专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20170136149A1 BONE MATRIX COMPOSITIONS HAVING NANOSCALE TEXTURED SURFACES 审中-公开
公开(公告)号：US20170136149A1
公开(公告)日：2017-05-18
申请号：US15418351
申请日：2017-01-27
申请人： Warsaw Orthopedic, Inc.
发明人： Guobao Wei , Keyvan Behnam , Nanette Forsyth
IPC分类号： A61L27/36 , A61L27/18 , A61L27/54 , A61L27/24 , A61F2/46 , A61F2/30
CPC分类号： A61L27/3608 , A61F2/28 , A61F2/3094 , A61F2/4644 , A61F2002/3084 , A61F2002/4646 , A61L27/18 , A61L27/24 , A61L27/3683 , A61L27/3687 , A61L27/48 , A61L27/54 , A61L27/56 , A61L2300/62 , A61L2400/12 , A61L2430/02 , A61L2430/40
摘要： Bone matrix compositions having nanoscale textured surfaces and methods for their production are provided. In some embodiments, bone matrix is prepared for implantation and retains nanoscale textured surfaces. In other embodiments, nanostructures are imparted to bone matrix wherein collagen fibrils on the surface of the bone matrix have been compromised, thus imparting a nanoscale textured surface to the bone matrix. Generally, these methods may be applied to mineralized or demineralized bone including partially or surface demineralized bone.

2. 发明授权

US10328179B2 Bone matrix compositions and methods 有权
公开(公告)号：US10328179B2
公开(公告)日：2019-06-25
申请号：US14661712
申请日：2015-03-18
申请人： WARSAW ORTHOPEDIC, INC.
发明人： Keyvan Behnam , David Knaack
IPC分类号： A61L27/36 , A61K35/32 , A61K38/01 , A61K38/18 , A61L27/12 , A61L27/42 , A61L27/48 , A61L27/54 , C07K14/51 , A61F2/28 , A61F2/30
摘要： An osteoinductive composition, corresponding osteoimplants, and methods for making the osteoinductive composition are disclosed. The osteoinductive composition comprises osteoinductive factors, such as may be extracted from demineralized bone, and a carrier. The osteoinductive composition is prepared by providing demineralized bone, extracting osteoinductive factors from the demineralized bone, and adding the extracted osteoinductive factors to a carrier. Further additives such as bioactive agents may be added to the osteoinductive composition. The carrier and osteoinductive factors may form an osteogenic osteoimplant. The osteoimplant, when implanted in a mammalian body, can induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization, and bone marrow differentiation. Also, in some embodiments, the osteoinductive composition can be used as a delivery device to administer bioactive agents.

3. 发明授权

US09717822B2 Bone matrix compositions and methods 有权
公开(公告)号：US09717822B2
公开(公告)日：2017-08-01
申请号：US14885649
申请日：2015-10-16
申请人： Warsaw Orthopedic, Inc.
发明人： Keyvan Behnam , Guobao Wei , Nanette Forsyth
IPC分类号： A61K35/00 , A61K35/32 , A61L27/36 , A61L27/54 , A61F2/28 , A61F2/30
CPC分类号： A61K35/00 , A61F2/28 , A61F2002/30059 , A61F2310/00359 , A61K35/32 , A61L27/3604 , A61L27/3608 , A61L27/3683 , A61L27/3695 , A61L27/3834 , A61L27/54 , A61L2430/02 , A61L2430/40
摘要： Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosis-inducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity. In one embodiment, a method for producing an osteoinductive composition comprises providing partially demineralized bone, treating the partially demineralized bone to disrupt the collagen structure of the bone. In another embodiment, an implantable osteoinductive and osteoconductive composition comprises partially demineralized bone, wherein the collagen structure of the bone has been disrupted, and, optionally, a tissue-derived extract.

4. 发明授权

US09597431B2 Compositions and methods for promoting bone formation 有权
公开(公告)号：US09597431B2
公开(公告)日：2017-03-21
申请号：US14274897
申请日：2014-05-12
申请人： Warsaw Orthopedic, Inc.
发明人： Lawrence A. Shimp , Keyvan Behnam , Guobao Wei , Abdulhafez A. Selim
IPC分类号： A61K35/28 , A61K38/16 , A61K38/17 , A61K38/18 , A61K38/19 , A61K38/22 , A61L27/54 , A61K9/00 , A61K35/32 , A61K38/29 , A61L27/12 , A61K38/20 , A61K31/573 , A61K33/42 , A61L27/36 , A61L27/38 , A61F2/28
CPC分类号： A61L27/54 , A61F2/28 , A61F2002/2817 , A61F2310/00359 , A61K9/0024 , A61K31/573 , A61K33/42 , A61K35/32 , A61K38/177 , A61K38/1866 , A61K38/191 , A61K38/193 , A61K38/2006 , A61K38/202 , A61K38/29 , A61L27/12 , A61L27/3608 , A61L27/3821 , A61L2300/258 , A61L2300/412 , A61L2300/414 , A61L2300/426 , A61L2300/428 , A61L2300/43 , A61L2300/45 , A61L2400/18 , A61L2430/02 , A61K2300/00
摘要： A method for promoting bone formation is provided. More specifically, a method for promoting bone formation by promoting osteoclast formation is provided. In one embodiment, an implant comprising an implantable material and an osteoclast stimulating substance is provided.

5. 发明申请

US20150037386A1 COMPOSITIONS AND METHODS FOR PROMOTING BONE FORMATION 审中-公开
标题翻译：用于促进骨形成的组合物和方法
公开(公告)号：US20150037386A1
公开(公告)日：2015-02-05
申请号：US14274897
申请日：2014-05-12
申请人： Warsaw Orthopedic, Inc.
发明人： Lawrence A. Shimp , Keyvan Behnam , Guobao Wei , Abdulhafez A. Selim
IPC分类号： A61L27/54 , A61L27/12 , A61L27/36 , A61K33/42 , A61K35/32 , A61K38/19 , A61K38/20 , A61K31/573 , A61L27/38 , A61K9/00
CPC分类号： A61L27/54 , A61F2/28 , A61F2002/2817 , A61F2310/00359 , A61K9/0024 , A61K31/573 , A61K33/42 , A61K35/32 , A61K38/177 , A61K38/1866 , A61K38/191 , A61K38/193 , A61K38/2006 , A61K38/202 , A61K38/29 , A61L27/12 , A61L27/3608 , A61L27/3821 , A61L2300/258 , A61L2300/412 , A61L2300/414 , A61L2300/426 , A61L2300/428 , A61L2300/43 , A61L2300/45 , A61L2400/18 , A61L2430/02 , A61K2300/00
摘要： A method for promoting bone formation is provided. More specifically, a method for promoting bone formation by promoting osteoclast formation is provided. In one embodiment, an implant comprising an implantable material and an osteoclast stimulating substance is provided.
摘要翻译：提供了促进骨形成的方法。更具体地，提供了促进破骨细胞形成促进骨形成的方法。在一个实施例中，提供包括可植入材料和破骨细胞刺激物质的植入物。

6. 发明申请

US20130136777A1 Bone Matrix Compositions and Methods 有权
标题翻译：骨骼组成和方法
公开(公告)号：US20130136777A1
公开(公告)日：2013-05-30
申请号：US13746516
申请日：2013-01-22
申请人： Warsaw Orthopedic, Inc.
发明人： Keyvan Behnam , Guobao Wei , Nanette Forsyth
IPC分类号： A61K35/32
CPC分类号： A61K35/00 , A61F2/28 , A61F2002/30059 , A61F2310/00359 , A61K35/32 , A61L27/3604 , A61L27/3608 , A61L27/3683 , A61L27/3695 , A61L27/3834 , A61L27/54 , A61L2430/02 , A61L2430/40
摘要： Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosis-inducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity. In one embodiment, a method for producing an osteoinductive composition comprises providing partially demineralized bone, treating the partially demineralized bone to disrupt the collagen structure of the bone, and optionally providing a tissue-derived extract and adding the tissue-derived extract to the partially demineralized bone. In another embodiment, an implantable osteoinductive and osteoconductive composition comprises partially demineralized bone, wherein the collagen structure of the bone has been disrupted, and, optionally, a tissue-derived extract.
摘要翻译：提供具有增加的生物活性的骨诱导组合物和植入物及其生产方法。可能增加的生物活性包括但不限于骨形成; 骨愈合; 骨诱导活性，成骨活性，软骨形成活性，伤口愈合活性，神经源性活性，收缩诱导活性，有丝分裂诱导活性，分化诱导活性，趋化活性，血管生成或血管发生活性，以及胞吐作用或内吞诱导活性。在一个实施方案中，用于产生骨诱导性组合物的方法包括提供部分去矿物质的骨，处理所述部分去矿物质的骨以破坏所述骨的胶原结构，以及任选地提供组织衍生的提取物并将所述组织衍生的提取物加入到部分去矿物质骨。在另一个实施方案中，可植入的骨诱导和骨传导性组合物包含部分脱矿质骨，其中所述骨的胶原结构已被破坏，并且任选地包含组织衍生的提取物。

7. 发明授权

US10220115B2 Bone matrix compositions having nanoscale textured surfaces 有权
公开(公告)号：US10220115B2
公开(公告)日：2019-03-05
申请号：US15418351
申请日：2017-01-27
申请人： Warsaw Orthopedic, Inc.
发明人： Guobao Wei , Keyvan Behnam , Nanette Forsyth
IPC分类号： A61F2/30 , A61F2/46 , A61L27/18 , A61L27/36 , A61F2/28 , A61L27/48 , A61L27/56 , A61L27/24 , A61L27/54
摘要： Bone matrix compositions having nanoscale textured surfaces and methods for their production are provided. In some embodiments, bone matrix is prepared for implantation and retains nanoscale textured surfaces. In other embodiments, nanostructures are imparted to bone matrix wherein collagen fibrils on the surface of the bone matrix have been compromised, thus imparting a nanoscale textured surface to the bone matrix. Generally, these methods may be applied to mineralized or demineralized bone including partially or surface demineralized bone.

8. 发明授权

US10028837B2 Delivery system attachment 有权
公开(公告)号：US10028837B2
公开(公告)日：2018-07-24
申请号：US15148886
申请日：2016-05-06
申请人： Warsaw Orthopedic, Inc.
发明人： Guobao Wei , Keyvan Behnam , Nanette Forsyth , John Winterbottom , James Beisser , Todd Boyce , Mohamed Attawia , Cristy J. Richards , Lawrence A. Shimp
IPC分类号： A61F2/28 , A61B17/70 , A61F2/46 , A61F2/30 , A61F2/00 , A61F2/44
CPC分类号： A61F2/2846 , A61B17/7097 , A61B17/7098 , A61F2/0095 , A61F2/28 , A61F2/4455 , A61F2/4601 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/285 , A61F2002/30588 , A61F2002/30738
摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.

9. 发明授权

US09415136B2 Osteoinductive demineralized cancellous bone 有权
标题翻译：骨诱导软骨松质骨
公开(公告)号：US09415136B2
公开(公告)日：2016-08-16
申请号：US14286640
申请日：2014-05-23
申请人： WARSAW ORTHOPEDIC, INC.
发明人： Keyvan Behnam , Nanette Forsyth , James Russell , John Winterbottom , Todd Boyce
IPC分类号： A61L27/36 , A61F2/28 , A61L27/38 , A61K35/32 , A61F2/30
CPC分类号： A61K35/32 , A61F2/28 , A61F2002/2817 , A61F2002/30059 , A61F2310/00359 , A61L27/3608 , A61L27/3641 , A61L27/3645 , A61L27/3683 , A61L27/3687 , A61L27/3691 , A61L27/3695 , A61L27/3878 , A61L2430/02
摘要： An osteoinductive demineralized bone matrix, corresponding osteoimplants, and methods for making the osteoinductive demineralized bone matrix are disclosed. The osteoinductive demineralized bone matrix may be prepared by providing demineralized bone and altering the collagenous structure of the bone. The osteoinductive demineralized bone matrix may also be prepared by providing demineralized bone and compacting the bone, for example via mechanical compaction, grinding into a particulate, or treatment with a chemical. Additives such as growth factors or bioactive agents may be added to the osteoinductive demineralized bone matrix. The osteoinductive demineralized bone matrix may form an osteogenic osteoimplant. The osteoimplant, when implanted in a mammalian body, may induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization, and bone marrow differentiation. The osteoinductive demineralized bone matrix may also be used as a delivery device to administer bioactive agents.
摘要翻译：公开了一种骨诱导的软骨骨架，相应的骨关节植入物以及用于制造骨诱导性软骨骨架的方法。可以通过提供软化骨和改变骨的胶原结构来制备骨诱导的软骨骨架。还可以通过提供脱矿质骨和压实骨，例如通过机械压实，研磨成颗粒或用化学品处理来制备骨诱导的软化骨基质。添加剂如生长因子或生物活性剂可以加入到骨诱导的软化骨基质中。骨诱导的骨质疏松骨质可形成成骨植骨。当植入植入哺乳动物体内的植骨植入物可能在植入物的位置诱导软骨内骨形成的完全发育级联，包括血管化，矿化和骨髓分化。骨诱导的软化骨基质也可以用作施用生物活性剂的递送装置。

10. 发明申请

US20160144075A1 BONE MATRIX COMPOSITIONS AND METHODS 审中-公开
标题翻译：骨基质组合物和方法
公开(公告)号：US20160144075A1
公开(公告)日：2016-05-26
申请号：US14885649
申请日：2015-10-16
申请人： Warsaw Orthopedic, Inc.
发明人： Keyvan Behnam , Guobao Wei , Nanette Forsyth
IPC分类号： A61L27/36 , A61L27/54
CPC分类号： A61K35/00 , A61F2/28 , A61F2002/30059 , A61F2310/00359 , A61K35/32 , A61L27/3604 , A61L27/3608 , A61L27/3683 , A61L27/3695 , A61L27/3834 , A61L27/54 , A61L2430/02 , A61L2430/40
摘要： Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosis-inducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity. In one embodiment, a method for producing an osteoinductive composition comprises providing partially demineralized bone, treating the partially demineralized bone to disrupt the collagen structure of the bone. In another embodiment, an implantable osteoinductive and osteoconductive composition comprises partially demineralized bone, wherein the collagen structure of the bone has been disrupted, and, optionally, a tissue-derived extract.
摘要翻译：提供具有增加的生物活性的骨诱导组合物和植入物及其生产方法。可能增加的生物活性包括但不限于骨形成; 骨愈合; 骨诱导活性，成骨活性，软骨形成活性，伤口愈合活性，神经源性活性，收缩诱导活性，有丝分裂诱导活性，分化诱导活性，趋化活性，血管生成或血管发生活性，以及胞吐作用或内吞诱导活性。在一个实施方案中，用于生产骨诱导性组合物的方法包括提供部分去矿物质的骨，处理所述部分去矿物质的骨以破坏所述骨的胶原结构。在另一个实施方案中，可植入的骨诱导和骨传导性组合物包含部分脱矿质骨，其中所述骨的胶原结构已被破坏，并且任选地包含组织衍生的提取物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式