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1. 发明申请

US20200150097A1 MECHANISMS AND METHODS FOR LIQUID SAMPLE INTRODUCTION INTO A CHROMATOGRAPHY SYSTEM 审中-公开
公开(公告)号：US20200150097A1
公开(公告)日：2020-05-14
申请号：US16678454
申请日：2019-11-08
申请人： Waters Technologies Corporation
发明人： Jason Hill , Abhijit Tarafder , Michael O. Fogwill , Thomas McDonald , Sylvain Cormier
IPC分类号： G01N30/20 , B01D15/40 , G01N30/34 , G01N30/32
摘要： The disclosure relates to a system for liquid sample introduction into a chromatography system. The system includes a syringe, a first valve in fluid communication with the syringe, a second valve in fluid communication with the sample, a vessel located between, and in fluid communication with, the first and second valves, a third valve in fluid communication with the first valve, the second valve and a chromatography column, and a pump in fluid communication with the third valve and a mobile phase. When the valves are in a first position the syringe draws the sample into the vessel. The mobile phase flows to the chromatography column. When the valves are in a second position, a portion of the mobile phase flows into the vessel, mixing with and pressurizing the sample. When the valves are in a third position, the mixed and pressurized sample flows to the chromatography column.

2. 发明授权

US10385995B2 Fluidic coupling seal 有权
公开(公告)号：US10385995B2
公开(公告)日：2019-08-20
申请号：US14651835
申请日：2013-12-16
申请人： Waters Technologies Corporation
发明人： Sylvain Cormier , Joshua A. Shreve , Joseph A. Luongo , Paul Keenan , Kenneth Plant
IPC分类号： G01N30/22 , F16L19/02 , G01N30/60
摘要： Described is a coupling seal that includes a polymeric body having a bore extending from a first end to an internal sealing surface and a fluid channel extending from the internal sealing surface to a second end. The bore is configured to receive a tube having a fluid channel so that an endface of the tube engages the internal sealing surface. The second end of the polymeric body is configured to contact a sealing surface of a coupling body that has a fluid channel extending from the sealing surface. A fluidic seal occurs when the coupling seal is compressed between the endface and the sealing surface. A void between an outer surface of the polymeric body and an inner surface of the coupling body receives the deformation of the coupling seal while under compression to thereby prevent the fluid channel of the tube from being crushed or obstructed.

3. 发明授权

US10323763B2 Check valve having polymeric seat and poppet 有权
公开(公告)号：US10323763B2
公开(公告)日：2019-06-18
申请号：US14907857
申请日：2014-07-30
申请人： Waters Technologies Corporation
发明人： Sylvain Cormier , Joshua A. Shreve
IPC分类号： F16K25/00 , F04B53/10 , F16K1/38 , F16K15/02 , B01D15/14 , F16K15/06 , G01N30/36 , G01N30/26 , G01N30/32
摘要： A check valve comprises a valve seat element along a fluid path that is formed of a polymeric material and comprises a hole that extends from an input end of the valve seat element to an output end of the valve seat element. The valve seat element includes an inner taper that transitions the input end to the output end, the valve seat element including a sealing surface along the inner taper. A poppet body is formed of a polymeric material and configured to engage the internal tapered sealing surface of the valve seat element. The poppet body moves between a first position at which the poppet body sealingly engages the tapered sealing surface of the valve seat element and a second position at which the poppet body is separate from the inner taper of the valve seat member.

4. 发明授权

US09441996B2 Phase detection in multi-phase fluids 有权
标题翻译：多相流体中的相位检测
公开(公告)号：US09441996B2
公开(公告)日：2016-09-13
申请号：US14511636
申请日：2014-10-10
申请人： Waters Technologies Corporation
发明人： Ryan Hill , Joshua A. Shreve , Robert Dumas , Sylvain Cormier , Edwin Denecke , Kenneth R. Plant , Kurt D. Joudrey
IPC分类号： G01N21/00 , G01J3/00 , G01N21/55 , G01F1/74 , G01N21/41 , G01N30/74
CPC分类号： G01F1/74 , G01N21/41 , G01N30/74
摘要： The present disclosure relates to phase detection in multi-phase fluids where two fluid phases can be present in the fluid. Phase detection apparatus and methods are disclosed for determining the phase(s) (e.g., supercritical, liquid, and/or gas) of a fluid in a multi-phase fluid system, such as carbon dioxide based separation and chromatography system.
摘要翻译：本公开涉及在流体中可以存在两个流体相的多相流体中的相位检测。公开了用于确定多相流体系统中的流体（例如基于二氧化碳的分离和色谱系统）的相（例如超临界，液体和/或气体）的相位检测装置和方法。

5. 发明申请

US20160178078A1 CHECK VALVE HAVING POLYMERIC SEAT AND POPPET 审中-公开
标题翻译：检查阀门有聚合物座椅和POPPET
公开(公告)号：US20160178078A1
公开(公告)日：2016-06-23
申请号：US14907857
申请日：2014-07-30
申请人： Waters Technologies Corporation
发明人： Sylvain Cormier , Joshua A. Shreve
IPC分类号： F16K25/00 , B01D15/14 , F16K15/06
CPC分类号： F16K25/005 , B01D15/14 , F04B53/10 , F16K1/38 , F16K15/026 , F16K15/063 , G01N30/26 , G01N30/36 , G01N2030/328
摘要： A check valve comprises a valve seat element along a fluid path that is formed of a polymeric material and comprises a hole that extends from an input end of the valve seat element to an output end of the valve seat element. The valve seat element includes an inner taper that transitions the input end to the output end, the valve seat element including a sealing surface along the inner taper. A poppet body is formed of a polymeric material and configured to engage the internal tapered sealing surface of the valve seat element. The poppet body moves between a first position at which the poppet body sealingly engages the tapered sealing surface of the valve seat element and a second position at which the poppet body is separate from the inner taper of the valve seat member.
摘要翻译：止回阀包括沿着流体路径的阀座元件，该阀座元件由聚合物材料形成并且包括从阀座元件的输入端延伸到阀座元件的输出端的孔。阀座元件包括将输入端过渡到输出端的内锥形件，阀座元件包括沿内锥形的密封表面。提升阀体由聚合物材料形成并构造成接合阀座元件的内锥形密封表面。提升阀体在提升阀体密封地接合阀座元件的锥形密封表面的第一位置和提升阀体与阀座构件的内锥形分离的第二位置之间移动。

6. 发明申请

US20160054274A1 INJECTOR SAMPLE DILUTION FOR A LIQUID CHROMATOGRAPHY SYSTEM 审中-公开
标题翻译：用于液相色谱系统的注射剂样品稀释液
公开(公告)号：US20160054274A1
公开(公告)日：2016-02-25
申请号：US14824431
申请日：2015-08-12
申请人： Waters Technologies Corporation
发明人： Sylvain Cormier , Mark W. Moeller , Peyton C. Beals
IPC分类号： G01N30/20
CPC分类号： G01N30/20 , G01N30/06 , G01N30/24 , G01N2030/027 , G01N2030/201 , G01N2030/202 , G01N2030/207
摘要： Described are a method and a system for diluting a sample at a location of injection in a liquid chromatography system. The method includes loading a sample into a first fluid channel, separating a flow of a mobile phase into a first flow in the first fluid channel and a second flow in a second fluid channel, and combining the sample that is displaced from the first fluid channel and the mobile phase exiting the second fluid channel at the location of injection into the system flow to thereby generate a diluted sample in the system flow. The dilution ratio of the diluted sample is responsive to the flow rates of the first and second flows. Advantageously, the flow rates can be changed by changing the flow restriction of one of the fluid channels. Thus providing the proper flow restriction enables a user to obtain a desired dilution ratio.
摘要翻译：描述了在液相色谱系统中在注射位置稀释样品的方法和系统。该方法包括将样品装载到第一流体通道中，将流动相的流分离成第一流体通道中的第一流量，以及在第二流体通道中的第二流量，以及将从第一流体通道以及在注入系统流程的位置处离开第二流体通道的流动相，从而在系统流中产生稀释的样品。稀释样品的稀释比对第一和第二流量的流量有反应。有利地，可以通过改变流体通道之一的流量限制来改变流量。因此，提供适当的流量限制使得用户能够获得期望的稀释比。

7. 发明授权

US11656208B2 Multi-injection mode valve module 有权
公开(公告)号：US11656208B2
公开(公告)日：2023-05-23
申请号：US17206994
申请日：2021-03-19
申请人： Waters Technologies Corporation
发明人： Sylvain Cormier , Richard W. Andrews , Peyton C. Beals
IPC分类号： G01N30/32 , G01N30/34 , G01N30/20 , G01N30/24 , G01N30/22 , G01N30/86 , G01N30/88 , G01N30/02
CPC分类号： G01N30/32 , G01N30/20 , G01N30/22 , G01N30/24 , G01N30/34 , G01N30/8665 , G01N30/88 , G01N2030/027 , G01N2030/201 , G01N2030/202 , G01N2030/328 , G01N2030/347 , G01N2030/8804 , G01N2030/889 , G01N2030/8881
摘要： A chromatography system includes a gradient delay volume defined as an overall fluid volume between where gradient is proportioned until an inlet of a chromatography column, a pump pumping a flow of gradient; and at least one valve located downstream from the pump, the at least one valve having a plurality of ports including an inlet port that receives the flow of gradient from the pump and an outlet port through which the flow of gradient exits the at least one valve, the at least one valve having at least two positions. A first position of the at least two positions of the at least one valve increases the gradient delay volume of the chromatography system relative to when the at least one valve is in a second position.

8. 发明授权

US11105780B2 Compression fitting with coupled ferrule 有权
公开(公告)号：US11105780B2
公开(公告)日：2021-08-31
申请号：US15309421
申请日：2014-05-07
申请人： Waters Technologies Corporation
发明人： Sylvain Cormier , Kurt D. Joudrey , Joshua A. Shreve
IPC分类号： G01N30/60 , B01D15/22 , G01N30/02
摘要： The invention provides compression fittings and methods of assembling compression fittings. In exemplary embodiments, compression fittings are provided that include a fitting body, a ferrule and a tube. For example, the fitting body can be removably coupled to the ferrule when the tube is disposed therethrough.

9. 发明授权

US09816971B2 Controllable injector sample dilution for a liquid chromatography system 有权
公开(公告)号：US09816971B2
公开(公告)日：2017-11-14
申请号：US14824440
申请日：2015-08-12
申请人： Waters Technologies Corporation
发明人： Michael R. Jackson , Sylvain Cormier
IPC分类号： G01N30/20 , G01N30/06 , G01N30/24 , G01N30/02
CPC分类号： G01N30/20 , G01N30/06 , G01N30/24 , G01N2030/027 , G01N2030/201 , G01N2030/202
摘要： Described are a method and a system for injecting a sample into a flow of a liquid chromatography system. The method includes combining a flow of a sample and a flow of a mobile phase to create a diluted sample in the system flow. The volumetric flow rate of the sample is controlled to be at a value that yields a desired dilution ratio for the diluted sample. The particular value at which the volumetric flow rate is maintained can be determined from the desired value of the dilution ratio and the volumetric flow rate of the mobile phase. System embodiments include a syringe that can be used to provide a sample solution at a controllable volumetric flow rate for combination with a high pressure mobile phase.

10. 发明申请

US20160077061A1 SAMPLING SYSTEMS AND METHODS OF USING THE SAME 审中-公开
标题翻译：采样系统及其使用方法
公开(公告)号：US20160077061A1
公开(公告)日：2016-03-17
申请号：US14850366
申请日：2015-09-10
申请人： Waters Technologies Corporation
发明人： Sylvain Cormier
IPC分类号： G01N30/20 , G01N30/24
CPC分类号： G01N30/20 , G01N30/24 , G01N2030/202
摘要： A sampling system comprising an external sampling assembly in fluidic communication with a process sample manager is provided herein. The sampling system can automatically acquire sample from one or more sources of sample to prepare sample for injection into a column or detector. The external sampling assembly has an external sampling valve connected to an external pump and is in fluidic communication with a process sample manager. The external sampling valve has a first configuration and a second configuration useful in three steps of drawing, loading and discharging sample. Two selection valves can be connected to a plurality of external sampling valves for sequential sampling of multiple sources of sample. Sample can also be diluted in the process sample manager and then combined in a solvent composition stream for injection into the column or the detector.
摘要翻译：本文提供了一种包括与过程样品管理器流体连通的外部采样组件的采样系统。采样系统可以自动从一个或多个样品来源获取样品，以准备样品注入柱或检测器。外部采样组件具有连接到外部泵的外部采样阀，并且与过程样品管理器流体连通。外部采样阀具有第一配置和第二配置，其用于三个步骤的抽取，加载和排放样品。两个选择阀可以连接到多个外部取样阀，用于顺序取样多个样品源。样品也可以在过程样品管理器中稀释，然后在溶剂组合物流中混合以注入柱或检测器。

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