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1. 发明授权

US10322209B2 Polyurethanes for osteoimplants 有权
公开(公告)号：US10322209B2
公开(公告)日：2019-06-18
申请号：US15974146
申请日：2018-05-08
申请人： Warsaw Orthopedic, Inc.
发明人： David Knaack , John Winterbottom , David R. Kaes , Todd Boyce , Lawrence A. Shimp
IPC分类号： A61L27/18 , A61L27/36 , A61L27/46 , C08G18/10 , C08G18/36 , C08G18/38 , C08G18/64 , C08G18/73 , C08G18/77 , C08G18/79 , A61L27/54 , A61L27/58 , C08L75/04
摘要： Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.

2. 发明授权

US09999520B2 Osteoimplant and method of making same 有权
公开(公告)号：US09999520B2
公开(公告)日：2018-06-19
申请号：US15040526
申请日：2016-02-10
申请人： WARSAW ORTHOPEDIC, INC.
发明人： Albert Manrique , Jean T. Edwards , Nelson L. Scarborough , Scott D. Boden , Kathy Traianedes , Lawrence A. Shimp , James L. Russell
IPC分类号： A61F2/28 , A61F2/46 , A61B17/86 , A61F2/44 , A61L27/36 , A61L31/00 , B29C41/22 , B29C41/46 , A61F2/30 , B29K105/16 , B29K511/06 , B29L31/00
CPC分类号： A61F2/4644 , A61B17/866 , A61F2/28 , A61F2/3094 , A61F2/442 , A61F2/446 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30059 , A61F2002/30075 , A61F2002/30113 , A61F2002/30131 , A61F2002/30153 , A61F2002/30154 , A61F2002/30156 , A61F2002/30158 , A61F2002/302 , A61F2002/30205 , A61F2002/30224 , A61F2002/30225 , A61F2002/30238 , A61F2002/30261 , A61F2002/3028 , A61F2002/30733 , A61F2002/30879 , A61F2002/30891 , A61F2002/30892 , A61F2002/30957 , A61F2002/30971 , A61F2002/4649 , A61F2210/0061 , A61F2230/0006 , A61F2230/0013 , A61F2230/0019 , A61F2230/0021 , A61F2230/0023 , A61F2230/0026 , A61F2230/0063 , A61F2230/0065 , A61F2230/0067 , A61F2230/0069 , A61F2230/0082 , A61F2310/00365 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3691 , A61L31/005 , A61L2430/02 , B29C41/22 , B29C41/46 , B29K2105/16 , B29K2511/06 , B29L2031/7532
摘要： An osteoimplant is provided which comprises a coherent aggregate of elongate bone particles, the osteoimplant possessing predetermined dimensions and shape. The osteoimplant is highly absorbent and sponge-like in nature. Also provided herein are a method of fabricating the osteoimplant and a method of repairing and/or treating bone defects utilizing the osteoimplant.

3. 发明授权

US09849215B2 Implantable compositions and methods for preparing the same 有权
公开(公告)号：US09849215B2
公开(公告)日：2017-12-26
申请号：US15048589
申请日：2016-02-19
申请人： Warsaw Orthopedic, Inc.
发明人： Christina Mossaad , Lawrence A. Shimp , Guobao Wei , John Winterbottom
IPC分类号： A61L27/36 , A61L27/54 , A61K38/18 , A61K9/00 , A61K47/10 , A61K47/36 , A61K9/06 , A61K35/32 , A61L27/26
CPC分类号： A61L27/3608 , A61K9/0024 , A61K9/06 , A61K35/32 , A61K38/1875 , A61K47/10 , A61K47/36 , A61L27/26 , A61L27/54 , A61L2300/412 , A61L2300/414 , A61L2430/02
摘要： Methods for forming implantable compositions are provided. In some embodiments, the methods include (i) providing a gel base, (ii) adding water and a hydrating agent to the gel base to form a mixture, (iii) reducing the water content of the mixture; and (iv) adding a delivered material before, during, and/or after step (ii) or (iii). The water content is reduced to about 5% or less by weight of the implantable composition.

4. 发明申请

US20170304496A1 POLYURETHANES FOR OSTEOIMPLANTS 审中-公开
公开(公告)号：US20170304496A1
公开(公告)日：2017-10-26
申请号：US15643137
申请日：2017-07-06
申请人： Warsaw Orthopedic, Inc.
发明人： David Knaack , John Winterbottom , David R. Kaes , Todd M. Boyce , Lawrence A. Shimp
IPC分类号： A61L27/36 , C08G18/38 , A61L27/46 , A61L27/54 , A61L27/58 , C08G18/10 , C08G18/77 , C08G18/73 , C08G18/64 , A61L27/18 , C08L75/04 , C08G18/79
CPC分类号： A61L27/3608 , A61L27/18 , A61L27/46 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/426 , A61L2430/02 , C08G18/10 , C08G18/36 , C08G18/3878 , C08G18/3882 , C08G18/6484 , C08G18/73 , C08G18/771 , C08G18/798 , C08G2230/00 , C08L75/04
摘要： Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.

5. 发明申请

US20150306276A1 COLLAGEN MATRIX 有权
公开(公告)号：US20150306276A1
公开(公告)日：2015-10-29
申请号：US14260430
申请日：2014-04-24
申请人： Warsaw Orthopedic, Inc.
发明人： Lawrence A. Shimp
IPC分类号： A61L27/24 , A61L27/54 , A61L27/58
CPC分类号： A61L27/24 , A61L27/46 , A61L27/50 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2430/02 , C08L89/06
摘要： Methods for making a biodegradable collagen matrix having increased osteoinductivity and a biodegradable collagen matrix prepared by these methods are provided. In various embodiments, the methods include providing an acidic collagen slurry and mixing it with at least one water soluble and/or hydrophilic bioactive agent under conditions sufficient to cause the collagen slurry to self-assemble into macroscopic collagen fibers and cause the at least one bioactive agent to form a collagen matrix containing the bioactive agent. Conditions sufficient to cause the collagen slurry to self-assembly include raising the pH of the slurry to from about 5 to about a pH of 9 and/or adding bone powder, calcium phosphate, hydroxyapatite, DBM or a mixture thereof to the acidic collagen slurry in order to raise the pH from about 5 to about 9.
摘要翻译：提供了通过这些方法制备具有增强的骨诱导性的可生物降解的胶原基质和可生物降解的胶原基质的方法。在各种实施方案中，所述方法包括提供酸性胶原浆液并将其与至少一种水溶性和/或亲水性生物活性剂在足以使胶原浆液自组装成宏观胶原纤维的条件下混合，并引起至少一种生物活性试剂以形成含有生物活性剂的胶原基质。足以引起胶原浆液自组装的条件包括将浆料的pH提高到约5至约pH 9，和/或将骨粉末，磷酸钙，羟基磷灰石，DBM或其混合物添加到酸性胶原浆液中以将pH从约5提高到约9。

6. 发明授权

US08753689B2 Method of making demineralized bone particles 有权
标题翻译：脱矿质颗粒的制备方法
公开(公告)号：US08753689B2
公开(公告)日：2014-06-17
申请号：US14021179
申请日：2013-09-09
申请人： Warsaw Orthopedic, Inc.
发明人： John W. Morris , Lawrence A. Shimp , Kenneth C. Petersen , Albert Manrique , David Kaes , Nelson Scarborough , Michael Dowd
IPC分类号： A61K35/32
CPC分类号： A61K35/32 , A61F2/4644 , A61F2002/4645 , A61K45/06 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3691 , A61L27/3695 , A61L2430/40 , C07K14/78
摘要： Demineralized bone particles are obtained by demineralizing whole bone and thereafter subdividing the demineralized bone to provide the demineralized bone particles.
摘要翻译：通过使整个骨骼软化，然后再次分解脱矿质骨以提供脱矿质骨颗粒，获得脱矿质骨颗粒。

7. 发明授权

US10098681B2 Segmented delivery system 有权
公开(公告)号：US10098681B2
公开(公告)日：2018-10-16
申请号：US14821191
申请日：2015-08-07
申请人： Warsaw Orthopedic, Inc.
发明人： Guobao Wei , Todd M. Boyce , Robert Cohen , Cristy Richards , Lawrence A. Shimp
IPC分类号： A61B17/88 , A61F2/30 , A61F2/46 , A61B17/82 , A61F2/00 , A61F2/28
摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust the release of the substance. In various embodiments, the covering may be formed of a collagen material and is suitable for a variety of procedure specific uses.

8. 发明申请

US20160038207A1 SEGMENTED DELIVERY SYSTEM 审中-公开
标题翻译：分段交付系统
公开(公告)号：US20160038207A1
公开(公告)日：2016-02-11
申请号：US14821191
申请日：2015-08-07
申请人： Warsaw Orthopedic, Inc.
发明人： Guobao Wei , Todd M. Boyce , Robert Cohen , Cristy Richards , Lawrence A. Shimp
IPC分类号： A61B17/88
CPC分类号： A61B17/8819 , A61B17/823 , A61B17/8825 , A61B2017/8813 , A61F2/30 , A61F2/4603 , A61F2002/0086 , A61F2002/2825 , A61F2002/2835 , A61F2002/30059 , A61F2002/30064 , A61F2002/3007 , A61F2002/30072 , A61F2002/30588 , A61F2002/30677 , A61F2002/3068 , A61F2002/3093 , A61F2002/30971 , A61F2002/4623 , A61F2002/4627 , A61F2250/0068 , A61F2310/00592 , A61F2310/00958 , A61F2310/0097
摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust the release of the substance. In various embodiments, the covering may be formed of a collagen material and is suitable for a variety of procedure specific uses.
摘要翻译：提供了将物质或材料输送到手术部位的覆盖物。其中提供的物质的覆盖物可以被称为递送系统。通常，覆盖物可以是能够至少部分地保留其中提供的物质的单室或多室结构，直到覆盖物被放置在手术部位。放置时，覆盖物可以促进物质或周围材料的转移。例如，物质可以被主动地或被动地释放到手术部位。覆盖物可以参与，控制或以其他方式调节物质的释放。在各种实施方案中，覆盖物可以由胶原材料形成，并且适用于各种程序特异性用途。

9. 发明申请

US20130236547A1 POLYURETHANES FOR OSTEOIMPLANTS 有权
标题翻译：聚氨酯泡沫塑料
公开(公告)号：US20130236547A1
公开(公告)日：2013-09-12
申请号：US13867689
申请日：2013-04-22
申请人： WARSAW ORTHOPEDIC, INC. ORTHOPEDIC, INC.
发明人： David A. Knaack , John Winterbottom , David R. Kaes , Todd M. Boyce , Lawrence A. Shimp
IPC分类号： A61L27/18
CPC分类号： A61L27/3608 , A61L27/18 , A61L27/46 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/426 , A61L2430/02 , C08G18/10 , C08G18/36 , C08G18/3878 , C08G18/3882 , C08G18/6484 , C08G18/73 , C08G18/771 , C08G18/798 , C08G2230/00 , C08L75/04
摘要： Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.
摘要翻译：生物基聚氨酯及其制备方法。聚氨酯通过可生物降解的多异氰酸酯（例如赖氨酸二异氰酸酯）与任选羟基化的生物分子反应形成聚氨酯而形成。形成的聚合物可以与陶瓷和/或骨颗粒结合以形成可用作骨样植入物的复合物。

10. 发明授权

US10603407B2 Collagen matrix for cell therapy 有权
公开(公告)号：US10603407B2
公开(公告)日：2020-03-31
申请号：US15388936
申请日：2016-12-22
申请人： Warsaw Orthopedic, Inc.
发明人： Abdulhafez A. Selim , Lawrence A. Shimp , Hsiu Ying Sherry Wang
IPC分类号： A61K35/28 , A61L27/24 , A61K9/00 , A61K9/06 , A61K38/39 , C12N5/00 , A61L27/38 , A61L27/48
摘要： The invention relates to the use of an active collagen matrix for culturing mammalian cells and the use of the active collagen matrix and cells for the treatment of disease.

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