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1. 再颁专利

USRE40377E1 Means and method of replacing a heart valve in a minimally invasive manner 有权
标题翻译：以微创方式更换心脏瓣膜的方法和方法
公开(公告)号：USRE40377E1
公开(公告)日：2008-06-10
申请号：US10863862
申请日：2004-06-07
申请人： Warren P. Williamson, IV , Paul A. Spence , George T. Christakis , Mark Ortiz
发明人： Warren P. Williamson, IV , Paul A. Spence , George T. Christakis , Mark Ortiz
IPC分类号： A61F2/24
摘要： A heart valve can be replaced using minimally invasive methods which include a sutureless sewing cuff that and a fastener delivery tool that holds the cuff against the patient's tissue while delivering fasteners to attach the cuff to the tissue from the inside out. The tool stores a plurality of fasteners and is self-contained whereby a fastener is delivered and placed all from inside a vessel. The fasteners are self-forming whereby they do not need an anvil to be formed. Anchor elements are operated from outside the patient's body to cinch a prosthesis to an anchoring cuff of the valve body. The cuff is releasably mounted on the tool and the tool holds the cuff against tissue and drives the fastener through the cuff and the tissue before folding over the legs of the fastener whereby secure securement between the cuff and the tissue is assured. Fasteners are placed and formed whereby fasteners are located continuously throughout the entire circumference of the cuff. A minimally invasive surgical method is disclosed, and a method and tool are disclosed for repairing abdominal aortic aneurysms in a minimally invasive manner. Fasteners that are permanently deformed during the process of attaching the cuff are disclosed as are fasteners that are not permanently deformed during the attaching process.
摘要翻译：可以使用微创方法来替换心脏瓣膜，所述方法包括无缝线缝合套，以及紧固件递送工具，其将袖带保持抵靠患者组织，同时递送紧固件以将袖带从内向外附接到组织。该工具存储多个紧固件并且是独立的，由此紧固件全部从容器内部输送和放置。紧固件是自成型的，由此它们不需要形成砧座。锚杆元件从患者身体外部操作，将假体固定到阀体的锚定箍。袖带可释放地安装在工具上，并且工具将袖带保持抵靠组织，并且在折叠紧固件的腿部之前通过袖口和组织驱动紧固件，从而确保袖带和组织之间的牢固固定。紧固件被放置和形成，由此紧固件连续地位于袖带的整个圆周上。公开了一种微创手术方法，并且公开了一种以微创方式修复腹主动脉瘤的方法和工具。在附接袖带的过程中永久变形的紧固件公开为在附接过程中不会永久变形的紧固件。

2. 再颁专利

USRE44075E1 Means and method of replacing a heart valve in a minimally invasive manner 有权
公开(公告)号：USRE44075E1
公开(公告)日：2013-03-12
申请号：US12134170
申请日：2008-06-05
申请人： Warren P. Williamson , Paul A. Spence , George T. Christakis , Mark Ortiz
发明人： Warren P. Williamson , Paul A. Spence , George T. Christakis , Mark Ortiz
IPC分类号： A61F2/24
摘要： A heart valve can be replaced using minimally invasive methods which include a sutureless sewing cuff that and a fastener delivery tool that holds the cuff against the patient's tissue while delivering fasteners to attach the cuff to the tissue from the inside out. The tool stores a plurality of fasteners and is self-contained whereby a fastener is delivered and placed all from inside a vessel. The fasteners are self-forming whereby they do not need an anvil to be formed. Anchor elements are operated from outside the patient's body to cinch a prosthesis to an anchoring cuff of the valve body. The cuff is releasably mounted on the tool and the tool holds the cuff against tissue and drives the fastener through the cuff and the tissue before folding over the legs of the fastener whereby secure securement between the cuff and the tissue is assured. Fasteners are placed and formed whereby fasteners are located continuously throughout the entire circumference of the cuff. A minimally invasive surgical method is disclosed, and a method and tool are disclosed for repairing abdominal aortic aneurysms in a minimally invasive manner. Fasteners that are permanently deformed during the process of attaching the cuff are disclosed as are fasteners that are not permanently deformed during the attaching process.

3. 发明授权

US07497865B2 Method and apparatus for performing anastomosis with eversion of tissue edges and joining of exposed intima of the everted tissue 失效
标题翻译：用于通过外翻组织边缘进行吻合的方法和装置，以及接合外露组织的暴露内膜
公开(公告)号：US07497865B2
公开(公告)日：2009-03-03
申请号：US10855604
申请日：2004-05-26
申请人： Geoffrey H. Willis , Thomas A. Kramer , Paul A. Spence , George T. Christakis , Timothy J. McCoy , John W. Davis , Bradley D. Blackwood , Peter Callas , Michael Francis Wei , Jonathan L. Podmore , Andrew Knight , Thomas J. Ward , Warren P. Williamson, IV
发明人： Geoffrey H. Willis , Thomas A. Kramer , Paul A. Spence , George T. Christakis , Timothy J. McCoy , John W. Davis , Bradley D. Blackwood , Peter Callas , Michael Francis Wei , Jonathan L. Podmore , Andrew Knight , Thomas J. Ward , Warren P. Williamson, IV
IPC分类号： A61B17/08 , A61B17/10 , A61B17/04
CPC分类号： A61B17/1152 , A61B17/11 , A61B17/115 , A61B2017/1107 , A61B2017/1132 , A61B2017/1135 , A61B2017/1139
摘要： A ring for use in anastomosis. Preferably, the ring is integrally formed from metal, and includes a ring portion and tines and docking members that extend from the ring portion. The ring portion and tines are malleable, and preferably also the docking members are malleable. The ring portion and tines are malleable in the sense that once deformed from a first shape into a second shape, they will not relax back into the first shape from the second. To install the ring in a vessel with the ring portion extending around an incision or other orifice, the tines pierce the tissue around the orifice and are curled against an anvil. The action of curling the tines inverts the tissue near the orifice edges to expose the inside surface of the vessel or organ. Other aspects of the invention are a method and apparatus for installing an anastomosis ring in an incision or other orifice in a vessel or other organ, a method and apparatus for precisely aligning two anastomosis rings (each installed in an incision or other orifice of a different organ) and fastening the aligned rings together. The clips can be crimped onto the aligned rings, or they can be spring clips which are sprung onto the aligned rings to clamp the rings together by spring force. Also within the scope of the invention are crimping and spring clips for use in listening together two aligned anastomosis rings. In other embodiments, the invention is a method for performing an anastomosis by installing an anastomosis ring in an orifice in an organ, installing another anastomosis ring in an orifice in another organ, precisely aligning the two installed anastomosis rings, and fastening the aligned rings together.
摘要翻译：用于吻合的戒指。优选地，环由金属一体地形成，并且包括从环部延伸的环部分和尖齿和对接构件。环形部分和尖齿是可延展的，并且优选的是对接部件是可延展的。环形部分和尖齿在从第一形状变形成第二形状的意义上是可延展的，它们将不会从第二形状放松回第一形状。为了将环安装在具有围绕切口或其他孔口延伸的环部分的容器中，齿刺穿孔周围的组织并且卷绕在砧座上。卷曲尖齿的作用使孔边缘附近的组织反转以暴露血管或器官的内表面。本发明的其它方面是用于将吻合环安装在容器或其他器官中的切口或其它孔中的方法和装置，用于精确地对准两个吻合环（每个安装在切口或不同的其他孔中的其他孔中的方法和装置）器官）并将对准的环固定在一起。夹子可以压接在对准的环上，或者它们可以是弹簧夹，弹簧夹被弹簧上对准的环，以通过弹簧力将环夹在一起。也在本发明的范围内的是压接和弹簧夹，用于一起收听两个对准的吻合环。在其他实施例中，本发明是一种通过在器官中的孔中安装吻合环来进行吻合的方法，在另一个器官的孔中安装另一个吻合环，精确对准两个安装的吻合环，并将对准的环固定在一起。

4. 发明授权

US06811555B1 Method and apparatus for performing anastomosis with eversion of tissue edges and joining of exposed intima of the everted tissue 失效
标题翻译：用于通过外翻组织边缘进行吻合的方法和装置，以及接合外露组织的暴露的内膜
公开(公告)号：US06811555B1
公开(公告)日：2004-11-02
申请号：US09654605
申请日：2000-09-01
申请人： Geoffrey H. Willis , Thomas A. Kramer , Paul A. Spence , George T. Christakis , Timothy J. McCoy , John W. Davis , Bradley D. Blackwood , Peter Callas , Michael Francis Wei , Jonathan L. Podmore , Andrew Knight , Thomas J. Ward , Warren P. Williamson, IV
发明人： Geoffrey H. Willis , Thomas A. Kramer , Paul A. Spence , George T. Christakis , Timothy J. McCoy , John W. Davis , Bradley D. Blackwood , Peter Callas , Michael Francis Wei , Jonathan L. Podmore , Andrew Knight , Thomas J. Ward , Warren P. Williamson, IV
IPC分类号： A61B1708
CPC分类号： A61B17/1152 , A61B17/11 , A61B17/115 , A61B2017/1107 , A61B2017/1132 , A61B2017/1135 , A61B2017/1139
摘要： A ring for use in anastomosis. Preferably, the ring is integrally formed from metal, and includes a ring portion and tines and docking members that extend from the ring portion. The ring portion and tines are malleable, and preferably also the docking members are malleable. The ring portion and tines are malleable in the sense that once deformed from a first shape into a second shape, they will not relax back into the first shape from the second. To install the ring in a vessel with the ring portion extending around an incision or other orifice, the tines pierce the tissue around the orifice and are curled against an anvil. The action of curling the tines inverts the tissue near the orifice edges to expose the inside surface of the vessel or organ. Other aspects of the invention are a method and apparatus for installing an anastomosis ring in an incision or other orifice in a vessel or other organ, a method and apparatus for precisely aligning two anastomosis rings (each installed in an incision or other orifice of a different organ) and fastening the aligned rings together. The clips can be crimped onto the aligned rings, or they can be spring clips which are sprung onto the aligned rings to clamp the rings together by spring force. Also within the scope of the invention are crimping and spring clips for use in fastening together two aligned anastomosis rings. In other embodiments, the invention is a method for performing an anastomosis by installing an anastomosis ring in an orifice in an organ, installing another anastomosis ring in an orifice in another organ, precisely aligning the two installed anastomosis rings, and fastening the aligned rings together.
摘要翻译：用于吻合的戒指。优选地，环由金属一体地形成，并且包括从环部延伸的环部分和尖齿和对接构件。环形部分和尖齿是可延展的，并且优选的是对接部件是可延展的。环形部分和尖齿在从第一形状变形成第二形状的意义上是可延展的，它们将不会从第二形状放松回第一形状。为了将环安装在具有围绕切口或其他孔口延伸的环部分的容器中，齿刺穿孔周围的组织并且卷绕在砧座上。卷曲尖齿的作用使孔边缘附近的组织反转以暴露血管或器官的内表面。本发明的其它方面是用于将吻合环安装在容器或其他器官中的切口或其它孔中的方法和装置，用于精确地对准两个吻合环（每个安装在切口或不同的其他孔中的其他孔中的方法和装置）器官）并将对准的环固定在一起。夹子可以压接在对准的环上，或者它们可以是弹簧夹，弹簧夹被弹簧上对准的环，以通过弹簧力将环夹在一起。也在本发明的范围内的是压接和弹簧夹，用于将两个对准的吻合环紧固在一起。在其他实施例中，本发明是一种通过在器官中的孔中安装吻合环来进行吻合的方法，在另一个器官的孔中安装另一个吻合环，精确对准两个安装的吻合环，并将对准的环固定在一起。

5. 发明授权

US5891160A Fastener delivery and deployment mechanism and method for placing the fastener in minimally invasive surgery 失效
标题翻译：用于将紧固件放置在微创手术中的紧固件递送和部署机构和方法
公开(公告)号：US5891160A
公开(公告)日：1999-04-06
申请号：US985355
申请日：1997-12-04
申请人： Warren P. Williamson, IV , George T. Christakis , Paul Spence , Thomas Ward , Douglas P. Allen
发明人： Warren P. Williamson, IV , George T. Christakis , Paul Spence , Thomas Ward , Douglas P. Allen
IPC分类号： A61B17/00 , A61B17/04 , A61B17/064 , A61B17/068 , A61B17/072 , A61B17/115 , A61B17/34 , A61B19/00 , A61F2/24
CPC分类号： A61B17/0469 , A61B17/0644 , A61B17/0684 , A61B17/072 , A61F2/2409 , A61F2/2427 , A61B17/0401 , A61B17/0467 , A61B17/0487 , A61B17/064 , A61B17/115 , A61B2017/00243 , A61B2017/0406 , A61B2017/0458 , A61B2017/0464 , A61B2017/047 , A61B2017/0641 , A61B2017/3486 , A61B2090/061 , A61B2090/395
摘要： A one-piece fastener or staple includes a base that contacts tissue and a prong that extends through the tissue. A suture lead is anchored to the base and a needle is attached to the suture lead. A tool positions the fastener adjacent to the tissue, and is operated to drive the prong and the suture needle through the tissue. The tool includes a needle grabber that is operated to grab the needle and pull the needle out of the patient. Since the suture lead is attached to the fastener, a prosthesis can be placed on the suture lead and pushed down to the tissue. A cassette is releasably mounted on the tool and contains the fastener, the suture lead and the suture needle. Alternative forms of the anchor have sutures attached to a base at locations that are spaced apart from each other, and sutures associated with each of two adjacent anchors can be tied together or sutures associated with a single anchor can be tied together. A suture threadably connected to an anchor can be used as a running suture. A prosthetic device can have a running suture associated therewith that is threadably attached to each of a plurality of anchors. Another form of the system includes a running suture with loops that can have additional anchors attached thereto as needed if the surgeon decides to add further anchors to the system to customize the system to the particular patient.
摘要翻译：单件紧固件或订书钉包括接触组织的基部和延伸穿过组织的插脚。缝合线被锚固到基部并且针被附接到缝合线。工具将紧固件邻近组织定位，并且被操作以通过组织驱动叉和缝合针。该工具包括用于抓住针头并将针从患者中拉出的针抓取器。由于缝线引导件连接到紧固件上，假体可以放置在缝合线上并向下推到组织。盒可释放地安装在工具上并且包含紧固件，缝合线和缝合针。锚的替代形式具有在彼此间隔开的位置处附接到基部的缝合线，并且与两个相邻锚固件中的每一个相关联的缝线可以被捆绑在一起，或者可以将与单个锚相关联的缝线连接在一起。螺纹连接到锚固件的缝合线可以用作运行缝合线。假体装置可以具有与其相关联的运行缝合线，该缝合线可螺纹连接到多个锚固件中的每一个上。系统的另一种形式包括具有循环的运行缝合线，如果外科医生决定向系统添加另外的锚点以根据特定患者定制系统，则可以根据需要具有连接到其上的附加锚固件。

6. 发明授权

US6042607A Means and method of replacing a heart valve in a minimally invasive manner 失效
标题翻译：以微创方式更换心脏瓣膜的方法和方法
公开(公告)号：US6042607A
公开(公告)日：2000-03-28
申请号：US802948
申请日：1997-02-21
申请人： Warren Williamson, IV , Paul A. Spence , George T. Christakis , Thomas J. Ward , Dominic P. DiNovo , George A. Keller , Cecil R. Robinson , E. Dale VanHoose
发明人： Warren Williamson, IV , Paul A. Spence , George T. Christakis , Thomas J. Ward , Dominic P. DiNovo , George A. Keller , Cecil R. Robinson , E. Dale VanHoose
IPC分类号： A61B17/00 , A61B17/04 , A61B17/064 , A61B17/068 , A61B17/072 , A61B17/115 , A61B17/34 , A61B19/00 , A61F2/24
CPC分类号： A61B17/072 , A61B17/0469 , A61B17/0644 , A61B17/0684 , A61F2/2409 , A61F2/2427 , A61F2/2496 , A61B17/0401 , A61B17/0467 , A61B17/0487 , A61B17/064 , A61B17/115 , A61B2017/00243 , A61B2017/0406 , A61B2017/047 , A61B2017/3486 , A61B2090/061 , A61B2090/395
摘要： A heart valve can be replaced using minimally invasive methods which include a sutureless sewing cuff that and a fastener delivery tool that holds the cuff against the patient's tissue while delivering fasteners, two at a time to attach the cuff to the tissue from the inside out. The tool stores a plurality of fasteners. Drawstrings are operated from outside the patient's body and cinch the sewing cuff to the valve body. The cuff is releasably mounted on the tool and the tool holds the cuff against tissue and drives the fastener through the cuff and the tissue before folding over the legs of the fastener whereby secure securement between the cuff and the tissue is assured. At least two rows of staggered fasteners are formed whereby fasteners are located continuously throughout the entire circumference of the cuff. A minimally invasive surgical method is disclosed, and a method and tool are disclosed for repairing abdominal aortic aneurysms in a minimally invasive manner.
摘要翻译：可以使用微创方法来替换心脏瓣膜，所述方法包括无缝线缝合口袋，以及紧固件递送工具，其在递送紧固件的同时将袖带保持在患者组织上，同时两次将袖带从内向外连接到组织。该工具存储多个紧固件。束带从患者身体外部进行操作，并将缝合袖带固定在阀体上。袖带可释放地安装在工具上，并且工具将袖带保持抵靠组织，并且在折叠紧固件的腿部之前通过袖口和组织驱动紧固件，从而确保袖带和组织之间的牢固固定。形成至少两排交错的紧固件，由此紧固件连续地位于袖带的整个圆周上。公开了一种微创手术方法，并且公开了一种以微创方式修复腹主动脉瘤的方法和工具。

7. 发明授权

US5716370A Means for replacing a heart valve in a minimally invasive manner 失效
标题翻译：用于以微创方式更换心脏瓣膜的方法
公开(公告)号：US5716370A
公开(公告)日：1998-02-10
申请号：US606343
申请日：1996-02-23
申请人： Warren Williamson, IV , Paul A. Spense , George T. Christakis
发明人： Warren Williamson, IV , Paul A. Spense , George T. Christakis
IPC分类号： A61B17/00 , A61B17/04 , A61B17/064 , A61B17/068 , A61B17/072 , A61B17/115 , A61B17/34 , A61B19/00 , A61F2/24 , A61B17/08
CPC分类号： A61B17/072 , A61B17/0469 , A61B17/0644 , A61B17/0684 , A61F2/2409 , A61F2/2427 , A61F2/2496 , A61B17/0401 , A61B17/0467 , A61B17/0487 , A61B17/064 , A61B17/115 , A61B2017/00243 , A61B2017/0406 , A61B2017/047 , A61B2017/3486 , A61B2090/061 , A61B2090/395
摘要： A heart valve can be replaced using minimally invasive methods which include a sutureless sewing cuff that and a fastener delivery tool that holds the cuff against the patient's tissue while delivering fasteners, two at a time in opposite directions, to attach the cuff to the tissue from the inside out. Drawstrings are operated from outside the patient's body and cinch the sewing cuff to the valve body. The cuff is releasably mounted on the tool. The tool stores a plurality of fasteners thereon. Two rows of staggered fasteners are formed whereby fasteners are located continuously throughout the entire circumference of the cuff. A minimally invasive surgical method is disclosed, and a method and tool are disclosed for repairing abdominal aortic aneurysms in a minimally invasive manner.
摘要翻译：可以使用微创方法来替换心脏瓣膜，所述方法包括无缝线缝合袖口，以及紧固件递送工具，其将袖带保持抵靠患者组织，同时递送紧固件，两次在相反方向上，以将袖带附着到组织上里面出来束带从患者身体外部进行操作，并将缝合袖带固定在阀体上。袖带可拆卸地安装在工具上。该工具在其上存储多个紧固件。形成两排交错紧固件，其中紧固件连续地位于袖带的整个圆周上。公开了一种微创手术方法，并且公开了一种以微创方式修复腹主动脉瘤的方法和工具。

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