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1. 发明授权

US10363323B2 Hydrophobic modified peptides for liver specific diagnosis 有权
公开(公告)号：US10363323B2
公开(公告)日：2019-07-30
申请号：US13984715
申请日：2012-02-10
申请人： Walter Mier , Stephan Urban , Stefan Mehrle , Uwe Haberkorn , Thomas Müller , Vasileios Askoxylakis
发明人： Walter Mier , Stephan Urban , Stefan Mehrle , Uwe Haberkorn , Thomas Müller , Vasileios Askoxylakis
IPC分类号： A61K51/08 , A61K38/00 , A61K49/00 , A61K49/08 , A61K49/14 , C07K14/005 , C12N7/00
摘要： The present invention relates to hydrophobic modified peptides for the specific delivery of labels to the liver, preferably to hepatocytes, in vitro as well as in vivo. The present invention relates to pharmaceutical compositions comprising said hydrophobic modified peptide(s) and the label(s) to be specifically delivered to the liver. The present invention furthermore relates to the diagnostic use of the inventive hydrophobic modified peptides as well as to a method for the diagnosis of liver diseases or disorders.

2. 发明授权

US09726041B2 Disabling circuit in steam turbines for shutting off saturated steam 有权
公开(公告)号：US09726041B2
公开(公告)日：2017-08-08
申请号：US13823143
申请日：2011-09-14
申请人： Henning Almstedt , Peter Dumstorff , Martin Kuhn , Thomas Müller , Rudolf Pötter , Norbert Thamm , Uwe Zander
发明人： Henning Almstedt , Peter Dumstorff , Martin Kuhn , Thomas Müller , Rudolf Pötter , Norbert Thamm , Uwe Zander
IPC分类号： F01D25/24 , F01D25/00 , F01D3/04 , F01D3/02
CPC分类号： F01D25/24 , F01D3/02 , F01D3/04 , F01D25/007 , F05D2220/31 , F05D2260/608 , F05D2260/95
摘要： A cooling option for a steam turbine is provided, wherein the steam turbine includes a high-pressure zone and a medium-pressure zone, wherein the saturated steam streaming out of the high-pressure zone is discharged via a saturated steam conduit to a first pressure chamber in a second flow channel of the medium-pressure zone and thus the possibility of the saturated steam causing damage by corrosion and erosion in the high-pressure zone is prevented.

3. 发明授权

US09056344B2 Method for producing hot rolled hollow sections having a rectangular cross-section and small edge radii 有权
标题翻译：用于生产具有矩形横截面和小边缘半径的热轧中空部分的方法
公开(公告)号：US09056344B2
公开(公告)日：2015-06-16
申请号：US13393030
申请日：2010-08-12
申请人： Thomas Müller , Nicolas Trapp , Norbert Arzt , Burkhard Helten , Thorsten Schmitz
发明人： Thomas Müller , Nicolas Trapp , Norbert Arzt , Burkhard Helten , Thorsten Schmitz
IPC分类号： B21C37/15 , B21D3/14 , B21D47/01 , B66C23/28 , B66C23/62
CPC分类号： B21C37/15 , B21D3/14 , B21D47/01 , B66C23/286 , B66C23/62 , Y10T428/12292
摘要： In a method for producing hot-rolled sections of steel with a rectangular or square cross-section, a substantially round pipe blank produced seamlessly by hot rolling or cold finished and welded and having a defined nominal outside diameter is initially produced and then formed at a forming temperature into a hollow section having the required cross-section, with visible edges C1 and C2 of the hollow section having a value ≦1.5×t (t=wall thickness). The pipe blank has a nominal outer diameter determined from a reduction ratio of the pipe blank to be achieved and the hollow section dimensions to be achieved, wherein the reduction ration lies within a range of −2% to −13% and is determined according to the following formula: Reduction ratio R[%]=[(2×(H+B))−π×D]×100%/[2×(H+B)].
摘要翻译：在用于制造具有矩形或正方形横截面的钢的热轧部分的方法中，最初产生通过热轧或冷加工无缝地制造并且具有限定的标称外径的基本圆形的管坯，然后形成在形成具有所需横截面的中空部分，中空部分的可见边缘C1和C2具有值n1E; 1.5×t（t =壁厚）。管坯的标称外径由要实现的管坯的减速比和要实现的中空截面尺寸确定，其中所述还原比在-2％至-13％的范围内，并且根据下式：还原比R [％] = [（2×（H + B）） - ＆pgr×D]×100％/ [2×（H + B）]。

4. 发明授权

US09031202B2 Rotary anode for a rotary anode X-ray tube and method for manufacturing a rotary anode 有权
标题翻译：用于旋转阳极X射线管的旋转阳极和用于制造旋转阳极的方法
公开(公告)号：US09031202B2
公开(公告)日：2015-05-12
申请号：US13390145
申请日：2010-08-10
申请人： Ulrich Hove , Zoryana Terletska , Christoph Bathe , Peter Rödhammer , Jürgen Schatte , Wolfgang Glatz , Thomas Müller
发明人： Ulrich Hove , Zoryana Terletska , Christoph Bathe , Peter Rödhammer , Jürgen Schatte , Wolfgang Glatz , Thomas Müller
IPC分类号： H01J35/10
CPC分类号： H01J35/108 , H01J2235/081 , H01J2235/085
摘要： A rotary anode for a rotary anode X-ray tube has an anode disc with a supporting portion. A focal track is located in the vicinity of an outer diameter of the anode disc. The supporting portion has inhomogeneous material properties along a radial coordinate of the anode disc to provide a high mechanical load capacity in the area of an inner diameter of the anode disc and a high thermal load capacity at the focal track. These measures provide for a rotary anode for a rotary anode X-ray tube that meets the extreme thermal and mechanical loads during operation. Further, a method for manufacturing such a rotary anode is described as well.
摘要翻译：用于旋转阳极X射线管的旋转阳极具有带支撑部分的阳极盘。焦点轨道位于阳极盘的外径附近。支撑部分沿着阳极盘的径向坐标具有不均匀的材料特性，以在阳极盘的内径区域中提供高机械负载能力，并且在焦点轨道处具有高的热负荷能力。这些措施为旋转阳极X射线管提供了旋转阳极，可在运行期间满足极端的热负荷和机械负载。此外，还描述了制造这种旋转阳极的方法。

5. 发明授权

US08980933B2 Combretastatin analogs for use in the treatment of cancer 有权
标题翻译： Combretastatin类似物用于治疗癌症
公开(公告)号：US08980933B2
公开(公告)日：2015-03-17
申请号：US13695804
申请日：2011-05-05
申请人： Rainer Schobert , Bernhard Biersack , Thomas Müller
发明人： Rainer Schobert , Bernhard Biersack , Thomas Müller
IPC分类号： A61K31/4164 , A61K31/4178 , A61K31/42 , C07D233/64 , C07D263/32 , C07D403/04 , A61K45/06 , A61N5/10 , C07D233/58 , C07D403/10
CPC分类号： A61K31/4164 , A61K31/4178 , A61K31/42 , A61K45/06 , A61N5/10 , C07D233/58 , C07D233/64 , C07D263/32 , C07D403/04 , C07D403/10 , A61K2300/00
摘要： The present invention relates to specific analogs of combretastatin, in particular the compounds of formula (I) as described and defined herein, and pharmaceutical compositions comprising the compounds, as well as their medical use, in particular in the treatment or prevention of cancer, including multidrug-resistant cancer.
摘要翻译：本发明涉及考布他汀特异性类似物，特别是本文所述和定义的式（I）化合物，以及包含该化合物的药物组合物及其医疗用途，特别是治疗或预防癌症，包括多重耐药性癌症。

6. 发明申请

US20120266532A1 PROCESS TO GENERATE SYNTHESIS GAS AND/OR LIQUID RAW MATERIALS AND/OR ENERGY MATERIALS FROM WASTE AND/OR BIOMASS 审中-公开
标题翻译：从废物和/或生物量产生合成气体和/或液体原料和/或能源的方法
公开(公告)号：US20120266532A1
公开(公告)日：2012-10-25
申请号：US13131136
申请日：2009-11-20
申请人： Wenzel Bergmann , Thomas Müller
发明人： Wenzel Bergmann , Thomas Müller
IPC分类号： C10G1/06 , C10L1/00 , C10J3/66
CPC分类号： C10G1/10 , C08H8/00 , C10G1/002 , C10G2300/1003 , C10G2300/1011 , C10G2300/4006 , C10G2300/4012 , C10G2300/44 , C10G2300/807 , C10J3/00 , C10J2300/0916 , C10J2300/0946 , Y02P20/145 , Y02P30/20
摘要： Process to generate synthesis gas and/or liquid raw materials and/or energy materials from waste and/or biomass by performing the following steps: a) solvolysis of the organic components of waste and/or biomass in an alkaline solution or hydrate smelter at a temperature range of 150° to 250° C. and pressure between 3 and 12 bar, whereby the organic components are converted into at least one liquid phase and the inorganic components are sedimented; b) elimination of the inorganic components from the liquid phase by physical separation methods; c) transfer of the vapors generated during the solvolysis into a rectification column, where the organic components are separated from water; and d) further separation of the organic components by rectification, extraction and sorption and/or conversion by thermal gasification into synthesis gas or burnable gas.
摘要翻译：通过执行以下步骤从废物和/或生物质产生合成气和/或能源材料的方法：a）在碱性溶液或水合冶炼厂中将废物和/或生物质的有机组分溶解在温度范围为150〜250℃，压力为3〜12巴，有机成分转化为至少一个液相，无机成分沉淀; b）通过物理分离方法从液相中除去无机成分; c）将溶剂分解期间产生的蒸气转移到精馏塔中，其中有机组分与水分离; 和d）通过精馏，萃取和吸附和/或通过热气化转化为合成气体或可燃气体来进一步分离有机组分。

7. 发明授权

US08215448B2 Sound damper for vehicle compressed air systems 有权
标题翻译：汽车压缩空气系统的阻尼器
公开(公告)号：US08215448B2
公开(公告)日：2012-07-10
申请号：US12997306
申请日：2009-02-27
申请人： Hendrik Harting , Heinz-Werner König , Thomas Müller , Karl-Heinz Riediger-Janisch
发明人： Hendrik Harting , Heinz-Werner König , Thomas Müller , Karl-Heinz Riediger-Janisch
IPC分类号： F02M35/00
CPC分类号： B60T17/008
摘要： A sound damper for compressed air systems of vehicles includes a housing, an insulator and at least one web. The housing has an air inlet and an air outlet. The insulator is located in the housing, and the web is located in the housing such that it protrudes at least partially into the insulator. Air that flows through the housing from the air inlet to the air outlet is conducted by the web into the insulator.
摘要翻译：用于车辆的压缩空气系统的隔音器包括壳体，绝缘体和至少一个腹板。外壳有一个进气口和一个出风口。绝缘体位于壳体中，并且腹板位于壳体中，使得其至少部分地突出到绝缘体中。通过外壳从空气入口流到空气出口的空气通过腹板进入绝缘体。

8. 发明申请

US20120018287A1 Tripping Apparatus, Particularly For Circuit Breakers 有权
标题翻译：脱扣器，特别适用于断路器
公开(公告)号：US20120018287A1
公开(公告)日：2012-01-26
申请号：US13145619
申请日：2010-01-22
申请人： Jörg Gassmann , Matthias Kulke , Thomas Müller
发明人： Jörg Gassmann , Matthias Kulke , Thomas Müller
IPC分类号： H01H5/06
CPC分类号： H01H71/1072 , H01H3/3031 , H01H71/44 , H01H71/46 , H01H71/505
摘要： At least one embodiment of the invention relates to a tripping apparatus, particularly for circuit breakers, which includes at least one controllable tripping magnet having an armature that is operatively connected to a downstream tripping gear, which engages in a tripping mechanism that acts on the circuit breaker and is coupled to a preloaded spring serving as a force amplifier. According to at least one embodiment of the invention, the tripping mechanism includes a camshaft having a plurality of cam lobes, wherein at least one actuating device is associated with each cam lobe having an offset rotational angle, and wherein, when tripped, at least two actuating processes associated with the respective actuating means take place consecutively, so that the full spring force is transmitted by way of the camshaft to at least one of said actuating means so as to perform the relevant actuating process.
摘要翻译：本发明的至少一个实施例涉及一种特别用于断路器的脱扣装置，其包括至少一个可控制的跳闸磁体，其具有可操作地连接到下游跳闸齿轮的电枢，其接合作用在电路上的跳闸机构断路器并且耦合到用作力放大器的预加载弹簧。根据本发明的至少一个实施例，跳闸机构包括具有多个凸轮凸角的凸轮轴，其中至少一个致动装置与具有偏置旋转角度的每个凸轮凸角相关联，并且其中当跳闸时，至少两个与相应的致动装置相关联的致动过程连续进行，使得整个弹簧力通过凸轮轴传递到至少一个所述致动装置，以便执行相关的致动过程。

9. 发明授权

US07982072B2 Process for the obtention of purified heptafluoropropane 有权
标题翻译：获得纯化七氟丙烷的方法
公开(公告)号：US07982072B2
公开(公告)日：2011-07-19
申请号：US12965177
申请日：2010-12-10
申请人： Thomas Müller , Dominique Balthasart , Bernd Kutzner
发明人： Thomas Müller , Dominique Balthasart , Bernd Kutzner
IPC分类号： C07C19/08 , C07C17/00
CPC分类号： C07C19/08 , C07C17/087 , C07C17/383
摘要： Process for the obtention of HFC-227ea having a reduced content of organic impurities, comprising at least subjecting a crude HFC-227ea to two distillation steps at different pressures.
摘要翻译：获得具有降低的有机杂质含量的HFC-227ea的方法，包括至少使粗HFC-227ea在不同压力下进行两个蒸馏步骤。

10. 发明授权

US07707077B2 Electronic financial transaction with balancing invoice and credit items via page 有权
标题翻译：电子金融交易与平衡发票和信用项目通过页面
公开(公告)号：US07707077B2
公开(公告)日：2010-04-27
申请号：US10400582
申请日：2003-03-28
申请人： Thomas Müller , Jürgen Köhling
发明人： Thomas Müller , Jürgen Köhling
IPC分类号： G07B17/00
CPC分类号： G06Q30/04 , G06Q20/382 , G06Q40/12
摘要： An electronic transaction, in which a payment amount is deducted from a customer account and added to a provider account, is prepared in cooperation between an account computer and a browser-enabled customer computer. The account computer forwards invoice and credit information as well as calculation instructions in portions of a page to the customer computer. The customer computer interprets a first page portion with a browser to present different invoice items and credit items on a screen. A user selection of the invoice and credit items is received and then the payment amount is calculated by offsetting the amounts of the invoice and credit items with instructions in a second page portion. Thereafter, a response with the payment amount is returned to the account computer.
摘要翻译：在帐户计算机和启用浏览器的客户计算机之间合作准备从客户帐户中扣除支付金额并添加到提供商帐户的电子交易。帐户计算机将发票和信用信息以及页面部分的计算指令转发到客户计算机。客户电脑用浏览器解释第一页部分，以在屏幕上显示不同的发票项目和信用项目。收到发票和信用项目的用户选择，然后通过利用第二页面部分中的指令来抵销发票和信用项的金额来计算支付金额。此后，将具有支付金额的响应返回到帐户计算机。

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