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1. 发明授权

US07708682B2 Method and device for planning a radiation therapy 有权
标题翻译：辐射治疗方法和装置
公开(公告)号：US07708682B2
公开(公告)日：2010-05-04
申请号：US10573730
申请日：2004-09-10
申请人： Vladimir Pekar , Michael R. Kaus , Todd McNutt
发明人： Vladimir Pekar , Michael R. Kaus , Todd McNutt
IPC分类号： A61N5/00
CPC分类号： A61N5/103 , A61N5/1049 , A61N5/1065 , A61N2005/1055 , A61N2005/1061 , G06F19/00 , G06F19/3481
摘要： A method and apparatus for planning a radiation therapy are disclosed. A radiation dose distribution is adapted on the basis of shape and position variations of the organs of interest determined from a comparison of a first image and a second image which were taken at different points of time during the radiation treatment process.
摘要翻译：公开了一种用于规划放射治疗的方法和装置。基于在放射治疗过程中从不同时间点拍摄的第一图像和第二图像的比较确定的感兴趣器官的形状和位置变化来调整辐射剂量分布。

2. 发明申请

US20090279739A1 POINT SUBSELECTION FOR FAST DEFORMABLE POINT-BASED IMAGING 有权
标题翻译：基于快速基于点的成像的点选择
公开(公告)号：US20090279739A1
公开(公告)日：2009-11-12
申请号：US11915752
申请日：2006-05-31
申请人： Michael Kaus , Todd McNutt , Vladimir Pekar
发明人： Michael Kaus , Todd McNutt , Vladimir Pekar
IPC分类号： G06T7/60
CPC分类号： G06T7/30
摘要： A method for selecting vertices for performing deformable registration of imaged objects is provided. The selected vertices form corresponding pairs, each pair including a vertex from a first imaged object and a vertex from a second imaged object. The corresponding vertex pairs are sorted in order of distance between the vertices making up the corresponding vertex pair. The corresponding vertex pair with the greatest distance is given top priority. Corresponding vertex pairs that lie within a selected distance from the selected corresponding vertex pair are discarded. In this manner, the number of vertex pairs used for deformable registration of the imaged objects is reduced and therefore allows for processing times that are clinically acceptable.
摘要翻译：提供了一种用于选择用于执行成像对象的变形登记的顶点的方法。所选择的顶点形成对应的对，每对包括来自第一成像对象的顶点和来自第二成像对象的顶点。对应的顶点对按照构成相应顶点对的顶点之间的距离的顺序进行排序。具有最大距离的相应顶点对被赋予最高优先级。位于距所选择的对应顶点对的选定距离内的相应顶点对被丢弃。以这种方式，用于成像对象的可变形登记的顶点对的数量减少，因此允许临床可接受的处理时间。

3. 发明申请

US20070049785A1 Method and device for planning a radiation therapy 有权
标题翻译：辐射治疗方法和装置
公开(公告)号：US20070049785A1
公开(公告)日：2007-03-01
申请号：US10573730
申请日：2004-09-10
申请人： Vladimir Pekar , Michael Kaus , Todd McNutt
发明人： Vladimir Pekar , Michael Kaus , Todd McNutt
IPC分类号： A61N5/00
CPC分类号： A61N5/103 , A61N5/1049 , A61N5/1065 , A61N2005/1055 , A61N2005/1061 , G06F19/00 , G06F19/3481
摘要： A method and apparatus for planning a radiation therapy are disclosed. A radiation dose distribution is adapted on the basis of shape and position variations of the organs of interest determined from a comparison of a first image and a second image which were taken at different points of time during the radiation treatment process.
摘要翻译：公开了一种用于规划放射治疗的方法和装置。基于在放射治疗过程中从不同时间点拍摄的第一图像和第二图像的比较确定的感兴趣器官的形状和位置变化来调整辐射剂量分布。

4. 发明授权

US07596207B2 Method of accounting for tumor motion in radiotherapy treatment 有权
标题翻译：放射治疗肿瘤移动计算方法
公开(公告)号：US07596207B2
公开(公告)日：2009-09-29
申请号：US11995337
申请日：2006-07-10
申请人： Michael Kaus , Vladimir Pekar , Todd Mcnutt
发明人： Michael Kaus , Vladimir Pekar , Todd Mcnutt
IPC分类号： A61N5/10 , G01N23/04
CPC分类号： A61N5/103 , A61N5/1037 , A61N5/1038 , A61N5/1065 , A61N2005/1061
摘要： A method and apparatus accounting for tumor motion during radiation therapy is provided. The method allows for radiation therapy treatments based on updated radiation therapy plans. For each fractionate radiation treatment that results in an updated radiation treatment, radiation treatment images are acquired, automatically segmented, and then subject to deformable registration to develop updated contours and an updated radiation therapy plan.
摘要翻译：提供了放射治疗期间肿瘤移动的方法和装置。该方法允许基于更新的放射治疗计划的放射治疗治疗。对于导致更新的辐射治疗的每个分级放射治疗，获取放射治疗图像，自动分割，然后进行变形注册以开发更新的轮廓和更新的放射治疗计划。

5. 发明申请

US20070211939A1 REGION-COMPETITIVE DEFORMABLE MESH ADAPTATION 有权
标题翻译：区域竞争性可变网适应
公开(公告)号：US20070211939A1
公开(公告)日：2007-09-13
申请号：US11573290
申请日：2005-07-28
申请人： Michael Kaus , Todd McNutt , Vladimir Pekar , Matthias Meyer
发明人： Michael Kaus , Todd McNutt , Vladimir Pekar , Matthias Meyer
IPC分类号： G06K9/34
CPC分类号： G06T7/0083 , A61B6/00 , G06K9/6209 , G06T7/11 , G06T7/12 , G06T7/149 , G06T17/20 , G06T17/205 , G06T2207/10081 , G06T2207/20116 , G06T2207/30008 , G06T2207/30028
摘要： An image segmentation method segments a plurality of image features in an image. The plurality of image features are segmented non-simultaneously in succession. The segmenting of each image feature includes adapting an initial mesh to boundaries of the image feature. The segmenting of each image feature further includes preventing the adapted mesh from overlapping any previously adapted mesh.
摘要翻译：图像分割方法分割图像中的多个图像特征。多个图像特征被连续非同时分割。每个图像特征的分割包括使初始网格适应图像特征的边界。每个图像特征的分割还包括防止适配的网格与任何先前适应的网格重叠。

6. 发明申请

US20080219406A1 Method of Accounting for Tumor Motion in Radiotherapy Treatment 有权
标题翻译：放射治疗肿瘤运动会计方法
公开(公告)号：US20080219406A1
公开(公告)日：2008-09-11
申请号：US11995337
申请日：2006-07-10
申请人： Michael Kaus , Vladimir Pekar , Todd Mcnutt
发明人： Michael Kaus , Vladimir Pekar , Todd Mcnutt
IPC分类号： A61N5/10
CPC分类号： A61N5/103 , A61N5/1037 , A61N5/1038 , A61N5/1065 , A61N2005/1061
摘要： A method and apparatus accounting for tumor motion during radiation therapy is provided. The method allows for radiation therapy treatments based on updated radiation therapy plans. For each fractionate radiation treatment that results in an updated radiation treatment, radiation treatment images are acquired, automatically segmented, and then subject to deformable registration to develop updated contours and an updated radiation therapy plan.
摘要翻译：提供了放射治疗期间肿瘤移动的方法和装置。该方法允许基于更新的放射治疗计划的放射治疗治疗。对于导致更新的辐射治疗的每个分级放射治疗，获取放射治疗图像，自动分割，然后进行变形注册以开发更新的轮廓和更新的放射治疗计划。

7. 发明申请

US20070133848A1 Manual tools for model based image segmentation 有权
标题翻译：用于基于模型的图像分割的手动工具
公开(公告)号：US20070133848A1
公开(公告)日：2007-06-14
申请号：US10595357
申请日：2004-10-06
申请人： Todd McNutt , Michael Kaus , Vladimir Pekar
发明人： Todd McNutt , Michael Kaus , Vladimir Pekar
IPC分类号： G06K9/00
CPC分类号： G06T19/00 , G06K9/209 , G06K9/34 , G06K2009/366 , G06K2209/05 , G06T7/11 , G06T7/12 , G06T7/149 , G06T2200/24 , G06T2207/10081 , G06T2207/30004 , G06T2219/2021
摘要： A scanner (18) acquires images of a subject. A 3D model (52) of an organ is selected from an organ model database (50) and dropped over an image of an actual organ. A best fitting means (62) globally scales, translates and/or rotates the model (52) to best fit the actual organ represented by the image. A user uses a mouse (38) to use a set of manual tools (68) to segment and manipulate the model (52)1:o match the image data. The set of tools (68) includes: a Gaussian tool (72) for deforming a surface portion of the model along a Gaussian curve, a spherical push tool (80) for deforming the surface portion along a spherical surface segment, and a pencil tool (90) for manually drawing a line to which the surface portion is redefined.
摘要翻译：扫描器（18）获取被摄体的图像。从器官模型数据库（50）中选择器官的3D模型（52）并且落在实际器官的图像上。最佳拟合装置（62）在全局范围内缩放，平移和/或旋转模型（52）以最佳地适合由图像表示的实际器官。用户使用鼠标（38）使用一组手动工具（68）来分割和操纵模型（52）1：o匹配图像数据。所述工具集（68）包括：用于使模型的表面部分沿着高斯曲线变形的高斯工具（72），用于使表面部分沿着球形表面段变形的球形推动工具（80）和铅笔工具（90），用于手动绘制重新定义表面部分的线。

8. 发明申请

US20060210158A1 Object-specific segmentation 审中-公开
标题翻译：对象特定的分割
公开(公告)号：US20060210158A1
公开(公告)日：2006-09-21
申请号：US10564657
申请日：2004-07-13
申请人： Vladimir Pekar , Michael Kaus , Todd McNutt
发明人： Vladimir Pekar , Michael Kaus , Todd McNutt
IPC分类号： G06K9/34 , G06K9/00
CPC分类号： G06T7/0012 , G06T7/12 , G06T7/149 , G06T2207/10072 , G06T2207/20104 , G06T2207/30004
摘要： The invention relates to the field of efficient segmentation of collections of anatomical structures in medical imaging. For example, in radiotherapy planning, the segmentation of a collection of several anatomical structures, which represent the target volume in risk organs is required. When using model based segmentation, organ models represented by flexible surfaces are adapted to the boundaries of the object of interest. According to an aspect of the present invention, object-specific a priori information is incorporated in the segmentation process, which allows to provide for an improved segmentation. Furthermore, the segmentation process according to the present invention, may have an improved robustness, also the time required for the segmentation maybe reduced.
摘要翻译：本发明涉及医学成像中解剖结构集合的有效分割领域。例如，在放射治疗计划中，需要分割几个解剖结构的集合，其代表风险器官中的目标体积。当使用基于模型的分割时，由柔性表面表示的器官模型适应于感兴趣对象的边界。根据本发明的一个方面，将特定于对象的先验信息并入分割过程中，这允许提供改进的分割。此外，根据本发明的分割处理可以具有改进的鲁棒性，也可以减少分割所需的时间。

9. 发明授权

US07536041B2 3D image segmentation 失效
标题翻译： 3D图像分割
公开(公告)号：US07536041B2
公开(公告)日：2009-05-19
申请号：US10560185
申请日：2004-06-09
申请人： Vladimir Pekar , Michael Reinhold Kaus , Todd McNutt
发明人： Vladimir Pekar , Michael Reinhold Kaus , Todd McNutt
IPC分类号： G06K9/00 , G06K9/34
CPC分类号： G06T17/20 , G06T7/12 , G06T7/149 , G06T2207/10081 , G06T2207/20092 , G06T2207/30004
摘要： A delineation of a structure of interest can be performed by fitting 3D deformable models, for example, represented by polygonal measures, to the boundaries of the structure of interest. The deformable model fitting process is guided by minimization of the sum of an external energy, based on image feature information, which attracts the mesh to the organ boundaries and an internal energy, which preserves the consistent shape of the mesh. A frequent problem is that the images do not contain sufficient reliable image feature information, such as image gradients, to attract the mesh. According to the present invention, manually drawn attractors in the form of complete or partial contours corresponding to boundaries of the structure of interest are placed into the images which do not contain sufficient feature information. These attractors may easily be discriminated by a subsequent segmentation process. Due to this, advantageously, a 3D deformable model can be fitted to structures of interest in images with poor contrast, noise or image artifacts.
摘要翻译：可以通过将例如由多边形度量表示的3D可变形模型拟合到感兴趣的结构的边界来执行感兴趣的结构的描绘。可变形模型拟合过程是基于图像特征信息的最小化引导的，该图像特征信息将网格吸引到器官边界和内部能量，这保留了网格的一致形状。一个常见的问题是，图像不包含足够可靠的图像特征信息，如图像梯度，以吸引网格。根据本发明，将对应于感兴趣结构的边界的完整或部分轮廓形式的手动吸引器放置在不包含足够的特征信息的图像中。这些吸引子可以容易地被随后的分割过程区分开。因此，有利地，可以将3D可变形模型拟合到具有差的对比度，噪声或图像伪像的图像中的感兴趣的结构。

10. 发明授权

US08094895B2 Point subselection for fast deformable point-based imaging 有权
标题翻译：点选择快速可变形点基成像
公开(公告)号：US08094895B2
公开(公告)日：2012-01-10
申请号：US11915752
申请日：2006-05-31
申请人： Michael Kaus , Todd McNutt , Vladimir Pekar
发明人： Michael Kaus , Todd McNutt , Vladimir Pekar
IPC分类号： G06K9/00 , G06K9/62 , G06K9/32
CPC分类号： G06T7/30
摘要： A method for selecting vertices for performing deformable registration of imaged objects is provided. The selected vertices form corresponding pairs, each pair including a vertex from a first imaged object and a vertex from a second imaged object. The corresponding vertex pairs are sorted in order of distance between the vertices making up the corresponding vertex pair. The corresponding vertex pair with the greatest distance is given top priority. Corresponding vertex pairs that lie within a selected distance from the selected corresponding vertex pair are discarded. In this manner, the number of vertex pairs used for deformable registration of the imaged objects is reduced and therefore allows for processing times that are clinically acceptable.
摘要翻译：提供了一种用于选择用于执行成像对象的变形登记的顶点的方法。所选择的顶点形成对应的对，每对包括来自第一成像对象的顶点和来自第二成像对象的顶点。对应的顶点对按照构成相应顶点对的顶点之间的距离的顺序进行排序。具有最大距离的相应顶点对被赋予最高优先级。位于距所选择的对应顶点对的选定距离内的相应顶点对被丢弃。以这种方式，用于成像对象的可变形登记的顶点对的数量减少，因此允许临床可接受的处理时间。

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