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1. 发明授权

US07653490B2 Nuclear magnetic resonance assembly of chemical entities 失效
标题翻译：化学实体的核磁共振组件
公开(公告)号：US07653490B2
公开(公告)日：2010-01-26
申请号：US10172485
申请日：2002-06-13
申请人： Daniel S. Sem , Maurizio Pellecchia , Qing Dong , Mark Kelly , Min S. Lee
发明人： Daniel S. Sem , Maurizio Pellecchia , Qing Dong , Mark Kelly , Min S. Lee
IPC分类号： G06F7/00
CPC分类号： G01N33/542 , G01N24/08
摘要： The invention provides a method for obtaining a binding compound for a protein family, wherein the members of the protein family bind a common ligand. The method includes the steps of (a) providing a sample containing a protein from the protein family, a first ligand and a second ligand under conditions wherein the first ligand, the second ligand and the protein form a bound complex; (b) detecting magnetization transfer between the first ligand and the second ligand in the bound complex, thereby determining that the two ligands are proximal in the bound complex; and (c) obtaining a candidate binding compound including the first ligand, or a fragment thereof linked to the second ligand, or a homolog thereof, whereby the population contains binding compounds that bind to members of the protein family.
摘要翻译：本发明提供了一种获得蛋白质家族的结合化合物的方法，其中蛋白质家族的成员结合共同的配体。该方法包括以下步骤：（a）在第一配体，第二配体和蛋白质形成结合复合物的条件下，提供含有来自蛋白质家族的蛋白质的样品，第一配体和第二配体; （b）检测结合的络合物中第一配体和第二配体之间的磁化转移，由此确定两个配体在结合复合物中的近端; 和（c）获得包含与第二配体连接的第一配体或其片段或其同系物的候选结合化合物，其中所述群体含有结合蛋白家族成员的结合化合物。

2. 发明授权

US07964534B2 Nuclear magnetic resonance assembly of chemical entities using advanced antenna probes 有权
标题翻译：使用先进天线探头的化学实体的核磁共振组件
公开(公告)号：US07964534B2
公开(公告)日：2011-06-21
申请号：US10799934
申请日：2004-03-12
申请人： Mark Kelly , Hugo Villar , Jianqiang Wang , Min S. Lee , Yong Qin , Daniel S. Sem
发明人： Mark Kelly , Hugo Villar , Jianqiang Wang , Min S. Lee , Yong Qin , Daniel S. Sem
IPC分类号： C40B20/04 , C40B20/08 , C40B30/04 , C40B30/10 , G01N33/53 , G01N33/48 , G06G7/58
CPC分类号： G01N24/088 , G01N24/08 , G01N33/542 , G01R33/4608 , G01R33/465
摘要： The invention provides a method for identifying a ligand that binds to a macromolecular target. The methods involve (a) attaching an antenna moiety to a first ligand, wherein the ligand binds specifically to a macromolecular target; (b) providing a sample comprising the macromolecular target, the first ligand and a candidate second ligand under conditions wherein the first ligand and the macromolecular target form a bound complex; (c) detecting a subset of magnetization transfer signals between the antenna moiety of the first ligand and the second candidate ligand, wherein the signals are obtained from an isotope edited NOESY spectrum of the sample; thereby determining that the two ligands are proximal in a bound complex, and identifying a second ligand that binds to the macromolecular target.
摘要翻译：本发明提供了鉴定与大分子靶标结合的配体的方法。所述方法包括（a）将天线部分连接到第一配体，其中所述配体特异性结合于大分子靶; （b）在第一配体和大分子靶形成结合复合物的条件下提供包含大分子靶，第一配体和候选第二配体的样品; （c）检测第一配体的天线部分和第二候选配体之间的磁化传递信号的子集，其中信号是从样品的同位素编辑的NOESY光谱获得的; 从而确定两个配体在结合的复合物中是近端的，并鉴定结合大分子靶标的第二配体。

3. 发明申请

US20110118148A1 NUCLEAR MAGNETIC RESONANCE ASSEMBLY OF CHEMICAL ENTITIES USING ADVANCED ANTENNA PROBES 有权
标题翻译：使用高级天线探针的化学实验的核磁共振组装
公开(公告)号：US20110118148A1
公开(公告)日：2011-05-19
申请号：US10799934
申请日：2004-03-12
申请人： Mark Kelly , Hugo Villar , Jianqiang Wang , Min S. Lee , Yong Qin , Daniel S. Sem
发明人： Mark Kelly , Hugo Villar , Jianqiang Wang , Min S. Lee , Yong Qin , Daniel S. Sem
IPC分类号： C40B50/00 , C40B20/04 , G01N33/68 , C07D401/04
CPC分类号： G01N24/088 , G01N24/08 , G01N33/542 , G01R33/4608 , G01R33/465
摘要： The invention provides a method for identifying a ligand that binds to a macromolecular target. The methods involve (a) attaching an antenna moiety to a first ligand, wherein the ligand binds specifically to a macromolecular target; (b) providing a sample comprising the macromolecular target, the first ligand and a candidate second ligand under conditions wherein the first ligand and the macromolecular target form a bound complex; (c) detecting a subset of magnetization transfer signals between the antenna moiety of the first ligand and the second candidate ligand, wherein the signals are obtained from an isotope edited NOESY spectrum of the sample; thereby determining that the two ligands are proximal in a bound complex, and identifying a second ligand that binds to the macromolecular target.
摘要翻译：本发明提供了鉴定与大分子靶标结合的配体的方法。所述方法包括（a）将天线部分连接到第一配体，其中所述配体特异性结合于大分子靶; （b）在第一配体和大分子靶形成结合复合物的条件下提供包含大分子靶，第一配体和候选第二配体的样品; （c）检测第一配体的天线部分和第二候选配体之间的磁化传递信号的子集，其中信号是从样品的同位素编辑的NOESY光谱获得的; 从而确定两个配体在结合的复合物中是近端的，并鉴定结合大分子靶标的第二配体。

4. 发明授权

US08173370B2 Nucleic acid-based tests for RHD typing, gender determination and nucleic acid quantification 有权
标题翻译：用于RHD分型，性别测定和核酸定量的基于核酸的测试
公开(公告)号：US08173370B2
公开(公告)日：2012-05-08
申请号：US12027954
申请日：2008-02-07
申请人： Paul A. Oeth , Mathias Ehrich , Min S. Lee
发明人： Paul A. Oeth , Mathias Ehrich , Min S. Lee
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6881 , C12Q2600/156 , C12Q2600/16
摘要： The invention in part provides nucleic acid-based assays, which are particularly useful for non-invasive prenatal testing. The invention in part provides compositions and methods for RhD typing, detecting the presence of fetal nucleic in a sample, determining the relative amount of fetal nucleic acid in a sample and determining the sex of a fetus, wherein each of the assays may be performed alone or in combination.
摘要翻译：本发明部分提供基于核酸的测定法，其特别适用于非侵入性产前检测。本发明部分提供用于RhD分型的组合物和方法，检测样品中胎儿核酸的存在，确定样品中胎儿核酸的相对量并确定胎儿的性别，其中每个测定可以单独进行或组合。

5. 发明授权

US07008941B2 Reverse-turn mimetics and methods relating thereto 有权
标题翻译：反转模拟物及其相关方法
公开(公告)号：US07008941B2
公开(公告)日：2006-03-07
申请号：US10150481
申请日：2002-05-16
申请人： Jan Urban , Hiroshi Nakanishi , Min S. Lee
发明人： Jan Urban , Hiroshi Nakanishi , Min S. Lee
IPC分类号： G01N33/53 , G08D498/04
CPC分类号： C07D487/04 , C07D487/14
摘要： Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins having the following structure are disclosed: wherein A, B, X, R1, and R5 are as defined herein. Such compounds have utility over a wide range of fields, including use as diagnostic and therapeutic agents. In particular, compounds of this invention are useful in pharmaceutical compositions as anti-inflammatory agents as well as inhibitors of central nervous disorders. Libraries containing the compounds of this invention are also disclosed, as well as methods for screening the same to identify biologically active members.
摘要翻译：公开了具有以下结构的模拟具有生物活性肽和蛋白质的反向转转区域的二级结构的构象约束化合物：其中A，B，X，R 1和R 5， / SUB>如本文所定义。这些化合物可用于广泛的领域，包括用作诊断和治疗剂。特别地，本发明的化合物可用作作为抗炎剂的药物组合物以及中枢神经障碍的抑制剂。还公开了含有本发明化合物的文库，以及筛选该文库以鉴定生物活性成员的方法。

6. 发明申请

US20080299562A1 NUCLEIC ACID-BASED TESTS FOR RHD TYPING, GENDER DETERMINATION AND NUCLEIC ACID QUANTIFICATION 有权
标题翻译：基于核酸的测试用于RHD型，性别测定和核酸定量
公开(公告)号：US20080299562A1
公开(公告)日：2008-12-04
申请号：US12027954
申请日：2008-02-07
申请人： Paul A. Oeth , Mathias Ehrich , Min S. Lee
发明人： Paul A. Oeth , Mathias Ehrich , Min S. Lee
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q2600/156 , C12Q2600/16
摘要： The invention in part provides nucleic acid-based assays, which are particularly useful for non-invasive prenatal testing. The invention in part provides compositions and methods for RhD typing, detecting the presence of fetal nucleic in a sample, determining the relative amount of fetal nucleic acid in a sample and determining the sex of a fetus, wherein each of the assays may be performed alone or in combination.
摘要翻译：本发明部分提供基于核酸的测定法，其特别适用于非侵入性产前检测。本发明部分提供用于RhD分型的组合物和方法，检测样品中胎儿核酸的存在，确定样品中胎儿核酸的相对量并确定胎儿的性别，其中每个测定可以单独进行或组合。

7. 发明授权

US5355185A Nose pad-free eye glass frame 失效
标题翻译：鼻子无垫眼镜框
公开(公告)号：US5355185A
公开(公告)日：1994-10-11
申请号：US065230
申请日：1993-05-24
申请人： Min S. Lee
发明人： Min S. Lee
IPC分类号： G02C3/02 , G02C3/00 , G02C11/00 , G02C9/00
CPC分类号： G02C3/003 , G02C3/02
摘要： The eye glass frame is comprised of a pair of rims for receiving the lenses; side temples connected at one end to the outside edge of each rim, each side temple formed to rest behind the wearer's ears; and at least one supporting member attached to the side temple for securing the eye glass frame to the wearer's hair to properly position the lenses relative to the wearer's eyes. The glass frame may have several supporting members, which have several alternative configurations. That is, the supporting member may be comprised of at least one joint member attached to the side temple, and at least one head seating member formed at the free end of the joint member. The supporting member may be further comprised of at least one connecting member provided between the joint member and the head seating member. The head seating member has several alternative configurations.
摘要翻译：眼镜架由一对用于接收镜片的边缘组成; 在一端连接到每个边缘的外边缘的侧腿部，每个侧部镜腿形成为搁置在佩戴者耳朵后面; 以及至少一个支撑构件，其附接到侧面镜腿，用于将眼镜框架固定到穿戴者的头发上，以相对于佩戴者的眼睛适当地定位透镜。玻璃框架可以具有几个支撑构件，其具有若干替代构造。也就是说，支撑构件可以由附接到侧镜的至少一个关节构件和形成在接合构件的自由端处的至少一个头座构件构成。支撑构件还可以包括设置在接头构件和头座构件之间的至少一个连接构件。顶座构件具有若干替代构造。

8. 发明授权

US5116323A Arterial catheter 失效
标题翻译：动脉导管
公开(公告)号：US5116323A
公开(公告)日：1992-05-26
申请号：US644067
申请日：1991-01-22
申请人： James A. Kreuzer , Min S. Lee
发明人： James A. Kreuzer , Min S. Lee
IPC分类号： A61M25/06
CPC分类号： A61M25/0612
摘要： An assembly is provided for easing the insertion and placement of an arterial catheter in the blood vessel of a patient. The assembly includes the combination of an insertion needle and guide tube which pass through the lumen of a catheter, and prior to use extends slightly out of the distal end of the catheter. The needle, in turn, extends slightly out of the distal end of the guide tube and serves to make the initial insertion through the skin and into the blood vessel. Once initial insertion is made, as indicated by blood "flash back" to the transparent needle hub, the guide tube is advanced through the catheter to provide a tracking path for the catheter. Once the distal end of the catheter has followed the guide tube path, the guide tube and needle are withdrawn. A feature of the invention is a guide tube slide arrangement for controlling the advance and retraction of the guide tube.
摘要翻译：提供了一种用于减轻动脉导管在患者的血管中的插入和放置的组件。该组件包括穿过导管内腔的插入针和引导管的组合，并且在使用之前稍微延伸出导管的远端。针又反过来从引导管的远端稍微延伸，并用于初始插入穿过皮肤并进入血管。一旦进行初始插入，如血液“闪回”到透明针座所示，引导管前进通过导管以提供用于导管的跟踪路径。一旦导管的远端跟随引导管路径，引导管和针就被撤回。本发明的特征是用于控制导管的前进和后退的导向管滑动装置。

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