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1. 发明申请

US20090148487A1 MOLDABLE BIOMATERIAL FOR BONE REGENERATION 审中-公开
标题翻译：用于骨再生的模具生物材料
公开(公告)号：US20090148487A1
公开(公告)日：2009-06-11
申请号：US12097154
申请日：2006-12-14
申请人： Michael Siedler , Klaus Hellerbrand , Andreas Schuetz , Sabrina Tauer
发明人： Michael Siedler , Klaus Hellerbrand , Andreas Schuetz , Sabrina Tauer
IPC分类号： A61F2/00 , A61K9/14 , A61K38/18
CPC分类号： A61L27/56 , A61L27/58
摘要： The present invention is directed to a moldable biomaterial comprising a particulate solid porous material and a biodegradable paste material. The paste material and the particulate solid porous material form a matrix usable for the replacement or augmentation of bone. In various embodiments the matrix has a high structural integrity, which does not immediately or shortly after implantation collapse into an amorphous non-porous mass, maintains its porosity after implantation, shows biphasic degradation after implantation and/or has a good resistance against being washed out when it is applied to a wet opened implant site. Active agents can be incorporated in the moldable biomaterial of the present invention, such as bone growth factors. Kits, implants, method of manufacturing as well as medicinal uses are also provided.
摘要翻译：本发明涉及一种可模制的生物材料，其包括颗粒状固体多孔材料和可生物降解的糊料。糊料和颗粒状固体多孔材料形成可用于骨的更换或增加的基质。在各种实施方案中，基质具有高的结构完整性，其在植入塌陷成无定形无孔质体之后不立即或不久，在植入后维持其孔隙度，在植入后显示双相降解和/或具有良好的耐洗涤性当它被施加到湿开放的植入位置时。活性剂可以掺入本发明的可模制生物材料中，例如骨生长因子。还提供了套件，植入物，制造方法以及医药用途。

2. 发明授权

US08372895B2 Biomaterial containing degradation stabilized polymer 失效
标题翻译：含降解稳定聚合物的生物材料
公开(公告)号：US08372895B2
公开(公告)日：2013-02-12
申请号：US12305333
申请日：2007-06-28
申请人： Wolfgang Friess , Klaus Hellerbrand , Samuel Herberg , Cornelius Pompe , Andreas Schuetz , Michael Siedler
发明人： Wolfgang Friess , Klaus Hellerbrand , Samuel Herberg , Cornelius Pompe , Andreas Schuetz , Michael Siedler
IPC分类号： A61K47/30 , A61F2/00 , C08K3/10 , C08K3/30 , C08K3/34
CPC分类号： C08L67/04 , A61L27/505 , A61L27/58
摘要： The present invention relates to a polymer based material comprising a water binding agent, whereas the water binding agent is present in an amount sufficient to chemically and/or physically absorb and/or adsorb water to prevent degradation of the polymer. It also relates to a polymer based material which comprises a plasticizer or organic solvent as well as a multi-component material or composite including materials encompassing a second polymer and/or an active agent. Furthermore it relates to a method for manufacturing the polymer comprising material and use of the material for the preparation of a pharmaceutical composition to be used for treatment of bone, cartilage and/or periodontal defects. The invention also encompasses a kit using the polymeric material. Further, the present invention encompasses the use of a water binding agent for inhibiting water induced degradation of a polymer comprising material, for inducing blood clot stabilization in a polymer comprising material and for increasing storage stability in a polymer comprising material, wherein the water binding agent is not removed prior to application of the material.
摘要翻译：本发明涉及包含水结合剂的聚合物基材料，而水结合剂以足以化学和/或物理吸收和/或吸附水的量存在以防止聚合物降解。它还涉及包含增塑剂或有机溶剂的聚合物基材料以及包含第二聚合物和/或活性剂的材料的多组分材料或复合材料。此外，本发明涉及制备包含材料的聚合物的方法和用于制备用于治疗骨，软骨和/或牙周缺陷的药物组合物的材料的用途。本发明还包括使用聚合物材料的试剂盒。此外，本发明包括水粘合剂用于抑制包含材料的聚合物的水诱导降解的用途，用于在包含聚合物的材料中诱导血块稳定性并增加包含材料的聚合物的储存稳定性，其中水结合剂在施加材料之前不被去除。

3. 发明申请

US20090209660A1 BIOMATERIAL CONTAINING DEGRADATION STABILIZED POLYMER 失效
标题翻译：含生物降解稳定聚合物
公开(公告)号：US20090209660A1
公开(公告)日：2009-08-20
申请号：US12305333
申请日：2007-06-28
申请人： Wolfgang Friess , Klaus Hellerbrand , Samuel Herberg , Cornelius Pompe , Andreas Schuetz , Michael Siedler
发明人： Wolfgang Friess , Klaus Hellerbrand , Samuel Herberg , Cornelius Pompe , Andreas Schuetz , Michael Siedler
IPC分类号： A61K47/34 , C08K11/00
CPC分类号： C08L67/04 , A61L27/505 , A61L27/58
摘要： The present invention relates to a polymer based material comprising a water binding agent, whereas the water binding agent is present in an amount sufficient to chemically and/or physically absorb and/or adsorb water to prevent degradation of the polymer. It also relates to a polymer based material which comprises a plasticizer or organic solvent as well as a multi-component material or composite including materials encompassing a second polymer and/or an active agent. Furthermore it relates to a method for manufacturing the polymer comprising material and use of the material for the preparation of a pharmaceutical composition to be used for treatment of bone, cartilage and/or periodontal defects. The invention also encompasses a kit using the polymeric material. Further, the present invention encompasses the use of a water binding agent for inhibiting water induced degradation of a polymer comprising material, for inducing blood clot stabilization in a polymer comprising material and for increasing storage stability in a polymer comprising material, wherein the water binding agent is not removed prior to application of the material.
摘要翻译：本发明涉及包含水结合剂的聚合物基材料，而水结合剂以足以化学和/或物理吸收和/或吸附水的量存在以防止聚合物降解。它还涉及包含增塑剂或有机溶剂的聚合物基材料以及包含第二聚合物和/或活性剂的材料的多组分材料或复合材料。此外，本发明涉及制备包含材料的聚合物的方法和用于制备用于治疗骨，软骨和/或牙周缺陷的药物组合物的材料的用途。本发明还包括使用聚合物材料的试剂盒。此外，本发明包括水粘合剂用于抑制包含材料的聚合物的水诱导降解的用途，用于在包含聚合物的材料中诱导血块稳定性并增加包含材料的聚合物的储存稳定性，其中水结合剂在施加材料之前不被去除。

4. 发明申请

US20070202144A1 Coated Implants, Their Manufcturing And Use Thereof 失效
标题翻译：涂层植入物，其制造和使用
公开(公告)号：US20070202144A1
公开(公告)日：2007-08-30
申请号：US10598698
申请日：2005-03-09
申请人： Klaus Hellerbrand , Michael Siedler , Andreas Schutz , Bernd Schimkat , Karin Wiedenmann-Schlembach
发明人： Klaus Hellerbrand , Michael Siedler , Andreas Schutz , Bernd Schimkat , Karin Wiedenmann-Schlembach
IPC分类号： A61F2/02 , B05D3/02
CPC分类号： A61L27/54 , A61B17/72 , A61B17/7291 , A61B17/80 , A61B17/865 , A61B17/866 , A61B50/30 , A61C8/0012 , A61C8/0013 , A61C8/0087 , A61F2/0077 , A61F2240/001 , A61L27/34 , A61L31/10 , A61L31/16 , A61L2300/252 , A61L2420/02 , B05C3/02 , B65B55/00 , C23C10/20 , C23C26/00
摘要： The present invention relates to a method of coating of a device, preferably implants, with a substance comprising the steps of (a) contacting said device into a solution of said substrate or substance, and (b) drying said device while being submerged in said solution. The present invention also relates to a packaging container for a device, preferably an implant. Said packaging container being adapted such that said device is coatable within said packaging container. Moreover, the present invention relates to a method of coating the inner surfaces of a packaging container for a device, preferably implants, to be coated by a substance, comprising the steps of (a) siliconizing said inner surfaces of said container using a silicone emulsion, and (b) heat-curing to form a baked-in silicone layer on said inner surfaces of said container.
摘要翻译：本发明涉及一种用物质涂覆装置，优选植入物的方法，包括以下步骤：（a）将所述装置接触所述基底或物质的溶液，和（b）在浸没在所述基底或物质中时干燥所述装置解。本发明还涉及用于装置的包装容器，优选地是植入物。所述包装容器适于使得所述装置可涂覆在所述包装容器内。此外，本发明涉及一种涂覆用于装置的包装容器的内表面的方法，优选是由物质涂覆的植入物，其包括以下步骤：（a）使用硅氧烷乳液将所述容器的所述内表面硅化，和（b）热固化以在所述容器的所述内表面上形成烘烤的硅氧烷层。

5. 发明授权

US08372419B2 Coated implants, their manufacturing and use thereof 失效
标题翻译：涂覆植入物，其制造和使用
公开(公告)号：US08372419B2
公开(公告)日：2013-02-12
申请号：US10598698
申请日：2005-03-09
申请人： Klaus Hellerbrand , Michael Siedler , Andreas Schutz , Bernd Schimkat , Karin Wiedenmann-Schlembach
发明人： Klaus Hellerbrand , Michael Siedler , Andreas Schutz , Bernd Schimkat , Karin Wiedenmann-Schlembach
IPC分类号： A61F2/02 , B05D3/02
CPC分类号： A61L27/54 , A61B17/72 , A61B17/7291 , A61B17/80 , A61B17/865 , A61B17/866 , A61B50/30 , A61C8/0012 , A61C8/0013 , A61C8/0087 , A61F2/0077 , A61F2240/001 , A61L27/34 , A61L31/10 , A61L31/16 , A61L2300/252 , A61L2420/02 , B05C3/02 , B65B55/00 , C23C10/20 , C23C26/00
摘要： The present invention relates to a method of coating of a device, preferably implants, with a substance comprising the steps of (a) contacting said device into a solution of said substrate or substance, and (b) drying said device while being submerged in said solution. The present invention also relates to a packaging container for a device, preferably an implant. Said packaging container being adapted such that said device is coatable within said packaging container. Moreover, the present invention relates to a method of coating the inner surfaces of a packaging container for a device, preferably implants, to be coated by a substance, comprising the steps of (a) siliconizing said inner surfaces of said container using a silicone emulsion, and (b) heat-curing to form a baked-in silicone layer on said inner surfaces of said container.
摘要翻译：本发明涉及一种用物质涂覆装置，优选植入物的方法，包括以下步骤：（a）将所述装置接触所述基底或物质的溶液，和（b）在浸没在所述基底或物质中时干燥所述装置解。本发明还涉及用于装置的包装容器，优选地是植入物。所述包装容器适于使得所述装置可涂覆在所述包装容器内。此外，本发明涉及一种涂覆用于装置的包装容器的内表面的方法，优选是由物质涂覆的植入物，其包括以下步骤：（a）使用硅氧烷乳液将所述容器的所述内表面硅化，和（b）热固化以在所述容器的所述内表面上形成烘烤的硅氧烷层。

6. 发明申请

US20090048145A1 In situ hardening paste, its manufacturing and use 审中-公开
标题翻译：原位硬化膏，其制造和使用
公开(公告)号：US20090048145A1
公开(公告)日：2009-02-19
申请号：US11629119
申请日：2005-06-09
申请人： Klaus Hellerbrand , Michael Siedler , Andreas Schutz , Cornelius Pompe , Wolfgang Friess
发明人： Klaus Hellerbrand , Michael Siedler , Andreas Schutz , Cornelius Pompe , Wolfgang Friess
IPC分类号： A61K38/02 , A61K47/30 , A61P19/08
CPC分类号： A61L27/46 , A61F2/28 , A61F2/4601 , A61F2002/2817 , A61F2002/30062 , A61F2002/30583 , A61F2002/30766 , A61F2210/0004 , A61F2210/0085 , A61F2310/00293 , A61L27/446 , A61L27/48 , A61L27/502 , A61L27/54 , A61L2300/25 , A61L2300/252 , A61L2300/414 , A61L2300/43
摘要： An in-situ-hardening paste, containing an organic or inorganic filling material, a biodegradable polymer and a water soluble polymeric plasticizer was developed as a delivery system for an active agent with scaffold properties in the field of tissue regeneration. The hardened paste is sufficient mechanical stable to can be used as bone and cartilage replacement matrix. All components are full biocompatible, preferably bioresorbable and certified for parenteral application. The sustained release of peptides and proteins can be modulated by the composition and process design. The invention encompasses a pharmaceutical composition comprising the paste of the invention and relates to the use of said paste for the preparation of a pharmaceutical composition to be used for bone augmentation, for treating bone defects, for treating degenerative and traumatic disc disease, for treating bone dehiscence or to be used for sinus floor elevation.
摘要翻译：开发了含有有机或无机填充材料的生物降解聚合物和水溶性聚合物增塑剂的原位硬化浆料作为在组织再生领域具有支架特性的活性剂的递送系统。硬化浆料足够机械稳定，可用作骨和软骨替代基质。所有组分都是完全生物相容的，优选是生物可再吸收的并经过非肠道应用的认证。肽和蛋白质的持续释放可以通过组合物和工艺设计来调节。本发明包括一种药物组合物，其包含本发明的糊剂，并且涉及所述糊剂用于制备用于骨增大，用于治疗骨缺损，用于治疗退行性和创伤性椎间盘疾病，用于治疗骨骼的药物组合物的用途开裂或用于窦底抬高。

7. 发明申请

US20100112028A1 Composite material for use as protein carrier 审中-公开
标题翻译：用作蛋白质载体的复合材料
公开(公告)号：US20100112028A1
公开(公告)日：2010-05-06
申请号：US11628993
申请日：2005-06-09
申请人： Klaus Hellerbrand , Michael Siedler , Andreas Schütz
发明人： Klaus Hellerbrand , Michael Siedler , Andreas Schütz
IPC分类号： A61K9/00 , A61K9/16 , A61K47/02 , A61K38/02 , B05D3/00 , A61P19/00
CPC分类号： A61L27/54 , A61L27/26 , A61L27/42 , A61L2300/252 , A61L2300/414 , A61L2300/602
摘要： The present invention relates to a material having osteoinductive and osteoconductive properties in vivo comprising a ceramic carrier, preferably containing calcium phosphate, and an active agent, preferably an osteoinductive protein/peptide or a drug, and a polymer, wherein the active agent is homogeneously coated on the carrier and within the polymer, which is preferably a degradable polymer. Said polymer modulates the release kinetic of the active agent and protects same from degradation to prolong the half-life in vivo. Moreover, the present invention relates to a method for the production of a material having osteoinductive and osteoconductive properties in vivo.
摘要翻译：本发明涉及在体内具有骨诱导和骨传导性质的材料，其包含优选含有磷酸钙的陶瓷载体，以及活性剂，优选骨诱导蛋白/肽或药物和聚合物，其中活性剂均匀地涂覆在载体上和聚合物内，其优选是可降解聚合物。所述聚合物调节活性剂的释放动力学并保护其免受降解以延长体内半衰期。此外，本发明涉及一种在体内生产具有骨诱导和骨传导性质的材料的方法。

8. 发明授权

US09610301B2 Powdered protein compositions and methods of making same 有权
公开(公告)号：US09610301B2
公开(公告)日：2017-04-04
申请号：US12354665
申请日：2009-01-15
申请人： Peter K. Lassner , Michael Adler , Geoffrey Lee , Hans-Juergen Krause , Michael Siedler
发明人： Peter K. Lassner , Michael Adler , Geoffrey Lee , Hans-Juergen Krause , Michael Siedler
IPC分类号： A61K39/395 , A61K31/70 , A61K9/16 , A61K31/715 , A61K47/26 , C07K16/24
CPC分类号： A61K31/70 , A61K9/1605 , A61K31/715 , A61K39/39591 , A61K47/26 , C07K16/241 , C07K2317/55
摘要： A method for preparing a protein or peptide powder is provided that includes spray drying a solution including more than, e.g., about 50 mg/mL of a protein or peptide (e.g., an antibody or antigen binding portion thereof), and at least one excipient. Also provided are stable powdered compositions including a protein and an excipient having less than, e.g., about 6% residual moisture.

9. 发明申请

US20140161817A1 STABLE DUAL VARIABLE DOMAIN IMMUNOGLOBULIN PROTEIN FORMULATIONS 审中-公开
标题翻译：稳定的双变量域免疫球蛋白蛋白质配方
公开(公告)号：US20140161817A1
公开(公告)日：2014-06-12
申请号：US14070155
申请日：2013-11-01
申请人： Michael Siedler , Vineet Kumar , Ravi Chari , Sonal Saluja , Vishwesh Patil
发明人： Michael Siedler , Vineet Kumar , Ravi Chari , Sonal Saluja , Vishwesh Patil
IPC分类号： C07K16/24
CPC分类号： C07K16/245 , A61K9/0019 , A61K9/08 , A61K9/19 , A61K39/39591 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/22 , A61K47/26 , A61K2039/505 , C07K16/18 , C07K16/22 , C07K16/241 , C07K16/244 , C07K16/247 , C07K16/26 , C07K16/2827 , C07K16/2875 , C07K16/2887 , C07K16/32 , C07K16/4291 , C07K2317/31 , C07K2317/56 , C07K2317/60 , C07K2317/94
摘要： The invention provides stable aqueous formulations comprising an Aqueous Stable Dual Variable Domain Immunoglobulin (AS-DVD-Ig) protein. The invention also provides stable lyophilized formulations comprising a Lyophilized Stable Dual Variable Domain Immunoglobulin (LS-DVD-Ig) protein.
摘要翻译：本发明提供了包含水稳定双重可变域免疫球蛋白（AS-DVD-Ig）蛋白质的稳定的水性制剂。本发明还提供了包含冻干稳定的双可变域免疫球蛋白（LS-DVD-Ig）蛋白质的稳定的冻干制剂。

10. 发明申请

US20110256135A1 ANTI-NERVE GROWTH FACTOR (NGF) ANTIBODY COMPOSITIONS 审中-公开
标题翻译：抗神经生长因子（NGF）抗体组合物
公开(公告)号：US20110256135A1
公开(公告)日：2011-10-20
申请号：US13049473
申请日：2011-03-16
申请人： Wolfgang FRAUNHOFER , Ravi Chari , Vineet Kumar , Rainer Saedler , Michael Siedler , William B. Stine , Carsten Weber
发明人： Wolfgang FRAUNHOFER , Ravi Chari , Vineet Kumar , Rainer Saedler , Michael Siedler , William B. Stine , Carsten Weber
IPC分类号： A61K39/395 , A61M15/00 , A61M5/30 , A61P25/04 , A61M5/178
CPC分类号： C07K16/22 , A61K39/39591 , A61K47/183 , A61K47/26 , C07K2317/53 , C07K2317/94
摘要： The present invention relates to stable compositions of anti-NGF antibodies, and antigen-binding fragments thereof, and their uses in the prevention and/or treatment of various diseases and disorders in which NGF activity is detrimental, e.g., pain disorders.
摘要翻译：本发明涉及抗NGF抗体及其抗原结合片段的稳定组合物及其在预防和/或治疗其中NGF活性有害的各种疾病和病症（例如疼痛障碍）中的用途。

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