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1. 发明申请

US20050193434A1 IL-21 as a regulator of immunoglobin production 有权
标题翻译： IL-21作为免疫球蛋白生产的调节剂
公开(公告)号：US20050193434A1
公开(公告)日：2005-09-01
申请号：US11027868
申请日：2004-12-30
申请人： Warren Leonard , Katsutoshi Ozaki , Rosanne Spolski , Herbert Morse , Peter Lipsky , Derry Roopenian
发明人： Warren Leonard , Katsutoshi Ozaki , Rosanne Spolski , Herbert Morse , Peter Lipsky , Derry Roopenian
IPC分类号： A01K67/027 , C07K14/54 , C07K14/715 , C12N20060101 , C12N15/85 , C12Q1/68 , G01N33/53
CPC分类号： C07K14/7155 , A01K67/0276 , A01K2217/05 , A01K2227/105 , A01K2267/0381 , C07K14/5406 , C12N15/8509
摘要： A transgenic mouse is disclosed herein whose somatic and germ cells comprise a disrupted IL-21 receptor gene, the disruption being sufficient to inhibit the binding of IL-21 to an IL-21 receptor, and a disrupted IL-4 gene, the disruption being sufficient to inhibit the production of IL-4 or the binding of IL-4 to the IL-4 receptor. A mouse homozygous for the disrupted IL-21 receptor gene and homozygous for the disrupted IL-4 gene has diminished B cell function. A method is disclosed for altering a B cell activity. The method includes administering a therapeutically effective amount of an agent that interferes with the interaction of IL-21 with an IL-21 receptor, thereby altering the B cell activity. A method is also disclosed for of treating a subject with Job's disorder or atopic disease. A method is also disclosed for treating or preventing an allergic reaction in a subject. A method is also disclosed for treating a subject with an autoimmune or antibody mediated disorder.
摘要翻译：本文公开了一种转基因小鼠，其体细胞和生殖细胞包含破坏的IL-21受体基因，所述破坏足以抑制IL-21与IL-21受体的结合以及破坏的IL-4基因，所述破坏是足以抑制IL-4的产生或IL-4与IL-4受体的结合。对于破坏的IL-21受体基因纯合的小鼠和破坏的IL-4基因是纯合的，具有减少的B细胞功能。公开了用于改变B细胞活性的方法。该方法包括施用治疗有效量的干扰IL-21与IL-21受体相互作用的试剂，由此改变B细胞活性。还公开了用于治疗患有约瑟病或特应性疾病的受试者的方法。还公开了用于治疗或预防受试者的过敏反应的方法。还公开了用自身免疫或抗体介导的病症治疗受试者的方法。

2. 发明申请

US20080166338A1 IL-21 AS A REGULATOR OF IMMUNOGLOBIN PRODUCTION 审中-公开
标题翻译： IL-21作为免疫球蛋白生产的调节剂
公开(公告)号：US20080166338A1
公开(公告)日：2008-07-10
申请号：US11958540
申请日：2007-12-18
申请人： Warren J. Leonard , Katsutoshi Ozaki , Rosanne Spolski , Herbert C. Morse , Peter E. Lipsky , Derry Roopenian
发明人： Warren J. Leonard , Katsutoshi Ozaki , Rosanne Spolski , Herbert C. Morse , Peter E. Lipsky , Derry Roopenian
IPC分类号： A61K39/395 , A61P43/00
CPC分类号： C07K14/7155 , A01K67/0276 , A01K2217/05 , A01K2227/105 , A01K2267/0381 , C07K14/5406 , C12N15/8509
摘要： A transgenic mouse is disclosed herein whose somatic and germ cells comprise a disrupted IL-21 receptor gene, the disruption being sufficient to inhibit the binding of IL-21 to an IL-21 receptor, and a disrupted IL-4 gene, the disruption being sufficient to inhibit the production of IL-4 or the binding of IL-4 to the IL-4 receptor. A mouse homozygous for the disrupted IL-21 receptor gene and homozygous for the disrupted IL-4 gene has diminished B cell function. A method is disclosed for altering a B cell activity. The method includes administering a therapeutically effective amount of an agent that interferes with the interaction of IL-21 with an IL-21 receptor, thereby altering the B cell activity. A method is also disclosed for of treating a subject with Job's disorder or atopic disease. A method is also disclosed for treating or preventing an allergic reaction in a subject. A method is also disclosed for treating a subject with an autoimmune or antibody mediated disorder.
摘要翻译：本文公开了一种转基因小鼠，其体细胞和生殖细胞包含破坏的IL-21受体基因，所述破坏足以抑制IL-21与IL-21受体的结合以及破坏的IL-4基因，所述破坏是足以抑制IL-4的产生或IL-4与IL-4受体的结合。对于破坏的IL-21受体基因纯合的小鼠和破坏的IL-4基因是纯合的，具有减少的B细胞功能。公开了用于改变B细胞活性的方法。该方法包括施用治疗有效量的干扰IL-21与IL-21受体相互作用的试剂，由此改变B细胞活性。还公开了用于治疗患有约瑟病或特应性疾病的受试者的方法。还公开了用于治疗或预防受试者的过敏反应的方法。还公开了用自身免疫或抗体介导的病症治疗受试者的方法。

3. 发明申请

US20100135958A1 METHOD FOR TREATING CANCER IN HUMANS 审中-公开
标题翻译：人类治疗癌症的方法
公开(公告)号：US20100135958A1
公开(公告)日：2010-06-03
申请号：US12651858
申请日：2010-01-04
申请人： Patrick Hwu , Gang Wang , Warren Leonard , Rosanne Spolski , Katsutoshi Ozaki
发明人： Patrick Hwu , Gang Wang , Warren Leonard , Rosanne Spolski , Katsutoshi Ozaki
IPC分类号： A61K38/20 , A61K31/7088 , A61P37/00
CPC分类号： A61K38/2013 , A61K38/20 , A61K38/2046 , A61K38/2086 , A61K39/0011 , A61K48/005 , A61K2039/55527 , A61K2300/00
摘要： A method of treating and/or preventing cancer in a subject, preferably mammalian, more preferably human, by administering in an effective amount IL-21 polypeptide, polynucleotide, vector comprising an IL-21 nucleic acid sequence encoding an IL-21 polypeptide, variants, and fragments thereof, thereby acting as an anti-cancer agent by reducing, ameliorating, and/or eliminating the cancer; and a method of treating and/or preventing cancer in a subject by co-administering the IL-21 polypeptide, polynucleotide, IL-21 vector, variant, and fragments thereof, with an immunotherapeutic and/or chemotherapeutic agent for the treatment and/or prevention of cancer in a subject.
摘要翻译：通过施用有效量的IL-21多肽，多核苷酸，包含编码IL-21多肽的IL-21核酸序列的载体的载体，变体（或其组合）的变体，治疗和/或预防受试者，优选哺乳动物，更优选人的癌症的方法及其片段，从而通过减少，改善和/或消除癌症作为抗癌剂; 以及通过与用于治疗和/或免疫治疗的免疫治疗剂和/或化学治疗剂共同施用IL-21多肽，多核苷酸，IL-21载体，变体及其片段来治疗和/或预防受试者的癌症的方法。预防受试者的癌症。

4. 发明授权

US07332645B2 IL-21 as a regulator of immunoglobin production 有权
标题翻译： IL-21作为免疫球蛋白生产的调节剂
公开(公告)号：US07332645B2
公开(公告)日：2008-02-19
申请号：US11027868
申请日：2004-12-30
申请人： Warren J. Leonard , Katsutoshi Ozaki , Rosanne Spolski
发明人： Warren J. Leonard , Katsutoshi Ozaki , Rosanne Spolski
IPC分类号： A01K67/00 , A01K67/033 , A01K67/027 , C07H21/02 , C07H21/04 , C12N15/00
CPC分类号： C07K14/7155 , A01K67/0276 , A01K2217/05 , A01K2227/105 , A01K2267/0381 , C07K14/5406 , C12N15/8509
摘要： A transgenic mouse is disclosed herein whose somatic and germ cells comprise a disrupted IL-21 receptor gene, the disruption being sufficient to inhibit the binding of IL-21 to an IL-21 receptor, and a disrupted IL-4 gene, the disruption being sufficient to inhibit the production of IL-4 or the binding of IL-4 to the IL-4 receptor. A mouse homozygous for the disrupted IL-21 receptor gene and homozygous for the disrupted IL-4 gene has diminished B cell function. A method is disclosed for altering a B cell activity. The method includes administering a therapeutically effective amount of an agent that interferes with the interaction of IL-21 with an IL-21 receptor, thereby altering the B cell activity. A method is also disclosed for of treating a subject with Job's disorder or atopic disease. A method is also disclosed for treating or preventing an allergic reaction in a subject. A method is also disclosed for treating a subject with an autoimmune or antibody mediated disorder.
摘要翻译：本文公开了一种转基因小鼠，其体细胞和生殖细胞包含破坏的IL-21受体基因，所述破坏足以抑制IL-21与IL-21受体的结合以及破坏的IL-4基因，所述破坏是足以抑制IL-4的产生或IL-4与IL-4受体的结合。对于破坏的IL-21受体基因纯合的小鼠和破坏的IL-4基因是纯合的，具有减少的B细胞功能。公开了用于改变B细胞活性的方法。该方法包括施用治疗有效量的干扰IL-21与IL-21受体相互作用的试剂，由此改变B细胞活性。还公开了用于治疗患有约瑟病或特应性疾病的受试者的方法。还公开了用于治疗或预防受试者的过敏反应的方法。还公开了用自身免疫或抗体介导的病症治疗受试者的方法。

5. 发明申请

US20050170410A1 Thymic stromal lymphopoietin receptor molecules and uses thereof 有权
公开(公告)号：US20050170410A1
公开(公告)日：2005-08-04
申请号：US11052527
申请日：2005-02-07
申请人： Akhilesh Pandey , Katsutoshi Ozaki , Heinz Baumann , Steven Levin , Andrew Farr , Warren Leonard , Harvey Lodish
发明人： Akhilesh Pandey , Katsutoshi Ozaki , Heinz Baumann , Steven Levin , Andrew Farr , Warren Leonard , Harvey Lodish
IPC分类号： A61K38/00 , C07K14/715 , C12Q1/68 , A61K38/17 , C07H21/04 , C07K14/72
CPC分类号： C07K14/7155 , A61K38/00 , C07K2319/30
摘要： The present invention provides Thymic Stromal Lymphopoietin Receptor (TSLPR) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing TSLPR polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with TSLPR polypeptides.

6. 发明申请

US20050170459A1 Thymic stromal lymphopoietin receptor molecules and uses thereof 审中-公开
标题翻译：胸腺基质淋巴细胞生成素受体分子及其用途
公开(公告)号：US20050170459A1
公开(公告)日：2005-08-04
申请号：US11052427
申请日：2005-02-07
申请人： Akhilesh Pandey , Katsutoshi Ozaki , Heinz Baumann , Steven Levin , Andrew Farr , Warren Leonard , Harvey Lodish
发明人： Akhilesh Pandey , Katsutoshi Ozaki , Heinz Baumann , Steven Levin , Andrew Farr , Warren Leonard , Harvey Lodish
IPC分类号： A61K38/00 , C07K14/715 , C07H21/04 , C07K16/18 , C12N5/06
CPC分类号： C07K14/7155 , A61K38/00 , C07K2319/30
摘要： The present invention provides Thymic Stromal Lymphopoietin Receptor (TSLPR) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing TSLPR polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with TSLPR polypeptides.
摘要翻译：本发明提供了胸腺基质淋巴细胞生成素受体（TSLPR）多肽和编码其的核酸分子。本发明还提供选择性结合剂，载体，宿主细胞和用于产生TSLPR多肽的方法。本发明还提供了用于诊断，治疗，改善和/或预防与TSLPR多肽相关的疾病，病症和病症的药物组合物和方法。

7. 发明申请

US20120309170A1 EXPANDABLE FILM, DICING FILM, AND METHOD OF PRODUCING SEMICONDUCTOR DEVICE 有权
标题翻译：可扩展膜，定影膜和生产半导体器件的方法
公开(公告)号：US20120309170A1
公开(公告)日：2012-12-06
申请号：US13576786
申请日：2011-09-28
申请人： Eiji Hayashishita , Katsutoshi Ozaki , Mitsuru Sakai , Setsuko Oike
发明人： Eiji Hayashishita , Katsutoshi Ozaki , Mitsuru Sakai , Setsuko Oike
IPC分类号： H01L21/78 , C08L23/20 , C08L23/14 , C09J7/02
CPC分类号： H01L21/6836 , B32B27/08 , B32B27/308 , B32B27/32 , B32B2270/00 , B32B2274/00 , B32B2405/00 , B32B2457/14 , C08J5/18 , C08J2323/16 , C08J2323/20 , C09J7/241 , C09J7/29 , C09J2201/162 , C09J2203/326 , C09J2423/006 , Y10T156/1052 , Y10T428/24942 , Y10T428/28
摘要： To provide an olefinic expandable substrate and a dicing film that exhibits less contamination characteristics, high expandability without necking, which cannot be achieved by conventional olefinic expandable substrates. In order to achieve the object, an expandable film comprises a 1-butene-α-olefin copolymer (A) having a tensile modulus at 23° C. of 100 to 500 MPa and a propylenic elastomer composition (B) comprising a propylene-α-olefin copolymer (b1) and having a tensile modulus at 23° C. of 10 to 50 MPa, wherein the amount of the component (B) is 30 to 70 weight parts relative to 100 weight parts in total of components (A) and (B).
摘要翻译：提供通过常规的烯烃可发性基材不能实现的烯烃发泡基材和显影剂污染特性较小，无颈缩的高扩展性的切割薄膜。为了实现该目的，可发性膜包含在23℃下的拉伸弹性模量为100-500MPa的1-丁烯-α-烯烃共聚物（A）和包含丙烯-α-丙烯的丙烯类弹性体组合物（B） α-烯烃共聚物（b1），并且在23℃下的拉伸弹性模量为10〜50MPa，其中组分（B）的量相对于组分（A）和（A）的总重量相对于100重量份为30〜70重量份（B）。

8. 发明授权

US07402659B2 Thymic stromal lymphopoietin receptor molecules and uses thereof 有权
标题翻译：胸腺基质淋巴细胞生成素受体分子及其用途
公开(公告)号：US07402659B2
公开(公告)日：2008-07-22
申请号：US11052527
申请日：2005-02-07
申请人： Akhilesh Pandey , Katsutoshi Ozaki , Heinz Baumann , Steven D. Levin , Andrew G. Farr , Warren J. Leonard , Harvey F. Lodish
发明人： Akhilesh Pandey , Katsutoshi Ozaki , Heinz Baumann , Steven D. Levin , Andrew G. Farr , Warren J. Leonard , Harvey F. Lodish
IPC分类号： C07K14/475 , C12N15/02 , C12P21/02
CPC分类号： C07K14/7155 , A61K38/00 , C07K2319/30
摘要： The present invention provides Thymic Stromal Lymphopoietin Receptor (TSLPR) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing TSLPR polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with TSLPR polypeptides.
摘要翻译：本发明提供了胸腺基质淋巴细胞生成素受体（TSLPR）多肽和编码其的核酸分子。本发明还提供选择性结合剂，载体，宿主细胞和用于产生TSLPR多肽的方法。本发明还提供了用于诊断，治疗，改善和/或预防与TSLPR多肽相关的疾病，病症和病症的药物组合物和方法。

9. 发明授权

US08476740B2 Sheet for protecting surface of semiconductor wafer, semiconductor device manufacturing method and semiconductor wafer protection method using sheet 有权
标题翻译：用于保护半导体晶片表面的片，半导体器件制造方法和使用片的半导体晶片保护方法
公开(公告)号：US08476740B2
公开(公告)日：2013-07-02
申请号：US13520110
申请日：2011-05-31
申请人： Eiji Hayashishita , Yoshihisa Saimoto , Makoto Kataoka , Katsutoshi Ozaki , Mitsuru Sakai
发明人： Eiji Hayashishita , Yoshihisa Saimoto , Makoto Kataoka , Katsutoshi Ozaki , Mitsuru Sakai
IPC分类号： H01L23/58 , H01L21/30 , H01L21/46 , H01L21/00 , B32B9/00 , B32B33/00
CPC分类号： H01L21/67132 , Y10T428/1471
摘要： To provide a semiconductor wafer surface protection sheet having good adhesion to irregularities on a patterned surface of a semiconductor wafer and having good peelability after wafer grinding. Specifically, a semiconductor wafer surface protection sheet is provided that includes a base layer having a tensile elasticity at 25° C., E(25), of 1 GPa or more; a resin layer A that satisfies the condition EA(60)/EA(25)
摘要翻译：提供对半导体晶片的图案化表面上的凹凸具有良好粘附性并且在晶片研磨之后具有良好剥离性的半导体晶片表面保护片。具体地说，提供一种半导体晶片表面保护片，其包括在25℃，E（25），1GPa以上的拉伸弹性的基层; 满足条件EA（60）/ EA（25）<0.1的树脂层A，其中EA（25）为25℃时的拉伸弹性，EA（60）为60℃时的拉伸弹性， EA（60）为0.005MPa〜1MPa; 和EB（60）大于EA（60）的树脂层B，EB（60）为1MPa以上，厚度为0.1μm以上且小于100μm的EB（60））树脂层A.

10. 发明申请

US20070172649A1 Adhesive material, pressure sensitive adhesive film and method of use thereof 审中-公开
标题翻译：粘合材料，压敏粘合剂膜及其使用方法
公开(公告)号：US20070172649A1
公开(公告)日：2007-07-26
申请号：US10599044
申请日：2005-03-18
申请人： Shin Aihara , Katsutoshi Ozaki , Ryoji Mori , Masumi Saruwatari , Takashi Yokoyama
发明人： Shin Aihara , Katsutoshi Ozaki , Ryoji Mori , Masumi Saruwatari , Takashi Yokoyama
IPC分类号： B32B37/12 , B32B38/04 , B32B38/10 , B32B7/12
CPC分类号： C09J123/14 , B32B2310/0843 , C09J7/381 , C09J2203/31 , C09J2423/00 , Y10T156/1052 , Y10T428/28
摘要： An adhesive material and a pressure sensitive adhesive film containing the same of the present invention are characterized in that they satisfy the following requirements (a) and (b). These adhesive material and pressure sensitive adhesive film of the present invention exhibit excellent stability against not only light and heat but also various chemicals. Consequently, they are suitable applications in surface protection uses, transport storage uses, heating treatment uses, grinding/polishing uses, cutting processing uses and transport/storage uses in the fields of electronic/semiconductor materials, optical/display materials and the like, where demands for performances and qualities are strict. The above requirements are: (a) an olefinic polymer is contained, and (b) by measurement according to a differential scanning calorimetry test, the melting temperature Tm is in the range of 80° C. to 180° C. and the heat of fusion ΔH is at least 1 J/g.
摘要翻译：含有本发明的粘合剂材料和压敏粘合剂膜的特征在于它们满足以下要求（a）和（b）。本发明的这些粘合材料和压敏粘合剂膜不仅对光和热具有优异的稳定性，而且显示出各种化学物质的稳定性。因此，它们适用于电子/半导体材料，光学/显示材料等领域的表面保护用途，运输存储用途，加热处理用途，研磨/抛光用途，切割加工用途和运输/储存用途，其中对表演和品质的要求是严格的。上述要求是：（a）含有烯烃聚合物，（b）通过差示扫描量热法测定，熔融温度Tm在80℃〜180℃的范围内，融合DeltaH至少为1J / g。

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