液及其制备方法
公开(公告)号：US20130189793A1
公开(公告)日：2013-07-25
申请号：US13744633
申请日：2013-01-18
申请人： Wei Qian , Yong Che
发明人： Wei Qian , Yong Che
IPC分类号： G01N21/64
CPC分类号： G01N21/64 , A61K47/6923 , B01J13/0034 , B01J13/0043 , B82Y30/00 , G01N21/554
摘要： In the present invention, a method for determining the stability threshold amount of a stabilizer component for gold nanoparticles to prevent their aggregation in any electrolyte solution, is disclosed. The method permits for very low levels of stabilizer components to be used while still permitting conjugation with other functional ligands. The method comprises preparation of stable gold nanoparticles conjugated with different amount of stabilizing agents in deionized water first and then testing the stability of colloidal suspension of these gold nanoparticles in the presence of the electrolyte solution by monitoring the absorbance at 520 nm. The invention also comprises a method for fabrication of nanoconjugates comprising gold nanoparticles and only the stabilizer components or comprising gold nanoparticles, stabilizer components and functional ligands, which are stable in the presence of electrolytes.
摘要翻译：在本发明中，公开了一种用于确定金纳米颗粒的稳定剂组分以防止其在任何电解质溶液中聚集的稳定剂阈值量的方法。该方法允许使用非常低水平的稳定剂组分，同时仍允许与其它官能配体缀合。该方法首先制备在去离子水中与不同量的稳定剂缀合的稳定金纳米颗粒，然后通过监测520nm处的吸光度，测定这些金纳米粒子在电解质溶液存在下的胶体悬浮液的稳定性。本发明还包括一种制造纳米缀合物的方法，其包括金纳米颗粒并且仅包含稳定剂组分或包含在电解质存在下稳定的金纳米颗粒，稳定剂组分和官能配体。

5. 发明申请

US20210327801A1 PLATFORM POWER INTEGRITY DESIGN INCLUDING PACKAGE STANDARD POWER INTEGRITY MODEL AND COMPACT VOLTAGE REGULATOR MODULE MODEL 有权
公开(公告)号：US20210327801A1
公开(公告)日：2021-10-21
申请号：US17359514
申请日：2021-06-26
申请人： Xing Jian Cai , Chi-Te Chen , Wei Qian , Yihong Yang , Jue Chen , Long Wang , Chung-Hao Joseph Chen , Su Mi Sam , Srinivas Thota
发明人： Xing Jian Cai , Chi-Te Chen , Wei Qian , Yihong Yang , Jue Chen , Long Wang , Chung-Hao Joseph Chen , Su Mi Sam , Srinivas Thota
IPC分类号： H01L23/50 , G06F30/39 , G05F1/66 , H01L23/528 , G06F30/20
摘要： Some embodiments include apparatuses and electrical models associated with the apparatus. One of the apparatuses includes an integrated circuit having a die; a package substrate; first conductive connections coupled between the die and a first side of the package substrate; second conductive connections located on a second side of the package substrate opposite from the first side. The second conductive connections are coupled to the first conductive connections through conductive paths in the package substrate. The first conductive connections and the conductive connections are associated with an S-parameter of an electrical model of the integrated circuit package. The electrical model further includes at least one of a current value associated with a power rail of the integrated circuit package, an impedance target associated with a location at the integrated circuit package, and a mapping associated with the first and second conductive connections.

6. 发明授权

US08688423B2 Subsurface hydrogeologic system modeling 有权
标题翻译：地下水文地质系统建模
公开(公告)号：US08688423B2
公开(公告)日：2014-04-01
申请号：US13363158
申请日：2012-01-31
申请人： Michael L. Jessop , Michael J. Wallace , Wei Qian , Jerry R. Montgomery , Rondo Jeffery , Val O. Kofoed
发明人： Michael L. Jessop , Michael J. Wallace , Wei Qian , Jerry R. Montgomery , Rondo Jeffery , Val O. Kofoed
IPC分类号： G06G7/48
CPC分类号： G01V3/02 , G01V3/081 , G01V3/10 , G01V9/02 , G06F17/5009 , G06T17/05 , Y02A90/344
摘要： A method of modeling a subsurface hydrogeologic system within a study area can include applying an electric current directly to the subsurface hydrogeologic system and monitoring a magnetic field generated by the electric current in the subsurface hydrogeologic system. An electric current distribution can be identified within the study area by an inversion process based on the magnetic field. A model of the electric current distribution can be created.
摘要翻译：在研究区域内对地下水文地质系统建模的方法可以包括将电流直接施加到地下水文地质系统，并监测地下水文地质系统中的电流产生的磁场。可以通过基于磁场的反演过程在研究区域内识别电流分布。可以创建电流分布模型。

7. 发明申请

US20130316484A1 Enhancing uniformity of slab region thickness in optical components 有权
标题翻译：提高光学部件中板坯厚度的均匀性
公开(公告)号：US20130316484A1
公开(公告)日：2013-11-28
申请号：US13506910
申请日：2012-05-23
申请人： Joan Fong , Wei Qian , Dazeng Feng , Mehdi Asghari
发明人： Joan Fong , Wei Qian , Dazeng Feng , Mehdi Asghari
IPC分类号： H01L31/02
CPC分类号： G02F1/025 , G02B6/136 , H01S5/209 , H01S5/22
摘要： A method of forming an optical device includes generating a device precursor having a layer of a light-transmitting medium on a base. The method also includes forming an etch stop on the layer of light-transmitting medium. An active medium is grown on the etch stop and on the light-transmitting medium such that the light-transmitting medium is between the base and the grown active medium. The grown active medium is etched down to the etch stop so as to define a ridge in the active medium. The ridge of active medium defines a portion of a component waveguide that will guide a light signal through an active component on the device.
摘要翻译：形成光学器件的方法包括在基底上产生具有透光介质层的器件前体。该方法还包括在光透射介质层上形成蚀刻停止层。在蚀刻停止点和透光介质上生长活性介质，使得透光介质位于基底和生长的活性介质之间。将生长的活性介质蚀刻到蚀刻停止层，以便限定活性介质中的脊。有源介质的脊限定了将导引光信号穿过器件上的有源部件的部件波导的一部分。

8. 发明申请

US20130020664A1 Application of electrical field power to light-transmitting medium 有权
标题翻译：电场功率应用于透光介质
公开(公告)号：US20130020664A1
公开(公告)日：2013-01-24
申请号：US13136828
申请日：2011-08-10
申请人： Wei Qian , Dazeng Feng , Joan Fong , Mehdi Asghari
发明人： Wei Qian , Dazeng Feng , Joan Fong , Mehdi Asghari
IPC分类号： H01L31/0232 , H01L31/18
CPC分类号： G02B6/12004 , G02B6/131 , G02B2006/12061 , G02B2006/12176
摘要： A device includes an input waveguide on a base. The input waveguide guides a light signal through a light-transmitting medium to a light sensor. The light sensor includes a sensor waveguide on the base. The device also includes a sensor waveguide on the base. The sensor waveguide includes a light-absorbing medium that receives the light signal from the input waveguide. The light-absorbing medium has one or more continuous doped regions that are each positioned such that an application of electrical energy to the doped regions forms an electrical field in the light-absorbing medium. One or more of the doped regions has a first portion that is located within the light-absorbing medium and a second portion located outside of the light-absorbing medium. The device also includes an electrical conductor for applying the electrical energy to one of the doped regions. The electrical conductor contacts the portion of the doped regions that is located outside of the light-absorbing medium.
摘要翻译：装置包括在基座上的输入波导。输入波导通过光传输介质将光信号引导到光传感器。光传感器包括在基座上的传感器波导。该装置还包括在基座上的传感器波导。传感器波导包括从输入波导接收光信号的光吸收介质。光吸收介质具有一个或多个连续掺杂区域，每个连续掺杂区域被定位成使得向掺杂区域施加电能在光吸收介质中形成电场。一个或多个掺杂区域具有位于光吸收介质内的第一部分和位于光吸收介质外部的第二部分。该装置还包括用于将电能施加到一个掺杂区域的电导体。电导体接触位于光吸收介质外部的掺杂区域的部分。

9. 发明申请

US20120126738A1 Rotating Machinery Condition Monitoring Using Position Sensor 有权
标题翻译：使用位置传感器进行旋转机械状态监测
公开(公告)号：US20120126738A1
公开(公告)日：2012-05-24
申请号：US12948951
申请日：2010-11-18
申请人： Linglai Li , Wei Qian , Thomas D. Lundell
发明人： Linglai Li , Wei Qian , Thomas D. Lundell
IPC分类号： H02K11/00
CPC分类号： H02P29/0241
摘要： Continuous monitoring and fault diagnosis of rotating machinery during variable speed operation is performed using only a position feedback signal. The position sensor generates a periodic waveform having multiple pulses per revolution of the machine. A circuit is included to detect, for example, a zero crossing or edge of the periodic waveform. At each detected zero crossing or edge, the time and position of the event is stored in memory. Other data, such as the current in the motor, may also be sampled and stored in memory. Because the sampled data is triggered by repeated feature of the position feedback signal, the sampled data is in a stationary reference frame in the position domain. Frequency analysis is performed on the sampled data, and the frequency components present in either the sampled signal are analyzed to identify the presence of a fault in the rotating machinery.
摘要翻译：只能使用位置反馈信号，进行变速运转时旋转机械的连续监控和故障诊断。位置传感器产生每单位具有多个脉冲的周期性波形。包括电路以检测例如周期性波形的过零或边缘。在每个检测到的零交叉或边缘，事件的时间和位置存储在存储器中。其他数据，例如电动机中的电流也可以被采样并存储在存储器中。由于采样数据由位置反馈信号的重复特征触发，采样数据位于位置域中的静止参考帧。对采样数据进行频率分析，并分析存在于采样信号中的频率分量，以识别旋转机械中故障的存在。

10. 发明申请

US20080183308A1 RESONANT FREQUENCY IDENTIFICATION 有权
标题翻译：共振频率识别
公开(公告)号：US20080183308A1
公开(公告)日：2008-07-31
申请号：US11669048
申请日：2007-01-30
申请人： Zhengrong Li , Wei Qian , Peter B. Schmidt , Sang Hoon Lee
发明人： Zhengrong Li , Wei Qian , Peter B. Schmidt , Sang Hoon Lee
IPC分类号： G05B15/00 , G01H13/00 , H02P31/00
CPC分类号： H02P6/06 , B41J19/202 , H02P23/04 , H02P29/50
摘要： Systems and methods that determine resonant frequencies of a motor system via employing an output of a velocity regulator. The velocity regulator enables the motor drive to command the rotation of the motor at predetermined rotations, by setting rotational speeds of the motor. The output of the velocity regulator can then be stored as a function of time, and a Fast Fourier Transform performed on such time data to obtain a frequency data and a signal power spectrum.
摘要翻译：通过采用速度调节器的输出来确定电机系统的谐振频率的系统和方法。速度调节器使马达驱动器通过设定马达的转速来以预定转速来指令马达的旋转。速度调节器的输出可以作为时间的函数存储，并且对这种时间数据执行快速傅立叶变换以获得频率数据和信号功率谱。

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