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1. 发明授权

US06593347B2 Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use 失效
公开(公告)号：US06593347B2
公开(公告)日：2003-07-15
申请号：US09938560
申请日：2001-08-27
申请人： Upul K. Bandarage , Qing Dong , Xinqin Fang , David S. Garvey , Gregory J. Mercer , Stewart K. Richardson , Joseph D. Schroeder , Tiansheng Wang
发明人： Upul K. Bandarage , Qing Dong , Xinqin Fang , David S. Garvey , Gregory J. Mercer , Stewart K. Richardson , Joseph D. Schroeder , Tiansheng Wang
IPC分类号： A61K31445
CPC分类号： C07D207/08 , A61K45/06 , C07C381/00 , C07C2601/14 , C07D209/28 , C07D211/22 , C07D211/26 , C07D211/54 , C07D211/62 , C07D239/47 , C07D241/06 , C07D263/20 , C07D295/088 , C07D295/185 , C07D295/192 , C07D317/32 , C07F9/4006 , C07F9/4075
摘要： The present invention describes novel nitrosated and/or nitrosylated nonsteroidal antiinflammatory compounds, and novel compositions comprising at least one nitrosated and/or nitrosylated nonsteroidal antiinflammatory compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase. The present invention also provides methods for treating, preventing and/or reducing inflammation, pain, and fever; decreasing or reversing the gastrointestinal, renal and other toxicities resulting from the use of nonsteroidal antiinflammatory drugs; treating and/or preventing gastrointestinal disorders; treating inflammatory disease states and disorders; and treating and/or preventing ophthalmic diseases or disorders.

2. 发明授权

US06297260B1 Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use 失效
标题翻译：亚硝化和亚硝化非甾体抗炎化合物，组合物和使用方法
公开(公告)号：US06297260B1
公开(公告)日：2001-10-02
申请号：US09429019
申请日：1999-10-29
申请人： Upul K. Bandarage , Qing Dong , Xinqin Fang , David S. Garvey , Gregory J. Mercer , Stewart K. Richardson , Joseph D. Schroeder , Tiansheng Wang
发明人： Upul K. Bandarage , Qing Dong , Xinqin Fang , David S. Garvey , Gregory J. Mercer , Stewart K. Richardson , Joseph D. Schroeder , Tiansheng Wang
IPC分类号： A61K31445
CPC分类号： C07D207/08 , A61K45/06 , C07C381/00 , C07C2601/14 , C07D209/28 , C07D211/22 , C07D211/26 , C07D211/54 , C07D211/62 , C07D239/47 , C07D241/06 , C07D263/20 , C07D295/088 , C07D295/185 , C07D295/192 , C07D317/32 , C07F9/4006 , C07F9/4075
摘要： The present invention describes novel nitrosated and/or nitrosylated nonsteroidal antiinflammatory compounds, and novel compositions comprising at least one nitrosated and/or nitrosylated nonsteroidal antiinflammatory compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase. The present invention also provides methods for treating, preventing and/or reducing inflammation, pain, and fever; decreasing or reversing the gastrointestinal, renal and other toxicities resulting from the use of nonsteroidal antiinflammatory drugs; treating and/or preventing gastrointestinal disorders; treating inflammatory disease states and disorders; and treating and/or preventing ophthalmic diseases or disorders.
摘要翻译：本发明描述了新的亚硝化和/或亚硝基化的非甾族化合物抗炎化合物，以及包含至少一种亚硝化和/或亚硝基化的非甾族化合物抗炎化合物的新组合物，以及任选的至少一种捐赠，转移或释放一氧化氮的化合物，提高内源性水平的内皮衍生的松弛因子，刺激一氧化氮的内源性合成，或是一氧化氮合酶的底物。本发明还提供了治疗，预防和/或减轻炎症，疼痛和发烧的方法; 减少或逆转使用非甾体抗炎药物引起的胃肠道，肾脏和其他毒性; 治疗和/或预防胃肠道疾病; 治疗炎性疾病状态和障碍; 以及治疗和/或预防眼科疾病或病症。

3. 发明授权

US08600566B1 Thermal management smart valve with rupture detection and isolation 失效
标题翻译：具有破裂检测和隔离的热管理智能阀
公开(公告)号：US08600566B1
公开(公告)日：2013-12-03
申请号：US13021580
申请日：2011-02-04
申请人： Donald R. Longo , Donald D. Dalessandro , Qing Dong , Frank T. Ferrese , John M. Roach , Michael G. Zink
发明人： Donald R. Longo , Donald D. Dalessandro , Qing Dong , Frank T. Ferrese , John M. Roach , Michael G. Zink
IPC分类号： G05D7/00
CPC分类号： F17D5/00 , F16K37/0075 , F17D3/18 , F17D5/005 , G01M3/00
摘要： The condition of a fluid piping system is monitored by multiple intercommunicative smart valves, each executing a computer algorithm that designates smart valves as critical or non-critical, compares measurement data versus simulation data, and makes decisions based on the critical-or-noncritical designations and the measurement-versus-simulation comparisons. Initial measurement-versus-simulation comparisons are made for downstream pressure, flow rate, and temperature. If a measurement-versus-simulation discrepancy is found in either the downstream pressure or the flow rate, then the algorithm compares a measurement rupture determinant versus a simulation rupture determinant; if a measurement-versus-simulation discrepancy is found in the rupture determinant, then the smart valve is closed. If a measurement-versus-simulation discrepancy is found in the temperature, then the smart valve, if non-critical, is closed; however, if the smart valve is critical, then the nearest upstream non-critical smart valve is closed. Any measurement-versus-simulation discrepancy results, at least, in an alarm or warning.
摘要翻译：流体管道系统的状况由多个互通智能阀监控，每个执行一个将智能阀指定为关键或非关键的计算机算法，将测量数据与模拟数据进行比较，并根据关键或非关键指标进行决策和测量与模拟的比较。对下游压力，流量和温度进行初始测量与模拟比较。如果在下游压力或流速中发现测量与模拟的差异，则该算法将测量断裂行为与模拟破裂行列式进行比较; 如果在断裂决定因素中发现测量与模拟的差异，则智能阀关闭。如果在温度中发现测量与模拟的差异，则智能阀（如果不重要）关闭; 然而，如果智能阀是关键的，则最近的上游非关键智能阀关闭。至少在报警或警告中，任何测量与模拟的差异都会产生。

4. 发明授权

US08509060B1 Active-avoidance-based routing in a wireless ad hoc network 失效
标题翻译：无线自组织网络中基于主动回避的路由
公开(公告)号：US08509060B1
公开(公告)日：2013-08-13
申请号：US13172137
申请日：2011-06-29
申请人： Qing Dong , Albert Ortiz , Donald D. Dalessandro , David J. Kocsik
发明人： Qing Dong , Albert Ortiz , Donald D. Dalessandro , David J. Kocsik
IPC分类号： H04J1/16 , H04L12/28 , G06F15/173 , H04L12/56
CPC分类号： H04L45/28 , H04L45/02 , H04L45/12 , H04W40/205
摘要： Conventional multi-hop routing of ad hoc wireless networks involves considerations such as costs, connection quality, distances, and numbers of hops. A conventional wireless routing algorithm may fail when a destructive event takes place and is rapidly expanding in area, as the route discoveries may perpetually lag behind the rate of expansion of the destructive area. As typically embodied, the present invention's wireless routing algorithm detects a destructive event early, assumes rapid expansion of the destruction area, establishes “subnets” of nodes, and predetermines one or more routes that circumvent the rapidly expanding destruction area by exiting from and returning to the subnet in which the destructive event originates. Typical inventive practice avails itself of the architectural character of the physical setting for the wireless network, for instance by establishing subnets corresponding to compartments formed by wall-like structures (e.g., shipboard bulkheads), which represent natural barriers to expansion of a destruction area.
摘要翻译： ad hoc无线网络的传统多跳路由涉及诸如成本，连接质量，距离和跳数的考虑。传统的无线路由算法可能在破坏性事件发生并且在区域中迅速扩大时失败，因为路由发现可能永久落后于破坏性区域的扩展速率。如通常实施的，本发明的无线路由算法早期检测到破坏性事件，假定破坏区域的快速扩展，建立节点的“子网”，并且通过退出并返回到预定义来规避快速扩大的破坏区域的一个或多个路由破坏性事件起源的子网。典型的创造性实践利用了无线网络的物理设置的架构特征，例如通过建立对应于由壁状结构（例如，船上舱壁）形成的隔间的子网，其代表破坏区域的扩展的自然障碍。

5. 发明授权

US08440689B2 Fused heteroaromatic pyrrolidinones 有权
公开(公告)号：US08440689B2
公开(公告)日：2013-05-14
申请号：US12972333
申请日：2010-12-17
申请人： Yasuyoshi Arikawa , Qing Dong , Victoria Feher , Benjamin Jones , Betty Lam , Zhe Nie , Christopher Smith , Masashi Takahashi
发明人： Yasuyoshi Arikawa , Qing Dong , Victoria Feher , Benjamin Jones , Betty Lam , Zhe Nie , Christopher Smith , Masashi Takahashi
IPC分类号： C07D471/04 , A61K31/437 , A61P11/06 , A61P19/02 , A61P17/06 , A61P35/00 , C07D487/04 , A61K31/519
CPC分类号： C07D487/04 , A61K31/437 , A61K31/519 , A61K31/527 , A61K45/06 , C07D471/04 , C07D487/10 , C07D519/00
摘要： Disclosed are compounds of Formula 1, and pharmaceutically acceptable salts thereof, wherein G, L1, L2, R1, R2, R3, and R4 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, pharmaceutical compositions containing them, and their use for treating disorders, diseases, and conditions involving the immune system and inflammation, including rheumatoid arthritis, hematological malignancies, epithelial cancers (i.e., carcinomas), and other disorders, diseases, and conditions for which inhibition of SYK is indicated.

6. 发明申请

US20120095233A1 KINASE INHIBITORS 失效
标题翻译：激酶抑制剂
公开(公告)号：US20120095233A1
公开(公告)日：2012-04-19
申请号：US12103882
申请日：2008-04-16
申请人： Jason W. Brown , Qing Dong , Bheema R. Paraselli , Jeffrey A. Stafford , Michael B. Wallace , Hasanthi Wijesekera , Nicholas Scorah
发明人： Jason W. Brown , Qing Dong , Bheema R. Paraselli , Jeffrey A. Stafford , Michael B. Wallace , Hasanthi Wijesekera , Nicholas Scorah
IPC分类号： C07D471/04 , C07D209/88
CPC分类号： C07D471/14 , C07D241/18 , C07D401/12 , C07D471/04 , C07D487/04
摘要： Compounds are provided for use with kinases that comprise a compound selected from the group consisting of: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译：提供化合物用于与包含选自以下的化合物的激酶一起使用：其中变量如本文所定义。还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。

7. 发明授权

US08119655B2 Kinase inhibitors 失效
公开(公告)号：US08119655B2
公开(公告)日：2012-02-21
申请号：US11539857
申请日：2006-10-09
申请人： Qing Dong , Bheema R. Paraselli , Nicholas Scorah , Jeffrey A. Stafford , Michael B. Wallace
发明人： Qing Dong , Bheema R. Paraselli , Nicholas Scorah , Jeffrey A. Stafford , Michael B. Wallace
IPC分类号： A61K31/437 , C07D471/04
CPC分类号： C07D471/04 , C07D471/12 , C07D487/04 , C07D487/14
摘要： Compounds, pharmaceutical compositions, kits and methods are provided for use with kinases that comprise a compound selected from the group consisting of: wherein the variables are as defined herein.

8. 发明授权

US07855288B2 Pyrrolo [1,2-d] [1,2-4] triazine as inhibitors of c-Jun N terminal kinases (JNK) and p-38 kinases 失效
标题翻译：吡咯并[1,2-d] [1,2-4]三嗪作为c-Jun N末端激酶（JNK）和p-38激酶的抑制剂
公开(公告)号：US07855288B2
公开(公告)日：2010-12-21
申请号：US11576301
申请日：2005-10-25
申请人： Qing Dong
发明人： Qing Dong
IPC分类号： C07D487/04 , A61K31/53 , A61P19/02 , A61P1/00
CPC分类号： C07D487/04
摘要： A compound of formula (I): wherein the substituents are as defined in the specification as inhibitor of C-Jun N terminal Kinases (JNK) and P-38 Kinases.
摘要翻译：式（I）的化合物：其中取代基如说明书中所定义为C-Jun N末端激酶（JNK）和P-38激酶的抑制剂。

9. 发明授权

US07653490B2 Nuclear magnetic resonance assembly of chemical entities 失效
标题翻译：化学实体的核磁共振组件
公开(公告)号：US07653490B2
公开(公告)日：2010-01-26
申请号：US10172485
申请日：2002-06-13
申请人： Daniel S. Sem , Maurizio Pellecchia , Qing Dong , Mark Kelly , Min S. Lee
发明人： Daniel S. Sem , Maurizio Pellecchia , Qing Dong , Mark Kelly , Min S. Lee
IPC分类号： G06F7/00
CPC分类号： G01N33/542 , G01N24/08
摘要： The invention provides a method for obtaining a binding compound for a protein family, wherein the members of the protein family bind a common ligand. The method includes the steps of (a) providing a sample containing a protein from the protein family, a first ligand and a second ligand under conditions wherein the first ligand, the second ligand and the protein form a bound complex; (b) detecting magnetization transfer between the first ligand and the second ligand in the bound complex, thereby determining that the two ligands are proximal in the bound complex; and (c) obtaining a candidate binding compound including the first ligand, or a fragment thereof linked to the second ligand, or a homolog thereof, whereby the population contains binding compounds that bind to members of the protein family.
摘要翻译：本发明提供了一种获得蛋白质家族的结合化合物的方法，其中蛋白质家族的成员结合共同的配体。该方法包括以下步骤：（a）在第一配体，第二配体和蛋白质形成结合复合物的条件下，提供含有来自蛋白质家族的蛋白质的样品，第一配体和第二配体; （b）检测结合的络合物中第一配体和第二配体之间的磁化转移，由此确定两个配体在结合复合物中的近端; 和（c）获得包含与第二配体连接的第一配体或其片段或其同系物的候选结合化合物，其中所述群体含有结合蛋白家族成员的结合化合物。

10. 发明申请

US20080312307A1 MAPK/ERK KINASE INHIBITORS 审中-公开
标题翻译： MAPK / ERK激酶抑制剂
公开(公告)号：US20080312307A1
公开(公告)日：2008-12-18
申请号：US12126772
申请日：2008-05-23
申请人： Mark E. Adams , Qing Dong , Stephen W. Kaldor , Jeffrey A. Stafford , Michael B. Wallace
发明人： Mark E. Adams , Qing Dong , Stephen W. Kaldor , Jeffrey A. Stafford , Michael B. Wallace
IPC分类号： A61K31/403 , C07D209/02 , A61P11/00 , A61P13/12 , A61P29/00 , A61P35/00 , C07D209/52
CPC分类号： C07D209/42 , C07D209/52
摘要： Compounds are provided for inhibition of MEK that comprise: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译：提供化合物用于抑制MEK，其包含：其中变量如本文所定义。还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。

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