专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08435515B2 Poly-N-acetyl glucosamine (PNAG/dPNAG)-binding peptides and methods of use thereof 有权
标题翻译：聚-N-乙酰氨基葡萄糖（PNAG / dPNAG）结合肽及其使用方法
公开(公告)号：US08435515B2
公开(公告)日：2013-05-07
申请号：US13334807
申请日：2011-12-22
申请人： Gerald B. Pier , Casie Anne Kelly-Quintos , Lisa Cavacini , Marshall R. Posner
发明人： Gerald B. Pier , Casie Anne Kelly-Quintos , Lisa Cavacini , Marshall R. Posner
IPC分类号： A61K38/00 , A61K39/395 , A61K39/40 , C07K1/00 , C07K16/00
CPC分类号： C07K16/1271 , A61K2039/505 , C07K16/12 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , Y02A50/407
摘要： The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to poly-N-acetyl glucosamine (PNAG), such as Staphylococcal PNAG, in acetylated, partially acetylated and/or fully deacetylated form. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of infections by bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Some antibodies of the invention enhance opsonophagocytic killing and in vivo protection against bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.
摘要翻译：本发明涉及在乙酰化，部分乙酰化和/或完全脱乙酰化形式中特异性结合聚-N-乙酰葡糖胺（PNAG）如葡萄球菌PNAG的肽，特别是人单克隆抗体。本发明还提供了在诊断，预防和治疗表达PNAG（例如但不限于葡萄球菌和大肠杆菌）的细菌的感染中使用这些肽的方法。本发明的一些抗体增强对表达PNAG（例如但不限于葡萄球菌和大肠杆菌）的细菌的调理吞噬杀伤和体内保护。还提供了这些肽的组合物，包括药物组合物，以及这些肽的功能上等同的变体。

2. 发明申请

US20120201833A1 POLY-N-ACETYL GLUCOSAMINE (PNAG/dPNAG)-BINDING PEPTIDES AND METHODS OF USE THEREOF 有权
标题翻译：聚N-乙酰葡萄糖胺（PNAG / dPNAG）联蛋白及其使用方法
公开(公告)号：US20120201833A1
公开(公告)日：2012-08-09
申请号：US13334807
申请日：2011-12-22
申请人： Gerald B. Pier , Casie Anne Kelly-Quintos , Lisa Cavacini , Marshall R. Posner
发明人： Gerald B. Pier , Casie Anne Kelly-Quintos , Lisa Cavacini , Marshall R. Posner
IPC分类号： A61K39/40 , A61P31/04 , C07K16/12
CPC分类号： C07K16/1271 , A61K2039/505 , C07K16/12 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , Y02A50/407
摘要： The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to poly-N-acetyl glucosamine (PNAG), such as Staphylococcal PNAG, in acetylated, partially acetylated and/or fully deacetylated form. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of infections by bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Some antibodies of the invention enhance opsonophagocytic killing and in vivo protection against bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.
摘要翻译：本发明涉及在乙酰化，部分乙酰化和/或完全脱乙酰化形式中特异性结合聚-N-乙酰葡糖胺（PNAG）如葡萄球菌PNAG的肽，特别是人单克隆抗体。本发明还提供了在诊断，预防和治疗表达PNAG（例如但不限于葡萄球菌和大肠杆菌）的细菌的感染中使用这些肽的方法。本发明的一些抗体增强对表达PNAG（例如但不限于葡萄球菌和大肠杆菌）的细菌的调理吞噬杀伤和体内保护。还提供了这些肽的组合物，包括药物组合物，以及这些肽的功能上等同的变体。

3. 发明授权

US5852186A Reactive neutralizing human anti-GP120 recombinant antibody, DNA coding the same and use thereof 失效
标题翻译：反应中和人抗GP120重组抗体，DNA编码相同并使用
公开(公告)号：US5852186A
公开(公告)日：1998-12-22
申请号：US480774
申请日：1995-06-07
申请人： Joseph G. Sodroski , Wayne A. Marasco , Marshall R. Posner , William A. Haseltine
发明人： Joseph G. Sodroski , Wayne A. Marasco , Marshall R. Posner , William A. Haseltine
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61P31/12 , A61P37/04 , C07K14/155 , C07K16/10 , C12N15/13 , C12P21/08 , C12Q1/68 , C12R1/19 , C07H21/04 , A61K39/42
CPC分类号： C07K16/1063 , A61K38/00
摘要： The present invention is directed to a recombinant human monoclonal antibody which binds to a discontinuous epitope on the HIV gp120 envelope glycoprotien, blocks the binding of gp120 to the CD4 receptor, and neutralizes a broad range of HIV isolates. The present invention also provides the primary nucleotide and deduced amino acid sequences of the rearranged heavy and light chains of the recombinant monoclonal antibody of the present invention, and a method of screening for antibodies which block binding of envelope glycoprotein to the CD4 receptor.
摘要翻译：本发明涉及结合HIV gp120包膜糖支原体上的不连续表位的重组人单克隆抗体，阻断gp120与CD4受体的结合，并中和大范围的HIV分离物。本发明还提供本发明的重组单克隆抗体重排的重链和轻链的主要核苷酸和推断的氨基酸序列，以及筛选封闭糖蛋白与CD4受体结合的抗体的方法。

4. 发明授权

US5215913A IgG-1 human monoclonal antibody reactive with an HIV-1 antigen and methods of use 失效
标题翻译：与HIV-1抗原反应的IgG-1人单克隆抗体和使用方法
公开(公告)号：US5215913A
公开(公告)日：1993-06-01
申请号：US485179
申请日：1990-02-26
申请人： Marshall R. Posner
发明人： Marshall R. Posner
IPC分类号： A61K39/395 , A61K38/00 , A61P35/00 , C07K16/10 , C07K16/12 , C07K16/30 , C12N5/10 , C12N5/26 , C12N5/28 , C12N15/02 , C12N15/09 , C12N15/13 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/569 , G01N33/577
CPC分类号： C07K16/1282 , C07K16/1045 , C07K16/30 , C07K16/3046 , C07K16/3061 , C12N5/166 , A61K38/00
摘要： The present invention provides a human-mouse myeloma analog, designated HMMA 2.11TG/O, which has been deposited with the American Type Culture Collection (ATCC) under Accession Number HB 9583. The invention also provides a hybridoma designated F 105, which also has been deposited with the ATCC under Accession Number HB 10363.The invention also concerns a monoclonal antibody-producing hybridoma produced by the fusion of the human-mouse myeloma analog and an antibody-producing cell. Other embodiments of the invention provide a method for producing a monoclonal antibody-producing hybridoma which comprises fusing the human-mouse myeloma analog with a human antibody-producing cell and a therapeutic method for treating a subject having a pathogen- or tumor-related disease which comprises administering to the subject a monoclonal antibody specific for the disease produced by the monoclonal antibody-producing hybridoma. In addition, a method of blocking binding of the human immunodeficiency virus and method of preventing infection of human cells by the human immunodeficiency virus are disclosed, as well as methods of detecting the virus or its antigen.
摘要翻译：本发明提供了一种称为HMMA 2.11TG / O的人小鼠骨髓瘤类似物，其以保藏号HB9583保藏在美国典型培养物保藏中心（ATCC）中。本发明还提供了一种称为F105的杂交瘤，其也具有已经以ATCC号10363保藏在ATCC中。本发明还涉及通过人 - 小鼠骨髓瘤类似物和产生抗体的细胞融合产生的产生单克隆抗体的杂交瘤。本发明的其它实施方案提供了产生产生单克隆抗体的杂交瘤的方法，其包括将人小鼠骨髓瘤类似物与人抗体产生细胞融合，以及用于治疗患有病原体或肿瘤相关疾病的受试者的治疗方法，包括向受试者施用对由产生单克隆抗体的杂交瘤产生的疾病特异性的单克隆抗体。此外，公开了一种阻断人免疫缺陷病毒结合的方法和人体免疫缺陷病毒预防人细胞感染的方法，以及检测病毒或其抗原的方法。

5. 发明授权

US08410249B2 Poly-N-acetyl glucosamine (PNAG/dPNAG)-binding peptides and methods of use thereof 有权
公开(公告)号：US08410249B2
公开(公告)日：2013-04-02
申请号：US13334869
申请日：2011-12-22
申请人： Gerald B. Pier , Casie Anne Kelly-Quintos , Lisa Cavacini , Marshall R. Posner
发明人： Gerald B. Pier , Casie Anne Kelly-Quintos , Lisa Cavacini , Marshall R. Posner
IPC分类号： C07K1/00 , C07K16/00 , C12P21/08
CPC分类号： C07K16/1271 , A61K2039/505 , C07K16/12 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , Y02A50/407
摘要： The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to poly-N-acetyl glucosamine (PNAG), such as Staphylococcal PNAG, in acetylated, partially acetylated and/or fully deacetylated form. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of infections by bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Some antibodies of the invention enhance opsonophagocytic killing and in vivo protection against bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.

6. 发明申请

US20110002932A1 POLY-N-ACETYL GLUCOSAMINE (PNAG/dPNAG)-BINDING PEPTIDES AND METHODS OF USE THEREOF 有权
标题翻译：聚N-乙酰葡萄糖胺（PNAG / dPNAG）联蛋白及其使用方法
公开(公告)号：US20110002932A1
公开(公告)日：2011-01-06
申请号：US12824510
申请日：2010-06-28
申请人： Gerald B. Pier , Casie Anne Kelly-Quintos , Lisa Cavacini , Marshall R. Posner
发明人： Gerald B. Pier , Casie Anne Kelly-Quintos , Lisa Cavacini , Marshall R. Posner
IPC分类号： A61K39/395 , C07K7/06 , C07K7/08 , C07K16/12 , C07H21/00 , C12N15/63 , C12N5/10 , A61P31/04
CPC分类号： C07K16/1271 , A61K2039/505 , C07K16/12 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , Y02A50/407
摘要： The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to poly-N-acetyl glucosamine (PNAG), such as Staphylococcal PNAG, in acetylated, partially acetylated and/or fully deacetylated form. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of infections by bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Some antibodies of the invention enhance opsonophagocytic killing and in vivo protection against bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.
摘要翻译：本发明涉及在乙酰化，部分乙酰化和/或完全脱乙酰化形式中特异性结合聚-N-乙酰葡糖胺（PNAG）如葡萄球菌PNAG的肽，特别是人单克隆抗体。本发明还提供了在诊断，预防和治疗表达PNAG（例如但不限于葡萄球菌和大肠杆菌）的细菌的感染中使用这些肽的方法。本发明的一些抗体增强对表达PNAG（例如但不限于葡萄球菌和大肠杆菌）的细菌的调理吞噬杀伤和体内保护。还提供了这些肽的组合物，包括药物组合物，以及这些肽的功能上等同的变体。

7. 发明授权

US07786255B2 Poly-N-acetyl glucosamine (PNAG/dPNAG)-binding peptides and methods of use thereof 有权
标题翻译：聚-N-乙酰氨基葡萄糖（PNAG / dPNAG）结合肽及其使用方法
公开(公告)号：US07786255B2
公开(公告)日：2010-08-31
申请号：US11111688
申请日：2005-04-21
申请人： Gerald B. Pier , Casie Anne Kelly-Quintos , Lisa Cavacini , Marshall R. Posner
发明人： Gerald B. Pier , Casie Anne Kelly-Quintos , Lisa Cavacini , Marshall R. Posner
IPC分类号： C07K14/00 , C07K17/00 , C12P21/08
CPC分类号： C07K16/1271 , A61K2039/505 , C07K16/12 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , Y02A50/407
摘要： The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to poly-N-acetyl glucosamine (PNAG), such as Staphylococcal PNAG, in acetylated, partially acetylated and/or fully deacetylated form. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of infections by bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Some antibodies of the invention enhance opsonophagocytic killing and in vivo protection against bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.
摘要翻译：本发明涉及在乙酰化，部分乙酰化和/或完全脱乙酰化形式中特异性结合聚-N-乙酰葡糖胺（PNAG）如葡萄球菌PNAG的肽，特别是人单克隆抗体。本发明还提供了在诊断，预防和治疗表达PNAG（例如但不限于葡萄球菌和大肠杆菌）的细菌的感染中使用这些肽的方法。本发明的一些抗体增强对表达PNAG（例如但不限于葡萄球菌和大肠杆菌）的细菌的调理吞噬杀伤和体内保护。还提供了这些肽的组合物，包括药物组合物，以及这些肽的功能上等同的变体。

8. 发明授权

US08350017B2 Poly-N-acetyl glucosamine (PNAG/dPNAG)-binding peptides and methods of use thereof 有权
公开(公告)号：US08350017B2
公开(公告)日：2013-01-08
申请号：US13334775
申请日：2011-12-22
申请人： Gerald B. Pier , Casie Anne Kelly-Quintos , Lisa Cavacini , Marshall R. Posner
发明人： Gerald B. Pier , Casie Anne Kelly-Quintos , Lisa Cavacini , Marshall R. Posner
IPC分类号： C07H21/02 , C07H21/04 , C12N1/20 , C12N15/00
CPC分类号： C07K16/1271 , A61K2039/505 , C07K16/12 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , Y02A50/407
摘要： The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to poly-N-acetyl glucosamine (PNAG), such as Staphylococcal PNAG, in acetylated, partially acetylated and/or fully deacetylated form. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of infections by bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Some antibodies of the invention enhance opsonophagocytic killing and in vivo protection against bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.

9. 发明申请

US20120208270A1 POLY-N-ACETYL GLUCOSAMINE (PNAG/dPNAG)-BINDING PEPTIDES AND METHODS OF USE THEREOF 有权
公开(公告)号：US20120208270A1
公开(公告)日：2012-08-16
申请号：US13334840
申请日：2011-12-22
申请人： Gerald B. Pier , Casie Anne Kelly-Quintos , Lisa Cavacini , Marshall R. Posner
发明人： Gerald B. Pier , Casie Anne Kelly-Quintos , Lisa Cavacini , Marshall R. Posner
IPC分类号： C12N5/10 , C07H21/04 , C12N15/63
CPC分类号： C07K16/1271 , A61K2039/505 , C07K16/12 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , Y02A50/407
摘要： The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to poly-N-acetyl glucosamine (PNAG), such as Staphylococcal PNAG, in acetylated, partially acetylated and/or fully deacetylated form. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of infections by bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Some antibodies of the invention enhance opsonophagocytic killing and in vivo protection against bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.

10. 发明授权

US08084595B2 Poly-N-acetyl glucosamine (PNAG/dPNAG)-binding peptides and methods of use thereof 有权
标题翻译：聚-N-乙酰氨基葡萄糖（PNAG / dPNAG）结合肽及其使用方法
公开(公告)号：US08084595B2
公开(公告)日：2011-12-27
申请号：US12824510
申请日：2010-06-28
申请人： Gerald B. Pier , Casie Anne Kelly-Quintos , Lisa Cavacini , Marshall R. Posner
发明人： Gerald B. Pier , Casie Anne Kelly-Quintos , Lisa Cavacini , Marshall R. Posner
IPC分类号： C07H21/04 , C12N1/20 , C12N15/00
CPC分类号： C07K16/1271 , A61K2039/505 , C07K16/12 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , Y02A50/407
摘要： The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to poly-N-acetyl glucosamine (PNAG), such as Staphylococcal PNAG, in acetylated, partially acetylated and/or fully deacetylated form. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of infections by bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Some antibodies of the invention enhance opsonophagocytic killing and in vivo protection against bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.
摘要翻译：本发明涉及在乙酰化，部分乙酰化和/或完全脱乙酰化形式中特异性结合聚-N-乙酰葡糖胺（PNAG）如葡萄球菌PNAG的肽，特别是人单克隆抗体。本发明还提供了在诊断，预防和治疗表达PNAG（例如但不限于葡萄球菌和大肠杆菌）的细菌的感染中使用这些肽的方法。本发明的一些抗体增强对表达PNAG（例如但不限于葡萄球菌和大肠杆菌）的细菌的调理吞噬杀伤和体内保护。还提供了这些肽的组合物，包括药物组合物，以及这些肽的功能上等同的变体。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式