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1. 发明授权

US07653490B2 Nuclear magnetic resonance assembly of chemical entities 失效
标题翻译：化学实体的核磁共振组件
公开(公告)号：US07653490B2
公开(公告)日：2010-01-26
申请号：US10172485
申请日：2002-06-13
申请人： Daniel S. Sem , Maurizio Pellecchia , Qing Dong , Mark Kelly , Min S. Lee
发明人： Daniel S. Sem , Maurizio Pellecchia , Qing Dong , Mark Kelly , Min S. Lee
IPC分类号： G06F7/00
CPC分类号： G01N33/542 , G01N24/08
摘要： The invention provides a method for obtaining a binding compound for a protein family, wherein the members of the protein family bind a common ligand. The method includes the steps of (a) providing a sample containing a protein from the protein family, a first ligand and a second ligand under conditions wherein the first ligand, the second ligand and the protein form a bound complex; (b) detecting magnetization transfer between the first ligand and the second ligand in the bound complex, thereby determining that the two ligands are proximal in the bound complex; and (c) obtaining a candidate binding compound including the first ligand, or a fragment thereof linked to the second ligand, or a homolog thereof, whereby the population contains binding compounds that bind to members of the protein family.
摘要翻译：本发明提供了一种获得蛋白质家族的结合化合物的方法，其中蛋白质家族的成员结合共同的配体。该方法包括以下步骤：（a）在第一配体，第二配体和蛋白质形成结合复合物的条件下，提供含有来自蛋白质家族的蛋白质的样品，第一配体和第二配体; （b）检测结合的络合物中第一配体和第二配体之间的磁化转移，由此确定两个配体在结合复合物中的近端; 和（c）获得包含与第二配体连接的第一配体或其片段或其同系物的候选结合化合物，其中所述群体含有结合蛋白家族成员的结合化合物。

2. 发明授权

US07964534B2 Nuclear magnetic resonance assembly of chemical entities using advanced antenna probes 有权
标题翻译：使用先进天线探头的化学实体的核磁共振组件
公开(公告)号：US07964534B2
公开(公告)日：2011-06-21
申请号：US10799934
申请日：2004-03-12
申请人： Mark Kelly , Hugo Villar , Jianqiang Wang , Min S. Lee , Yong Qin , Daniel S. Sem
发明人： Mark Kelly , Hugo Villar , Jianqiang Wang , Min S. Lee , Yong Qin , Daniel S. Sem
IPC分类号： C40B20/04 , C40B20/08 , C40B30/04 , C40B30/10 , G01N33/53 , G01N33/48 , G06G7/58
CPC分类号： G01N24/088 , G01N24/08 , G01N33/542 , G01R33/4608 , G01R33/465
摘要： The invention provides a method for identifying a ligand that binds to a macromolecular target. The methods involve (a) attaching an antenna moiety to a first ligand, wherein the ligand binds specifically to a macromolecular target; (b) providing a sample comprising the macromolecular target, the first ligand and a candidate second ligand under conditions wherein the first ligand and the macromolecular target form a bound complex; (c) detecting a subset of magnetization transfer signals between the antenna moiety of the first ligand and the second candidate ligand, wherein the signals are obtained from an isotope edited NOESY spectrum of the sample; thereby determining that the two ligands are proximal in a bound complex, and identifying a second ligand that binds to the macromolecular target.
摘要翻译：本发明提供了鉴定与大分子靶标结合的配体的方法。所述方法包括（a）将天线部分连接到第一配体，其中所述配体特异性结合于大分子靶; （b）在第一配体和大分子靶形成结合复合物的条件下提供包含大分子靶，第一配体和候选第二配体的样品; （c）检测第一配体的天线部分和第二候选配体之间的磁化传递信号的子集，其中信号是从样品的同位素编辑的NOESY光谱获得的; 从而确定两个配体在结合的复合物中是近端的，并鉴定结合大分子靶标的第二配体。

3. 发明申请

US20110118148A1 NUCLEAR MAGNETIC RESONANCE ASSEMBLY OF CHEMICAL ENTITIES USING ADVANCED ANTENNA PROBES 有权
标题翻译：使用高级天线探针的化学实验的核磁共振组装
公开(公告)号：US20110118148A1
公开(公告)日：2011-05-19
申请号：US10799934
申请日：2004-03-12
申请人： Mark Kelly , Hugo Villar , Jianqiang Wang , Min S. Lee , Yong Qin , Daniel S. Sem
发明人： Mark Kelly , Hugo Villar , Jianqiang Wang , Min S. Lee , Yong Qin , Daniel S. Sem
IPC分类号： C40B50/00 , C40B20/04 , G01N33/68 , C07D401/04
CPC分类号： G01N24/088 , G01N24/08 , G01N33/542 , G01R33/4608 , G01R33/465
摘要： The invention provides a method for identifying a ligand that binds to a macromolecular target. The methods involve (a) attaching an antenna moiety to a first ligand, wherein the ligand binds specifically to a macromolecular target; (b) providing a sample comprising the macromolecular target, the first ligand and a candidate second ligand under conditions wherein the first ligand and the macromolecular target form a bound complex; (c) detecting a subset of magnetization transfer signals between the antenna moiety of the first ligand and the second candidate ligand, wherein the signals are obtained from an isotope edited NOESY spectrum of the sample; thereby determining that the two ligands are proximal in a bound complex, and identifying a second ligand that binds to the macromolecular target.
摘要翻译：本发明提供了鉴定与大分子靶标结合的配体的方法。所述方法包括（a）将天线部分连接到第一配体，其中所述配体特异性结合于大分子靶; （b）在第一配体和大分子靶形成结合复合物的条件下提供包含大分子靶，第一配体和候选第二配体的样品; （c）检测第一配体的天线部分和第二候选配体之间的磁化传递信号的子集，其中信号是从样品的同位素编辑的NOESY光谱获得的; 从而确定两个配体在结合的复合物中是近端的，并鉴定结合大分子靶标的第二配体。

4. 发明授权

US08535364B2 Methods and apparati for the close application of therapeutic and other devices to the pelvic area 有权
标题翻译：治疗和其他设备对骨盆区域的紧密应用的方法和设备
公开(公告)号：US08535364B2
公开(公告)日：2013-09-17
申请号：US12572267
申请日：2009-10-01
申请人： Geoffrey Margolis , Mark Kelly , Peter Loisides
发明人： Geoffrey Margolis , Mark Kelly , Peter Loisides
IPC分类号： A61F7/00 , A61F7/02
CPC分类号： A61F7/00 , A61F7/10 , A61F2007/0048 , A61F2007/023
摘要： Embodiments of the present invention are directed to apparati and associated methods for an easy on-off device to support and provide direct therapeutic cooling relief to the affected genitalia of persons having post-operative pain and swelling.
摘要翻译：本发明的实施例涉及用于容易开关装置的装置和相关方法，以支持并向患有手术后疼痛和肿胀的人的受影响的生殖器提供直接的治疗性冷却缓解。

5. 发明申请

US20130091224A1 Managing Meetings Relative to Messages 审中-公开
标题翻译：管理与消息相关的会议
公开(公告)号：US20130091224A1
公开(公告)日：2013-04-11
申请号：US13253401
申请日：2011-10-05
申请人： Al Chakra , Liam Harpur , Mark Kelly , John Rice
发明人： Al Chakra , Liam Harpur , Mark Kelly , John Rice
IPC分类号： G06F15/16
CPC分类号： G06Q10/107 , H04L12/1818
摘要： Methods and systems of managing meetings may involve intercepting an outgoing message from a sender to a recipient, and conducting an analysis of the outgoing message with respect to a calendar associated with the sender. In addition, delivery of the message may be suspended if the analysis indicates that the sender and the recipient have a scheduled meeting. In one example, the outgoing message includes at least one of an email message, a chat message and a text message.
摘要翻译：管理会议的方法和系统可能涉及截取从发送者到接收方的外发消息，并且对与发送者相关联的日历进行对外发消息的分析。此外，如果分析指示发送者和接收者有预定会议，则可能会暂停邮件的传递。在一个示例中，传出消息包括电子邮件消息，聊天消息和文本消息中的至少一个。

6. 发明申请

US20120233563A1 Acclimatizing a User to a Scheduling Pattern Change 有权
标题翻译：将用户适应调度模式更改
公开(公告)号：US20120233563A1
公开(公告)日：2012-09-13
申请号：US13045226
申请日：2011-03-10
申请人： Al Chakra , Liam Harpur , Mark Kelly , John Rice
发明人： Al Chakra , Liam Harpur , Mark Kelly , John Rice
IPC分类号： G06F3/048
CPC分类号： G06Q10/06312 , G06F3/0481 , G06Q10/1093
摘要： Acclimatizing a user to a scheduling pattern change includes: in a calendar system implemented by at least one processor, determining an anticipated scheduling pattern change for the user; establishing with the calendar system an acclimatization period to transition the user to the scheduling pattern change; receiving in the calendar system a request to schedule an event for the user at a time within the acclimatization period; and prompting the user to reschedule the event to a time outside of the acclimatization period with the calendar system.
摘要翻译：将用户适应调度模式改变包括：在由至少一个处理器实现的日历系统中，确定用户的预期调度模式改变; 与日历系统建立适应期，以将用户转变为调度模式变化; 在日历系统中接收在适应期内的时间段为用户安排事件的请求; 并提示用户使用日历系统将活动重新安排到适应期之外的时间。

7. 发明申请

US20070243062A1 Steam turbine variable clearance packing 失效
标题翻译：蒸汽轮机可变间隙包装
公开(公告)号：US20070243062A1
公开(公告)日：2007-10-18
申请号：US11404956
申请日：2006-04-14
申请人： Richard Chevrette , Flor Rivas , Frederick Baily , William Adis , Mark Kelly , Bernard Couture , Kurt Laurer
发明人： Richard Chevrette , Flor Rivas , Frederick Baily , William Adis , Mark Kelly , Bernard Couture , Kurt Laurer
IPC分类号： F04D29/10
CPC分类号： F01D11/003 , F05D2220/31 , F16J15/442 , F16J15/445
摘要： Disclosed herein is a packing ring assembly including a packing ring segment, a bar, a cover plate, and a spring. The packing ring segment has an axial slot. The bar is disposed within the slot. The cover plate is disposed along an outer periphery of the packing ring segment. And, the spring is compressed between the bar and the cover plate.
摘要翻译：本文公开了一种包装环组件，其包括填料环段，棒，盖板和弹簧。填料环段具有轴向槽。该栏设置在槽内。盖板沿着包装环段的外周设置。并且，弹簧在杆和盖板之间被压缩。

8. 发明申请

US20070090256A1 Heated/Cooled Cup Holder and Sealing Unit 有权
标题翻译：加热/冷却杯支架和密封单元
公开(公告)号：US20070090256A1
公开(公告)日：2007-04-26
申请号：US11539701
申请日：2006-10-09
申请人： Alison Hansen , Christopher Reynolds , Mark Kelly
发明人： Alison Hansen , Christopher Reynolds , Mark Kelly
IPC分类号： A47K1/08
CPC分类号： B60N3/101 , B60N3/108
摘要： A cup holder, wherein the cup holder comprises a well adapted to receive a beverage container through an open top of the well. The cup holder also includes a sealing unit having a ring seal secured to the well adjacent to the open top of the well. The ring seal engages the container when the container is disposed in the well to cooperate with the well in providing a substantially closed and sealed chamber resistant to heat transfer to or from the chamber.
摘要翻译：一种杯架，其中所述杯架包括适于通过所述井的敞开顶部容纳饮料容器的井。杯架还包括密封单元，该密封单元具有固定到与井的开口顶部相邻的井的环形密封件。当容器设置在井中时，环形密封件接合容器，以与井相配合，以提供基本上封闭且密封的室，其耐受到室或从室的传热。

9. 发明申请

US20070053772A1 Methods and apparatus for assembling a rotary machine 失效
标题翻译：组装旋转机器的方法和装置
公开(公告)号：US20070053772A1
公开(公告)日：2007-03-08
申请号：US11219268
申请日：2005-09-02
申请人： Bernard Couture , Flor Del Rivas , Mark Kelly , Jason Mortzheim
发明人： Bernard Couture , Flor Del Rivas , Mark Kelly , Jason Mortzheim
IPC分类号： F01D11/08
CPC分类号： F16J15/445 , F01D11/001 , F01D11/025 , F05D2220/31 , F16J15/442
摘要： A method for assembling at least one seal assembly to a turbine having a casing extending at least partially around a rotor is provided. The method includes coupling the seal assembly to the casing such that the seal assembly extends into a fluid flow passage defined between the rotor and the casing and coupling at least one spring between the seal assembly and the casing to bias each seal assembly.
摘要翻译：提供了一种用于将至少一个密封组件组装到具有至少部分地围绕转子延伸的壳体的涡轮机的方法。该方法包括将密封组件联接到壳体，使得密封组件延伸到限定在转子和壳体之间的流体流动通道中，并且在密封组件和壳体之间联接至少一个弹簧以偏置每个密封组件。

10. 发明授权

US6046126A Titanium process for making catalyst 失效
标题翻译：钛催化剂工艺
公开(公告)号：US6046126A
公开(公告)日：2000-04-04
申请号：US76515
申请日：1998-05-12
申请人： Mark Kelly , Dusan Jeremic , Victoria Ker , Charles Russell
发明人： Mark Kelly , Dusan Jeremic , Victoria Ker , Charles Russell
IPC分类号： B01J31/12 , B01J31/14 , C08F4/617 , C08F210/16 , B01J31/38 , B01J31/26
CPC分类号： B01J31/128 , B01J31/143 , C08F210/16
摘要： The present invention provides a novel process for preparing a catalyst, preferably free of electron donor, useful in gas phase polymerization of olefins having a broad polydispersity.
摘要翻译：本发明提供了一种制备催化剂的新方法，该催化剂优选不含电子给体，可用于具有广泛多分散性的烯烃的气相聚合。

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