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1. 发明授权

US09717822B2 Bone matrix compositions and methods 有权
公开(公告)号：US09717822B2
公开(公告)日：2017-08-01
申请号：US14885649
申请日：2015-10-16
申请人： Warsaw Orthopedic, Inc.
发明人： Keyvan Behnam , Guobao Wei , Nanette Forsyth
IPC分类号： A61K35/00 , A61K35/32 , A61L27/36 , A61L27/54 , A61F2/28 , A61F2/30
CPC分类号： A61K35/00 , A61F2/28 , A61F2002/30059 , A61F2310/00359 , A61K35/32 , A61L27/3604 , A61L27/3608 , A61L27/3683 , A61L27/3695 , A61L27/3834 , A61L27/54 , A61L2430/02 , A61L2430/40
摘要： Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosis-inducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity. In one embodiment, a method for producing an osteoinductive composition comprises providing partially demineralized bone, treating the partially demineralized bone to disrupt the collagen structure of the bone. In another embodiment, an implantable osteoinductive and osteoconductive composition comprises partially demineralized bone, wherein the collagen structure of the bone has been disrupted, and, optionally, a tissue-derived extract.

2. 发明申请

US20140302112A1 BONE MATRIX COMPOSITIONS AND METHODS 有权
标题翻译：骨基质组合物和方法
公开(公告)号：US20140302112A1
公开(公告)日：2014-10-09
申请号：US14310804
申请日：2014-06-20
申请人： Warsaw Orthopedic, Inc.
发明人： Kevyan Benham , Guobao Wei , Nanette Forsyth
IPC分类号： A61L27/36 , A61L27/54
CPC分类号： A61K35/00 , A61F2/28 , A61F2002/30059 , A61F2310/00359 , A61K35/32 , A61L27/3604 , A61L27/3608 , A61L27/3683 , A61L27/3695 , A61L27/3834 , A61L27/54 , A61L2430/02 , A61L2430/40
摘要： Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosis-inducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity. In one embodiment, a method for producing an osteoinductive composition comprises providing partially demineralized bone, treating the partially demineralized bone to disrupt the collagen structure of the bone. In another embodiment, an implantable osteoinductive and osteoconductive composition comprises partially demineralized bone, wherein the collagen structure of the bone has been disrupted, and, optionally, a tissue-derived extract.
摘要翻译：提供具有增加的生物活性的骨诱导组合物和植入物及其生产方法。可能增加的生物活性包括但不限于骨形成; 骨愈合; 骨诱导活性，成骨活性，软骨形成活性，伤口愈合活性，神经源性活性，收缩诱导活性，有丝分裂诱导活性，分化诱导活性，趋化活性，血管生成或血管发生活性，以及胞吐作用或内吞诱导活性。在一个实施方案中，用于生产骨诱导性组合物的方法包括提供部分去矿物质的骨，处理所述部分去矿物质的骨以破坏所述骨的胶原结构。在另一个实施方案中，可植入的骨诱导和骨传导性组合物包含部分脱矿质骨，其中所述骨的胶原结构已被破坏，并且任选地包含组织衍生的提取物。

3. 发明申请

US20130136777A1 Bone Matrix Compositions and Methods 有权
标题翻译：骨骼组成和方法
公开(公告)号：US20130136777A1
公开(公告)日：2013-05-30
申请号：US13746516
申请日：2013-01-22
申请人： Warsaw Orthopedic, Inc.
发明人： Keyvan Behnam , Guobao Wei , Nanette Forsyth
IPC分类号： A61K35/32
CPC分类号： A61K35/00 , A61F2/28 , A61F2002/30059 , A61F2310/00359 , A61K35/32 , A61L27/3604 , A61L27/3608 , A61L27/3683 , A61L27/3695 , A61L27/3834 , A61L27/54 , A61L2430/02 , A61L2430/40
摘要： Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosis-inducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity. In one embodiment, a method for producing an osteoinductive composition comprises providing partially demineralized bone, treating the partially demineralized bone to disrupt the collagen structure of the bone, and optionally providing a tissue-derived extract and adding the tissue-derived extract to the partially demineralized bone. In another embodiment, an implantable osteoinductive and osteoconductive composition comprises partially demineralized bone, wherein the collagen structure of the bone has been disrupted, and, optionally, a tissue-derived extract.
摘要翻译：提供具有增加的生物活性的骨诱导组合物和植入物及其生产方法。可能增加的生物活性包括但不限于骨形成; 骨愈合; 骨诱导活性，成骨活性，软骨形成活性，伤口愈合活性，神经源性活性，收缩诱导活性，有丝分裂诱导活性，分化诱导活性，趋化活性，血管生成或血管发生活性，以及胞吐作用或内吞诱导活性。在一个实施方案中，用于产生骨诱导性组合物的方法包括提供部分去矿物质的骨，处理所述部分去矿物质的骨以破坏所述骨的胶原结构，以及任选地提供组织衍生的提取物并将所述组织衍生的提取物加入到部分去矿物质骨。在另一个实施方案中，可植入的骨诱导和骨传导性组合物包含部分脱矿质骨，其中所述骨的胶原结构已被破坏，并且任选地包含组织衍生的提取物。

4. 发明授权

US10220115B2 Bone matrix compositions having nanoscale textured surfaces 有权
公开(公告)号：US10220115B2
公开(公告)日：2019-03-05
申请号：US15418351
申请日：2017-01-27
申请人： Warsaw Orthopedic, Inc.
发明人： Guobao Wei , Keyvan Behnam , Nanette Forsyth
IPC分类号： A61F2/30 , A61F2/46 , A61L27/18 , A61L27/36 , A61F2/28 , A61L27/48 , A61L27/56 , A61L27/24 , A61L27/54
摘要： Bone matrix compositions having nanoscale textured surfaces and methods for their production are provided. In some embodiments, bone matrix is prepared for implantation and retains nanoscale textured surfaces. In other embodiments, nanostructures are imparted to bone matrix wherein collagen fibrils on the surface of the bone matrix have been compromised, thus imparting a nanoscale textured surface to the bone matrix. Generally, these methods may be applied to mineralized or demineralized bone including partially or surface demineralized bone.

5. 发明授权

US10028837B2 Delivery system attachment 有权
公开(公告)号：US10028837B2
公开(公告)日：2018-07-24
申请号：US15148886
申请日：2016-05-06
申请人： Warsaw Orthopedic, Inc.
发明人： Guobao Wei , Keyvan Behnam , Nanette Forsyth , John Winterbottom , James Beisser , Todd Boyce , Mohamed Attawia , Cristy J. Richards , Lawrence A. Shimp
IPC分类号： A61F2/28 , A61B17/70 , A61F2/46 , A61F2/30 , A61F2/00 , A61F2/44
CPC分类号： A61F2/2846 , A61B17/7097 , A61B17/7098 , A61F2/0095 , A61F2/28 , A61F2/4455 , A61F2/4601 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/285 , A61F2002/30588 , A61F2002/30738
摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.

6. 发明授权

US09415136B2 Osteoinductive demineralized cancellous bone 有权
标题翻译：骨诱导软骨松质骨
公开(公告)号：US09415136B2
公开(公告)日：2016-08-16
申请号：US14286640
申请日：2014-05-23
申请人： WARSAW ORTHOPEDIC, INC.
发明人： Keyvan Behnam , Nanette Forsyth , James Russell , John Winterbottom , Todd Boyce
IPC分类号： A61L27/36 , A61F2/28 , A61L27/38 , A61K35/32 , A61F2/30
CPC分类号： A61K35/32 , A61F2/28 , A61F2002/2817 , A61F2002/30059 , A61F2310/00359 , A61L27/3608 , A61L27/3641 , A61L27/3645 , A61L27/3683 , A61L27/3687 , A61L27/3691 , A61L27/3695 , A61L27/3878 , A61L2430/02
摘要： An osteoinductive demineralized bone matrix, corresponding osteoimplants, and methods for making the osteoinductive demineralized bone matrix are disclosed. The osteoinductive demineralized bone matrix may be prepared by providing demineralized bone and altering the collagenous structure of the bone. The osteoinductive demineralized bone matrix may also be prepared by providing demineralized bone and compacting the bone, for example via mechanical compaction, grinding into a particulate, or treatment with a chemical. Additives such as growth factors or bioactive agents may be added to the osteoinductive demineralized bone matrix. The osteoinductive demineralized bone matrix may form an osteogenic osteoimplant. The osteoimplant, when implanted in a mammalian body, may induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization, and bone marrow differentiation. The osteoinductive demineralized bone matrix may also be used as a delivery device to administer bioactive agents.
摘要翻译：公开了一种骨诱导的软骨骨架，相应的骨关节植入物以及用于制造骨诱导性软骨骨架的方法。可以通过提供软化骨和改变骨的胶原结构来制备骨诱导的软骨骨架。还可以通过提供脱矿质骨和压实骨，例如通过机械压实，研磨成颗粒或用化学品处理来制备骨诱导的软化骨基质。添加剂如生长因子或生物活性剂可以加入到骨诱导的软化骨基质中。骨诱导的骨质疏松骨质可形成成骨植骨。当植入植入哺乳动物体内的植骨植入物可能在植入物的位置诱导软骨内骨形成的完全发育级联，包括血管化，矿化和骨髓分化。骨诱导的软化骨基质也可以用作施用生物活性剂的递送装置。

7. 发明申请

US20160144075A1 BONE MATRIX COMPOSITIONS AND METHODS 审中-公开
标题翻译：骨基质组合物和方法
公开(公告)号：US20160144075A1
公开(公告)日：2016-05-26
申请号：US14885649
申请日：2015-10-16
申请人： Warsaw Orthopedic, Inc.
发明人： Keyvan Behnam , Guobao Wei , Nanette Forsyth
IPC分类号： A61L27/36 , A61L27/54
CPC分类号： A61K35/00 , A61F2/28 , A61F2002/30059 , A61F2310/00359 , A61K35/32 , A61L27/3604 , A61L27/3608 , A61L27/3683 , A61L27/3695 , A61L27/3834 , A61L27/54 , A61L2430/02 , A61L2430/40
摘要： Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosis-inducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity. In one embodiment, a method for producing an osteoinductive composition comprises providing partially demineralized bone, treating the partially demineralized bone to disrupt the collagen structure of the bone. In another embodiment, an implantable osteoinductive and osteoconductive composition comprises partially demineralized bone, wherein the collagen structure of the bone has been disrupted, and, optionally, a tissue-derived extract.
摘要翻译：提供具有增加的生物活性的骨诱导组合物和植入物及其生产方法。可能增加的生物活性包括但不限于骨形成; 骨愈合; 骨诱导活性，成骨活性，软骨形成活性，伤口愈合活性，神经源性活性，收缩诱导活性，有丝分裂诱导活性，分化诱导活性，趋化活性，血管生成或血管发生活性，以及胞吐作用或内吞诱导活性。在一个实施方案中，用于生产骨诱导性组合物的方法包括提供部分去矿物质的骨，处理所述部分去矿物质的骨以破坏所述骨的胶原结构。在另一个实施方案中，可植入的骨诱导和骨传导性组合物包含部分脱矿质骨，其中所述骨的胶原结构已被破坏，并且任选地包含组织衍生的提取物。

8. 发明申请

US20140255506A1 OSTEOINDUCTIVE DEMINERALIZED CANCELLOUS BONE 有权
公开(公告)号：US20140255506A1
公开(公告)日：2014-09-11
申请号：US14286640
申请日：2014-05-23
申请人： WARSAW ORTHOPEDIC, INC.
发明人： Keyvan Behnam , Nanette Forsyth , James Russell , John Winterbottom , Todd Boyce
IPC分类号： A61L27/36
CPC分类号： A61K35/32 , A61F2/28 , A61F2002/2817 , A61F2002/30059 , A61F2310/00359 , A61L27/3608 , A61L27/3641 , A61L27/3645 , A61L27/3683 , A61L27/3687 , A61L27/3691 , A61L27/3695 , A61L27/3878 , A61L2430/02
摘要： An osteoinductive demineralized bone matrix, corresponding osteoimplants, and methods for making the osteoinductive demineralized bone matrix are disclosed. The osteoinductive demineralized bone matrix may be prepared by providing demineralized bone and altering the collagenous structure of the bone. The osteoinductive demineralized bone matrix may also be prepared by providing demineralized bone and compacting the bone, for example via mechanical compaction, grinding into a particulate, or treatment with a chemical. Additives such as growth factors or bioactive agents may be added to the osteoinductive demineralized bone matrix. The osteoinductive demineralized bone matrix may form an osteogenic osteoimplant. The osteoimplant, when implanted in a mammalian body, may induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization, and bone marrow differentiation. The osteoinductive demineralized bone matrix may also be used as a delivery device to administer bioactive agents.

9. 发明授权

US10357511B2 Bone matrix compositions and methods 有权
公开(公告)号：US10357511B2
公开(公告)日：2019-07-23
申请号：US15639692
申请日：2017-06-30
申请人： Warsaw Orthopedic, Inc.
发明人： Keyvan Behnam , Guobao Wei , Nanette Forsyth
IPC分类号： A61F2/28 , A61F2/30 , A61K35/00 , A61K35/12 , A61K35/32 , A61L27/36 , A61L27/38 , A61L27/54
摘要： Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosis-inducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity. In one embodiment, a method for producing an osteoinductive composition comprises providing partially demineralized bone, treating the partially demineralized bone to disrupt the collagen structure of the bone. In another embodiment, an implantable osteoinductive and osteoconductive composition comprises partially demineralized bone, wherein the collagen structure of the bone has been disrupted, and, optionally, a tissue-derived extract.

10. 发明申请

US20150258245A1 METHOD OF DELIPIDATION AND/OR TERMINAL STERILIZATION FOR BONE MATERIAL 审中-公开
标题翻译：骨质疏松和/或终端消毒方法
公开(公告)号：US20150258245A1
公开(公告)日：2015-09-17
申请号：US14209499
申请日：2014-03-13
申请人： Warsaw Orthopedic. Inc.
发明人： Keyvan Behnam , Guobao Wei , Nanette Forsyth , James A. Beisser
IPC分类号： A61L27/36 , A61L2/00
CPC分类号： A61L27/3687 , A61L2/0082 , A61L27/3608 , A61L27/3691 , A61L2430/02
摘要： Methods for delipidation, viral inactivation and terminal sterilization are provided for bone grafting material. The methods include contacting bone material with an amount of supercritical fluid effective to remove at least lipids and at least contaminants from the bone material, thereby obtaining a terminally sterilized and delipidated bone material. In various embodiments, the substantially terminally sterilized and delipidated bone material is 99.0%, 99.5% or 99.9% free of lipids and contaminants. Contaminants that are removed from bone material by terminal sterilization with supercritical fluid include infectious organisms, such as bacteria, viruses, protozoa, parasites, fungi and mold. Bone material or bone compositions that can be treated with critical or supercritical fluids comprise mineralized or demineralized bone particles, mineralized or demineralized bone matrix, partially demineralized bone matrix or combinations thereof.
摘要翻译：为骨移植材料提供脱脂，病毒灭活和末端灭菌的方法。所述方法包括使骨材料与一定量的超临界流体接触，该超临界流体有效地从骨材料中除去至少脂质和至少污染物，从而获得终末消毒和脱脂的骨材料。在各种实施方案中，基本上终末灭菌和脱脂的骨材料为99.0％，99.5％或99.9％，不含脂质和污染物。通过用超临界流体终端灭菌从骨材料中除去的污染物包括感染性生物，如细菌，病毒，原生动物，寄生虫，真菌和霉菌。可以用临界或超临界流体处理的骨材料或骨组合物包括矿化或脱矿质骨颗粒，矿化或软化骨基质，部分软化骨基质或其组合。

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