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1. 发明授权

US06348321B1 Methods of identifying agents inhibiting fatty acid transport proteins 失效
标题翻译：鉴定抑制脂肪酸转运蛋白的试剂的方法
公开(公告)号：US06348321B1
公开(公告)日：2002-02-19
申请号：US09232201
申请日：1999-01-14
申请人： Andreas Stahl , David J. Hirsch , Harvey F. Lodish , Ruth E. Gimeno , Louis A. Tartaglia
发明人： Andreas Stahl , David J. Hirsch , Harvey F. Lodish , Ruth E. Gimeno , Louis A. Tartaglia
IPC分类号： G01N3353
CPC分类号： C12N9/93 , C07K2319/02
摘要： A family of fatty acid transport proteins (FATPS) mediate transport of long chain fatty acids (LCFAs) across cell membranes into cells. These proteins exhibit different expression patterns among the organs of mammals. Nucleic acids encoding FATPs of this family, vectors comprising these nucleic acids, as well as the production of FATP proteins in host cells are described. Also described are methods to test FATPs for fatty acid transport function, and methods to identify inhibitors or enhancers of transport function. The altering of LCFA uptake by administering to the mammal an inhibitor or enhancer of FATP transport function of a FATP in the small intestine can decrease or increase calories available as fats, and can decrease or increase circulating fatty acids. The organ specificity of FATP distribution can be exploited in methods to direct drugs, diagnostic indicators and so forth to an organ such as the heart.
摘要翻译：一系列脂肪酸转运蛋白（FATPS）介导长链脂肪酸（LCFAs）在细胞膜中的转运到细胞中。这些蛋白质在哺乳动物的器官中表现出不同的表达模式。描述了编码该家族的FATP的核酸，包含这些核酸的载体以及宿主细胞中FATP蛋白的产生。还描述了测试脂肪酸转运功能的FATP的方法，以及鉴定转运功能的抑制剂或增强子的方法。通过向哺乳动物施用FATP在小肠中的FATP转运功能的抑制剂或增强剂，LCFA摄取的改变可以降低或增加作为脂肪获得的卡路里，并且可以减少或增加循环脂肪酸。 FATP分布的器官特异性可以用于将药物，诊断指标等引导到诸如心脏的器官的方法中。

2. 发明授权

US6008011A TGF-.beta. type II receptor cDNAs 失效
标题翻译： TGF-βII型受体cDNA
公开(公告)号：US6008011A
公开(公告)日：1999-12-28
申请号：US446938
申请日：1995-05-23
申请人： Herbert Y. Lin , Xiao-Fan Wang , Robert A. Weinberg , Harvey F. Lodish
发明人： Herbert Y. Lin , Xiao-Fan Wang , Robert A. Weinberg , Harvey F. Lodish
IPC分类号： A61K38/00 , A61K38/17 , A61K38/18 , C07K14/71 , C12N15/12 , C07K14/715
CPC分类号： C07K14/71 , A61K38/00
摘要： The mammalian TGF-.beta. type II receptor has been cloned. Nucleic acids encoding full-length and soluble receptor polypeptides, as well as fragments of such nucleic acids useful as probes, are provided. Corresponding vectors, transformed host cells, and their use to produce recombinant TGF-.beta. receptors are also described.
摘要翻译：已经克隆了哺乳动物TGF-β2型受体。提供了编码全长和可溶性受体多肽的核酸，以及可用作探针的这种核酸的片段。还描述了相应的载体，转化的宿主细胞及其用于产生重组TGF-β受体的用途。

3. 发明授权

US6001969A Recombinant TGF-.beta. type II receptor polypeptides 失效
标题翻译：重组TGF-β2型受体多肽
公开(公告)号：US6001969A
公开(公告)日：1999-12-14
申请号：US451946
申请日：1995-05-26
申请人： Herbert Y. Lin , Xiao-Fan Wang , Robert A. Weinberg , Harvey F. Lodish
发明人： Herbert Y. Lin , Xiao-Fan Wang , Robert A. Weinberg , Harvey F. Lodish
IPC分类号： A61K38/00 , A61K38/17 , A61K38/18 , C07K14/71 , C12N15/12 , C07K14/715
CPC分类号： C07K14/71 , A61K38/00
摘要： The mammalian TGF-.beta. type II receptor has been cloned. Recombinant full-length and soluble receptor polypeptides, as well as TGF-.beta.-binding fragments of such polypeptides, are provided.
摘要翻译：已经克隆了哺乳动物TGF-β2型受体。提供重组全长和可溶性受体多肽，以及这些多肽的TGF-β结合片段。

4. 发明授权

US5869330A DNA encoding a novel serum protein produced exclusively in adipocytes 失效
标题翻译：编码仅在脂肪细胞产生的新型血清蛋白的DNA
公开(公告)号：US5869330A
公开(公告)日：1999-02-09
申请号：US463911
申请日：1995-06-05
申请人： Philipp E. Scherer , Harvey F. Lodish
发明人： Philipp E. Scherer , Harvey F. Lodish
IPC分类号： A61K38/00 , C07K14/47 , C07H21/04 , C12N15/63
CPC分类号： C07K14/4702 , A61K38/00
摘要： The present invention relates to DNA encoding Acrp30, of vertebrate (e.g., mammalian) origin, and particularly of human and rodent origin. The present invention further relates to isolated, recombinantly produced or synthetic DNA which hybridizes to the nucleotide sequences described herein and RNA transcribed from the nucleotides sequence described herein. In addition, the invention relates to expression vectors comprising DNA encoding Acrp30, which is expressed when the vector is present in an appropriate host cell. The invention further relates to isolated, recombinantly produced or synthetic mammalian Acrp30 of vertebrate (e.g., mammalian) origin, and particularly of human and rodent origin. Also encompassed by the present invention is an inhibitor or enhancer of Acrp30. The present invention further relates to a method of identifying inhibitors or enhancers of Acrp30. Isolation of Acrp30 makes it possible to detect Acrp30 or adipocytes in a sample (e.g., test sample). In addition, the present invention relates to a method of regulating the energy balance (e.g., nutritional status) of a mammal by administering to the mammal an inhibitor or enhancer of the Acrp30.
摘要翻译：本发明涉及编码Acrp30的脊椎动物（例如哺乳动物）来源，特别是人和啮齿动物来源的DNA。本发明还涉及与本文所述的核苷酸序列杂交的分离的，重组产生的或合成的DNA，以及从本文所述的核苷酸序列转录的RNA。此外，本发明涉及包含编码Acrp30的DNA的表达载体，其在载体存在于合适的宿主细胞中时表达。本发明还涉及脊椎动物（例如哺乳动物）来源，特别是人和啮齿动物来源的分离的重组产生或合成的哺乳动物Acrp30。本发明还包括Acrp30的抑制剂或增强剂。本发明还涉及鉴定Acrp30抑制剂或增强剂的方法。 Acrp30的分离使得可以检测样品中的Acrp30或脂肪细胞（例如测试样品）。此外，本发明涉及通过向哺乳动物施用Acrp30的抑制剂或增强剂来调节哺乳动物的能量平衡（例如营养状态）的方法。

5. 发明授权

US08506955B2 Methods for expansion and analysis of cultured hematopoietic stem cells 有权
标题翻译：扩增和分析培养的造血干细胞的方法
公开(公告)号：US08506955B2
公开(公告)日：2013-08-13
申请号：US12853677
申请日：2010-08-10
申请人： Chengcheng Zhang , Harvey F. Lodish
发明人： Chengcheng Zhang , Harvey F. Lodish
IPC分类号： C12N5/00
CPC分类号： C12N5/00 , A61K2035/124 , C12N5/0647 , C12N2500/90 , C12N2501/105 , C12N2501/113 , C12N2501/125 , C12N2501/145 , C12N2501/17 , C12N2501/91
摘要： Methods and kits for propagating hematopoietic stem cells are provided. The methods comprise culturing cells in medium comprising one or more angiopoietin-like proteins, under conditions sufficient for expansion of HSCs. Angiopoietin-like proteins include angiopoietin-like protein 2, angiopoietin-like protein 3, angiopoietin-like protein 4, angiopoietin-like protein 5, angiopoietin-like protein 7, and microfibrillar-associated glycoprotein (Mfap4). Methods for identifying hematopoietic stem cells are provided and isolated hematopoietic stem cells are also provided.
摘要翻译：提供了用于繁殖造血干细胞的方法和试剂盒。所述方法包括在足以扩增HSC的条件下，在包含一种或多种血管生成素样蛋白的培养基中培养细胞。血管生成素样蛋白包括血管生成素样蛋白2，血管生成素样蛋白3，血管生成素样蛋白4，血管生成素样蛋白5，血管生成素样蛋白7和微原纤维相关糖蛋白（Mfap4）。提供鉴定造血干细胞的方法，并提供分离的造血干细胞。

6. 发明授权

US07402659B2 Thymic stromal lymphopoietin receptor molecules and uses thereof 有权
标题翻译：胸腺基质淋巴细胞生成素受体分子及其用途
公开(公告)号：US07402659B2
公开(公告)日：2008-07-22
申请号：US11052527
申请日：2005-02-07
申请人： Akhilesh Pandey , Katsutoshi Ozaki , Heinz Baumann , Steven D. Levin , Andrew G. Farr , Warren J. Leonard , Harvey F. Lodish
发明人： Akhilesh Pandey , Katsutoshi Ozaki , Heinz Baumann , Steven D. Levin , Andrew G. Farr , Warren J. Leonard , Harvey F. Lodish
IPC分类号： C07K14/475 , C12N15/02 , C12P21/02
CPC分类号： C07K14/7155 , A61K38/00 , C07K2319/30
摘要： The present invention provides Thymic Stromal Lymphopoietin Receptor (TSLPR) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing TSLPR polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with TSLPR polypeptides.
摘要翻译：本发明提供了胸腺基质淋巴细胞生成素受体（TSLPR）多肽和编码其的核酸分子。本发明还提供选择性结合剂，载体，宿主细胞和用于产生TSLPR多肽的方法。本发明还提供了用于诊断，治疗，改善和/或预防与TSLPR多肽相关的疾病，病症和病症的药物组合物和方法。

7. 发明授权

US6086867A Modulation of TGF-.beta. by TGF-.beta. type III receptor polypeptides 有权
标题翻译： TGF-β受体多肽调节TGF-β
公开(公告)号：US6086867A
公开(公告)日：2000-07-11
申请号：US183543
申请日：1998-10-30
申请人： Herbert Y. Lin , Xiao-Fan Wang , Robert A. Weinberg , Harvey F. Lodish
发明人： Herbert Y. Lin , Xiao-Fan Wang , Robert A. Weinberg , Harvey F. Lodish
IPC分类号： A61K38/00 , A61K38/17 , A61K38/18 , A61K39/395 , A61K48/00 , A61P43/00 , C07H21/04 , C07K14/495 , C07K14/52 , C07K14/705 , C07K14/71 , C07K14/715 , C07K16/00 , C07K16/28 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/91 , G01N33/53 , G01N33/566
CPC分类号： C07K16/2863 , C07K14/70575 , C07K14/71 , A61K38/00 , A61K48/00
摘要： DNA encoding TGF-.beta. TYPE III receptor of mammalian origin, DNA encoding TGF-.beta. type II receptor of mammalian origin, TGF-.beta. type III receptor. TGF-.beta. type II receptor and uses therefor.
摘要翻译：编码哺乳动物来源的TGF-βTYPE III受体的DNA，编码哺乳动物来源的TGF-βII型受体的DNA，TGF-βIII型受体。 TGF-βII型受体并用于其。

8. 发明申请

US20130059783A1 COMPOSITIONS AND METHODS FOR EXPANDING BFU-E CELLS 审中-公开
标题翻译：用于扩增BFU-E细胞的组合物和方法
公开(公告)号：US20130059783A1
公开(公告)日：2013-03-07
申请号：US13634399
申请日：2011-03-12
申请人： Johan Flygare , Harvey F. Lodish
发明人： Johan Flygare , Harvey F. Lodish
IPC分类号： C12N5/078 , A61K38/02 , A61P7/06 , C12Q1/02
CPC分类号： A61K31/56 , C12N5/0641 , C12N2501/998 , C12N2501/999
摘要： The invention provides methods of expanding BFU-E cells comprising contacting one or more BFU-E cells with a hypoxia inducible factor 1 activator and a glucocorticoid receptor (GR) activator, e.g., a GR agonist. In some embodiments, the FIIF-1 activator is a prolyl hydroxylase inhibitor (PHI). In some embodiments, the method comprises culturing BFU-E in medium containing a HIF-1a activator and a glucocorticoid receptor (GR) activator, e.g., a GR agonist. In some embodiments the BFU-E cells are human cells. The invention provides cell culture media useful for expanding BFU-Es, wherein the cell culture media comprise a HIF-1 activator and a GR activator (e.g., a GR agonist) The invention provides a method comprises administering a HIF-1 activator and a GR agonist to a subject in need thereof. In some embodiments, the subject suffers from anemia. In some embodiments, the anemia is an Epo-resistant anemia. In some embodiments, the anemia is Diamond-Blackfan anemia.
摘要翻译：本发明提供扩增BFU-E细胞的方法，包括使一种或多种BFU-E细胞与缺氧诱导因子1激活剂和糖皮质激素受体（GR）激活剂例如GR激动剂接触。在一些实施方案中，FIIF-1活化剂是脯氨酰羟化酶抑制剂（PHI）。在一些实施方案中，该方法包括在含有HIF-1a激活剂和糖皮质激素受体（GR）激活剂例如GR激动剂的培养基中培养BFU-E。在一些实施方案中，BFU-E细胞是人细胞。本发明提供可用于扩增BFU-Es的细胞培养基，其中细胞培养基包含HIF-1激活剂和GR激活剂（例如，GR激动剂）本发明提供了一种方法，其包括施用HIF-1激活剂和GR 对有需要的受试者的激动剂。在一些实施方案中，受试者患有贫血。在一些实施方案中，贫血是Epo抗性贫血。在一些实施方案中，贫血是Diamond-Blackfan贫血。

9. 发明申请

US20110196343A1 Methods for Expansion and Analysis of Cultured Hematopoietic Stem Cells 有权
标题翻译：培养造血干细胞的扩增和分析方法
公开(公告)号：US20110196343A1
公开(公告)日：2011-08-11
申请号：US12853677
申请日：2010-08-10
申请人： Chengcheng Zhang , Harvey F. Lodish
发明人： Chengcheng Zhang , Harvey F. Lodish
IPC分类号： A61M37/00 , C12N5/0789
CPC分类号： C12N5/00 , A61K2035/124 , C12N5/0647 , C12N2500/90 , C12N2501/105 , C12N2501/113 , C12N2501/125 , C12N2501/145 , C12N2501/17 , C12N2501/91
摘要： Methods and kits for propagating hematopoietic stem cells are provided. The methods comprise culturing cells in medium comprising one or more angiopoietin-like proteins, under conditions sufficient for expansion of HSCs. Angiopoietin-like proteins include angiopoietin-like protein 2, angiopoietin-like protein 3, angiopoietin-like protein 4, angiopoietin-like protein 5, angiopoietin-like protein 7, and microfibrillar-associated glycoprotein (Mfap4). Methods for identifying hematopoietic stem cells are provided and isolated hematopoietic stem cells are also provided.
摘要翻译：提供了用于繁殖造血干细胞的方法和试剂盒。所述方法包括在足以扩增HSC的条件下，在包含一种或多种血管生成素样蛋白的培养基中培养细胞。血管生成素样蛋白包括血管生成素样蛋白2，血管生成素样蛋白3，血管生成素样蛋白4，血管生成素样蛋白5，血管生成素样蛋白7和微原纤维相关糖蛋白（Mfap4）。提供鉴定造血干细胞的方法，并提供分离的造血干细胞。

10. 发明授权

US06632924B2 Method of measuring plasma membrane targeting of GLUT4 失效
标题翻译：测定GLUT4质膜靶向的方法
公开(公告)号：US06632924B2
公开(公告)日：2003-10-14
申请号：US09894927
申请日：2001-06-28
申请人： Jonathan S. Bogan , Harvey F. Lodish
发明人： Jonathan S. Bogan , Harvey F. Lodish
IPC分类号： C07K1400
CPC分类号： C12N15/62 , C07K14/705 , C07K2319/00 , C07K2319/035 , C07K2319/41 , C07K2319/60 , C12N2799/021
摘要： A method of measuring translocation of a protein in cells from an intracellular location to a plasma membrane or from the plasma membrane to an intracellular location, with particular reference to GLUT4 and modified GLUT4 useful in the method.
摘要翻译：测量细胞内蛋白质从细胞膜到质膜或从质膜到细胞内位置的易位的方法，特别参考用于该方法的GLUT4和修饰的GLUT4。

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