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1. 发明授权

US06830892B2 Lentiviral vector system for high quantity screening 有权
标题翻译：用于大量筛选的慢病毒载体系统
公开(公告)号：US06830892B2
公开(公告)日：2004-12-14
申请号：US09953343
申请日：2001-09-14
申请人： Wayne A. Marasco , Sandra Ogueta
发明人： Wayne A. Marasco , Sandra Ogueta
IPC分类号： C12Q168
CPC分类号： C40B40/02 , A61K48/00 , C07K14/005 , C07K14/52 , C12N7/00 , C12N15/1037 , C12N15/86 , C12N2740/15022 , C12N2740/16043 , C12N2740/16045 , C12N2740/16052 , C12N2740/16062 , C12N2760/20222 , C12N2810/50 , C12N2810/60 , C12N2810/6081 , C12N2830/003 , C12N2830/38 , C12N2840/20 , C12N2840/203
摘要： A method of screening for a target molecule from a group of potential target molecules is described. This method involves using a library of lentiviral vectors where the members encode the group of target molecules, then transducing a group of cells and screening the transduced cell for a desired phenotype. The cell(s) displaying the desired phenotype is selected and the target molecule is identified.
摘要翻译：描述了从一组潜在的靶分子筛选靶分子的方法。该方法包括使用慢病毒载体文库，其中成员编码靶分子组，然后转导一组细胞并筛选转导的细胞以获得所需的表型。选择显示所需表型的细胞，鉴定靶分子。

2. 发明授权

US07078031B2 Pseudotyped lentiviral vectors and uses thereof 失效
公开(公告)号：US07078031B2
公开(公告)日：2006-07-18
申请号：US10844873
申请日：2004-05-13
申请人： Wayne A. Marasco , Sandra Ogueta
发明人： Wayne A. Marasco , Sandra Ogueta
IPC分类号： A61K48/00 , C12N15/867 , C12N15/63 , C12N15/64
CPC分类号： C40B40/02 , A61K48/00 , C07K14/005 , C07K14/52 , C12N7/00 , C12N15/1037 , C12N15/86 , C12N2740/16043 , C12N2740/16045 , C12N2740/16052 , C12N2740/16062 , C12N2760/20222 , C12N2810/50 , C12N2810/60 , C12N2810/6081 , C12N2830/003 , C12N2830/38 , C12N2840/203
摘要： A vector system that will produce a pseudotyped lentiviral vector that can be used to deliver a desired gene is disclosed. The vector constructs that are described include a number of modifications that enhance the safety of the vector. The vector can be used to more specifically target cells for expression of certain genes.

3. 发明申请

US20090130123A1 Antibodies to west nile virus polypeptides 审中-公开
标题翻译：西尼罗病毒多肽的抗体
公开(公告)号：US20090130123A1
公开(公告)日：2009-05-21
申请号：US11629825
申请日：2005-06-15
申请人： Erol Fikrig , Hannah Gould , Raymond A. Koski , Michel Ledizet , Wayne A. Marasco , Jianhua Sui
发明人： Erol Fikrig , Hannah Gould , Raymond A. Koski , Michel Ledizet , Wayne A. Marasco , Jianhua Sui
IPC分类号： A61K39/395 , C07K16/18 , C12N5/06 , C12N15/11 , C12N15/00 , C12P21/04 , A01K67/027 , A01H5/00 , A61K31/7088 , C12Q1/70
CPC分类号： C07K16/1081 , A61K2039/505 , C07K2317/21 , C07K2317/54 , C07K2317/56 , C07K2317/622 , C07K2317/76 , C07K2317/92 , Y02A50/386 , Y02A50/39 , Y02A50/394
摘要： The present invention relates to anti-West Nile virus E protein (WNE) antibodies, including human antibodies, and antigen-binding portions thereof. In particular, the invention relates to such antibodies and portions that prevent, inhibit, or treat a flavivirus infection, including a West Nile Virus infection. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or that are portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-WNE antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-WNE antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis, prophylaxis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-WNE antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
摘要翻译：本发明涉及包含人抗体的抗西尼罗病毒E蛋白（WNE）抗体及其抗原结合部分。特别地，本发明涉及预防，抑制或治疗黄病毒感染（包括西尼罗河病毒感染）的这些抗体和部分。本发明还涉及嵌合，双特异性，衍生的单链抗体或融合蛋白的部分的抗体。本发明还涉及衍生自人类抗WNE抗体的分离的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。本发明还涉及制备人抗WNE抗体的方法，包含这些抗体的组合物和使用抗体和组合物进行诊断，预防和治疗的方法。本发明还提供使用编码包含人抗WNE抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。本发明还涉及包含本发明的核酸分子的转基因动物或植物。

4. 发明授权

US06479284B1 Humanized antibody and uses thereof 失效
标题翻译：人源化抗体及其用途
公开(公告)号：US06479284B1
公开(公告)日：2002-11-12
申请号：US09660169
申请日：2000-09-12
申请人： Wayne A. Marasco , Joyce Lavecchio , Abner Mhashilkar , Urban Ramstedt , David Ring , Bridget Eberhardt , Julie Porter-Brooks
发明人： Wayne A. Marasco , Joyce Lavecchio , Abner Mhashilkar , Urban Ramstedt , David Ring , Bridget Eberhardt , Julie Porter-Brooks
IPC分类号： C12N506
CPC分类号： C07K16/1072 , A61K48/00 , C07K2317/24 , C07K2317/622 , C07K2317/81 , C07K2317/82 , C07K2319/00
摘要： A humanized antibody framework motif is described. Preferably, the motif is encoded by the VH gene of K5B8 and the VL gene of TR1.6. This humanized antibody preferably contains the variable region of a tat antibody.
摘要翻译：描述了人源化抗体框架基序。优选地，该基序由K5B8的VH基因和TR1.6的VL基因编码。该人源化抗体优选含有tat抗体的可变区。

5. 发明授权

US6072036A Method of intracellular binding of target molecules 失效
标题翻译：靶分子的细胞内结合方法
公开(公告)号：US6072036A
公开(公告)日：2000-06-06
申请号：US287145
申请日：1999-04-06
申请人： Wayne A. Marasco , William A. Haseltine
发明人： Wayne A. Marasco , William A. Haseltine
IPC分类号： A61K38/00 , C07K16/00 , C07K16/10 , C07K16/28 , C12N15/13 , C12N15/67 , C12N15/85 , C12P21/08
CPC分类号： C07K16/1063 , C07K16/00 , C07K16/1072 , C07K16/2866 , C12N15/67 , C12N15/85 , A61K2039/505 , A61K38/00 , C07K2317/21 , C07K2317/55 , C07K2317/622 , C07K2317/81 , C07K2317/82 , C07K2319/00
摘要： The present invention relates to a method by which one can target an undesired target molecule or target antigen, preferably a protein. The method comprises the intracellular expression of an antibody capable of binding to the target. A DNA sequence is delivered to a cell, the DNA sequence contains a sufficient number of nucleotides coding for the portion of an antibody capable of binding to the target operably linked to a promoter that will permit expression of the antibody in the cell(s) of interest. The antibody is then expressed intracellularly and binds to the target, thereby disrupting the target from its normal actions.
摘要翻译：本发明涉及一种可以靶向不想要的靶分子或靶抗原，优选靶蛋白的方法。该方法包括能够结合靶标的抗体的细胞内表达。将DNA序列递送至细胞，该DNA序列含有足够数量的核苷酸，该核苷酸编码抗体能够结合至靶的可操作连接的启动子部分，该启动子将允许抗体在细胞中表达利益。抗体然后在细胞内表达并与目标物结合，从而使目标不受其正常作用的干扰。

6. 发明申请

US20110250165A1 Antibodies against CXCR4 and Methods of Use Thereof 有权
公开(公告)号：US20110250165A1
公开(公告)日：2011-10-13
申请号：US11883258
申请日：2006-02-15
申请人： Wayne A. Marasco , Jianhun Sui , Chen Xu
发明人： Wayne A. Marasco , Jianhun Sui , Chen Xu
IPC分类号： A61K38/19 , A61K39/395 , A61P35/04 , A61P35/00 , A61P37/06 , C07K16/28 , A61P31/18
CPC分类号： C07K16/2866 , A61K2039/505 , C07K16/005 , C07K2317/21 , C07K2317/622
摘要： The invention provides human monoclonal antibodies, scFv antibodies, scFv-Fc fusions, a dAb (domain antibodies), Fab, Fab′ and F(ab)′2 fragments, single chain antibodies and/or minibodies that specifically bind to CXCR4. Also provided are methods of treating and/or preventing a CXCR4 disease or disorder such as cancer and X4-tropic HIV-I infection as well as uses of such antibodies and antibody fragments in the manufacture of a medicament for the treatment or prevention of a CXCR4 disorder. The invention also provides methods of preventing diseases or disorders associated with CXCR4 function or expression. The invention further provides for the use of the antibodies (or fragments thereof) of the invention in the manufacture of a medicament for the prevention of diseases or disorders associated with CXCR4 expression. Also provided are methods of treating or preventing cancer metastasis in a patient suffering from a cancer involving tumor cells that express CXCR4. The invention also encompasses the use of such antibodies and antibody fragments in the manufacture of a medicament for the treatment or prevention of cancer metastasis. The invention also includes methods of treating or preventing cancer metastasis in a patient suffering from a hypoxic tumor, such as any solid tumor characterized by HIF-dependent CXCR4 activation. The antibodies and fragments disclosed herein can be used in the manufacture of a medicament for the prevention of cancer metastasis in a patient suffering from a hypoxic tumor. The invention additionally provides methods of mobilizing CD34+ stem cells from the bone marrow as wells methods of blocking chemotaxis of CXCR4-expressing cells in response to SDF-1. Also provided are methods of treating or preventing graft-versus-host disease as well as the use of the antibodies and fragments thereof in the manufacture of a medicament for the prevention or treatment of GVHD. Finally, the invention also provides methods of inhibiting the formation of new tumor blood vessels and/or inhibiting tumor cell angiogenesis.

7. 发明申请

US20110038935A1 ANTIBODIES AGAINST INFLUENZA VIRUS AND METHODS OF USE THEREOF 审中-公开
标题翻译：抗流行性感冒病毒的抗体及其使用方法
公开(公告)号：US20110038935A1
公开(公告)日：2011-02-17
申请号：US12746622
申请日：2008-12-08
申请人： Wayne A. Marasco , Jianhua Sui , Robert C. Liddington
发明人： Wayne A. Marasco , Jianhua Sui , Robert C. Liddington
IPC分类号： A61K39/42 , C07K16/10 , C07H21/00 , A61K39/145 , A61K9/00 , C12Q1/70 , A61P31/16 , A61P37/04
CPC分类号： C07K16/1018 , A61K2039/505 , A61P31/16 , C07K14/005 , C07K2317/21 , C07K2317/52 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C07K2319/40 , C12N2760/16122
摘要： The invention provides human scFv antibodies and monoclonal antibodies that neutralize influenza virus. Also provided are methods of treating and/or preventing a influenza related disease or disorder such bird flu The invention also provides methods of vaccinating a patient against influenza. Also provided are methods of diagnosing influenza-related diseases or disorders and methods of detecting the presence of a influenza in a sample.
摘要翻译：本发明提供中和流感病毒的人scFv抗体和单克隆抗体。还提供了治疗和/或预防流感相关疾病或病症的方法，例如禽流感本发明还提供了针对流感疫苗接种患者的方法。还提供诊断流感相关疾病或病症的方法以及检测样品中流感的存在的方法。

8. 发明授权

US07786269B2 Antibody to latent membrane proteins and uses thereof 有权
标题翻译：潜伏膜蛋白的抗体及其用途
公开(公告)号：US07786269B2
公开(公告)日：2010-08-31
申请号：US10496861
申请日：2002-12-04
申请人： Wayne A. Marasco , Francesca Gennari
发明人： Wayne A. Marasco , Francesca Gennari
IPC分类号： A61K39/395 , A61K39/00 , A61K39/42 , A61K35/14 , C07K14/00 , C07K16/00 , A61K39/145
CPC分类号： C07K16/085 , A61K2039/505 , C07K16/32
摘要： The present invention provides antibodies and antibody fragments directed against extracellular domains of the EBV LMP proteins, including LMP1, LMP2A and LMP2B. The invention also provides methods of treating EBV-associated malignancies using these LMP specific antibodies.
摘要翻译：本发明提供针对EBV LMP蛋白的细胞外结构域的抗体和抗体片段，包括LMP1，LMP2A和LMP2B。本发明还提供了使用这些LMP特异性抗体治疗EBV相关恶性肿瘤的方法。

9. 发明授权

US5852186A Reactive neutralizing human anti-GP120 recombinant antibody, DNA coding the same and use thereof 失效
标题翻译：反应中和人抗GP120重组抗体，DNA编码相同并使用
公开(公告)号：US5852186A
公开(公告)日：1998-12-22
申请号：US480774
申请日：1995-06-07
申请人： Joseph G. Sodroski , Wayne A. Marasco , Marshall R. Posner , William A. Haseltine
发明人： Joseph G. Sodroski , Wayne A. Marasco , Marshall R. Posner , William A. Haseltine
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61P31/12 , A61P37/04 , C07K14/155 , C07K16/10 , C12N15/13 , C12P21/08 , C12Q1/68 , C12R1/19 , C07H21/04 , A61K39/42
CPC分类号： C07K16/1063 , A61K38/00
摘要： The present invention is directed to a recombinant human monoclonal antibody which binds to a discontinuous epitope on the HIV gp120 envelope glycoprotien, blocks the binding of gp120 to the CD4 receptor, and neutralizes a broad range of HIV isolates. The present invention also provides the primary nucleotide and deduced amino acid sequences of the rearranged heavy and light chains of the recombinant monoclonal antibody of the present invention, and a method of screening for antibodies which block binding of envelope glycoprotein to the CD4 receptor.
摘要翻译：本发明涉及结合HIV gp120包膜糖支原体上的不连续表位的重组人单克隆抗体，阻断gp120与CD4受体的结合，并中和大范围的HIV分离物。本发明还提供本发明的重组单克隆抗体重排的重链和轻链的主要核苷酸和推断的氨基酸序列，以及筛选封闭糖蛋白与CD4受体结合的抗体的方法。

10. 发明授权

US5851829A Method of intracellular binding of target molecules 失效
标题翻译：靶分子的细胞内结合方法
公开(公告)号：US5851829A
公开(公告)日：1998-12-22
申请号：US373190
申请日：1995-03-30
申请人： Wayne A. Marasco , William A. Haseltine
发明人： Wayne A. Marasco , William A. Haseltine
IPC分类号： C07K16/00 , C07K16/10 , C12N15/00
CPC分类号： C07K16/1072 , C07K16/00 , C07K16/1063
摘要： The present invention relates to a method by which one can target an undesired target molecule or target antigen, preferably a protein. The method comprises the intracellular expression of an antibody capable of binding to the target. A DNA sequence is delivered to a cell, the DNA sequence contains a sufficient number of nucleotides coding for the portion of an antibody capable of binding to the target operably linked to a promoter that will permit expression of the antibody in the cell(s) of interest. The antibody is then expressed intracellularly and binds to the target, thereby disrupting the target from its normal actions.
摘要翻译： PCT No.PCT / US93 / 06735 Sec。 371日期1995年3月30日 102（e）1995年3月30日PCT PCT 1993年7月16日PCT公布。出版物WO94 / 02610 日期1994年2月3日本发明涉及一种可靶向不想要的靶分子或靶抗原，优选靶蛋白的方法。该方法包括能够结合靶标的抗体的细胞内表达。将DNA序列递送至细胞，DNA序列含有足够数目的核苷酸，该核苷酸编码能够与可操作地连接至启动子的能够结合靶的部分的部分，所述启动子将允许抗体在细胞中表达利益。抗体然后在细胞内表达并与目标物结合，从而使目标不受其正常作用的干扰。

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