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1. 发明授权

US08237115B2 Method and apparatus for multiple electrospray emitters in mass spectrometry 有权
标题翻译：质谱法中多重电喷发射体的方法和装置
公开(公告)号：US08237115B2
公开(公告)日：2012-08-07
申请号：US12642617
申请日：2009-12-18
申请人： Viatcheslav V. Kovtoun , Eloy R. Wouters , R. Paul Atherton
发明人： Viatcheslav V. Kovtoun , Eloy R. Wouters , R. Paul Atherton
IPC分类号： H01J49/00
CPC分类号： H01J49/167 , H01J49/068
摘要： An electrospray ion source apparatus comprises: a plurality of emitter capillaries, each comprising an internal bore for transporting a portion of a liquid sample from a source, an electrode portion for providing a first applied electric potential and an emitter tip for emitting charged particles generated from the liquid sample portion; a counter electrode for providing a second applied electric potential different from the first applied electric potential; and at least one shield electrode disposed at least partially between the counter electrode and the emitter tip of at least one of the emitter capillaries for providing a third applied electric potential intermediate to the first and second applied electric potentials, wherein the at least one shield electrode is configured such that provision of the third applied electric potential to the at least one shield electrode provides a uniformity of emission of charged particles from the plurality of emitter tips.
摘要翻译：电喷雾离子源装置包括：多个发射器毛细管，每个发射器毛细管包括用于从源极输送液体样品的一部分的内孔，用于提供第一施加电位的电极部分和用于发射由液体样品部分; 用于提供不同于第一施加电位的第二施加电位的对电极; 以及至少一个屏蔽电极，至少部分地设置在所述发射极毛细管中的至少一个的所述对电极和所述发射极尖之间，用于向所述第一和第二施加电位提供中间的第三施加电位，其中所述至少一个屏蔽电极配置成使得向至少一个屏蔽电极提供第三施加电位提供了从多个发射极尖端发射带电粒子的均匀性。

2. 发明授权

US08546753B2 Method and apparatus for multiple electrospray emitters in mass spectrometry 有权
标题翻译：质谱法中多重电喷发射体的方法和装置
公开(公告)号：US08546753B2
公开(公告)日：2013-10-01
申请号：US13550369
申请日：2012-07-16
申请人： Viatcheslav V. Kovtoun , Eloy R. Wouters , R. Paul Atherton
发明人： Viatcheslav V. Kovtoun , Eloy R. Wouters , R. Paul Atherton
IPC分类号： H01J49/00
CPC分类号： H01J49/167 , H01J49/068
摘要： An electrospray ion source apparatus comprises: a plurality of emitter capillaries, each comprising an internal bore for transporting a portion of a liquid sample from a source, an electrode portion for providing a first applied electric potential and an emitter tip for emitting a cloud of charged particles generated from the liquid sample portion; a counter electrode for providing a second applied electric potential different from the first applied electric potential; and at least one shield electrode disposed at least partially between the counter electrode and the emitter tip of at least one of the emitter capillaries for providing a third applied electric potential intermediate to the first and second applied electric potentials, wherein the at least one shield electrode is configured such that provision of the third applied electric potential to the at least one shield electrode minimizes electric field interference effects between the plurality of emitter capillaries.
摘要翻译：电喷雾离子源设备包括：多个发射器毛细管，每个发射器毛细管包括用于从源极输送液体样品的一部分的内孔，用于提供第一施加电位的电极部分和用于发射带电的云的发射器尖端从液体样品部分产生的颗粒; 用于提供不同于第一施加电位的第二施加电位的对电极; 以及至少一个屏蔽电极，至少部分地设置在所述发射极毛细管中的至少一个的所述对电极和所述发射极尖之间，用于向所述第一和第二施加电位提供中间的第三施加电位，其中所述至少一个屏蔽电极被配置为使得向至少一个屏蔽电极提供第三施加电位使得多个发射器毛细管之间的电场干扰效应最小化。

3. 发明授权

US07781728B2 Ion transport device and modes of operation thereof 有权
标题翻译：离子输送装置及其操作模式
公开(公告)号：US07781728B2
公开(公告)日：2010-08-24
申请号：US12125013
申请日：2008-05-21
申请人： Michael W. Senko , Viatcheslav V. Kovtoun , Paul R. Atherton , Jean Jacques Dunyach , Eloy R. Wouters , Maurizio Splendore , William Siebert
发明人： Michael W. Senko , Viatcheslav V. Kovtoun , Paul R. Atherton , Jean Jacques Dunyach , Eloy R. Wouters , Maurizio Splendore , William Siebert
IPC分类号： H01J3/14 , B01D59/44
CPC分类号： H01J49/065 , H01J3/14 , H01J49/066
摘要： A device for transporting and focusing ions in a low vacuum or atmospheric-pressure region of a mass spectrometer is constructed from a plurality of longitudinally spaced apart electrodes to which oscillatory (e.g., radio-frequency) voltages are applied. In order to create a tapered field that focuses ions to a narrow beam near the device exit, the inter-electrode spacing or the oscillatory voltage amplitude is increased in the direction of ion travel.
摘要翻译：用于在质谱仪的低真空或大气压区域中输送和聚焦离子的装置由多个纵向间隔开的电极构成，施加振荡（例如，射频）电压。为了创建将离子聚焦到设备出口附近的窄波束的锥形场，电离间隔或振荡电压振幅在离子行进方向上增加。

4. 发明申请

US20090045062A1 ION TRANSPORT DEVICE AND MODES OF OPERATION THEREOF 有权
标题翻译：离子运输装置及其运行方式
公开(公告)号：US20090045062A1
公开(公告)日：2009-02-19
申请号：US12125013
申请日：2008-05-21
申请人： Michael W. Senko , Viatcheslav V. Kovtoun , Paul R. Atherton , Jean Jacques Dunyach , Eloy R. Wouters , Maurizio Splendore , William Siebert
发明人： Michael W. Senko , Viatcheslav V. Kovtoun , Paul R. Atherton , Jean Jacques Dunyach , Eloy R. Wouters , Maurizio Splendore , William Siebert
IPC分类号： C25B15/00 , C25B9/06 , C25B11/02
CPC分类号： H01J49/065 , H01J3/14 , H01J49/066
摘要： A device for transporting and focusing ions in a low vacuum or atmospheric-pressure region of a mass spectrometer is constructed from a plurality of longitudinally spaced apart electrodes to which oscillatory (e.g., radio-frequency) voltages are applied. In order to create a tapered field that focuses ions to a narrow beam near the device exit, the inter-electrode spacing or the oscillatory voltage amplitude is increased in the direction of ion travel.
摘要翻译：用于在质谱仪的低真空或大气压区域中输送和聚焦离子的装置由多个纵向间隔开的电极构成，施加振荡（例如，射频）电压。为了创建将离子聚焦到设备出口附近的窄波束的锥形场，电离间隔或振荡电压振幅在离子行进方向上增加。

5. 发明授权

US08785847B2 Mass spectrometer having an ion guide with an axial field 有权
标题翻译：质谱仪具有带轴向场的离子导向器
公开(公告)号：US08785847B2
公开(公告)日：2014-07-22
申请号：US13396982
申请日：2012-02-15
申请人： Viatcheslav V. Kovtoun , Philip M. Remes , Yevgeniy N. Zhuk
发明人： Viatcheslav V. Kovtoun , Philip M. Remes , Yevgeniy N. Zhuk
IPC分类号： H01J49/00 , H01J49/06
CPC分类号： H01J49/063 , H01J49/062
摘要： A mass spectrometer having an ion guide with an axial field is described. The ion guide includes electrodes with longitudinally extending gaps and inserts configured to be proximate to the gaps.
摘要翻译：描述了具有轴向场的离子导向器的质谱仪。离子导向器包括具有纵向延伸的间隙的电极和构造成靠近间隙的插入件。

6. 发明授权

US07351955B2 Reduction of chemical noise in a MALDI mass spectrometer by in-trap photodissociation of matrix cluster ions 失效
标题翻译：通过基质簇离子的陷阱光解作用减少MALDI质谱仪中的化学噪声
公开(公告)号：US07351955B2
公开(公告)日：2008-04-01
申请号：US11233825
申请日：2005-09-09
申请人： Viatcheslav V. Kovtoun
发明人： Viatcheslav V. Kovtoun
IPC分类号： H01J49/00
CPC分类号： H01J49/164 , H01J49/0059
摘要： A MALDI mass spectrometer includes a radiation source, such as a gas or solid state laser, that emits a beam of radiation (typically in the UV or IR wavelengths) directed along the central axis of a linear ion trap in which analyte ions and matrix cluster ions are confined. The radiation beam has a wavelength that is strongly absorbed by the matrix cluster ions. The absorption of radiation by the matrix cluster ions produces dissociation of the matrix cluster ion into fragments having mass-to-charge ratios that lie below a mass-to-charge ratio range of interest. Thus, chemical noise associated with matrix cluster ions is reduced or eliminated.
摘要翻译： MALDI质谱仪包括辐射源，例如气体或固体激光器，其发射沿着线性离子阱的中心轴引导的辐射束（通常在UV或IR波长），其中分析物离子和基质簇离子被限制。辐射束具有被基质簇离子强烈吸收的波长。基质簇离子对辐射的吸收会导致基质簇离子离解成具有低于感兴趣的质荷比范围的质荷比的片段。因此，减少或消除与基质簇离子相关的化学噪声。

7. 发明申请

US20080073497A1 High throughput quadrupolar ion trap 有权
公开(公告)号：US20080073497A1
公开(公告)日：2008-03-27
申请号：US11485055
申请日：2006-07-11
申请人： Viatcheslav V. Kovtoun
发明人： Viatcheslav V. Kovtoun
IPC分类号： B01D59/44
CPC分类号： H01J49/423 , H01J49/4225 , H01J49/427 , H01J49/4295
摘要： A method and apparatus are provided for operating a linear ion trap. A linear ion trap configuration is provided that allows for increased versatility in functions compared to a conventional three-sectioned linear ion trap. In operation, the linear ion trap provides multiple segments, the segments spatially portioning an initial population of ions into at least a first and a second ion population. Each segment is effectively independent and ions corresponding to the first ion population are able to be manipulated independently from ions corresponding to ions corresponding to the second ion population; the ions having been generated by an ion source under the same conditions. The ions can then be expelled from the ion trap.

8. 发明授权

US06963066B2 Rod assembly in ion source 有权
标题翻译：棒组件在离子源
公开(公告)号：US06963066B2
公开(公告)日：2005-11-08
申请号：US10456372
申请日：2003-06-05
申请人： Nicolae Izgarian , Viatcheslav V. Kovtoun
发明人： Nicolae Izgarian , Viatcheslav V. Kovtoun
IPC分类号： H01J49/16 , H01J49/42 , H01J49/10
CPC分类号： H01J49/164 , H01J49/063
摘要： Ion source assemblies for generating ions for laser desorption mass spectrometry. An ion source assembly includes a target for receiving analyte samples and a plurality of rods. The rods define an interior volume having an axis extending away from a surface of the target for transporting ions. One or more of the rods include an aperture defining an opening through a cross-section of the rod. The aperture is configured such that a laser beam can pass through the aperture to irradiate a location on the target surface to generate ions from an analyte sample deposited at the location.
摘要翻译：用于生成离子用于激光解吸质谱的离子源组件。离子源组件包括用于接收分析物样品和多个棒的靶。杆限定内部体积，其具有远离靶的表面延伸的轴线，用于输送离子。杆中的一个或多个包括限定穿过杆的横截面的开口的孔。孔被构造成使得激光束可以通过孔径以照射目标表面上的位置以从沉积在该位置处的分析物样品产生离子。

9. 发明授权

US06518568B1 Method and apparatus of mass-correlated pulsed extraction for a time-of-flight mass spectrometer 有权
标题翻译：飞行时间质谱仪质量相关脉冲提取的方法和装置
公开(公告)号：US06518568B1
公开(公告)日：2003-02-11
申请号：US09589480
申请日：2000-06-07
申请人： Viatcheslav V. Kovtoun , Robert J. Cotter
发明人： Viatcheslav V. Kovtoun , Robert J. Cotter
IPC分类号： H01J4840
CPC分类号： H01J49/40
摘要： A time-of-flight mass spectrometer includes a sample holder for a sample and an ionizer for ionizing the sample to form ions. A first element is spaced downstream from the sample holder, a second element is spaced downstream from the first element, and a drift region is downstream of the second element. An electric field is established between the sample holder and the first element at a time subsequent to ionizing the sample in order to extract the ions. A time-dependent and mass-correlated electric field is established between at least one of: (a) the first element and the second element, and (b) the sample holder and the first element. In turn, a detector detects the ions.
摘要翻译：飞行时间质谱仪包括用于样品的样品保持器和用于电离样品以形成离子的离子发生器。第一元件与样品保持器的下游间隔开，第二元件与第一元件的下游间隔开，漂移区域位于第二元件的下游。在电离样品之后的时间，在样品保持器和第一元件之间建立电场以提取离子。在（a）第一元件和第二元件中的至少一个以及（b）样品保持器和第一元件中的至少一个之间建立时间依赖和质量相关的电场。反过来，检测器检测离子。

10. 发明授权

US08581177B2 High duty cycle ion storage/ion mobility separation mass spectrometer 有权
标题翻译：高占空比离子存储/离子迁移分离质谱仪
公开(公告)号：US08581177B2
公开(公告)日：2013-11-12
申请号：US13084304
申请日：2011-04-11
申请人： Viatcheslav V. Kovtoun
发明人： Viatcheslav V. Kovtoun
IPC分类号： H01J49/00
CPC分类号： H01J49/004 , G01N27/622 , H01J49/06
摘要： A novel high ion storage/ion mobility separation mass spectrometer that provides for a high duty cycle of operation is presented herein. In particular, the example embodiments, as disclosed herein, provides for a high ion storage/ion mobility instrument that beneficially includes a two-dimensional (2D) plurality of adjacently arranged ion confinement channels to provide a high storage bank of a desired mass range of ions. Such ions, via ion mobility transport, are separated into smaller fractions of an overall mass window into desired confinement regions of the disclosed 2D confinement channels and thereafter transferred out in a manner so as to enable the aforementioned novel high-duty cycle of sequential operation.
摘要翻译：本文介绍了一种提供高占空比操作的新型高离子存储/离子迁移分离质谱仪。特别地，如本文所公开的示例性实施例提供了一种高离子存储/离子迁移仪器，其有利地包括二维（2D）多个相邻布置的离子限制通道，以提供期望质量范围的高存储体离子。通过离子迁移率传输将这样的离子分离成整个质量窗口的较小部分，形成所公开的二维限制通道的所需限制区域，然后以这样的方式转出，以便能够实现上述新型的连续操作的高占空比。

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