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1. 发明申请

US20060177919A1 Process for the preparation of (S) - or (R) -3,3,3- trifluoro-2-hydroxy-2-methylpropionic acid 失效
标题翻译：制备（S） - 或（R）-3,3,3-三氟-2-羟基-2-甲基丙酸的方法
公开(公告)号：US20060177919A1
公开(公告)日：2006-08-10
申请号：US11200182
申请日：2005-08-10
申请人： Walter Brieden , Andrew Naughton , Karen Robins , Nicholas Shaw , Andreas Tinschert , Thomas Zimmermann
发明人： Walter Brieden , Andrew Naughton , Karen Robins , Nicholas Shaw , Andreas Tinschert , Thomas Zimmermann
IPC分类号： C12N9/80 , C12N1/21
CPC分类号： C12N1/20 , C07C235/06 , C12N9/80 , C12P7/42 , C12P13/02 , C12P41/006
摘要： The present invention relates to a novel process for the preparation of (S)— or (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid and to novel microorganisms capable of utilizing the propionamide of the formula in the form of the racemate or of its optically active isomers as the sole nitrogen source.
摘要翻译：本发明涉及一种制备（S） - 或（R）-3,3,3-三氟-2-羟基-2-甲基丙酸的新方法，以及能够利用下式的丙酰胺的新型微生物外消旋体或其旋光异构体的形式作为唯一的氮源。

2. 发明授权

US07074606B2 Process for the preparation of (S) - or (R) -3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid 失效
公开(公告)号：US07074606B2
公开(公告)日：2006-07-11
申请号：US10086082
申请日：2002-02-28
申请人： Walter Brieden , Andrew Naughton , Karen Robins , Nicholas Shaw , Andreas Tinschert , Thomas Zimmermann
发明人： Walter Brieden , Andrew Naughton , Karen Robins , Nicholas Shaw , Andreas Tinschert , Thomas Zimmermann
IPC分类号： C12P21/06 , C12N9/00 , C12N9/80 , C07H21/04
CPC分类号： C12N1/20 , C07C235/06 , C12N9/80 , C12P7/42 , C12P13/02 , C12P41/006
摘要： The present invention relates to a novel process for the preparation of (S)- or (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid and to novel microorganisms capable of utilizing the propionamide of the formula in the form of the racemate or of its optically active isomers as the sole nitrogen source.

3. 发明授权

US07553652B2 Process for the preparation of (S)- or (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid 失效
标题翻译：制备（S） - 或（R）-3,3,3-三氟-2-羟基-2-甲基丙酸的方法
公开(公告)号：US07553652B2
公开(公告)日：2009-06-30
申请号：US11200182
申请日：2005-08-10
申请人： Walter Brieden , Andrew Naughton , Karen Robins , Nicholas Shaw , Andreas Tinschert , Thomas Zimmermann
发明人： Walter Brieden , Andrew Naughton , Karen Robins , Nicholas Shaw , Andreas Tinschert , Thomas Zimmermann
IPC分类号： C12N9/80
CPC分类号： C12N1/20 , C07C235/06 , C12N9/80 , C12P7/42 , C12P13/02 , C12P41/006
摘要： The present invention relates to a novel process for the preparation of (S)— or (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid and to novel microorganisms capable of utilizing the propionamide of the formula in the form of the racemate or of its optically active isomers as the sole nitrogen source.
摘要翻译：本发明涉及一种制备（S） - 或（R）-3,3,3-三氟-2-羟基-2-甲基丙酸的新方法，以及能够利用下式的丙酰胺的新型微生物外消旋体或其旋光异构体的形式作为唯一的氮源。

4. 发明授权

US06773910B1 Method of preparing (S)- or (R) -3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid 失效
标题翻译：制备（S） - 或（R）-3,3,3-三氟-2-羟基-2-甲基丙酸的方法
公开(公告)号：US06773910B1
公开(公告)日：2004-08-10
申请号：US09214679
申请日：1999-12-30
申请人： Walter Brieden , Andrew Naughton , Karen Robins , Nicholas Shaw , Andreas Tinschert , Thomas Zimmermann
发明人： Walter Brieden , Andrew Naughton , Karen Robins , Nicholas Shaw , Andreas Tinschert , Thomas Zimmermann
IPC分类号： C12N100
CPC分类号： C12N1/20 , C07C235/06 , C12N9/80 , C12P7/42 , C12P13/02 , C12P41/006
摘要： Described are new micro-organisms and a new enzyme capable of using as sole source of nitrogen the propionic acid amide of formula (VI), in racemate form or as optically active isomers. Described also is a method of preparing (S)- or (R)-3,3,2-trifluoro-2-hydroxy-2-methylpropionic acid of formulas (I) and (II) starting from trifluoroaceto-acetic ester. The first three process steps are chemical, the fourth process step microbiological.
摘要翻译：描述了新的微生物和能够以外消旋形式或作为光学活性异构体使用式（VI）的丙酸酰胺作为氮源的唯一来源的新酶。还描述了由三氟乙酸 - 乙酸酯制备式（I）和（II）的（S） - 或（R）-3,3,2-三氟-2-羟基-2-甲基丙酸的方法。前三个过程步骤是化学，第四个步骤微生物。

5. 发明授权

US06599721B2 Process for preparing optically active 3,3,3-trifluoromethyl-2-alkylpropionic acid derivatives 失效
标题翻译：光学活性3,3,3-三氟甲基-2-烷基丙酸衍生物的制备方法
公开(公告)号：US06599721B2
公开(公告)日：2003-07-29
申请号：US09938333
申请日：2001-08-23
申请人： Andrew Naughton , Nicholas Shaw
发明人： Andrew Naughton , Nicholas Shaw
IPC分类号： C12P1302
CPC分类号： C07C235/06 , C07B2200/07
摘要： The invention relates to a novel method for the preparation of optically active 3,3,3-trifluoromethyl-2-alkyl propionic acid derivatives of the general formulae (I) and (II), in which R is ethyl or methyl and X is OH or NH2, provided that if R is methyl X≠—OH. The method comprises the reaction of a racemic propionic acid amide of the general formula (III) either by means of microorganisms which are able to use the propionic acid amide in the form of the racemate or one of its optically active isomers as the only nitrogen source or by means of a polypeptide with amidohydrolase activity which is able to hydrolyze the propionic acid amide. The invention also relates to new optically active representatives of this category of compounds.
摘要翻译：本发明涉及一种制备通式（I）和（II）的光学活性3,3,3-三氟甲基-2-烷基丙酸衍生物的新方法，其中R是乙基或甲基，X是OH 或NH 2，条件是如果R是甲基X≠-OH。该方法包括通过能够使用外消旋体形式的丙酰胺或其旋光异构体之一的微生物作为唯一的氮源，使通式（III）的外消旋丙酸酰胺反应或通过能够水解丙酸酰胺的具有酰胺水解酶活性的多肽。本发明还涉及这类化合物的新的光学活性代表。

6. 发明授权

US5766893A Biotechnological process for the preparation of cyclic s-alpha-imino carboxylic acids and r-alpha-imino carboxamides 失效
标题翻译：用于制备环状α-α-亚氨基羧酸和r-α-亚氨基甲酰胺的生物技术方法
公开(公告)号：US5766893A
公开(公告)日：1998-06-16
申请号：US614345
申请日：1996-03-12
申请人： Andreas Kiener , Jean-Paul Roduit , Jorg Kohr , Nicholas Shaw
发明人： Andreas Kiener , Jean-Paul Roduit , Jorg Kohr , Nicholas Shaw
IPC分类号： C12N1/20 , C12P17/00 , C12P17/10 , C12P17/12 , C12P41/00 , C12R1/22 , C12R1/38 , C12R1/39 , C12R1/40 , C12P13/00
CPC分类号： C12R1/22 , C12P17/10 , C12P17/12 , C12P41/006 , C12R1/39 , C12R1/40 , Y10S435/852 , Y10S435/874 , Y10S435/876 , Y10S435/877 , Y10S435/878
摘要： Microorganisms of interest are capable of utilizing .alpha.-imino carboxamides, in the form of the racemate or of its optically active isomers, of the general formula ##STR1## wherein A together with --NH-- and --CH-- is an optionally substituted 5- or 6-membered saturated heterocyclic ring, as sole nitrogen source, and converting (RS)-.alpha.-imino carboxamides of Formula I into an S-.alpha.-imino carboxylic acid of the general formula ##STR2## These microorganisms are useful also for biconversion of an (RS)-.alpha.-imino carboxamide of Formula I into an S-.alpha.-imino carboxylic acid.
摘要翻译：感兴趣的微生物能够利用具有通式I的外消旋体或其旋光异构体形式的α-亚氨基甲酰胺，其中A与-NH-和-CH-是任选取代的5- 或6元饱和杂环作为唯一的氮源，并将式I的（RS）-α-亚氨基甲酰胺转化为通式为II的S-α-亚氨基羧酸。这些微生物也用于双转录的式（I）的（RS）-α-亚氨基甲酰胺加入到S-亚氨基羧酸中。

7. 发明授权

US6083712A Biotechnological method of producing biotin 失效
标题翻译：生物素生物技术方法
公开(公告)号：US6083712A
公开(公告)日：2000-07-04
申请号：US411768
申请日：1995-06-08
申请人： Olwen Birch , Johann Brass , Martin Fuhrmann , Nicholas Shaw
发明人： Olwen Birch , Johann Brass , Martin Fuhrmann , Nicholas Shaw
IPC分类号： C12N15/09 , C07K14/195 , C12N1/21 , C12N9/00 , C12N15/52 , C12N15/67 , C12P17/18 , C12P21/02 , C12R1/19 , C12P21/06 , C07H17/00 , C12N15/00
CPC分类号： C12P17/186 , C12N15/52 , C12N15/67
摘要： In DNA fragments and plasmids comprising the bioB, bioF, bioC, bioD and bioA genes responsible for biosynthesis of biotin, or their functionally equivalent genetic variants and mutants from enteric bacteria, the genes are arranged in a transcription unit. These DNA fragments and plasmids can be contained in microorganisms which can be used to produce biotin.
摘要翻译： PCT No.PCT / EP93 / 02688 Sec。 371日期：1995年6月8日 102（e）日期1995年6月8日PCT提交1993年10月1日PCT公布。公开号WO94 / 08023 日期1994年04月14日在包含负责生物素生物合成的bioB，bioF，bioC，bioD和bioA基因的DNA片段和质粒中，或其功能上等同的遗传变异体和来自肠细菌的突变体，将基因排列在转录单位中。这些DNA片段和质粒可以包含在可用于生产生物素的微生物中。

8. 发明申请

US20070196900A1 METHOD FOR THE MANUFACTURE OF LANTIBIOTICS 审中-公开
标题翻译：生态系统的制造方法
公开(公告)号：US20070196900A1
公开(公告)日：2007-08-23
申请号：US11674664
申请日：2007-02-13
申请人： Hubert Muellner , Martin Folger , Andreas Werner , Uwe Gierlich , Kurt Eyer , Klaus Heinzmann , Nicholas Shaw , Fabian Wyer
发明人： Hubert Muellner , Martin Folger , Andreas Werner , Uwe Gierlich , Kurt Eyer , Klaus Heinzmann , Nicholas Shaw , Fabian Wyer
IPC分类号： C12P21/06 , C12N1/21 , C07K7/60
CPC分类号： C07K14/31
摘要： The present invention relates to the manufacture of antibiotic compounds of the class known as lantibiotics. Preferably, the present invention relates to the purification of those lantibiotics.
摘要翻译：本发明涉及抗生素类化合物的制造，称为羊毛抗生素。优选地，本发明涉及这些羊毛硫抗生素的纯化。

9. 发明授权

US5622846A Biotechnological process for the preparation of cyclic-s-.alpha.-imino carboxylic acids and r-.alpha.-imino carboxamides 失效
标题翻译：用于制备环状α-α-亚氨基羧酸和r-α-亚氨基甲酰胺的生物技术方法
公开(公告)号：US5622846A
公开(公告)日：1997-04-22
申请号：US478960
申请日：1995-06-07
申请人： Andreas Kiener , Jean-Paul Roduit , J org Kohr , Nicholas Shaw
发明人： Andreas Kiener , Jean-Paul Roduit , J org Kohr , Nicholas Shaw
IPC分类号： C12N1/20 , C12P17/00 , C12P17/10 , C12P17/12 , C12P41/00 , C12R1/22 , C12R1/38 , C12R1/39 , C12R1/40 , C12P13/00
CPC分类号： C12R1/22 , C12P17/10 , C12P17/12 , C12P41/006 , C12R1/39 , C12R1/40 , Y10S435/852 , Y10S435/874 , Y10S435/876 , Y10S435/877 , Y10S435/878
摘要： Microorganisms of interest are capable of utilizing .alpha.-imino carboxamides, in the form of the racemate or of its optically active isomers, of the general formula ##STR1## wherein A together with --NH-- and --CH-- is an optionally substituted 5- or 6-membered saturated heterocyclic ring, as sole nitrogen source, and converting (RS)-.alpha.-imino carboximides of Formula I into an S-.alpha.-amino carboxylic acid of the general formula ##STR2## These microorganisms are useful also for biconversion of an (RS)-.alpha.-imino carboxamide of Formula I into an S-.alpha.-amino carboxylic acid.
摘要翻译：感兴趣的微生物能够利用具有通式I的外消旋体或其旋光异构体形式的α-亚氨基甲酰胺，其中A与-NH-和-CH-是任选取代的5- 或6元饱和杂环，作为唯一的氮源，并将式I的（RS）-α-亚氨基二甲酰亚胺转化为通式为“II”的S-α-氨基羧酸。这些微生物也可用于双转录的式（I）的（RS）-α-亚氨基甲酰胺转化成S-α-氨基羧酸。

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