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1. 发明授权

US4393947A Sound attenuating rock drill shank 失效
标题翻译：声音衰减的岩石钻杆
公开(公告)号：US4393947A
公开(公告)日：1983-07-19
申请号：US324522
申请日：1981-11-24
申请人： Uwe Lutze , Dieter Scholz , Ernst Brennsteiner
发明人： Uwe Lutze , Dieter Scholz , Ernst Brennsteiner
IPC分类号： B25D17/12 , B25D17/11 , E21B10/44 , E21B17/00 , E21B17/22
CPC分类号： E21B10/445 , B25D17/11 , E21B17/006 , E21B17/22 , Y10S173/02 , Y10S206/811
摘要： A rock drill includes a drill shank with a boring head at one end and laterally enclosed for at least a portion of its length by a tubular shell. A helix extends around the outside of the tubular shell for carrying borings away from the boring head. Supporting members formed of a sound attenuating material are located between the helix and the other parts of the rock drill.
摘要翻译：凿岩机包括钻杆，其一端具有钻头，并通过管状壳体横向封闭其长度的至少一部分。螺旋线围绕管状壳体的外部延伸，用于将钻孔带入远离钻头。由声音衰减材料形成的支撑构件位于螺旋和凿岩机的其他部分之间。

2. 发明授权

US4565472A Drill for hand-held drilling devices 失效
标题翻译：钻机用于手持式钻孔装置
公开(公告)号：US4565472A
公开(公告)日：1986-01-21
申请号：US727207
申请日：1985-04-29
申请人： Ernst Brennsteiner , Dieter Scholz
发明人： Ernst Brennsteiner , Dieter Scholz
IPC分类号： B23B51/00 , B23B31/00 , B25D17/08 , B28D1/14 , B23B31/08 , E21B10/36
CPC分类号： B23B31/005 , B25D17/088 , B23B2231/0264 , B25D2217/0034 , Y10T279/17042 , Y10T279/17085 , Y10T408/907
摘要： A drill is secured in percussion drilling machines and in tool holders of hammer drills by locking elements. The locking elements fit into axially extending grooves formed in the axially extending circumferential surface of the shank of the drill. Webs located intermediate the ends of the grooves divide the grooves into axially extending groove sections with the locking elements fitting into the groove sections. The outer surfaces of the webs are located in the circumferential surface of the shank and serve to support the jaws of the tool holder in the correct position.
摘要翻译：打击钻机中的钻头和锤击钻机的夹具固定在锁定元件上。锁定元件装配在形成在钻头柄的轴向延伸圆周表面中的轴向延伸槽中。位于槽的端部之间的网将沟槽分成轴向延伸的槽部分，其中锁定元件装配到槽部分中。腹板的外表面位于柄的圆周表面中，用于将刀架的夹爪支撑在正确的位置。

3. 发明授权

US5538997A 2,4-diamino-3-hydroxycarboxylic acid derivatives 失效
标题翻译： 2,4-二氨基-3-羟基羧酸衍生物
公开(公告)号：US5538997A
公开(公告)日：1996-07-23
申请号：US177687
申请日：1994-01-03
申请人： Andreas Billich , Brigitte Charpiot , Peter Ettmayer , Hubert Gstach , Philipp Lehr , Dieter Scholz
发明人： Andreas Billich , Brigitte Charpiot , Peter Ettmayer , Hubert Gstach , Philipp Lehr , Dieter Scholz
IPC分类号： C07D249/08 , A61K31/165 , A61K31/19 , A61K31/195 , A61K31/215 , A61K31/325 , A61P31/12 , A61P37/04 , A61P43/00 , C07C237/10 , C07C237/20 , C07C237/22 , C07C271/22 , C07C275/16 , C07C327/20 , C07C327/38 , C07D213/40 , C07D235/30 , C07D277/74 , C07D285/12 , C07D285/125 , C07D487/04 , A61K31/21 , C07C275/26
CPC分类号： C07D213/40 , C07C237/20 , C07C237/22 , C07C271/22 , C07C275/16 , C07D277/74 , C07D285/125 , C07D487/04 , C07C2102/08
摘要： The invention relates to compounds of formula I ##STR1## wherein the substituents have various significances. They can be prepared by conventional methods, e.g. coupling, substitution, deprotection or protection reactions.They possess interesting pharmacological properties and are thus indicated for use in the treatment of retroviral infections, particularly as HIV proteinase inhibitors.
摘要翻译：本发明涉及式I化合物的含义。它们可以通过常规方法制备，例如偶联，取代，去保护或保护反应。它们具有有趣的药理学性质，因此被指示用于治疗逆转录病毒感染，特别是作为HIV蛋白酶抑制剂。

4. 发明授权

US5225107A Nucleating agents (pore regulators) for the preparation of directly gassed thermoplastic foams 失效
标题翻译：用于制备直接放气的热塑性泡沫的成核剂（孔调节剂）
公开(公告)号：US5225107A
公开(公告)日：1993-07-06
申请号：US950101
申请日：1992-09-23
申请人： Gunther Kretzschmann , Dieter Scholz , Karl-Heinz Hilgert
发明人： Gunther Kretzschmann , Dieter Scholz , Karl-Heinz Hilgert
IPC分类号： C08J9/00 , C08K3/26 , C08K3/34 , C08K5/00 , C08K5/09
CPC分类号： C08K5/0083 , C08J9/0023 , C08J9/0066 , C08K3/26 , C08K3/34 , C08K5/0008 , C08K5/09
摘要： The invention relates to new nucleating agents for the preparation of directly gassed thermoplastic foams. The new agents comprise a combination of citric acid, the salts or esters thereof and carbonate or bicarbonate and talc.
摘要翻译：本发明涉及用于制备直接充气的热塑性泡沫的新的成核剂。新的试剂包括柠檬酸，其盐或酯与碳酸盐或碳酸氢盐和滑石的组合。

5. 发明授权

US4963662A Fluorinated nucleosides and method for treating retrovirus infections therewith 失效
标题翻译：氟化核苷和用于治疗逆转录病毒感染的方法
公开(公告)号：US4963662A
公开(公告)日：1990-10-16
申请号：US223677
申请日：1988-07-15
申请人： Eckart Matthes , Christine Lehmann , Dieter Scholz , Martin von Janta-Lipinski , Klaus Gaertner , Peter Langen , Hans-Alfred Rosenthal
发明人： Eckart Matthes , Christine Lehmann , Dieter Scholz , Martin von Janta-Lipinski , Klaus Gaertner , Peter Langen , Hans-Alfred Rosenthal
IPC分类号： C07H19/073 , A61K9/00 , A61K31/505 , A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61P31/12 , A61P31/18 , C07H17/00 , C07H19/06 , C07H19/09 , C07H19/14 , C07H19/16 , C07H19/173 , C07H19/19
CPC分类号： C07H19/06 , C07H19/16
摘要： A method for treating AIDS, which comprises administering to a patient in need therefor a pharmaceutical composition comprising a therapeutically effective amount of a compound having the formula ##STR1## wherein R.sub.1 is an adenine, cytosine, guanine, thymidine, uracil, 5-substituted uracil, 5-substituted cytosine derivative, 2-fluoroadenine, 2.6-diaminopurine, 2-aminopurine, 6-thioguanine, or 7-deazaadenine group;R.sub.2 is H, or a OH group;R.sub.3 is a OH, O-acyl, O-palmitoyl group, or phosphates (as free acid, or its alkali, ammonium or alkyl ammonium salts), or any other precursor group for the hydroxyl group;or a physiologically acceptable salt thereof. Furthermore, the present invention comprises the new compounds:2',3'-dideoxy-3'-fluoro-2-fluoroadenosine,2',3'-dideoxy-3'-fluoro-6-thioguanosine,2',3'-dideoxy-3'-fluoro-2,6-diaminopurineriboside,2',3'-dideoxy-3'-fluoro-2-aminopurineriboside,2',3'-dideoxy-3'-fluoro-5-aminomethyluridine,2',3'-dideoxy-3'-fluoro-5-azidomethyluridine, and2',3'-dideoxy-3'-fluoro-5-hydroxymethyluridine.
摘要翻译：一种治疗AIDS的方法，其包括向需要的患者施用包含治疗有效量的具有下式的化合物（I）的药物组合物，其中R1是腺嘌呤，胞嘧啶，鸟嘌呤，胸苷，尿嘧啶，5 取代尿嘧啶，5-取代胞嘧啶衍生物，2-氟腺嘌呤，2,6-二氨基嘌呤，2-氨基嘌呤，6-硫鸟嘌呤或7-脱氮腺嘌呤基团; R2是H或OH基; R3是OH，O-酰基，O-棕榈酰基或磷酸酯（作为游离酸，或其碱金属，铵或烷基铵盐）或羟基的任何其它前体基团; 或其生理上可接受的盐。此外，本发明包括新化合物：2'，3'-二脱氧-3'-氟-2-氟腺苷，2'，3'-二脱氧-3'-氟-6-硫代鸟苷，2'，3'- 二脱氧-3'-氟-2,6-二氨基嘌呤，2'，3'-二脱氧-3'-氟-2-氨基嘌呤，2'，3'-二脱氧-3'-氟-5-氨甲基尿苷，2' 3'-二脱氧-3'-氟-5-叠氮基甲基尿苷和2'，3'-二脱氧-3'-氟-5-羟甲基尿苷。

6. 发明申请

US20080300237A1 Pharmaceutically Active Diazepanes 审中-公开
标题翻译：药用活性二氮杂环庚烷
公开(公告)号：US20080300237A1
公开(公告)日：2008-12-04
申请号：US11911876
申请日：2006-04-19
申请人： Berndt Oberhauser , Dieter Scholz
发明人： Berndt Oberhauser , Dieter Scholz
IPC分类号： A61K31/551 , C07D243/08
CPC分类号： C07D405/12 , C07D243/08 , C07D401/12 , C07D401/14 , C07D403/12
摘要： Leukocyte Function-Associated Antigen One (LFA-1) is a cell adhesion molecule selectively expressed on leukocytes, and plays a major role in the activation and trafficking of T lymphocytes in the tissue at sites of inflammation. In the last decade a large body of preclinical data has accumulated to establish the importance of LFA-1 as a biological target, 10 particularly in chronic, T-cell driven inflammatory conditions. The present invention provides pharmaceutically active 1,4-diazepan-2-ones of formula I useful for the treatment of conditions related to LFA-1 activity.
摘要翻译：白细胞功能相关抗原一（LFA-1）是在白细胞上选择性表达的细胞粘附分子，在炎症部位组织中T淋巴细胞的活化和运输中起主要作用。在过去十年中，积累了大量临床前数据，以确定LFA-1作为生物靶标的重要性，特别是在慢性，T细胞驱动的炎症病症中。本发明提供可用于治疗与LFA-1活性相关的病症的式I的药学活性的1,4-二氮杂环庚烷-2-酮。

7. 发明授权

US5496935A 2',3'-dideoxynucleoside pyrimidine compounds and carbocyclic analogs 失效
标题翻译： 2'，3'-双脱氧核苷嘧啶化合物和碳环类似物
公开(公告)号：US5496935A
公开(公告)日：1996-03-05
申请号：US227587
申请日：1994-04-14
申请人： Eckart Matthes , Martin von Janta-Lipinski , Dieter Scholz , Klaus Gaertner , Juergen Schildt , Christine Lehmann , Peter Langen , Hans A. Rosenthal
发明人： Eckart Matthes , Martin von Janta-Lipinski , Dieter Scholz , Klaus Gaertner , Juergen Schildt , Christine Lehmann , Peter Langen , Hans A. Rosenthal
IPC分类号： C07D405/04 , C07H19/06 , C07H19/10 , C07H15/20
CPC分类号： C07D405/04 , C07H19/06 , C07H19/10
摘要： 2',3'-dideoxynucleoside pyrimidine compounds and 2-thiothymidine carbocyclic derivatives with antiviral activity are disclosed. These compounds are expected to exhibit antiviral activity recognized for 2',3'-dideoxynucleoside compounds and analogs thereof.
摘要翻译： 2'，3'-二脱氧核苷嘧啶化合物和具有抗病毒活性的2-硫代胸苷碳环衍生物。这些化合物预期表现出对2'，3'-二脱氧核苷化合物及其类似物所识别的抗病毒活性。

8. 发明授权

US4549616A Rock drill 失效
标题翻译：摇滚钻
公开(公告)号：US4549616A
公开(公告)日：1985-10-29
申请号：US597457
申请日：1984-04-05
申请人： Gerhard Rumpp , Dieter Scholz
发明人： Gerhard Rumpp , Dieter Scholz
IPC分类号： E21B10/00 , E21B10/44 , E21B17/22
CPC分类号： E21B17/22 , E21B10/445 , Y10T408/907 , Y10T408/9097
摘要： A rock drill is formed of an axially elongated member made up of a cutting bit at one end followed by a helically grooved shaft and then ending in a shank. At least a portion of the groove, viewed in the axial direction of the member, has a stepped bottom providing groove sections of different depths. The depth of the groove section from the surface of the shaft decreases in the direction toward the shank. The groove sections with stepped bottom commence at a certain axial length from the cutting bit.
摘要翻译：凿岩机由在一端由切割钻头构成的轴向细长构件形成，随后是螺旋槽的轴，然后结束在柄中。沿着构件的轴向观察的槽的至少一部分具有提供不同深度的槽部的阶梯状底部。从轴的表面凹槽部分的深度在朝向柄部的方向上减小。具有阶梯底部的槽部分从切削刀头开始在一定的轴向长度。

9. 发明授权

US4434859A Hammer drill for performing rotary drilling or percussive drilling 失效
标题翻译：用于执行旋转钻孔或冲击钻孔的锤钻
公开(公告)号：US4434859A
公开(公告)日：1984-03-06
申请号：US392121
申请日：1982-06-25
申请人： Gerhard Rumpp , Dieter Scholz , Manfred Spieth
发明人： Gerhard Rumpp , Dieter Scholz , Manfred Spieth
IPC分类号： B23B45/16 , B23Q3/12 , B25D17/08 , E02D7/02
CPC分类号： B23Q3/12 , B25D17/088 , B25D2217/0049 , Y10T279/17076 , Y10T279/17752
摘要： A hammer drill for performing percussive drilling or rotary drilling includes a housing and a tool holder mounted on and axially displaceable relative to the housing, the tool holder contains a retainer sleeve mounting locking member for securing the shank of a tool in the holder. When the hammer drill is used only for rotary drilling, the retainer sleeve is displaced into contacting engagement with the housing for centering the tool holder. The tool holder includes stops for securing the locking members against axial displacement during rotary drilling. One stop is movable relative to the retainer sleeve and can be locked in position. Another stop forms part of the retainer sleeve. The stops combine with the closed ends of the recesses in the tool shank for holding the locking members against axial displacement.
摘要翻译：用于进行冲击钻孔或旋转钻孔的锤钻包括安装在壳体上并可相对于壳体轴向移位的壳体和工具夹具，工具夹具包括用于将工具的柄固定在保持器中的保持器套筒安装锁定构件。当锤钻仅用于旋转钻孔时，保持器套筒被移位成与壳体接触接合，以使工具夹具居中。工具架包括用于在旋转钻孔期间固定锁定构件以防止轴向位移的止动件。一个止动件可相对于保持器套筒移动并且可以锁定就位。另一个止挡形成保持套的一部分。止动件与工具柄中的凹部的封闭端部结合，用于保持锁定构件抵抗轴向位移。

10. 发明授权

US5153180A Fluorinated nucleosides and process for treating retrovirus infections therewith 失效
标题翻译：氟化核苷和用于治疗逆转录病毒感染的方法
公开(公告)号：US5153180A
公开(公告)日：1992-10-06
申请号：US566486
申请日：1990-08-13
申请人： Eckart Matthes , Christine Lehmann , Dieter Scholz , Martin von Janta-Lipinski , Klaus Gaertner , Peter Langen , Hans-Alfred Rosenthal
发明人： Eckart Matthes , Christine Lehmann , Dieter Scholz , Martin von Janta-Lipinski , Klaus Gaertner , Peter Langen , Hans-Alfred Rosenthal
IPC分类号： C07H19/06 , C07H19/16
CPC分类号： C07H19/06 , C07H19/16
摘要： A process for treating AIDS, which comprises administering to a patient in need therefor a pharmaceutical composition comprising a therapeutically effective amount of a compound having the formula ##STR1## wherein: R.sub.1 is an adenine, cytosine, guanine, thymidine, uracil, 5-substituted uracil, 5-substituted cytosine derivative, 2-fluoroadenine, 2.6-diaminopurine, 2-aminopurine, 6-thioguanine, or 7-deazaadenine group;R.sub.2 is H, or a OH group;R.sub.3 is a OH, O-acyl, O-palmitoyl group or phosphates (as free acid, or its alkali, ammonium or alkyl ammonium salts), or any other precursor group for the hydroxyl group;or a physiologically acceptable salt thereof. Furthermore, the present invention comprises the new compounds:2',3'-dideoxy-3'-fluoro-2-fluoroadenosine,2',3'-dideoxy-3'-fluoro-6-thioguanosine,2',3'-dideoxy-3'-fluoro-2,6-diaminopurineriboside,2',3'-dideoxy-3'-fluoro-2-aminopurineriboside,2',3'-dideoxy-3'-fluoro-5-aminomethyluridine,2',3'-dideoxy-3'-fluoro-5-azidomethyluridine, and2',3'-dideoxy-3'-fluoro-5-hydroxymethyluridine.
摘要翻译：治疗AIDS的方法，其包括向需要的患者施用包含治疗有效量的具有下式的化合物（I）的药物组合物，其中：R1是腺嘌呤，胞嘧啶，鸟嘌呤，胸苷，尿嘧啶， 5-取代的尿嘧啶，5-取代的胞嘧啶衍生物，2-氟腺嘌呤，2,6-二氨基嘌呤，2-氨基嘌呤，6-硫鸟嘌呤或7-脱氮腺嘌呤基团; R2是H或OH基; R3是OH，O-酰基，O-棕榈酰基或磷酸酯（作为游离酸，或其碱金属，铵或烷基铵盐）或羟基的任何其它前体基团; 或其生理上可接受的盐。此外，本发明包括新化合物：2'，3'-二脱氧-3'-氟-2-氟腺苷，2'，3'-二脱氧-3'-氟-6-硫代鸟苷，2'，3'- 二脱氧-3'-氟-2,6-二氨基嘌呤，2'，3'-二脱氧-3'-氟-2-氨基嘌呤，2'，3'-二脱氧-3'-氟-5-氨甲基尿苷，2' 3'-二脱氧-3'-氟-5-叠氮基甲基尿苷和2'，3'-二脱氧-3'-氟-5-羟甲基尿苷。

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