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1. 发明授权

US6114532A Bicyclic heterocycles, the preparation thereof, and their use as pharmaceuticals 有权
标题翻译：双环杂环，其制备及其作为药物的用途
公开(公告)号：US6114532A
公开(公告)日：2000-09-05
申请号：US243200
申请日：1999-02-02
申请人： Uwe Ries , Norbert Hauel , Gerhard Mihm , Henning Priepke , Klaus Binder , Jean-Marie Stassen , Wolfgang Weinen , Rainer Zimmerman
发明人： Uwe Ries , Norbert Hauel , Gerhard Mihm , Henning Priepke , Klaus Binder , Jean-Marie Stassen , Wolfgang Weinen , Rainer Zimmerman
IPC分类号： C07D209/18 , C07D209/24 , C07D235/16 , C07D235/20 , C07D263/56 , C07D277/30 , C07D277/64 , C07D401/04 , C07D401/06 , C07D401/08 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/12 , C07D405/12 , C07D417/04 , C07D417/12 , C07F9/6506 , A61K31/4184 , C07D413/06 , C07D307/01
CPC分类号： C07D263/56 , C07D209/18 , C07D209/24 , C07D235/16 , C07D235/20 , C07D277/30 , C07D277/64 , C07D401/04 , C07D401/06 , C07D401/08 , C07D401/12 , C07D403/04 , C07D403/08 , C07D403/12 , C07D405/12 , C07D417/04 , C07D417/12 , C07F9/65068
摘要： The present invention relates to 5-membered heterocyclic condensed benzoderivatives of formula ##STR1## wherein R.sub.a to R.sub.c, A, X and Y are defined as in claim 1, the tautomers, stereoisomers, mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable properties.The compounds of the above formula I wherein R.sub.c denotes a cyano group are valuable intermediates for preparing the other compounds of formula I, and the compounds of the above formula I wherein R.sub.c denotes one of the following amidino groups and the tautomers and stereoisomers thereof have valuable pharmacological properties, particularly an antithrombotic activity.
摘要翻译：本发明涉及下式的5-元杂环稠合苯并衍生物：其中Ra至Rc，A，X和Y如权利要求1所定义，互变异构体，立体异构体，其混合物及其盐，特别是其与无机的生理学上可接受的盐或具有有价值性质的有机酸或碱。其中R c表示氰基的上式I化合物是制备其它式I化合物的有价值的中间体，其中R c表示以下脒基中的一种，其互变异构体和立体异构体具有有价值的上述式Ⅰ化合物药理特性，特别是抗血栓活性。

2. 发明授权

US06121308A Disubstituted bicyclic heterocycles, the preparation thereof and their use as pharmaceutical compositions 有权
标题翻译：二取代双环杂环，其制备及其作为药物组合物的用途
公开(公告)号：US06121308A
公开(公告)日：2000-09-19
申请号：US359487
申请日：1999-07-22
申请人： Norbert Hauel , Uwe Ries , Henning Priepke , Gerhard Mihm , Wolfgang Wienen , Jean Marie Stassen , Klaus Binder , Rainer Zimmermann
发明人： Norbert Hauel , Uwe Ries , Henning Priepke , Gerhard Mihm , Wolfgang Wienen , Jean Marie Stassen , Klaus Binder , Rainer Zimmermann
IPC分类号： A61K31/4184 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61P7/02 , C07D215/38 , C07D215/40 , C07D235/12 , C07D235/14 , C07D235/16 , C07D235/28 , C07D307/81 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/12 , C07D471/04 , A61K31/415 , A61K31/405 , C07D209/02 , C07D235/04 , C07D235/10
CPC分类号： C07D401/12 , C07D215/38 , C07D215/40 , C07D235/12 , C07D235/14 , C07D235/16 , C07D235/28 , C07D307/81 , C07D401/14 , C07D405/12 , C07D405/14 , C07D417/12 , C07D471/04
摘要： Novel disubstituted bicyclic heterocycles, of which the following are exemplary:(a) 1-methyl-2-[(4-amidinophenyl)-oxymethyl]-5-[N-(hydroxycarbonylmethyl)-quinoline-8-sulphonylamino]-benzimidazole,(b) 1-methyl-2-[2-(4-amidinophenyl)-ethyl]-5-[N-(N-(hydroxycarbonylmethyl)-aminocarbonylmethyl)-quinoline-8-sulphonylamino]-benzimidazole,(c) 1-methyl-2-[N-(4-amidinophenyl)-aminomethyl]-5-[N-(hydroxycarbonylmethyl)-quinoline-8-sulphonylamino]-benzimidazole and(d) 1-methyl-2-[N-(4-amidinophenyl)-aminomethyl]-5-[N-(hydroxycarbonylmethyl)-quinoline-8-sulphonylamino]-indole.These are useful for the treatment of thrombotic disease.
摘要翻译：新的二取代双环杂环，其中以下是示例性的：（a）1-甲基-2 - [（4-脒基苯基） - 氧甲基] -5- [N-（羟基羰基甲基） - 喹啉-8-磺酰基氨基] - 苯并咪唑， b）1-甲基-2- [2-（4-脒基苯基） - 乙基] -5- [N-（N-（羟基羰基甲基） - 氨基羰基甲基） - 喹啉-8-磺酰基氨基] - 苯并咪唑，（c） -2- [N-（4-脒基苯基） - 氨基甲基] -5- [N-（羟基羰基甲基） - 喹啉-8-磺酰基氨基] - 苯并咪唑和（d）1-甲基-2- [N-（4-脒基苯基） - 氨甲基] -5- [N-（羟基羰基甲基） - 喹啉-8-磺酰基氨基] - 吲哚。这些可用于治疗血栓性疾病。

3. 发明授权

US06300342B1 Antithrombotic phenylalkyl derivatives 失效
标题翻译：抗血栓苯基烷基衍生物
公开(公告)号：US06300342B1
公开(公告)日：2001-10-09
申请号：US09457961
申请日：1999-12-09
申请人： Armin Heckel , Rainer Soyka , Wolfgang Grell , Eric Haaksma , Klaus Binder , Rainer Zimmerman
发明人： Armin Heckel , Rainer Soyka , Wolfgang Grell , Eric Haaksma , Klaus Binder , Rainer Zimmerman
IPC分类号： A61K3147
CPC分类号： C07D215/227 , C07D209/08 , C07D215/14 , C07D215/18 , C07D215/36 , C07D215/38 , C07D215/48 , C07D217/06 , C07D223/16 , C07D401/04 , C07D401/06 , C07D401/12 , C07D409/12
摘要： Antithrombotic phenylalkyl derivatives of the formula Exemplary compounds are: (a) 1-[3-(4-amidino-phenyl)propionyl]-6-(4-fluoro-phenylsulphonamido)-1,2,3,4-tetrahydro-quinoline, (b) 1-[3-(4-amidino-phenyl)propionyl]-6-butylsulphonamido-1,2,3,4-tetrahydro-quinoline, (c) 1-[3-(4-amidino-phenyl)propionyl]-5-phenylsulphonamido-1,2,3,4-tetrahydro-quinoline, (d) 1-[3-(4-amidino-phenyl)propionyl]-3-methyl-6-phenylsulphonamido-1,2,3,4-tetrahydro-quinoline, and, (e) 1-[3-(4-amidino-phenyl)propionyl]-6-(5-chloro-thien-2-ylsulphonamido)-1,2,3,4-tetrahydro-quinoline.
摘要翻译：式（A）的1-（3-氨基苯基）丙酰基] -6-（4-氟 - 苯基磺酰氨基）-1,2,3,4-四氢 - 喹啉（ b）1- [3-（4-脒基 - 苯基）丙酰基] -6-丁基磺酰氨基-1,2,3,4-四氢 - 喹啉，（c）1- [3-（4-脒基 - 苯基）丙酰基] -5-苯基磺酰氨基-1,2,3,4-四氢 - 喹啉，（d）1- [3-（4-脒基 - 苯基）丙酰基] -3-甲基-6-苯基磺酰氨基-1,2,3,4 （e）1- [3-（4-脒基 - 苯基）丙酰基] -6-（5-氯 - 噻吩-2-基磺酰氨基）-1,2,3,4-四氢 - 喹啉。

4. 发明授权

US07763144B2 Device and method for the detachment of a tube blank from a support core 有权
标题翻译：用于将管坯从支撑芯分离的装置和方法
公开(公告)号：US07763144B2
公开(公告)日：2010-07-27
申请号：US10518479
申请日：2003-05-17
申请人： Markus Berger , Harald Kranz , Klaus Binder , Rainer Oehl
发明人： Markus Berger , Harald Kranz , Klaus Binder , Rainer Oehl
IPC分类号： B32B38/10
CPC分类号： B29C37/0017 , Y10T156/11 , Y10T156/1126 , Y10T156/1132 , Y10T156/19 , Y10T156/1928 , Y10T156/1944
摘要： The invention relates to a method and a device for the removal of a tube blank (3) located on a support core (2). The tube blank (3) is detached from the support core (2) by means of the introduction of a medium through a device (10), whereby a detachment may be alternatively or additionally achieved by the application of a vacuum to a sleeve (4) enclosing the tube blank (3).
摘要翻译：本发明涉及一种用于去除位于支撑芯（2）上的管坯（3）的方法和装置。管坯（3）借助于通过装置（10）的介质引入支撑芯（2）而脱离，由此通过向套筒（4）施加真空可以替代或附加地实现分离）封闭管坯（3）。

5. 发明申请

US20050133656A1 Spiraling device 有权
标题翻译：螺旋装置
公开(公告)号：US20050133656A1
公开(公告)日：2005-06-23
申请号：US10518851
申请日：2003-05-15
申请人： Markus Berger , Rainer Oehl , Klaus Binder
发明人： Markus Berger , Rainer Oehl , Klaus Binder
IPC分类号： B65H81/06 , B29C53/66 , B29C70/16 , B29L23/00
CPC分类号： B29C53/8016 , B29C70/16 , B65H49/32 , B65H59/16
摘要： A spiraling arrangement (1) for applying a spirally-shaped filament layer to an elongated carrier (2) which is drivable in the direction of the carrier longitudinal axis (X). The arrangement has a rotor (3), which is rotatable about the carrier longitudinal axis (X), and a plurality of filament bobbin carrier shafts (5) which extend in the direction of the carrier longitudinal axis (X). The carrier shafts (5) are arranged distributed on a circumscribed circle radius of the rotor (3) and are each configured to take up a plurality of filament bobbins (7). On one end face (6a) of the rotor (3), filament brake elements (10) are arranged distributed over the periphery and can be driven synchronously with respect to each other. The filaments (8) are taken off the filament bobbins (7) and are guided by filament guide elements (9) via the filament brake elements (10) and an annular comb (12), which encloses the carrier (2), onto the carrier (2).
摘要翻译：一种螺旋形布置（1），用于将螺旋状的细丝层施加到可沿着载体纵向轴线（X）的方向驱动的细长载体（2）。该装置具有绕托架纵向轴线X可转动的转子（3），以及沿托架纵向轴线（X）的方向延伸的多个长丝轴托架轴（5）。载体轴（5）分布在转子（3）的外接圆半径上，并且分别被构造成吸收多个长丝线轴（7）。在转子（3）的一个端面（6a）上，灯丝制动元件（10）布置成分布在周边上，并且可以相对于彼此同步地被驱动。灯丝（8）从灯丝筒（7）中取出，并经灯丝制动元件（10）和细丝引导元件（9）引导，环形梳（12）包围载体（2）载体（2）。

6. 发明授权

US06833272B1 Method and apparatus for determining the storage state of an ammonia-storing SCR catalyst 失效
标题翻译：用于确定储存氨的SCR催化剂的储存状态的方法和装置
公开(公告)号：US06833272B1
公开(公告)日：2004-12-21
申请号：US09608761
申请日：2000-06-30
申请人： Klaus Binder , Tillmann Braun , Michael-Rainer Busch , Aleksandar Knezevic , Klaus-Jürgen Marquardt , Ralf Moos , Carsten Plog
发明人： Klaus Binder , Tillmann Braun , Michael-Rainer Busch , Aleksandar Knezevic , Klaus-Jürgen Marquardt , Ralf Moos , Carsten Plog
IPC分类号： G01N3110
CPC分类号： B01D53/8631 , B01D53/8696 , B01D53/9431 , B01D53/9495 , F01N3/28 , F01N11/00 , F01N2550/02 , F01N2560/021 , F01N2560/12 , F01N2610/02 , F01N2900/1402 , F01N2900/1622 , Y02T10/47
摘要： A method for determining the storage state of an ammonia-storing SCR catalyst, the change in at least one physical property of the SCR catalyst material, changing with the NH3 storing process, being sensed, the measurement taking place on the SCR catalyst material itself by applying a measuring pickup to the SCR catalyst or bringing it into direct contact with the latter and determining the storage state on the basis of these results. In an alternative embodiment, a material identical or similar to the SCR catalyst material with regard to its physical properties is arranged in the exhaust-gas stream in addition to the SCR catalyst material, and the change in at least one physical property of this substitute material changing with the NH3 storing process, is sensed, the measurement taking place on the substitute material itself by applying the substitute material to the measuring pickup or bringing it into direct contact with the latter and determining the storage state of the SCR catalyst on the basis of these results.
摘要翻译：用于确定储存氨的SCR催化剂的储存状态的方法，检测到SCR催化剂材料的至少一种物理性能的变化，随着NH 3存储过程的变化而被检测，SCR催化剂材料本身由将测量拾取器施加到SCR催化剂或使其与后者直接接触，并基于这些结果确定存储状态。在替代实施例中，与SCR催化剂材料相同或相似的与其物理性质相同的材料除了SCR催化剂材料之外还布置在排气流中，并且该替代材料的至少一种物理性能的变化随着NH3储存过程的变化，通过将替代材料施加到测量拾取器或使其与后者直接接触，并且基于以下方式确定SCR催化剂的储存状态，在替代材料本身上进行测量这些结果。

7. 发明授权

US06766642B2 Exhaust-gas aftertreatment device with nitrogen oxide storage catalytic converter, and operating method therefor 有权
标题翻译：具有氮氧化物储存催化转化器的废气后处理装置及其操作方法
公开(公告)号：US06766642B2
公开(公告)日：2004-07-27
申请号：US10180567
申请日：2002-06-26
申请人： Klaus Binder , Josef Günther , Andreas Hertzberg , Brigitte Konrad , Bernd Krutzsch , Heinz-Jost Ölschlegel , Stefan Renfftlen , Dirk Voigtländer , Michel Weibel , Marko Weirich , Günter Wenninger , Rolf Wunsch
发明人： Klaus Binder , Josef Günther , Andreas Hertzberg , Brigitte Konrad , Bernd Krutzsch , Heinz-Jost Ölschlegel , Stefan Renfftlen , Dirk Voigtländer , Michel Weibel , Marko Weirich , Günter Wenninger , Rolf Wunsch
IPC分类号： F01N310
CPC分类号： F01N3/2066 , B01D53/9418 , B01D53/944 , B01D53/9477 , B01D53/9481 , B01D2255/20707 , B01D2255/20723 , B01D2255/20776 , B01D2257/304 , F01N3/0814 , F01N3/0821 , F01N3/0842 , F01N3/0885 , F01N13/009 , F01N13/0097 , F01N2570/04 , F01N2610/02 , F02B37/00 , F02D41/028 , F02D41/1475 , F02M26/00 , F02M26/05 , Y02A50/2325 , Y02T10/24
摘要： An exhaust-gas aftertreatment device with a nitrogen oxide storage catalytic converter for an internal combustion engine, and a method for operating an exhaust-gas aftertreatment device which is assigned to an internal combustion engine and has a nitrogen oxide storage catalytic converter. An SCR catalytic converter is arranged in the exhaust-gas aftertreatment device, it being possible for the exhaust gas which emerges from the nitrogen oxide storage catalytic converter to be fed to the SCR catalytic converter when the internal combustion engine is in a desulphating operating mode with a reducing exhaust-gas composition, in order for H2S which is formed during the desulphating to be removed. When the internal combustion engine is in a desulphating operating mode, the following steps are performed: establishing a reducing exhaust gas composition upstream of the nitrogen oxide storage catalytic converter; releasing the sulphur which is bound in the nitrogen oxide storage catalytic converter, to form hydrogen sulphide (H2S); feeding the hydrogen sulphide to an SCR catalytic converter which is arranged downstream of the nitrogen oxide storage catalytic converter in the exhaust-gas aftertreatment device; and reacting the hydrogen sulphide in the SCR catalytic converter to form sulphur dioxide under reducing exhaust-gas conditions. The method may be used in motor vehicles, e.g., passenger cars, with lean-burn internal combustion engines.
摘要翻译：一种用于内燃机的具有氮氧化物存储催化转化器的排气后处理装置，以及分配给内燃机并具有氮氧化物存储催化转化器的废气后处理装置的操作方法。在排气后处理装置中设置有SCR催化转换器，当内燃机处于脱硫运转模式时，从氮氧化物储存催化转化器排出的废气可以供给SCR催化转化器，还原废气组成，以便在脱硫期间形成的H 2 S被除去。当内燃机处于脱硫操作模式时，执行以下步骤：在氮氧化物存储催化转化器的上游建立还原废气组成; 释放结合在氮氧化物存储催化转化器中的硫，形成硫化氢（H 2 S）; 将硫化氢供给到排气后处理装置中的氮氧化物储存催化转化器的下游的SCR催化转化器; 并在SCR催化转化器中使硫化氢反应，在还原废气条件下形成二氧化硫。该方法可以用于具有贫燃内燃机的机动车辆，例如乘用车。

8. 发明授权

US07297220B2 Method and device for the production of curved thread-reinforced tubular structures 有权
标题翻译：用于生产弯曲螺纹加强管状结构的方法和装置
公开(公告)号：US07297220B2
公开(公告)日：2007-11-20
申请号：US10807407
申请日：2004-03-24
申请人： Markus Berger , Rainer Oehl , Klaus Binder
发明人： Markus Berger , Rainer Oehl , Klaus Binder
IPC分类号： B65H81/00
CPC分类号： B32B1/08 , B29C47/00 , B29C47/0023 , B29C47/02 , B29C47/065 , B29C53/083 , B29C53/588 , B29C53/68 , B29D22/023 , B29D23/001 , B29K2021/00 , B29K2105/101 , B29L2023/004 , B29L2023/005 , B32B25/10 , B32B37/00 , B32B2597/00 , F16L11/081
摘要： A method for the production of curved thread-reinforced tubular structures composed of rubber layers and of strengthening layers and an accompanying device. In one aspect, the method includes the application of a first rubber layer to the circumference of mandrels driven forward in a feed direction (X) and winding on of a multiplicity of parallel reinforcing threads, having defined thread angles (α) with respect to the feed axis (x), by means of a bobbin creel, to form a first thread ply. The mandrels are led through a rotating deflection element surrounding the mandrels and the reinforcing threads are guided so as to be distributed on the inner circumference. An application of a covering rubber layer may be performed (after the optionally multiple execution of the previous steps, alone or in combination). The mandrels are led through the deflection element of the bobbin creel eccentrically in the region of the deflection element.
摘要翻译：一种用于生产由橡胶层和加强层组成的弯曲螺纹加强管状结构的方法和伴随装置。在一个方面，该方法包括将第一橡胶层施加到在进给方向（X）向前驱动的心轴的圆周上，并且缠绕在多个平行的加强螺纹上，其具有相对于进给轴（x），通过梭筒架架形成第一螺纹层。心轴通过围绕心轴的旋转偏转元件引导，并且加强线被引导以分布在内圆周上。可以执行覆盖橡胶层的应用（在可选地多个执行前述步骤之后，单独地或组合地）。心轴在偏转元件的区域中偏心地穿过梭芯纱架的偏转元件。

9. 发明授权

US07063308B2 Air spring resilient member 失效
标题翻译：空气弹簧弹性件
公开(公告)号：US07063308B2
公开(公告)日：2006-06-20
申请号：US10475996
申请日：2002-04-22
申请人： Klaus Binder
发明人： Klaus Binder
IPC分类号： F16F9/04
CPC分类号： F16F9/0409
摘要： An air spring rolling-lobe flexible member is made of elastomeric material and has at least two layers of intersecting reinforcement filaments. The reinforcement filaments are arranged in an essentially parallel manner to each other at an angle between 40° and 80° to the direction of the periphery of the rolling-lobe flexible member. At least one component quantity of the reinforcement filaments (1, 2) within one layer exhibits another strength compared to the remaining component quantity thereof.
摘要翻译：空气弹簧滚动凸起柔性构件由弹性体材料制成并且具有至少两层相交的增强细丝。加强丝以与滚动凸起柔性构件的周边方向成40°至80°的角度彼此基本平行的方式布置。一层内的增强丝（1,2）的至少一个组分量与其剩余组分量相比具有另一强度。

10. 发明申请

US20050230044A1 Device and method for the detachment of a tube blank from a support core 有权
标题翻译：用于将管坯从支撑芯分离的装置和方法
公开(公告)号：US20050230044A1
公开(公告)日：2005-10-20
申请号：US10518479
申请日：2003-05-17
申请人： Markus Berger , Harald Kranz , Klaus Binder , Rainer Oehl
发明人： Markus Berger , Harald Kranz , Klaus Binder , Rainer Oehl
IPC分类号： B29C37/00 , B29C53/60 , B29D23/00 , B32B1/00
CPC分类号： B29C37/0017 , Y10T156/11 , Y10T156/1126 , Y10T156/1132 , Y10T156/19 , Y10T156/1928 , Y10T156/1944
摘要： The invention relates to a method and a device for the removal of a tube blank (3) located on a support core (2). The tube blank (2) is detached from the support core (2) by means of the introduction of a medium through a device (10), whereby a detachment may be alternatively or additionally achieved by the application of a vacuum to a sleeve (4) enclosing the tube blank (3).
摘要翻译：本发明涉及一种用于去除位于支撑芯（2）上的管坯（3）的方法和装置。管坯（2）通过介质通过装置（10）引入支撑芯（2）而脱离，由此通过向套筒（4）施加真空可以替代或附加地实现分离）封闭管坯（3）。

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