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1. 发明授权

US06180059B2 Method for the preparation and delivery of gas-enriched fluids 失效
标题翻译：用于制备和输送富含气体的流体的方法
公开(公告)号：US06180059B2
公开(公告)日：2001-01-30
申请号：US09122143
申请日：1998-07-24
申请人： Vincent Divino, Jr. , Seth A. Foerster , James M. Gessert , Robert A. Mest , Paul J. Zalesky , James Richard Spears
发明人： Vincent Divino, Jr. , Seth A. Foerster , James M. Gessert , Robert A. Mest , Paul J. Zalesky , James Richard Spears
IPC分类号： A61M134
CPC分类号： C01B13/02 , A61M1/1678 , A61M1/1698 , A61M1/32 , A61M1/3603 , A61M1/361 , A61M1/3612 , A61M1/3613 , A61M1/3621 , A61M1/3626 , A61M25/0028 , A61M25/0029 , A61M2025/0031 , A61M2025/0036 , A61M2025/004 , A61M2202/0476 , A61M2202/0007
摘要： A gas-enriched fluid is provided by the combination of a first fluid, such as a patient's blood, with a second gas-supersaturated fluid, such as an oxygen supersaturated fluid. In this example, a catheter assembly includes a portion that receives the patient's blood from a pump and that receives the oxygen supersaturated fluid from an appropriate fluid source. The oxygen supersaturated fluid is advantageously combined with the blood in an area of laminar flow, and then this gas-enriched fluid is delivered to the patient through an appropriate lumen coupled to the portion of the catheter assembly.
摘要翻译：通过第一流体（例如患者血液）与第二气体过饱和流体（例如氧过饱和流体）的组合来提供富气体流体。在该示例中，导管组件包括从泵接收患者血液并从适当的流体源接收氧过饱和流体的部分。氧过饱和流体有利地在层流区域中与血液组合，然后将该富含气体的流体通过耦合到导管组件的该部分的适当内腔递送至患者。

2. 发明授权

US06676900B1 Method for the preparation and delivery of gas-enriched fluids 失效
标题翻译：用于制备和输送富含气体的流体的方法
公开(公告)号：US06676900B1
公开(公告)日：2004-01-13
申请号：US09699751
申请日：2000-10-30
申请人： Vincent Divino, Jr. , Seth A. Foerster , James M. Gessert , Robert A. Mest , Paul J. Zalesky , James Richard Spears
发明人： Vincent Divino, Jr. , Seth A. Foerster , James M. Gessert , Robert A. Mest , Paul J. Zalesky , James Richard Spears
IPC分类号： A61M136
CPC分类号： C01B13/02 , A61M1/1678 , A61M1/1698 , A61M1/32 , A61M1/3603 , A61M1/361 , A61M1/3612 , A61M1/3613 , A61M1/3621 , A61M1/3626 , A61M25/007 , A61M25/09 , A61M2025/0036 , A61M2025/0037 , A61M2025/004 , A61M2202/0476 , Y10S261/28 , A61M2202/0007
摘要： A gas-enriched fluid is provided by the combination of a first fluid, such as a patient's blood, with a second gas-supersaturated fluid, such as an oxygen supersaturated fluid. In this example, a catheter assembly includes a portion that receives the patient's blood from a pump and that receives the oxygen supersaturated fluid from an appropriate fluid source. The oxygen supersaturated fluid is advantageously combined with the blood in an area of laminar flow, and then this gas-enriched fluid is delivered to the patient through an appropriate lumen coupled to the portion of the catheter assembly.
摘要翻译：通过第一流体（例如患者血液）与第二气体过饱和流体（例如氧过饱和流体）的组合来提供富气体流体。在该示例中，导管组件包括从泵接收患者血液并从适当的流体源接收氧过饱和流体的部分。氧过饱和流体有利地在层流区域中与血液组合，然后将该富含气体的流体通过耦合到导管组件的该部分的适当内腔递送至患者。

3. 发明授权

US06454997B1 Apparatus for the preparation and delivery of gas-enriched fluids 失效
标题翻译：用于制备和输送富含气体的流体的装置
公开(公告)号：US06454997B1
公开(公告)日：2002-09-24
申请号：US09122438
申请日：1998-07-24
申请人： Vincent Divino, Jr. , Seth A. Foerster , James M. Gessert , Robert A. Mest , Paul J. Zalesky
发明人： Vincent Divino, Jr. , Seth A. Foerster , James M. Gessert , Robert A. Mest , Paul J. Zalesky
IPC分类号： A61M136
CPC分类号： A61M1/3626 , A61M1/3603 , A61M1/361 , A61M1/3612 , A61M1/3613 , A61M1/3621 , A61M25/0028 , A61M25/0032 , A61M2025/0034 , A61M2025/0036 , A61M2202/0476 , Y10S128/03 , Y10S261/28
摘要： A gas-enriched fluid is provided by the combination of a first fluid, such as a patient's blood, with a second gas-supersaturated fluid, such as an oxygen supersaturated fluid. In this example, a catheter assembly includes a portion that receives the patient's blood from a pump and that receives the oxygen supersaturated fluid from an appropriate fluid source. The oxygen supersaturated fluid is advantageously combined with the blood in an area of laminar flow, and then this gas-enriched fluid is delivered to the patient through an appropriate lumen coupled to the portion of the catheter assembly.
摘要翻译：通过第一流体（例如患者血液）与第二气体过饱和流体（例如氧过饱和流体）的组合来提供富气体流体。在该示例中，导管组件包括从泵接收患者血液并从适当的流体源接收氧过饱和流体的部分。氧过饱和流体有利地在层流区域中与血液组合，然后将该富含气体的流体通过耦合到导管组件的该部分的适当内腔递送至患者。

4. 发明授权

US06558502B2 Method for forming atraumatic fluid delivery device 失效
标题翻译：形成无创流体输送装置的方法
公开(公告)号：US06558502B2
公开(公告)日：2003-05-06
申请号：US09859122
申请日：2001-05-16
申请人： Vincent Divino, Jr. , John Merritt , Seth A. Foerster , William C. Homet , Paul J. Zalesky
发明人： Vincent Divino, Jr. , John Merritt , Seth A. Foerster , William C. Homet , Paul J. Zalesky
IPC分类号： A61M2509
CPC分类号： A61M25/0029 , A61M25/003 , A61M25/0043 , A61M25/0068 , A61M25/0108 , A61M25/09 , A61M25/09033 , A61M31/005 , A61M2025/0039 , A61M2025/0057 , A61M2025/0073 , A61M2025/09083 , A61M2025/09091 , A61M2025/091 , A61M2025/09175 , Y10T156/1062
摘要： The present invention is a device for insertion into a human or animal body, in a preferred embodiment a perfusion guidewire capable of delivering perfusion fluids to a vascular site while at the same time exhibiting handling characteristics associated with existing non-perfusion guidewires. Preferred embodiments include a perfusion guidewire which closely matches the dimensions and physical characteristics of standard guidewires. Preferred embodiments also permit high pressure perfusion of oxygen-supersaturated solutions, and include a diffuser segment which divides the flow and reduces fluid velocity, thereby providing an atraumatic, non-cavitating, bubble-free delivery to the patient. The invention also encompasses the attachment of a core wire within a tubular housing to provide superior characteristics to such guidewires, balloon catheters and similar devices.
摘要翻译：本发明是一种用于插入人体或动物体内的装置，在优选实施例中，能够将灌注流体输送到血管部位同时具有与现有非灌注导丝相关联的处理特性的灌注导丝。优选实施例包括与标准导线的尺寸和物理特性紧密匹配的灌注导丝。优选的实施方案还允许氧 - 过饱和溶液的高压灌注，并且包括扩散段，其分流并减少流体速度，从而向患者提供无创伤，非气蚀，无气泡的递送。本发明还包括将芯线连接到管状外壳内，以提供对这种导线，气球导管和类似装置的优异特性。

5. 发明授权

US06235007B1 Atraumatic fluid delivery devices 失效
标题翻译：无创流体输送装置
公开(公告)号：US06235007B1
公开(公告)日：2001-05-22
申请号：US09092254
申请日：1998-06-05
申请人： Vincent Divino, Jr. , John Merritt , Seth A. Foerster , William C. Homet , Paul J. Zalesky
发明人： Vincent Divino, Jr. , John Merritt , Seth A. Foerster , William C. Homet , Paul J. Zalesky
IPC分类号： A61M2500
CPC分类号： A61M25/0029 , A61M25/003 , A61M25/0043 , A61M25/0068 , A61M25/0108 , A61M25/09 , A61M25/09033 , A61M31/005 , A61M2025/0039 , A61M2025/0057 , A61M2025/0073 , A61M2025/09083 , A61M2025/09091 , A61M2025/091 , A61M2025/09175 , Y10T156/1062
摘要： The present invention is a device for insertion into a human or animal body, in a preferred embodiment a perfusion guidewire capable of delivering perfusion fluids to a vascular site while at the same time exhibiting handling characteristics associated with existing non-perfusion guidewires. Preferred embodiments include a perfusion guidewire which closely matches the dimensions and physical characteristics of standard guidewires. Preferred embodiments also permit high pressure perfusion of oxygen-supersaturated solutions, and include a diffuser segment which divides the flow and reduces fluid velocity, thereby providing an atraumatic, non-cavitating, bubble-free delivery to the patient. The invention also encompasses the attachment of a core wire within a tubular housing to provide superior characteristics to such guidewires, balloon catheters and similar devices.
摘要翻译：本发明是一种用于插入人体或动物体内的装置，在优选实施例中，能够将灌注流体输送到血管部位同时具有与现有非灌注导丝相关联的处理特性的灌注导丝。优选实施例包括与标准导线的尺寸和物理特性紧密匹配的灌注导丝。优选的实施方案还允许氧 - 过饱和溶液的高压灌注，并且包括扩散段，其分流并减少流体速度，从而向患者提供无创伤，非气蚀，无气泡的递送。本发明还包括将芯线连接到管状外壳内，以提供对这种导线，气球导管和类似装置的优异特性。

6. 发明授权

US06248087B1 Apparatus for generalized extracorporeal support 有权
公开(公告)号：US06248087B1
公开(公告)日：2001-06-19
申请号：US09239076
申请日：1999-01-27
申请人： J. Richard Spears , Seth A. Foerster , James M. Gessert , Paul J. Zalesky
发明人： J. Richard Spears , Seth A. Foerster , James M. Gessert , Paul J. Zalesky
IPC分类号： A61M3700
CPC分类号： A61M1/3626 , A61M1/3603 , A61M1/361 , A61M1/3612 , A61M1/3613 , A61M1/3621 , A61M25/0028 , A61M25/0032 , A61M2025/0034 , A61M2025/0036 , A61M2202/0476 , Y10S128/03 , Y10S261/28
摘要： A system and method for increasing gas concentration in blood which has use as a generalized extracorporeal system and method to treat hypoxemic blood from a patient by mixing the blood with an oxygen supersaturated solution to generate hyperoxemic blood to be infused back to the patient. The extracorporeal system comprises an extracorporeal tubing through which blood from the patient is circulated, a blood pump for withdrawing blood from and delivering blood to the patient, at least one channel for delivering oxygen-supersaturated fluid and a mixing region for introducing supersaturated fluid without bubble formation. By infusing the oxygen-supersaturated fluid into the hypoxemic or normoxemic blood from the patient, hyperoxemic blood is thereby produced. The hyperoxemic blood is then returned to a central vein, right heart or artery of the patient with the blood pump at approximately the same volume delivery rate as blood volume withdrawal rate.

7. 发明授权

US06746417B2 Apparatus for generalized extracorporeal support 失效
标题翻译：用于广泛体外支持的装置
公开(公告)号：US06746417B2
公开(公告)日：2004-06-08
申请号：US09741625
申请日：2000-12-19
申请人： J. Richard Spears , Seth A. Foerster , James M. Gessert , Paul J. Zalesky
发明人： J. Richard Spears , Seth A. Foerster , James M. Gessert , Paul J. Zalesky
IPC分类号： A61M3700
CPC分类号： A61M1/3626 , A61M1/3603 , A61M1/361 , A61M1/3612 , A61M1/3613 , A61M1/3621 , A61M25/0028 , A61M25/0032 , A61M2025/0034 , A61M2025/0036 , A61M2202/0476 , Y10S128/03 , Y10S261/28
摘要： A system and method for increasing gas concentration in blood which has use as a generalized extracorporeal system and method to treat hypoxemic blood from a patient by mixing the blood with an oxygen supersaturated solution to generate hyperoxemic blood to be infused back to the patient. The extracorporeal system comprises an extracorporeal tubing through which blood from the patient is circulated, a blood pump for withdrawing blood from and delivering blood to the patient, at least one channel for delivering oxygen-supersaturated fluid and a mixing region for introducing supersaturated fluid without bubble formation. By infusing the oxygen-supersaturated fluid into the hypoxemic or normoxemic blood from the patient, hyperoxemic blood is thereby produced. The hyperoxemic blood is then returned to a central vein, right heart or artery of the patient with the blood pump at approximately the same volume delivery rate as blood volume withdrawal rate.
摘要翻译：一种用于增加血液中的气体浓度的系统和方法，其用作通用体外系统和用于通过将血液与氧过饱和溶液混合以产生高渗血液以输注给患者来治疗来自患者的低氧血液的方法。体外系统包括一个体外管道，血液从患者循环通过，用于从血液中抽出血液并将血液输送给患者的血液泵，用于输送氧过饱和流体的至少一个通道和用于引入过饱和流体而没有气泡的混合区域形成。通过将氧过饱和流体注入来自患者的低氧血症或常规血液中，由此产生高血氧。然后将高血氧血液以与血容量抽出速率大致相同的体积递送速率与血泵一起返回到患者的中心静脉，右心脏或动脉。

8. 发明授权

US06607698B1 Method for generalized extracorporeal support 失效
标题翻译：广泛体外支持方法
公开(公告)号：US06607698B1
公开(公告)日：2003-08-19
申请号：US08915532
申请日：1997-08-15
申请人： J. Richard Spears , Seth A. Foerster , James M. Gessert , Paul J. Zalesky
发明人： J. Richard Spears , Seth A. Foerster , James M. Gessert , Paul J. Zalesky
IPC分类号： A61M134
CPC分类号： A61M1/3626 , A61M1/3603 , A61M1/361 , A61M1/3612 , A61M1/3613 , A61M1/3621 , A61M25/0028 , A61M25/0032 , A61M2025/0034 , A61M2025/0036 , A61M2202/0476 , Y10S128/03 , Y10S261/28
摘要： A system and method for increasing gas concentration in blood which has use as a generalized extracorporeal system and method to treat hypoxemic blood from a patient by mixing the blood with an oxygen supersaturated solution to generate hyperoxemic blood to be infused back to the patient. The extracorporeal system comprises an extracorporeal tubing through which blood from the patient is circulated, a blood pump for withdrawing blood from and delivering blood to the patient, at least one channel for delivering oxygen-supersaturated fluid and a mixing region for introducing supersaturated fluid without bubble formation. By infusing the oxygen-supersaturated fluid into the hypoxemic or normoxemic blood from the patient, hyperoxemic blood is thereby produced. The hyperoxemic blood is then returned to a central vein, right heart or artery of the patient with the blood pump at approximately the same volume delivery rate as blood volume withdrawal rate.
摘要翻译：一种用于增加血液中的气体浓度的系统和方法，其用作通用体外系统和用于通过将血液与氧过饱和溶液混合以产生高渗血液以输注给患者来治疗来自患者的低氧血液的方法。体外系统包括一个体外管道，血液从患者循环通过，用于从血液中抽出血液并将血液输送给患者的血液泵，用于输送氧过饱和流体的至少一个通道和用于引入过饱和流体而没有气泡的混合区域形成。通过将氧过饱和流体注入来自患者的低氧血症或常规血液中，由此产生高血氧。然后将高血氧血液以与血容量抽出速率大致相同的体积递送速率与血泵一起返回到患者的中心静脉，右心脏或动脉。

9. 发明授权

US06596235B2 Method for blood oxygenation 失效
公开(公告)号：US06596235B2
公开(公告)日：2003-07-22
申请号：US09778433
申请日：2001-02-07
申请人： Vincent Divino, Jr. , Paul J. Zalesky , William R. Patterson
发明人： Vincent Divino, Jr. , Paul J. Zalesky , William R. Patterson
IPC分类号： A61M136
CPC分类号： A61M1/1698 , A61M1/3613 , A61M2202/0476 , B01F3/04758
摘要： An apparatus and method for blood oxygenation is provided, advantageously comprising an extracorporeal circuit for the preparation and delivery of hyperoxic or hyperbaric blood. In one embodiment, an apparatus for gas-supersaturating fluids, e.g., physiologic saline, includes a chamber having a first inlet to receive the fluid; a second inlet to receive a gas, e.g., oxygen, from a gas supply that maintains pressure within the chamber at a predetermined level, advantageously about 600 p.s.i.; and an outlet advantageously coupled to a capillary assembly. An atomizer nozzle coupled to the first inlet advantageously creates within the chamber fine droplets of fluid into which gas diffuses to create the gas-supersaturated fluid, which collects within the chamber below the atomizer nozzle for removal via the outlet. The removed gas-supersaturated fluid mixes with blood provided by a blood pump, the mixing occurring within a liquid-to-liquid oxygenation assembly including a pressurizable chamber having inlets for the gas-supersaturated fluid and blood, the inlets advantageously arranged to create a vortical or cyclonic fluid flow within the chamber to promote mixing. The mixed fluid exits the chamber via an outlet for delivery to a patient (e.g., sub-selective delivery) or other site via a catheter, infusion guidewire, or other interventional fluid delivery device, the mixed fluid advantageously comprising blood having increased oxygen levels, i.e., oxygenated blood. Alternately, the blood may be provided by the pump to a high pressure hollow fiber or other type membrane oxygenator within which oxygen, advantageously provided at a pressure greater than atmospheric, diffuses across the membrane(s) and into the blood to form oxygenated blood, again for delivery to a patient or other site. Advantageously, the oxygenated blood is delivered at a target pO2 greater than about 760 mm Hg and is delivered from the liquid-to-liquid oxygenation assembly or membrane oxygenator via a fluid conduit having an approximate pressure drop greater than the target pO2.

10. 发明授权

US5957899A High pressure transluminal fluid delivery device 失效
标题翻译：高压腔内输液装置
公开(公告)号：US5957899A
公开(公告)日：1999-09-28
申请号：US669662
申请日：1996-06-24
申请人： J. Richard Spears , Philip S. Levin , Paul J. Zalesky , Vincent Divino, Jr.
发明人： J. Richard Spears , Philip S. Levin , Paul J. Zalesky , Vincent Divino, Jr.
IPC分类号： A61M25/00 , A61M25/01 , A61M25/09 , A61M31/00
CPC分类号： A61M25/09 , A61M25/0043 , A61M31/005 , A61M2025/0057 , A61M2025/0073 , A61M2025/09083 , A61M2025/09091 , A61M2025/091 , A61M2025/09175 , A61M25/0108 , A61M25/09033
摘要： The present invention includes a fluid delivery device capable of delivering perfusion or other fluids to a vascular site. Preferred embodiments permit delivery of large quantities of fluid without causing recoil of the device, and without causing trauma to the vascular site.
摘要翻译：本发明包括能够向血管部位输送灌注或其它流体的流体输送装置。优选的实施方案允许大量流体的输送而不引起装置的反冲，并且不会对血管部位造成伤害。

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