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1. 发明授权

US5891160A Fastener delivery and deployment mechanism and method for placing the fastener in minimally invasive surgery 失效
标题翻译：用于将紧固件放置在微创手术中的紧固件递送和部署机构和方法
公开(公告)号：US5891160A
公开(公告)日：1999-04-06
申请号：US985355
申请日：1997-12-04
申请人： Warren P. Williamson, IV , George T. Christakis , Paul Spence , Thomas Ward , Douglas P. Allen
发明人： Warren P. Williamson, IV , George T. Christakis , Paul Spence , Thomas Ward , Douglas P. Allen
IPC分类号： A61B17/00 , A61B17/04 , A61B17/064 , A61B17/068 , A61B17/072 , A61B17/115 , A61B17/34 , A61B19/00 , A61F2/24
CPC分类号： A61B17/0469 , A61B17/0644 , A61B17/0684 , A61B17/072 , A61F2/2409 , A61F2/2427 , A61B17/0401 , A61B17/0467 , A61B17/0487 , A61B17/064 , A61B17/115 , A61B2017/00243 , A61B2017/0406 , A61B2017/0458 , A61B2017/0464 , A61B2017/047 , A61B2017/0641 , A61B2017/3486 , A61B2090/061 , A61B2090/395
摘要： A one-piece fastener or staple includes a base that contacts tissue and a prong that extends through the tissue. A suture lead is anchored to the base and a needle is attached to the suture lead. A tool positions the fastener adjacent to the tissue, and is operated to drive the prong and the suture needle through the tissue. The tool includes a needle grabber that is operated to grab the needle and pull the needle out of the patient. Since the suture lead is attached to the fastener, a prosthesis can be placed on the suture lead and pushed down to the tissue. A cassette is releasably mounted on the tool and contains the fastener, the suture lead and the suture needle. Alternative forms of the anchor have sutures attached to a base at locations that are spaced apart from each other, and sutures associated with each of two adjacent anchors can be tied together or sutures associated with a single anchor can be tied together. A suture threadably connected to an anchor can be used as a running suture. A prosthetic device can have a running suture associated therewith that is threadably attached to each of a plurality of anchors. Another form of the system includes a running suture with loops that can have additional anchors attached thereto as needed if the surgeon decides to add further anchors to the system to customize the system to the particular patient.
摘要翻译：单件紧固件或订书钉包括接触组织的基部和延伸穿过组织的插脚。缝合线被锚固到基部并且针被附接到缝合线。工具将紧固件邻近组织定位，并且被操作以通过组织驱动叉和缝合针。该工具包括用于抓住针头并将针从患者中拉出的针抓取器。由于缝线引导件连接到紧固件上，假体可以放置在缝合线上并向下推到组织。盒可释放地安装在工具上并且包含紧固件，缝合线和缝合针。锚的替代形式具有在彼此间隔开的位置处附接到基部的缝合线，并且与两个相邻锚固件中的每一个相关联的缝线可以被捆绑在一起，或者可以将与单个锚相关联的缝线连接在一起。螺纹连接到锚固件的缝合线可以用作运行缝合线。假体装置可以具有与其相关联的运行缝合线，该缝合线可螺纹连接到多个锚固件中的每一个上。系统的另一种形式包括具有循环的运行缝合线，如果外科医生决定向系统添加另外的锚点以根据特定患者定制系统，则可以根据需要具有连接到其上的附加锚固件。

2. 发明授权

US08034292B2 Apparatus and methods for automated handling and embedding of tissue samples 有权
标题翻译：用于自动处理和嵌入组织样本的装置和方法
公开(公告)号：US08034292B2
公开(公告)日：2011-10-11
申请号：US13047053
申请日：2011-03-14
申请人： Douglas P. Allen , Dominic P. DiNovo , George A. Keller , Rebeccah P. Quam , Thomas J. Ward , Warren P. Williamson, IV
发明人： Douglas P. Allen , Dominic P. DiNovo , George A. Keller , Rebeccah P. Quam , Thomas J. Ward , Warren P. Williamson, IV
IPC分类号： G01N21/00
CPC分类号： G01N1/36 , G01N35/00732 , G01N2001/366 , Y10T436/2525 , Y10T436/2575
摘要： An automated machine for handling and embedding tissue samples contained on microtome sectionable supports. The machine includes an input member configured to hold a plurality of the microtome sectionable supports prior to a tissue embedding operation. An output member is configured to hold a plurality of the microtome sectionable supports after the tissue embedding operation. A cooling unit is configured to hold at least one of the microtome sectionable supports during the tissue embedding operation. A motorized carrier assembly is mounted for movement and configured to hold at least one of the microtome sectionable supports. The carrier assembly moves the support from the input member to the cooling unit and, finally, to the output member. A dispensing device dispenses an embedding material onto the microtome sectionable support and at least one tissue sample carried by the microtome sectionable support during the embedding operation.
摘要翻译：一种用于处理和嵌入包含在切片机可切片支架上的组织样本的自动化机器。该机器包括一个输入构件，构造成在组织嵌入操作之前保持多个切片机可切割支架。输出构件被配置为在组织嵌入操作之后保持多个切片机可切割支撑件。冷却单元构造成在组织嵌入操作期间保持切片机可分段支撑件中的至少一个。安装电动载体组件用于移动并且构造成保持切片机可分段支撑件中的至少一个。托架组件将支撑件从输入构件移动到冷却单元，最后移动到输出构件。分配装置在嵌入操作期间将嵌入材料分配到切片机可切片支撑件和由切片机可切割支撑件携带的至少一个组织样本。

3. 发明申请

US20100129859A1 APPARATUS AND METHODS FOR AUTOMATED HANDLING AND EMBEDDING OF TISSUE SAMPLES 审中-公开
标题翻译：装置和组织样品的自动处理和嵌入方法
公开(公告)号：US20100129859A1
公开(公告)日：2010-05-27
申请号：US12696506
申请日：2010-01-29
申请人： Douglas P. Allen , Dominic P. DiNovo , Matthew J. Huddleston , Kenneth E. Hughes , George A. Keller , Keith A. Kuisick , Rebeccah P. Quam , Cecil R. Robinson , Jonathan E. Turner , Ernest D. VanHoose , Thomas J. Ward , Warren P. Williamson, IV
发明人： Douglas P. Allen , Dominic P. DiNovo , Matthew J. Huddleston , Kenneth E. Hughes , George A. Keller , Keith A. Kuisick , Rebeccah P. Quam , Cecil R. Robinson , Jonathan E. Turner , Ernest D. VanHoose , Thomas J. Ward , Warren P. Williamson, IV
IPC分类号： G01N1/30 , C12M1/34
CPC分类号： G01N1/36 , G01N35/00732 , G01N2001/366 , Y10T436/2525 , Y10T436/2575
摘要： An automated machine for handling and embedding tissue samples contained on microtome sectionable supports. The machine includes an input member configured to hold a plurality of the microtome sectionable supports prior to a tissue embedding operation. An output member is configured to hold a plurality of the microtome sectionable supports after the tissue embedding operation. A cooling unit is configured to hold at least one of the microtome sectionable supports during the tissue embedding operation. A motorized carrier assembly is mounted for movement and configured to hold at least one of the microtome sectionable supports. The carrier assembly moves the support from the input member to the cooling unit and, finally, to the output member. A dispensing device dispenses an embedding material onto the microtome sectionable support and at least one tissue sample carried by the microtome sectionable support during the embedding operation.
摘要翻译：一种用于处理和嵌入包含在切片机可切片支架上的组织样本的自动化机器。该机器包括一个输入构件，构造成在组织嵌入操作之前保持多个切片机可切割支架。输出构件被配置为在组织嵌入操作之后保持多个切片机可切割支撑件。冷却单元构造成在组织嵌入操作期间保持切片机可分段支撑件中的至少一个。安装电动载体组件用于移动并且构造成保持切片机可分段支撑件中的至少一个。托架组件将支撑件从输入构件移动到冷却单元，最后移动到输出构件。分配装置在嵌入操作期间将嵌入材料分配到切片机可切片支撑件和由切片机可切割支撑件承载的至少一个组织样本。

4. 发明授权

US06565581B1 Apparatus and method for performing an anastomosis 失效
标题翻译：用于进行吻合的装置和方法
公开(公告)号：US06565581B1
公开(公告)日：2003-05-20
申请号：US09641284
申请日：2000-08-17
申请人： Paul A. Spence , Warren P. Williamson IV , George Christakis , Mark Ortiz , Craig B. Berky , Douglas P. Allen , Matthew J. Huddleston , Delbert Ted Leimbach , Cecil R. Robinson , E. Dale VanHoose , Thomas J. Ward , Marty J. Warnecke
发明人： Paul A. Spence , Warren P. Williamson IV , George Christakis , Mark Ortiz , Craig B. Berky , Douglas P. Allen , Matthew J. Huddleston , Delbert Ted Leimbach , Cecil R. Robinson , E. Dale VanHoose , Thomas J. Ward , Marty J. Warnecke
IPC分类号： A61B1708
CPC分类号： A61B17/11 , A61B17/1152 , A61B2017/1135 , A61B2017/1139
摘要： An anastomosis is performed using a flexible mounting structure mounted on the outside of at least one vessel. Fasteners extend through the vessel and are bent towards the incision to attach the flexible mounting structure to the vessel in a manner that controls the edge of the vessel adjacent to the incision. The mounting structures are oriented on each vessel so fasteners on one mounting structure interdigitate with fasteners on the other mounting structure at the location of contact between the vessels when the two vessels are brought together. This creates two complementary sinusoidal-shaped vessel edges with peaks of one edge being accommodated in the valleys of the other edge. The peak-to-valley orientation forms a sinusoidal-shaped joint which is leak free. The fasteners are spaced so proper pressure is applied to the tissue to promote healing without leaking. Furthermore, the fasteners are sized and shaped to properly engage the tissue and bend in a desired manner. Methods and tools for carrying out the anastomosis according to the invention are also disclosed. Methods for forming the fastener and the tines having the proper characteristics are disclosed. An absorbable ring-shaped stent is also disclosed.
摘要翻译：使用安装在至少一个容器的外侧上的柔性安装结构进行吻合。紧固件延伸穿过容器并朝向切口弯曲，以将控制与切口相邻的容器边缘的方式将柔性安装结构附接到容器。安装结构被定向在每个容器上，因此当两个容器被接合在一起时，在一个安装结构上的紧固件与另一个安装结构上的紧固件在容器之间的接触位置处相互交错。这产生两个互补的正弦形容器边缘，其中一个边缘的峰值被容纳在另一个边缘的谷部中。峰 - 谷取向形成无泄漏的正弦形接头。紧固件间隔开，以便适当的压力施加到组织以促进愈合而不泄漏。此外，紧固件的尺寸和形状适于适当地接合组织并以期望的方式弯曲。还公开了用于进行根据本发明的吻合的方法和工具。公开了用于形成紧固件和具有适当特性的尖齿的方法。还公开了可吸收的环形支架。

5. 发明申请

US20110165615A1 APPARATUS AND METHODS FOR AUTOMATED HANDLING AND EMBEDDING OF TISSUE SAMPLES 有权
标题翻译：装置和组织样品的自动处理和嵌入方法
公开(公告)号：US20110165615A1
公开(公告)日：2011-07-07
申请号：US13047053
申请日：2011-03-14
申请人： Douglas P. Allen , Dominic P. DiNovo , George A. Keller , Rebeccah P. Quam , Thomas J. Ward , Warren P. Williamson, IV
发明人： Douglas P. Allen , Dominic P. DiNovo , George A. Keller , Rebeccah P. Quam , Thomas J. Ward , Warren P. Williamson, IV
IPC分类号： G01N1/30 , C12M1/34
CPC分类号： G01N1/36 , G01N35/00732 , G01N2001/366 , Y10T436/2525 , Y10T436/2575
摘要： An automated machine for handling and embedding tissue samples contained on microtome sectionable supports. The machine includes an input member configured to hold a plurality of the microtome sectionable supports prior to a tissue embedding operation. An output member is configured to hold a plurality of the microtome sectionable supports after the tissue embedding operation. A cooling unit is configured to hold at least one of the microtome sectionable supports during the tissue embedding operation. A motorized carrier assembly is mounted for movement and configured to hold at least one of the microtome sectionable supports. The carrier assembly moves the support from the input member to the cooling unit and, finally, to the output member. A dispensing device dispenses an embedding material onto the microtome sectionable support and at least one tissue sample carried by the microtome sectionable support during the embedding operation.
摘要翻译：一种用于处理和嵌入包含在切片机可切片支架上的组织样本的自动化机器。该机器包括一个输入构件，构造成在组织嵌入操作之前保持多个切片机可切割支架。输出构件被配置为在组织嵌入操作之后保持多个切片机可切割支撑件。冷却单元构造成在组织嵌入操作期间保持切片机可分段支撑件中的至少一个。安装电动载体组件用于移动并且构造成保持切片机可分段支撑件中的至少一个。托架组件将支撑件从输入构件移动到冷却单元，最后移动到输出构件。分配装置在嵌入操作期间将嵌入材料分配到切片机可切片支撑件和由切片机可切割支撑件携带的至少一个组织样本。

6. 发明授权

US06884251B2 Apparatus and method for performing an anastomosis 失效
标题翻译：用于进行吻合的装置和方法
公开(公告)号：US06884251B2
公开(公告)日：2005-04-26
申请号：US10384250
申请日：2003-03-06
申请人： Paul A. Spence , Warren P. Williamson, IV , George Christakis , Mark Ortiz , Craig B. Berky , Douglas P. Allen , Matthew J. Huddleston , Delbert Ted Leimbach , Cecil R. Robinson , E. Dale VanHoose , Thomas J. Ward , Marty J. Warnecke
发明人： Paul A. Spence , Warren P. Williamson, IV , George Christakis , Mark Ortiz , Craig B. Berky , Douglas P. Allen , Matthew J. Huddleston , Delbert Ted Leimbach , Cecil R. Robinson , E. Dale VanHoose , Thomas J. Ward , Marty J. Warnecke
IPC分类号： A61B17/11 , A61B17/115 , A61B17/08
CPC分类号： A61B17/11 , A61B17/1152 , A61B2017/1135 , A61B2017/1139
摘要： An anastomosis is performed using a flexible mounting structure mounted on the outside of at least one vessel. Fasteners extend through the vessel and are bent towards the incision to attach the flexible mounting structure to the vessel in a manner that controls the edge of the vessel adjacent to the incision. The mounting structures are oriented on each vessel so fasteners on one mounting structure interdigitate with fasteners on the other mounting structure at the location of contact between the vessels when the two vessels are brought together. This creates two complementary sinusoidal-shaped vessel edges with peaks of one edge being accommodated in the valleys of the other edge. The peak-to-valley orientation forms a sinusoidal-shaped joint which is leak free. The fasteners are spaced so proper pressure is applied to the tissue to promote healing without leaking. Furthermore, the fasteners are sized and shaped to properly engage the tissue and bend in a desired manner. Methods and tools for carrying out the anastomosis according to the invention are also disclosed. Methods for forming the fastener and the tines having the proper characteristics are disclosed. An absorbable ring-shaped stent is also disclosed.
摘要翻译：使用安装在至少一个容器的外部的柔性安装结构进行吻合。紧固件延伸穿过容器并朝向切口弯曲，以将控制与切口相邻的容器边缘的方式将柔性安装结构附接到容器。安装结构被定向在每个容器上，因此当两个容器被接合在一起时，在一个安装结构上的紧固件与另一个安装结构上的紧固件在容器之间的接触位置处相互交错。这产生两个互补的正弦形容器边缘，其中一个边缘的峰值被容纳在另一个边缘的谷部中。峰 - 谷取向形成无泄漏的正弦形接头。紧固件间隔开，以便适当的压力施加到组织以促进愈合而不泄漏。此外，紧固件的尺寸和形状适于适当地接合组织并以期望的方式弯曲。还公开了用于进行根据本发明的吻合的方法和工具。公开了用于形成紧固件和具有适当特性的尖齿的方法。还公开了可吸收的环形支架。

7. 发明授权

US07722810B2 Apparatus and methods for automated handling and embedding of tissue samples 有权
标题翻译：用于自动处理和嵌入组织样本的装置和方法
公开(公告)号：US07722810B2
公开(公告)日：2010-05-25
申请号：US11010773
申请日：2004-12-13
申请人： Douglas P. Allen , Dominic P. DiNovo , Matthew J. Huddleston , Kenneth E. Hughes , George A. Keller , Keith A. Kuisick , Rebeccah P. Quam , Cecil R. Robinson , Jonathan E. Turner , Ernest D. VanHoose , Thomas J. Ward , Warren P. Williamson, IV
发明人： Douglas P. Allen , Dominic P. DiNovo , Matthew J. Huddleston , Kenneth E. Hughes , George A. Keller , Keith A. Kuisick , Rebeccah P. Quam , Cecil R. Robinson , Jonathan E. Turner , Ernest D. VanHoose , Thomas J. Ward , Warren P. Williamson, IV
IPC分类号： G01N21/00
CPC分类号： G01N1/36 , G01N35/00732 , G01N2001/366 , Y10T436/2525 , Y10T436/2575
摘要： An automated machine for handling and embedding tissue samples contained on microtome sectionable supports. The machine includes an input member configured to hold a plurality of the microtome sectionable supports prior to a tissue embedding operation. An output member is configured to hold a plurality of the microtome sectionable supports after the tissue embedding operation. A cooling unit is configured to hold at least one of the microtome sectionable supports during the tissue embedding operation. A motorized carrier assembly is mounted for movement and configured to hold at least one of the microtome sectionable supports. The carrier assembly moves the support from the input member to the cooling unit and, finally, to the output member. A dispensing device dispenses an embedding material onto the microtome sectionable support and at least one tissue sample carried by the microtome sectionable support during the embedding operation.
摘要翻译：一种用于处理和嵌入包含在切片机可切片支架上的组织样本的自动化机器。该机器包括一个输入构件，构造成在组织嵌入操作之前保持多个切片机可切割支架。输出构件被配置为在组织嵌入操作之后保持多个切片机可切割支撑件。冷却单元构造成在组织嵌入操作期间保持切片机可分段支撑件中的至少一个。安装电动载体组件用于移动并且构造成保持切片机可分段支撑件中的至少一个。托架组件将支撑件从输入构件移动到冷却单元，最后移动到输出构件。分配装置在嵌入操作期间将嵌入材料分配到切片机可切片支撑件和由切片机可切割支撑件携带的至少一个组织样本。

8. 发明申请

US20190110674A1 SURGICAL ACCESS DEVICE INCORPORATING SCOPE CLEANER 审中-公开
公开(公告)号：US20190110674A1
公开(公告)日：2019-04-18
申请号：US15967357
申请日：2018-04-30
申请人： Douglas P. Allen , Robert M. Evans
发明人： Douglas P. Allen , Robert M. Evans
IPC分类号： A61B1/12 , A61B1/00 , A61B1/313
摘要： A surgical access device is configured to provide an access path via an elongated cannula so that a medical scope can be advanced into a surgical field within a patient. A housing of the surgical access device encloses a wipe assembly configured to clean a lens of the medical scope. An access passage having an axis can be defined within the housing, and the wipe assembly can be spaced from the access passage so that the medical scope is angled off of the access passage axis in order for the lens to engage the wipe assembly. Portions of the housing can define fulcrum surfaces about which the medical scope can be rotated in order to align the lens with the wipe assembly.

9. 发明申请

US20140249374A1 SYSTEMS, DEVICES AND METHODS FOR CREATING AN OPERATIVE SITE WITHIN A PATIENT 审中-公开
标题翻译：用于在患者中创建手术位置的系统，装置和方法
公开(公告)号：US20140249374A1
公开(公告)日：2014-09-04
申请号：US14274998
申请日：2014-05-12
申请人： Robert Evans , Douglas P. Allen
发明人： Robert Evans , Douglas P. Allen
IPC分类号： A61B17/02 , A61M29/02
CPC分类号： A61B17/0218 , A61B17/0293 , A61B2017/00557 , A61B2017/00818 , A61M29/02
摘要： A device for creating an operative space within a body lumen for the performance of a medical procedure, including a pressurizable, expandable balloon element insertable into the body lumen. The balloon element includes an interior space for receiving an inflation fluid. The device further includes an ingress valve coupled with the balloon element and insertable therewith into the body lumen. The ingress valve is capable of being opened to allow the interior space to be filled with the inflation fluid and closed to retain the inflation fluid in the interior space. The device may also include an egress valve coupled with the balloon element and insertable therewith into the body lumen. The egress valve is closed when the interior space is filled with the inflation fluid and is capable of being opened to allow the inflation fluid to vent from the interior space.
摘要翻译：一种用于在体腔内创建用于执行医疗程序的可操作空间的装置，包括可插入到体腔中的可加压的可扩张气囊元件。球囊元件包括用于接收充气流体的内部空间。该装置还包括与球囊元件联接并可插入到体腔中的入口阀。入口阀能够打开以允许内部空间充满膨胀流体并且关闭以将充气流体保持在内部空间中。该装置还可以包括与球囊元件联接并可插入到体腔中的出口阀。当内部空间充满膨胀流体并且能够被打开以允许膨胀流体从内部空间排出时，出口阀关闭。

10. 发明申请

US20130184534A1 SYSTEMS, DEVICES AND METHODS FOR CREATING AN OPERATIVE SITE WITHIN A PATIENT 审中-公开
标题翻译：用于在患者中创建手术位置的系统，装置和方法
公开(公告)号：US20130184534A1
公开(公告)日：2013-07-18
申请号：US13348807
申请日：2012-01-12
申请人： Robert Evans , Douglas P. Allen
发明人： Robert Evans , Douglas P. Allen
IPC分类号： A61B1/32
CPC分类号： A61B17/0293 , A61B17/0218 , A61B2017/00557 , A61B2017/00818
摘要： A device for creating an operative space within a body lumen for the performance of a medical procedure, including a pressurizable, expandable balloon element insertable into the body lumen. The balloon element includes an interior space for receiving an inflation fluid. The device further includes an ingress valve coupled with the balloon element and insertable therewith into the body lumen. The ingress valve is capable of being opened to allow the interior space to be filled with the inflation fluid and closed to retain the inflation fluid in the interior space. The device may also include an egress valve coupled with the balloon element and insertable therewith into the body lumen. The egress valve is closed when the interior space is filled with the inflation fluid and is capable of being opened to allow the inflation fluid to vent from the interior space.
摘要翻译：一种用于在体腔内创建用于执行医疗程序的可操作空间的装置，包括可插入到体腔中的可加压的可扩张气囊元件。球囊元件包括用于接收充气流体的内部空间。该装置还包括与球囊元件联接并可插入到体腔中的入口阀。入口阀能够打开以允许内部空间充满膨胀流体并且关闭以将充气流体保持在内部空间中。该装置还可以包括与球囊元件联接并可插入到体腔中的出口阀。当内部空间充满膨胀流体并且能够被打开以允许膨胀流体从内部空间排出时，出口阀关闭。

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