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1. 发明申请

US20060088565A1 Device having osteoinductive and osteoconductive properties 失效
标题翻译：具有骨诱导和骨传导性能的装置
公开(公告)号：US20060088565A1
公开(公告)日：2006-04-27
申请号：US10496399
申请日：2002-03-27
申请人： Ulrich Kohnert , Sylke Pohling , Klaus Hellerbrand , Peter Happersberger
发明人： Ulrich Kohnert , Sylke Pohling , Klaus Hellerbrand , Peter Happersberger
IPC分类号： A61K38/17 , A61K8/96 , A61K31/7012
CPC分类号： A61L27/227 , A61L24/02 , A61L24/108 , A61L27/12 , A61L27/34
摘要： The present invention relates to a device having osteoinductive and osteoconductive properties in vivo comprising a carrier containing calcium phosphate and an osteoinductive protein, wherein said carrier is homogenously coated with said protein. Moreover, the present invention relates to a method for the production of a device having osteoinductive and osteoconductive properties in vivo. The invention encompasses a pharmaceutical composition comprising the device of the invention or a device which is obtainable by the method of the invention and relates to the use of said device for the preparation of a pharmaceutical composition to be used for bone augmentation, for treating bone defects, for treating degenerative and traumatic disc disease, for treating bone dehiscence or to be used for sinus floor elevation. Finally, the invention relates to a kit comprising the device of the invention or a device which is obtainable by the method of the invention.
摘要翻译：本发明涉及一种在体内具有骨诱导和骨传导性质的装置，其包含含有磷酸钙和骨诱导蛋白的载体，其中所述载体均匀地涂覆有所述蛋白质。此外，本发明涉及在体内制造具有骨诱导性和骨传导性的装置的方法。本发明包括药物组合物，其包含本发明的装置或可通过本发明的方法获得的装置，并且涉及所述装置用于制备用于骨增大的药物组合物用于治疗骨缺损的用途用于治疗退行性和创伤性椎间盘疾病，用于治疗骨开裂或用于窦底抬高。最后，本发明涉及包含本发明的装置或可通过本发明的方法获得的装置的试剂盒。

2. 发明授权

US08546334B2 Device having osteoinductive and osteoconductive properties 失效
标题翻译：具有骨诱导和骨传导性能的装置
公开(公告)号：US08546334B2
公开(公告)日：2013-10-01
申请号：US10496399
申请日：2002-03-27
申请人： Ulrich Kohnert , Sylke Pohling , Klaus Hellerbrand , Peter Happersberger
发明人： Ulrich Kohnert , Sylke Pohling , Klaus Hellerbrand , Peter Happersberger
IPC分类号： A61K38/19 , A61K47/02 , C07K14/51 , A61P19/08
CPC分类号： A61L27/227 , A61L24/02 , A61L24/108 , A61L27/12 , A61L27/34
摘要： The present invention relates to a device having osteoinductive and osteoconductive properties in vivo comprising a carrier containing calcium phosphate and an osteoinductive protein, wherein the carrier is homogenously coated with the protein. Moreover, the present invention relates to a method for the production of a device having osteoinductive and osteoconductive properties in vivo. The invention encompasses a pharmaceutical composition comprising the device of the invention or a device which is obtainable by the method of the invention and relates to the use of the device for the preparation of a pharmaceutical composition to be used for bone augmentation, for treating bone defects, for treating degenerative and traumatic disc disease, for treating bone dehiscence or to be used for sinus floor elevation. Finally, the invention relates to a kit comprising the device of the invention or a device which is obtainable by the method of the invention.
摘要翻译：本发明涉及一种在体内具有骨诱导和骨传导性质的装置，其包含含有磷酸钙和骨诱导蛋白的载体，其中载体均匀地被蛋白质包被。此外，本发明涉及在体内制造具有骨诱导性和骨传导性的装置的方法。本发明包括药物组合物，其包含本发明的装置或可通过本发明的方法获得的装置，涉及该装置用于制备用于骨增大的药物组合物的用途，用于治疗骨缺损用于治疗退行性和创伤性椎间盘疾病，用于治疗骨开裂或用于窦底抬高。最后，本发明涉及包含本发明的装置或可通过本发明的方法获得的装置的试剂盒。

3. 发明授权

US07763270B2 Metal implant coated under reduced oxygen concentration with osteoinductive protein 失效
标题翻译：金属植入物在降低氧浓度下用骨诱导蛋白包被
公开(公告)号：US07763270B2
公开(公告)日：2010-07-27
申请号：US10527047
申请日：2003-07-09
申请人： Klaus Hellerbrand , Nicola Beaucamp , Ulrich Kohnert
发明人： Klaus Hellerbrand , Nicola Beaucamp , Ulrich Kohnert
IPC分类号： A61F2/00 , A61K33/00 , A61K33/24
CPC分类号： A61L27/04 , A61C8/0012 , A61C8/0013 , A61F2/30767 , A61F2/32 , A61F2/38 , A61F2/3804 , A61F2/4202 , A61F2/4241 , A61F2/44 , A61F2310/00023 , A61F2310/00976 , A61L27/227 , Y10T428/31678
摘要： The present invention relates to a method for producing a device comprising the steps of (a) providing a solution comprising dissolved osteoinductive protein, (b) contacting the solution of the preceding step with a carrier containing a surface of metal or a metal alloy, (c) allowing coating of the surface of said carrier with said dissolved protein and (d) drying of the coated carrier obtained in step (c) wherein steps (b) to (d) are carried out under a reduced concentration of oxygen. The invention also encompasses a device obtainable by the method of the present invention. Moreover, the present invention relates to a pharmaceutical composition comprising the said device and to the use of the device for the preparation of a pharmaceutical composition to be used for an accelerated osseointegration and new bone formation. Finally, the present invention relates to a kit comprising the device of the present invention.
摘要翻译：本发明涉及一种用于制备器件的方法，包括以下步骤：（a）提供包含溶解的骨诱导蛋白的溶液，（b）使前述步骤的溶液与含有金属或金属合金表面的载体接触（ c）允许用所述溶解的蛋白质涂覆所述载体的表面，和（d）干燥步骤（c）中获得的涂布载体，其中步骤（b）至（d）在氧浓度降低的情况下进行。本发明还包括可通过本发明的方法获得的装置。此外，本发明涉及包含所述装置的药物组合物和用于制备用于加速骨整合和新骨形成的药物组合物的该装置的用途。最后，本发明涉及包含本发明装置的试剂盒。

4. 发明授权

US08257728B2 Metal implant coated under reduced oxygen concentration with osteoinductive protein 有权
标题翻译：金属植入物在降低氧浓度下用骨诱导蛋白包被
公开(公告)号：US08257728B2
公开(公告)日：2012-09-04
申请号：US12790159
申请日：2010-05-28
申请人： Klaus Hellerbrand , Nicola Beaucamp , Ulrich Kohnert
发明人： Klaus Hellerbrand , Nicola Beaucamp , Ulrich Kohnert
IPC分类号： A61F2/00 , A61K33/00 , A61K33/24
CPC分类号： A61L27/04 , A61C8/0012 , A61C8/0013 , A61F2/30767 , A61F2/32 , A61F2/38 , A61F2/3804 , A61F2/4202 , A61F2/4241 , A61F2/44 , A61F2310/00023 , A61F2310/00976 , A61L27/227 , Y10T428/31678
摘要： The present invention relates to a method for producing a device comprising the steps of (a) providing a solution comprising dissolved osteoinductive protein, (b) contacting the solution of the preceding step with a carrier containing a surface of metal or a metal alloy, (c) allowing coating of the surface of said carrier with said dissolved protein and (d) drying of the coated carrier obtained in step (c) wherein steps (b) to (d) are carried out under a reduced concentration of oxygen. The invention also encompasses a device obtainable by the method of the present invention. Moreover, the present invention relates to a pharmaceutical composition comprising the said device and to the use of the device for the preparation of a pharmaceutical composition to be used for an accelerated osseointegration and new bone formation. Finally, the present invention relates to a kit comprising the device of the present invention.
摘要翻译：本发明涉及一种用于制备器件的方法，包括以下步骤：（a）提供包含溶解的骨诱导蛋白的溶液，（b）使前述步骤的溶液与含有金属或金属合金表面的载体接触（ c）允许用所述溶解的蛋白质涂覆所述载体的表面，和（d）干燥步骤（c）中获得的涂布载体，其中步骤（b）至（d）在氧浓度降低的情况下进行。本发明还包括通过本发明的方法可获得的装置。此外，本发明涉及包含所述装置的药物组合物和用于制备用于加速骨整合和新骨形成的药物组合物的该装置的用途。最后，本发明涉及包含本发明装置的试剂盒。

5. 发明申请

US20110020658A1 METAL IMPLANT COATED UNDER REDUCED OXYGEN CONCENTRATION WITH OSTEOINDUCTIVE PROTEIN 有权
标题翻译：金属植入物与氧化蛋白质的还原氧化浓度
公开(公告)号：US20110020658A1
公开(公告)日：2011-01-27
申请号：US12790159
申请日：2010-05-28
申请人： Klaus Hellerbrand , Nicola Beaucamp , Ulrich Kohnert
发明人： Klaus Hellerbrand , Nicola Beaucamp , Ulrich Kohnert
IPC分类号： B32B15/04 , A61L27/54
CPC分类号： A61L27/04 , A61C8/0012 , A61C8/0013 , A61F2/30767 , A61F2/32 , A61F2/38 , A61F2/3804 , A61F2/4202 , A61F2/4241 , A61F2/44 , A61F2310/00023 , A61F2310/00976 , A61L27/227 , Y10T428/31678
摘要： The present invention relates to a method for producing a device comprising the steps of (a) providing a solution comprising dissolved osteoinductive protein, (b) contacting the solution of the preceding step with a carrier containing a surface of metal or a metal alloy, (c) allowing coating of the surface of said carrier with said dissolved protein and (d) drying of the coated carrier obtained in step (c) wherein steps (b) to (d) are carried out under a reduced concentration of oxygen. The invention also encompasses a device obtainable by the method of the present invention. Moreover, the present invention relates to a pharmaceutical composition comprising the said device and to the use of the device for the preparation of a pharmaceutical composition to be used for an accelerated osseointegration and new bone formation. Finally, the present invention relates to a kit comprising the device of the present invention.
摘要翻译：本发明涉及一种用于制备器件的方法，包括以下步骤：（a）提供包含溶解的骨诱导蛋白的溶液，（b）使前述步骤的溶液与含有金属或金属合金表面的载体接触（ c）允许用所述溶解的蛋白质涂覆所述载体的表面，和（d）干燥步骤（c）中获得的涂布载体，其中步骤（b）至（d）在氧浓度降低的情况下进行。本发明还包括可通过本发明的方法获得的装置。此外，本发明涉及包含所述装置的药物组合物和用于制备用于加速骨整合和新骨形成的药物组合物的该装置的用途。最后，本发明涉及包含本发明装置的试剂盒。

6. 发明申请

US20060240062A1 Metal implant coated under reduced oxygen concentration with osteoinductive protein 失效
标题翻译：金属植入物在降低氧浓度下用骨诱导蛋白包被
公开(公告)号：US20060240062A1
公开(公告)日：2006-10-26
申请号：US10527047
申请日：2003-07-09
申请人： Klaus Hellerbrand , Nicola Beaucamp , Ulrich Kohnert
发明人： Klaus Hellerbrand , Nicola Beaucamp , Ulrich Kohnert
IPC分类号： A61F2/00
CPC分类号： A61L27/04 , A61C8/0012 , A61C8/0013 , A61F2/30767 , A61F2/32 , A61F2/38 , A61F2/3804 , A61F2/4202 , A61F2/4241 , A61F2/44 , A61F2310/00023 , A61F2310/00976 , A61L27/227 , Y10T428/31678
摘要： The present invention relates to a method for producing a device comprising the steps of (a) providing a solution comprising dissolved osteoinductive protein, (b) contacting the solution of the preceding step with a carrier containing a surface of metal or a metal alloy, (c) allowing coating of the surface of said carrier with said dissolved protein and (d) drying of the coated carrier obtained in step (c) wherein steps (b) to (d) are carried out under a reduced concentration of oxygen. The invention also encompasses a device obtainable by the method of the present invention. Moreover, the present invention relates to a pharmaceutical composition comprising the said device and to the use of the device for the preparation of a pharmaceutical composition to be used for an accelerated osseointegration and new bone formation. Finally, the present invention relates to a kit comprising the device of the present invention.
摘要翻译：本发明涉及一种用于制备器件的方法，包括以下步骤：（a）提供包含溶解的骨诱导蛋白的溶液，（b）使前述步骤的溶液与含有金属或金属合金表面的载体接触（ c）允许用所述溶解的蛋白质涂覆所述载体的表面，和（d）干燥步骤（c）中获得的涂布载体，其中步骤（b）至（d）在氧浓度降低的情况下进行。本发明还包括可通过本发明的方法获得的装置。此外，本发明涉及包含所述装置的药物组合物和用于制备用于加速骨整合和新骨形成的药物组合物的该装置的用途。最后，本发明涉及包含本发明装置的试剂盒。

7. 发明申请

US20090148487A1 MOLDABLE BIOMATERIAL FOR BONE REGENERATION 审中-公开
标题翻译：用于骨再生的模具生物材料
公开(公告)号：US20090148487A1
公开(公告)日：2009-06-11
申请号：US12097154
申请日：2006-12-14
申请人： Michael Siedler , Klaus Hellerbrand , Andreas Schuetz , Sabrina Tauer
发明人： Michael Siedler , Klaus Hellerbrand , Andreas Schuetz , Sabrina Tauer
IPC分类号： A61F2/00 , A61K9/14 , A61K38/18
CPC分类号： A61L27/56 , A61L27/58
摘要： The present invention is directed to a moldable biomaterial comprising a particulate solid porous material and a biodegradable paste material. The paste material and the particulate solid porous material form a matrix usable for the replacement or augmentation of bone. In various embodiments the matrix has a high structural integrity, which does not immediately or shortly after implantation collapse into an amorphous non-porous mass, maintains its porosity after implantation, shows biphasic degradation after implantation and/or has a good resistance against being washed out when it is applied to a wet opened implant site. Active agents can be incorporated in the moldable biomaterial of the present invention, such as bone growth factors. Kits, implants, method of manufacturing as well as medicinal uses are also provided.
摘要翻译：本发明涉及一种可模制的生物材料，其包括颗粒状固体多孔材料和可生物降解的糊料。糊料和颗粒状固体多孔材料形成可用于骨的更换或增加的基质。在各种实施方案中，基质具有高的结构完整性，其在植入塌陷成无定形无孔质体之后不立即或不久，在植入后维持其孔隙度，在植入后显示双相降解和/或具有良好的耐洗涤性当它被施加到湿开放的植入位置时。活性剂可以掺入本发明的可模制生物材料中，例如骨生长因子。还提供了套件，植入物，制造方法以及医药用途。

8. 发明申请

US20070202144A1 Coated Implants, Their Manufcturing And Use Thereof 失效
标题翻译：涂层植入物，其制造和使用
公开(公告)号：US20070202144A1
公开(公告)日：2007-08-30
申请号：US10598698
申请日：2005-03-09
申请人： Klaus Hellerbrand , Michael Siedler , Andreas Schutz , Bernd Schimkat , Karin Wiedenmann-Schlembach
发明人： Klaus Hellerbrand , Michael Siedler , Andreas Schutz , Bernd Schimkat , Karin Wiedenmann-Schlembach
IPC分类号： A61F2/02 , B05D3/02
CPC分类号： A61L27/54 , A61B17/72 , A61B17/7291 , A61B17/80 , A61B17/865 , A61B17/866 , A61B50/30 , A61C8/0012 , A61C8/0013 , A61C8/0087 , A61F2/0077 , A61F2240/001 , A61L27/34 , A61L31/10 , A61L31/16 , A61L2300/252 , A61L2420/02 , B05C3/02 , B65B55/00 , C23C10/20 , C23C26/00
摘要： The present invention relates to a method of coating of a device, preferably implants, with a substance comprising the steps of (a) contacting said device into a solution of said substrate or substance, and (b) drying said device while being submerged in said solution. The present invention also relates to a packaging container for a device, preferably an implant. Said packaging container being adapted such that said device is coatable within said packaging container. Moreover, the present invention relates to a method of coating the inner surfaces of a packaging container for a device, preferably implants, to be coated by a substance, comprising the steps of (a) siliconizing said inner surfaces of said container using a silicone emulsion, and (b) heat-curing to form a baked-in silicone layer on said inner surfaces of said container.
摘要翻译：本发明涉及一种用物质涂覆装置，优选植入物的方法，包括以下步骤：（a）将所述装置接触所述基底或物质的溶液，和（b）在浸没在所述基底或物质中时干燥所述装置解。本发明还涉及用于装置的包装容器，优选地是植入物。所述包装容器适于使得所述装置可涂覆在所述包装容器内。此外，本发明涉及一种涂覆用于装置的包装容器的内表面的方法，优选是由物质涂覆的植入物，其包括以下步骤：（a）使用硅氧烷乳液将所述容器的所述内表面硅化，和（b）热固化以在所述容器的所述内表面上形成烘烤的硅氧烷层。

9. 发明授权

US09526761B2 Dried reconstituted vesicle formation for pharmaceutical application 有权
标题翻译：用于制药应用的干重构囊泡形成
公开(公告)号：US09526761B2
公开(公告)日：2016-12-27
申请号：US12419167
申请日：2009-04-06
申请人： Klaus Hellerbrand , Andreas Schuetz , Rainer Sigl
发明人： Klaus Hellerbrand , Andreas Schuetz , Rainer Sigl
IPC分类号： A61K9/127 , A61K9/19 , A61K38/18 , A61K9/00
CPC分类号： A61K38/1875 , A61K9/0019 , A61K9/0085 , A61K9/127 , A61K9/1272 , A61K9/19 , A61K35/35 , A61K38/18
摘要： The present invention relates to dried reconstituted vesicle (DRV) compositions and water based formulations thereof, which contain one or more therapeutic agents (e.g. hydrophilic protein). More particularly, it relates to DRVs comprising at least one lipid and a fusion promoting agent which after reconstitution form large multilamellar liposomes encapsulating an active agent in an aqueous phase.
摘要翻译：本发明涉及含有一种或多种治疗剂（例如亲水性蛋白质）的干重建泡囊（DRV）组合物及其基于水的制剂。更具体地说，本发明涉及包含至少一种脂质和融合促进剂的DRV，其在重建后形成包封活性剂在水相中的大的多层脂质体。

10. 发明申请

US20090285880A1 DRIED RECONSTITUTED VESICLE FORMATION FOR PHARMACEUTICAL APPLICATION 有权
标题翻译：用于药物应用的干燥重建的VESICLE形成
公开(公告)号：US20090285880A1
公开(公告)日：2009-11-19
申请号：US12419167
申请日：2009-04-06
申请人： Klaus Hellerbrand , Andreas Schuetz , Rainer Sigl
发明人： Klaus Hellerbrand , Andreas Schuetz , Rainer Sigl
IPC分类号： A61K9/127 , A61K38/02 , A61P37/02 , A61K38/17
CPC分类号： A61K38/1875 , A61K9/0019 , A61K9/0085 , A61K9/127 , A61K9/1272 , A61K9/19 , A61K35/35 , A61K38/18
摘要： The present invention relates to dried reconstituted vesicle (DRV) compositions and water based formulations thereof, which contain one or more therapeutic agents (e.g. hydrophilic protein). More particularly, it relates to DRVs comprising at least one lipid and a fusion promoting agent which after reconstitution form large multilamellar liposomes encapsulating an active agent in an aqueous phase.
摘要翻译：本发明涉及含有一种或多种治疗剂（例如亲水性蛋白质）的干重建泡囊（DRV）组合物及其基于水的制剂。更具体地说，本发明涉及包含至少一种脂质和融合促进剂的DRV，其在重建后形成包封活性剂在水相中的大的多层脂质体。

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