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1. 发明申请

US20120249137A1 Method of dynamically compensating for magnetic field heterogeneity in magnetic resonance imaging 有权
标题翻译：动态补偿磁共振成像磁场异质性的方法
公开(公告)号：US20120249137A1
公开(公告)日：2012-10-04
申请号：US13414737
申请日：2012-03-08
申请人： Walter Witschey , Maxim Zaitsev , Jürgen Hennig , Gerrit Schultz , Daniel Gallichan
发明人： Walter Witschey , Maxim Zaitsev , Jürgen Hennig , Gerrit Schultz , Daniel Gallichan
IPC分类号： G01R33/58
CPC分类号： G01R33/3875
摘要： A method to compensate for the magnetic field heterogeneity inside an object of investigation in a MR device obtains an uncorrected magnetic field distribution of the object and executes an MR sequence with a desired k-space coverage by applying RF pulses to generate a transverse magnetization within the object. MR signal data is recorded, magnetic field shimming parameters are dynamically updated and MR signal data are reconstructed to produce images or localized spectroscopic data. Artifacts in a reconstructed image resulting from an uncorrected magnetic field distribution are suppressed by temporally separating MR signals originating from at least two different sub-volumes within a volume of transverse magnetization by generating a nonlinear phase distribution within the object and by dynamically updating shimming parameters to compensate for the field inhomogeneity distributions within the different sub-volumes in the volume of transverse magnetization.
摘要翻译：用于补偿MR装置内的调查对象内的磁场异质性的方法获得对象的未校正的磁场分布，并通过施加RF脉冲来产生具有期望的k空间覆盖的MR序列，以在其内产生横向磁化目的。记录MR信号数据，动态地更新磁场匀场参数，重建MR信号数据以产生图像或局部光谱数据。通过在对象内生成非线性相位分布，并且通过动态地更新匀场参数来暂时分离来自横向磁化体积内的至少两个不同子体积的MR信号，从而抑制由未校正的磁场分布产生的重构图像中的人造物补偿横向磁化量的不同子体积内的场不均匀性分布。

2. 发明授权

US09377517B2 Method of dynamically compensating for magnetic field heterogeneity in magnetic resonance imaging 有权
标题翻译：动态补偿磁共振成像磁场异质性的方法
公开(公告)号：US09377517B2
公开(公告)日：2016-06-28
申请号：US13414737
申请日：2012-03-08
申请人： Walter Witschey , Maxim Zaitsev , Jürgen Hennig , Gerrit Schultz , Daniel Gallichan
发明人： Walter Witschey , Maxim Zaitsev , Jürgen Hennig , Gerrit Schultz , Daniel Gallichan
IPC分类号： G01R33/58 , G01R33/3875
CPC分类号： G01R33/3875
摘要： A method to compensate for the magnetic field heterogeneity inside an object of investigation in a MR device obtains an uncorrected magnetic field distribution of the object and executes an MR sequence with a desired k-space coverage by applying RF pulses to generate a transverse magnetization within the object. MR signal data is recorded, magnetic field shimming parameters are dynamically updated and MR signal data are reconstructed to produce images or localized spectroscopic data. Artifacts in a reconstructed image resulting from an uncorrected magnetic field distribution are suppressed by temporally separating MR signals originating from at least two different sub-volumes within a volume of transverse magnetization by generating a nonlinear phase distribution within the object and by dynamically updating shimming parameters to compensate for the field inhomogeneity distributions within the different sub-volumes in the volume of transverse magnetization.
摘要翻译：用于补偿MR装置内的调查对象内的磁场异质性的方法获得对象的未校正的磁场分布，并通过施加RF脉冲来产生具有期望的k空间覆盖的MR序列，以在其内产生横向磁化目的。记录MR信号数据，动态地更新磁场匀场参数，重建MR信号数据以产生图像或局部光谱数据。通过在对象内生成非线性相位分布，并且通过动态地更新匀场参数来暂时分离来自横向磁化体积内的至少两个不同子体积的MR信号，从而抑制由未校正的磁场分布产生的重构图像中的人造物补偿横向磁化量的不同子体积内的场不均匀性分布。

3. 发明授权

US08791700B2 Method of MR (=magnetic resonance) with spatial encoding to generate an image or spectroscopic data 有权
标题翻译：使用空间编码的MR（=磁共振）方法来生成图像或光谱数据
公开(公告)号：US08791700B2
公开(公告)日：2014-07-29
申请号：US13137086
申请日：2011-07-20
申请人： Walter Witschey , Daniel Gallichan , Maxim Zaitsev , Gerrit Schultz , Juergen Hennig
发明人： Walter Witschey , Daniel Gallichan , Maxim Zaitsev , Gerrit Schultz , Juergen Hennig
IPC分类号： G01V3/00 , G01R33/44
CPC分类号： G01R33/445 , G01R33/4833
摘要： A method of MR with spatial encoding to generate an image or spectroscopic data of an object of investigation inside an MR apparatus comprises the steps of (a) selecting a volume of interest within the object of investigation, (b) applying an RF pulse to generate a transverse magnetization within the object of investigation, (c) preparing a nonlinear phase distribution within the object of investigation by application of spatially encoding magnetic fields (SEMs), the SEMs comprising of a nonlinear gradient field or a combination of linear and nonlinear gradient fields, (d) effecting primary spatial encoding through application of SEMs, and (e) recording MR signals originating from the object of investigation. Step (c) or (d) thereby comprises applying a sequence of at least two SEMs, at least one of which contains a nonlinear field gradient and at least two of the SEMs having different field geometries. The sequence of SEMs is applied at a point in time from and including the excitation of the object of interest in step (b) up to and including the recording of the MR signals in step (e), to thereby introduce a temporal shift of the signals arising from spatially different locations within the selected volume of interest, that is to thereby introduce a shift of local spatial frequency components. A sampling window for recording of the respective MR signals is set and signals originating from the volume of interest are recorded in step (e) and undesired signals originating from outside the volume of interest are suppressed.
摘要翻译：一种具有空间编码以在MR装置内产生调查对象的图像或光谱数据的MR的方法包括以下步骤：（a）选择调查对象内的感兴趣体积，（b）施加RF脉冲以产生在研究对象内的横向磁化，（c）通过应用空间编码磁场（SEM）在研究对象内准备非线性相位分布，包括非线性梯度场或线性和非线性梯度场的组合的SEM ，（d）通过应用SEM实现主要空间编码，（e）记录源自调查对象的MR信号。步骤（c）或（d）由此包括施加至少两个SEM序列，其中至少一个包含非线性场梯度和具有不同场几何形状的至少两个SEM。在从步骤（b）中的感兴趣对象的激发到包括步骤（e）中的MR信号的记录的时间点上施加SEM序列，从而引入时间偏移在所选择的感兴趣体积内由空间不同的位置产生的信号，从而引入局部空间频率分量的偏移。设置用于记录各个MR信号的采样窗口，并且在步骤（e）中记录来自感兴趣体积的信号，并且抑制源于感兴趣体积之外的不需要的信号。

4. 发明申请

US20120025822A1 Method of MR (=magnetic resonance) with spatial encoding to generate an image of spectroscopic data 有权
标题翻译：具有空间编码的MR（=磁共振）方法以产生光谱数据的图像
公开(公告)号：US20120025822A1
公开(公告)日：2012-02-02
申请号：US13137086
申请日：2011-07-20
申请人： Walter Witschey , Daniel Gallichan , Maxim Zaitsev , Gerrit Schultz , Juergen Hennig
发明人： Walter Witschey , Daniel Gallichan , Maxim Zaitsev , Gerrit Schultz , Juergen Hennig
IPC分类号： G01R33/48
CPC分类号： G01R33/445 , G01R33/4833
摘要： A method of MR with spatial encoding to generate an image or spectroscopic data of an object of investigation inside an MR apparatus comprises the steps of (a) selecting a volume of interest within the object of investigation, (b) applying an RF pulse to generate a transverse magnetization within the object of investigation, (c) preparing a nonlinear phase distribution within the object of investigation by application of spatially encoding magnetic fields (SEMs), the SEMs comprising of a nonlinear gradient field or a combination of linear and nonlinear gradient fields, (d) effecting primary spatial encoding through application of SEMs, and (e) recording MR signals originating from the object of investigation. Step (c) or (d) thereby comprises applying a sequence of at least two SEMs, at least one of which contains a nonlinear field gradient and at least two of the SEMs having different field geometries. The sequence of SEMs is applied at a point in time from and including the excitation of the object of interest in step (b) up to and including the recording of the MR signals in step (e), to thereby introduce a temporal shift of the signals arising from spatially different locations within the selected volume of interest, that is to thereby introduce a shift of local spatial frequency components. A sampling window for recording of the respective MR signals is set and signals originating from the volume of interest are recorded in step (e) and undesired signals originating from outside the volume of interest are suppressed.
摘要翻译：一种具有空间编码以在MR装置内产生调查对象的图像或光谱数据的MR的方法包括以下步骤：（a）选择调查对象内的感兴趣体积，（b）施加RF脉冲以产生在研究对象内的横向磁化，（c）通过应用空间编码磁场（SEM）在研究对象内准备非线性相位分布，包括非线性梯度场或线性和非线性梯度场的组合的SEM ，（d）通过应用SEM实现主要空间编码，（e）记录源自调查对象的MR信号。步骤（c）或（d）由此包括施加至少两个SEM序列，其中至少一个包含非线性场梯度和具有不同场几何形状的至少两个SEM。在从步骤（b）中的感兴趣对象的激发到包括步骤（e）中的MR信号的记录的时间点上施加SEM序列，从而引入时间偏移在所选择的感兴趣体积内由空间不同的位置产生的信号，从而引入局部空间频率分量的偏移。设置用于记录各个MR信号的采样窗口，并且在步骤（e）中记录来自感兴趣体积的信号，并且抑制源于感兴趣体积之外的不需要的信号。

5. 发明授权

US08823372B2 Method for homogenizing resolution in magnet resonance tomography measurements using non-linear encoding fields 有权
标题翻译：使用非线性编码区域在磁共振断层摄影测量中使分辨率均匀化的方法
公开(公告)号：US08823372B2
公开(公告)日：2014-09-02
申请号：US13064277
申请日：2011-03-16
申请人： Hans Weber , Maxim Zaitsev , Daniel Gallichan , Gerrit Schultz
发明人： Hans Weber , Maxim Zaitsev , Daniel Gallichan , Gerrit Schultz
IPC分类号： G01R33/48 , G01R33/483
CPC分类号： G01R33/4833
摘要： A method for magnetic resonance (=MR) imaging, wherein non-linear gradient fields are applied for the purpose of spatial encoding to acquire images of an object to be imaged and wherein the magnet resonance signal radiated from the object to be imaged is sampled on grids in time, to thereby obtain sampling points, is characterized in that the object to be imaged is mapped completely in regions of stronger gradient fields by increasing the density of the sampling points in the center of k-space, and additional sampling points are specifically acquired in the outer regions of k-space according to a k-space sampling pattern depending on the desired distribution of the resolution in the measurement, wherein the MR measurement is calculated with the additional sampling points. An MR imaging method is thereby provided by means of which homogenized resolution is achieved in the MR measurements using non-linear gradient fields for spatial encoding.
摘要翻译：一种用于磁共振（= MR）成像的方法，其中应用非线性梯度场用于空间编码以获取待成像对象的图像，并且其中从待成像对象辐射的磁共振信号被采样在时间上的网格，从而获得采样点，其特征在于通过增加k空间中心的采样点的密度，将要成像的对象完全映射在更强的梯度场的区域中，并且附加的采样点是具体的根据k-空间采样模式在k空间的外部区域中取决于测量中的分辨率的期望分布，其中用附加采样点计算MR测量值。由此提供MR成像方法，通过这种方法，使用非线性梯度场用于空间编码的MR测量中实现了均匀分辨率。

6. 发明申请

US20110241678A1 Method for homogenizing resolution in magnet resonance tomography measurements using non-linear encoding fields 有权
标题翻译：使用非线性编码区域在磁共振断层摄影测量中使分辨率均匀化的方法
公开(公告)号：US20110241678A1
公开(公告)日：2011-10-06
申请号：US13064277
申请日：2011-03-16
申请人： Hans Weber , Maxim Zaitsev , Daniel Gallichan , Gerrit Schultz
发明人： Hans Weber , Maxim Zaitsev , Daniel Gallichan , Gerrit Schultz
IPC分类号： G01R33/48
CPC分类号： G01R33/4833
摘要： A method for magnetic resonance (=MR) imaging, wherein non-linear gradient fields are applied for the purpose of spatial encoding to acquire images of an object to be imaged and wherein the magnet resonance signal radiated from the object to be imaged is sampled on grids in time, to thereby obtain sampling points, is characterized in that the object to be imaged is mapped completely in regions of stronger gradient fields by increasing the density of the sampling points in the center of k-space, and additional sampling points are specifically acquired in the outer regions of k-space according to a k-space sampling pattern depending on the desired distribution of the resolution in the measurement, wherein the MR measurement is calculated with the additional sampling points. An MR imaging method is thereby provided by means of which homogenized resolution is achieved in the MR measurements using non-linear gradient fields for spatial encoding.
摘要翻译：一种用于磁共振（= MR）成像的方法，其中应用非线性梯度场用于空间编码以获取待成像对象的图像，并且其中从待成像对象辐射的磁共振信号被采样在时间上的网格，从而获得采样点，其特征在于通过增加k空间中心的采样点的密度，将要成像的对象完全映射在更强的梯度场的区域中，并且附加的采样点是具体的根据k-空间采样模式在k空间的外部区域中取决于测量中的分辨率的期望分布，其中用附加采样点计算MR测量值。由此提供MR成像方法，通过这种方法，使用非线性梯度场用于空间编码的MR测量中实现了均匀分辨率。

7. 发明授权

US07906968B2 NMR tomography method based on NBSEM with 2D spatial encoding by two mutually rotated multipole gradient fields 有权
标题翻译：基于具有通过两个相互旋转的多极梯度场的2D空间编码的NBSEM的NMR层析成像方法
公开(公告)号：US07906968B2
公开(公告)日：2011-03-15
申请号：US12291680
申请日：2008-11-12
申请人： Juergen Hennig , Maxim Zaitsev , Anna Welz , Gerrit Schultz
发明人： Juergen Hennig , Maxim Zaitsev , Anna Welz , Gerrit Schultz
IPC分类号： G01V3/00
CPC分类号： G01R33/385 , G01R33/3415 , G01R33/3854 , G01R33/48
摘要： A nuclear magnetic resonance (NMR) imaging method in which, with the aid of a gradient system, a spatially and temporally variable magnetic field Bgrad is generated, for the at least two-dimensional spatial encoding of NMR measurement signals in a measurement sample region to be imaged, where the magnetic field Bgrad is employed in at least two forms Bgrad1 and Bgrad2 in the measurement sample region to be imaged during a single measurement cycle from excitation to reading of the NMR measurement signals, where the first form Bgrad1 has essentially ns poles, where ns is an even number > 2, and has ns essentially sectorial sub-regions, in each of which the magnetic field Bgrad is locally monotonic in one direction, where the measurement signals from the measurement sample are recorded by means of at least ns receiver coils which have different sensitivity over the ns sub-regions of the region to be imaged, is characterized in that the second form Bgrad2 is essentially identical to the first form Bgrad1 % with the second form Bgrad2 being rotated by an angle Δφ, where Δ ⁢ ⁢ φ = 360 ⁢ ° 2 · n ⁢ ⁢ s , relative to the first form Bgrad1. The invention provides an NMR imaging method in which a high-resolution image of the region to be imaged is obtained more quickly utilizing the advantages of NBSEMs.
摘要翻译：一种核磁共振（NMR）成像方法，其中借助于梯度系统产生空间和时间上可变的磁场Bgrad，对于测量样本区域中的NMR测量信号的至少二维空间编码，成像，其中在从激励到读取NMR测量信号的单个测量周期期间在要成像的测量样本区域中至少两种形式Bgrad1和Bgrad2采用磁场Bgrad，其中第一形式Bgrad1具有基本上为ns的极点，其中ns是偶数> 2，并且具有基本上是扇形子区域，其中每个子场中的磁场Bgrad在一个方向上局部单调，其中来自测量样本的测量信号通过至少ns 具有与要成像的区域的ns子区域不同的灵敏度的接收器线圈的特征在于，第二形式Bgrad2基本上与fi 第一种形式Bgrad1％，第二种形式Bgrad2旋转角度＆Dgr;＆phgr;其中＆Dgr; ⁢＆phgr = 360°2·n⁢s，相对于第一形式Bgrad1。本发明提供了一种NMR成像方法，其中使用NBSEM的优点更快地获得待成像区域的高分辨率图像。

8. 发明申请

US20090128148A1 NMR tomography method based on NBSEM with 2D spatial encoding by two mutually rotated multipole gradient fields 有权
公开(公告)号：US20090128148A1
公开(公告)日：2009-05-21
申请号：US12291680
申请日：2008-11-12
申请人： Juergen Hennig , Maxim Zaitsev , Anna Welz , Gerrit Schultz
发明人： Juergen Hennig , Maxim Zaitsev , Anna Welz , Gerrit Schultz
IPC分类号： G01R33/48 , G01R33/38
CPC分类号： G01R33/385 , G01R33/3415 , G01R33/3854 , G01R33/48
摘要： A nuclear magnetic resonance (NMR) imaging methodin which, with the aid of a gradient system, a spatially and temporally variable magnetic field Bgrad is generated, for the at least two-dimensional spatial encoding of NMR measurement signals in a measurement sample region to be imaged, where the magnetic field Bgrad is employed in at least two forms Bgrad1 and Bgrad2 in the measurement sample region to be imaged during a single measurement cycle from excitation to reading of the NMR measurement signals, where the first form Bgrad1 has essentially ns poles, where ns is an even number ≧2, and has ns essentially sectorial sub-regions, in each of which the magnetic field Bgrad is locally monotonic in one direction, where the measurement signals from the measurement sample are recorded by means of at least ns receiver coils which have different sensitivity over the ns sub-regions of the region to be imaged, is characterized in that the second form Bgrad2 is essentially identical to the first form Bgrad1, with the second form Bgrad2 being rotated by an angle Δφ, where Δ   ϕ = 360  ° 2 · ns , relative to the first form Bgrad1.The invention provides an NMR imaging method in which a high-resolution image of the region to be imaged is obtained more quickly utilizing the advantages of NBSEMs.

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