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1. 发明申请

US20070178529A1 ELECTROMAGNETICALLY ACTUATED VALVES FOR USE IN MICROFLUIDIC STRUCTURES 审中-公开
标题翻译：用于微流体结构的电磁致动阀
公开(公告)号：US20070178529A1
公开(公告)日：2007-08-02
申请号：US11622733
申请日：2007-01-12
申请人： Wayne Breidford , C. Battrell
发明人： Wayne Breidford , C. Battrell
IPC分类号： G01N33/53
CPC分类号： F16K15/185 , B01F11/04 , B01F13/0059 , B01F13/0827 , B01L3/502738 , B01L3/502761 , B01L2200/0647 , B01L2200/143 , B01L2300/0816 , B01L2300/0864 , B01L2300/0874 , B01L2300/0887 , B01L2400/0622 , B01L2400/0633 , B01L2400/0638 , F16K15/16 , F16K31/06 , F16K99/0001 , F16K99/0007 , F16K99/0046 , F16K2099/0084
摘要： Disclosed are micron-sized, electromagnetically actuated tongue valves, which find application in microfluidic devices and apparatuses. The present invention further relates to methods for manipulating fluid flow in a microfluidic assay system and for sorting and capturing target particles in fluid suspensions.
摘要翻译：公开了微米尺寸的电磁致动舌阀，其可应用于微流体装置和装置中。本发明还涉及用于操纵微流体测定系统中的流体流动并用于在流体悬浮液中分选和捕获目标颗粒的方法。

2. 发明申请

US20060246575A1 Microfluidic rare cell detection device 审中-公开
标题翻译：微流体稀有细胞检测装置
公开(公告)号：US20060246575A1
公开(公告)日：2006-11-02
申请号：US11331587
申请日：2006-01-13
申请人： Christy Lancaster , C. Battrell , Jason Capodanno , John Gerdes , Mark Kokoris , Melud Nabavi , Stephen Mordue , Robert McRuer , John Clemmens , Wayne Breidford
发明人： Christy Lancaster , C. Battrell , Jason Capodanno , John Gerdes , Mark Kokoris , Melud Nabavi , Stephen Mordue , Robert McRuer , John Clemmens , Wayne Breidford
IPC分类号： C12M1/34
CPC分类号： F16K99/0001 , B01L3/50273 , B01L3/502738 , B01L3/502753 , B01L3/502761 , B01L3/502776 , B01L7/52 , B01L2200/0636 , B01L2200/0647 , B01L2200/10 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2400/0487 , B01L2400/0633 , F16K99/0007 , F16K99/0034 , F16K99/0046 , F16K2099/008 , F16K2099/0084 , G01N1/34 , G01N15/1459 , G01N15/1463 , G01N15/1484 , G01N2015/0069 , G01N2015/1409 , G01N2015/1486 , G01N2015/149
摘要： The present invention relates to microfluidic devices and methods for detecting rare cells. The disclosed microfluidic devices and methods integrate and automate sample preparation, cell labeling, cell sorting and enrichment, and DNA/RNA analysis of sorted cells.
摘要翻译：本发明涉及用于检测稀有细胞的微流体装置和方法。所公开的微流体装置和方法将样品制备，细胞标记，细胞分选和富集以及分选细胞的DNA / RNA分析整合并自动化。

3. 发明申请

US20050013732A1 Method and system for microfluidic manipulation, amplification and analysis of fluids, for example, bacteria assays and antiglobulin testing 有权
标题翻译：用于流体微流控操作，扩增和分析的方法和系统，例如细菌测定和抗球蛋白测试
公开(公告)号：US20050013732A1
公开(公告)日：2005-01-20
申请号：US10762586
申请日：2004-01-21
申请人： C. Battrell , Mingchao Shen , Bernhard Weigl , Jeffrey Houkal , Christy Lancaster , Wayne Breidford
发明人： C. Battrell , Mingchao Shen , Bernhard Weigl , Jeffrey Houkal , Christy Lancaster , Wayne Breidford
IPC分类号： B01F5/04 , B01F5/06 , B01F13/00 , B01L3/00 , F04B43/04 , C12Q1/68
CPC分类号： F04B43/043 , B01F5/0473 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/502753 , B01L7/52 , B01L2200/10 , B01L2300/0636 , B01L2300/0681 , B01L2300/0816 , B01L2300/0861 , B01L2300/0867 , B01L2300/1805 , B01L2400/0487 , B01L2400/0633 , C12Q1/686 , Y10T436/107497 , Y10T436/25 , Y10T436/2525 , Y10T436/25375 , C12Q2565/625 , C12Q2565/629
摘要： A microfluidic system for isolation and amplification of DNA or RNA from aqueous solutions and detection of the DNA or RNA on a lateral flow detection strip, including a disposable microfluidic card for use in analysis of bacteria in platelets and an analysis of sexually transmitted diseases (STD) in urine. The card will include an embedded membrane that filters out cells and cellular debris. Any biological debris on the membrane will be lysed and the DNA or RNA amplified via PCR amplification protocol, including appropriate reagents and thermal cycling conditions. The amplified DNA or RNA are transferred to a lateral flow detection strip for a visual diagnostic read out. An alternate embodiment includes a microfluidic card for use in typing antiglobulin assays.
摘要翻译：一种用于从水溶液中分离和扩增DNA或RNA的微流体系统，并检测侧流检测条上的DNA或RNA，包括用于血小板中细菌分析的一次性微流控卡和性传播疾病分析（STD ）在尿液。该卡将包括一个过滤掉细胞和细胞碎片的嵌入膜。膜上的任何生物碎片将被裂解，并通过PCR扩增方案扩增DNA或RNA，包括适当的试剂和热循环条件。将扩增的DNA或RNA转移到侧向流动检测条中以进行视觉诊断读出。替代实施方案包括用于分选抗球蛋白测定的微流控卡。

4. 发明授权

US07416892B2 Method and system for microfluidic manipulation, amplification and analysis of fluids, for example, bacteria assays and antiglobulin testing 有权
标题翻译：用于流体微流控操作，扩增和分析的方法和系统，例如细菌测定和抗球蛋白测试
公开(公告)号：US07416892B2
公开(公告)日：2008-08-26
申请号：US10762586
申请日：2004-01-21
申请人： C. Frederick Battrell , Mingchao Shen , Bernhard H. Weigl , Jeffrey M. Houkal , Christy A. Lancaster , Wayne Breidford
发明人： C. Frederick Battrell , Mingchao Shen , Bernhard H. Weigl , Jeffrey M. Houkal , Christy A. Lancaster , Wayne Breidford
IPC分类号： G01N31/00 , G01N1/00
CPC分类号： F04B43/043 , B01F5/0473 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/502753 , B01L7/52 , B01L2200/10 , B01L2300/0636 , B01L2300/0681 , B01L2300/0816 , B01L2300/0861 , B01L2300/0867 , B01L2300/1805 , B01L2400/0487 , B01L2400/0633 , C12Q1/686 , Y10T436/107497 , Y10T436/25 , Y10T436/2525 , Y10T436/25375 , C12Q2565/625 , C12Q2565/629
摘要： A microfluidic system for isolation and amplification of DNA or RNA from aqueous solutions and detection of the DNA or RNA on a lateral flow detection strip, including a disposable microfluidic card for use in analysis of bacteria in platelets and an analysis of sexually transmitted diseases (STD) in urine. The card will include an embedded membrane that filters out cells and cellular debris. Any biological debris on the membrane will be lysed and the DNA or RNA amplified via PCR amplification protocol, including appropriate reagents and thermal cycling conditions. The amplified DNA or RNA are transferred to a lateral flow detection strip for a visual diagnostic read out. An alternate embodiment includes a microfluidic card for use in typing antiglobulin assays.
摘要翻译：一种用于从水溶液中分离和扩增DNA或RNA的微流体系统，并检测侧流检测条上的DNA或RNA，包括用于血小板中细菌分析的一次性微流控卡和性传播疾病分析（STD ）在尿液。该卡将包括一个过滤掉细胞和细胞碎片的嵌入膜。膜上的任何生物碎片将被裂解，并通过PCR扩增方案扩增DNA或RNA，包括适当的试剂和热循环条件。将扩增的DNA或RNA转移到侧向流动检测条中以进行视觉诊断读出。替代实施方案包括用于分选抗球蛋白测定的微流控卡。

5. 发明授权

US07544506B2 System and method for heating, cooling and heat cycling on microfluidic device 有权
标题翻译：微流体装置上加热，冷却和热循环的系统和方法
公开(公告)号：US07544506B2
公开(公告)日：2009-06-09
申请号：US10862826
申请日：2004-06-07
申请人： Wayne Breidford , Christy A Lancaster , Jon Wallace Hayenga , Ronald L Bardell , Jeffrey F Tonn , Bernhard H Weigl
发明人： Wayne Breidford , Christy A Lancaster , Jon Wallace Hayenga , Ronald L Bardell , Jeffrey F Tonn , Bernhard H Weigl
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： B01L7/52 , B01J2219/00873 , B01L3/5027 , B01L3/502707 , B01L2200/147 , B01L2300/0816 , B01L2300/0887 , B01L2300/18 , B01L2300/1822 , B01L2300/185 , B01L2300/1877 , B01L2400/0487 , Y10S435/809
摘要： An integrated heat exchange system on a microfluidic card. According to one aspect of the invention, the portable microfluidic card has a heating, cooling and heat cycling system on-board such that the card can be used portably. The microfluidic card includes one or more reservoirs containing exothermic or endothermic material. Once the chemical process of the reservoir material is activated, the reservoir provides heat or cooling to specific locations of the microfluidic card. Multiple reservoirs may be included on a single card to provide varying temperatures. The assay chemicals can be moved to the various reservoirs to create a thermal cycle useful in many biological reactions, for example, Polymerase Chain Reaction (PCR) or rtPCR. According to another aspect of the invention, the integrated heat exchanger is an adjacent microfluidic circuit containing fluid that is either independently heated or cooled, or is an exothermic or endothermic material, such that the fluid in the adjacent circuit imparts a change in temperature to the assay fluid in an independent circuit. According to yet another aspect of the invention, a thermal electric cooler (TEC) is used for thermocycling the amplification chamber of a disposable microfluidic card.
摘要翻译：微流控卡上集成的热交换系统。根据本发明的一个方面，便携式微流控卡具有板上的加热，冷却和热循环系统，使得卡可以可移动地使用。微流控卡包括一个或多个含有放热或吸热材料的储存器。一旦储存器材料的化学过程被激活，储存器就向微流控卡的特定位置提供热量或冷却。可以在单个卡上包括多个储存器以提供变化的温度。测定化学品可以移动到各种储存器以产生可用于许多生物反应的热循环，例如聚合酶链式反应（PCR）或rtPCR。根据本发明的另一方面，集成热交换器是包含独立加热或冷却的流体的相邻微流体回路，或者是放热或吸热材料，使得相邻回路中的流体将温度变化赋予独立电路中的分析流体。根据本发明的另一方面，热电冷却器（TEC）用于热循环一次性微流控卡的放大室。

6. 发明申请

US20050129582A1 System and method for heating, cooling and heat cycling on microfluidic device 有权
标题翻译：微流体装置上加热，冷却和热循环的系统和方法
公开(公告)号：US20050129582A1
公开(公告)日：2005-06-16
申请号：US10862826
申请日：2004-06-07
申请人： Wayne Breidford , Christy Lancaster , Jon Hayenga , Ronald Bardell , Jeffrey Tonn , Bernhard Weigl
发明人： Wayne Breidford , Christy Lancaster , Jon Hayenga , Ronald Bardell , Jeffrey Tonn , Bernhard Weigl
IPC分类号： B01L3/00 , B01L7/00
CPC分类号： B01L7/52 , B01J2219/00873 , B01L3/5027 , B01L3/502707 , B01L2200/147 , B01L2300/0816 , B01L2300/0887 , B01L2300/18 , B01L2300/1822 , B01L2300/185 , B01L2300/1877 , B01L2400/0487 , Y10S435/809
摘要： An integrated heat exchange system on a microfluidic card. According to one aspect of the invention, the portable microfluidic card has a heating, cooling and heat cycling system on-board such that the card can be used portably. The microfluidic card includes one or more reservoirs containing exothermic or endothermic material. Once the chemical process of the reservoir material is activated, the reservoir provides heat or cooling to specific locations of the microfluidic card. Multiple reservoirs may be included on a single card to provide varying temperatures. The assay chemicals can be moved to the various reservoirs to create a thermal cycle useful in many biological reactions, for example, Polymerase Chain Reaction (PCR) or rtPCR. According to another aspect of the invention, the integrated heat exchanger is an adjacent microfluidic circuit containing fluid that is either independently heated or cooled, or is an exothermic or endothermic material, such that the fluid in the adjacent circuit imparts a change in temperature to the assay fluid in an independent circuit. According to yet another aspect of the invention, a thermal electric cooler (TEC) is used for thermocycling the amplification chamber of a disposable microfluidic card.
摘要翻译：微流控卡上集成的热交换系统。根据本发明的一个方面，便携式微流控卡具有板上的加热，冷却和热循环系统，使得卡可以可移动地使用。微流控卡包括一个或多个含有放热或吸热材料的储存器。一旦储存器材料的化学过程被激活，储存器就向微流控卡的特定位置提供热量或冷却。可以在单个卡上包括多个储存器以提供变化的温度。测定化学品可以移动到各种储存器以产生可用于许多生物反应的热循环，例如聚合酶链式反应（PCR）或rtPCR。根据本发明的另一方面，集成热交换器是包含独立加热或冷却的流体的相邻微流体回路，或者是放热或吸热材料，使得相邻回路中的流体将温度变化赋予独立电路中的分析流体。根据本发明的另一方面，热电冷却器（TEC）用于热循环一次性微流控卡的放大室。

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