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1. 发明授权

US07000452B2 Phased micro fluid analyzer 有权
标题翻译：分阶段微流体分析仪
公开(公告)号：US07000452B2
公开(公告)日：2006-02-21
申请号：US10672894
申请日：2003-09-26
申请人： Ulrich Bonne , Robert Higashi , Cleopatra Cabuz
发明人： Ulrich Bonne , Robert Higashi , Cleopatra Cabuz
IPC分类号： G01N19/10
CPC分类号： G01N30/08 , G01N1/24 , G01N27/18 , G01N30/12 , G01N30/30 , G01N30/461 , G01N30/468 , G01N30/6095 , G01N30/66 , G01N30/88 , G01N33/0004 , G01N33/0011 , G01N33/22 , G01N35/00871 , G01N2030/121 , G01N2030/123 , G01N2030/3076 , G01N2035/00881 , G01N2030/3015
摘要： A micro fluid analyzer having a concentrator and separator. A strip continuous through a channel in the concentrator may provide a hot zone that may move with the flow of fluid through the channel of the concentrator to provide a concentration of heat in the flow. A pump may provide a flow to the fluid through the analyzer. Detectors may be positioned at places where the fluid may flow. A processor or controller may be connected to the strip, separator, pump and detectors. The concentrator, separator, detectors and processor may be integrated on one chip.
摘要翻译：具有浓缩器和分离器的微流体分析器。通过集中器中的通道连续的条带可以提供热区域，其可以随流体流动通过浓缩器的通道移动，以提供流体中的热量集中。泵可以通过分析器向流体提供流量。检测器可以位于流体可能流动的地方。处理器或控制器可以连接到条带，分离器，泵和检测器。集中器，分离器，检测器和处理器可以集成在一个芯片上。

2. 发明授权

US07222639B2 Electrostatically actuated gas valve 失效
标题翻译：静电致动气阀
公开(公告)号：US07222639B2
公开(公告)日：2007-05-29
申请号：US11025758
申请日：2004-12-29
申请人： Ulrich Bonne , Cleopatra Cabuz , Eugen I. Cabuz , Stephen J. Kemp , John T. Adams , Tzu-Yu Wang , Sybrandus B. V. Munsterhuis , Gerrit J. Baarda
发明人： Ulrich Bonne , Cleopatra Cabuz , Eugen I. Cabuz , Stephen J. Kemp , John T. Adams , Tzu-Yu Wang , Sybrandus B. V. Munsterhuis , Gerrit J. Baarda
IPC分类号： G05D16/06
CPC分类号： F16K31/402 , F16K31/02 , F16K31/385 , F23N1/005 , F23N2035/18 , F23N2035/20 , F23N2035/24 , Y10T137/7761 , Y10T137/87917
摘要： A gas valve body with a first flow chamber and, a second flow chamber including and a main valve positioned in line and between the first flow chamber and the second flow chamber. The main valve can be opened by creating a pressure differential across the main valve. An electrostatically controlled pilot valve is provided for controlling the pressure differential across the main valve for “on-ff” operation. The electrostatically controlled pilot valve may also be operated to “modulate” the pressure differential across the main valve along a range of pressure differential values.
摘要翻译：一种具有第一流动室的气体阀体，以及包括第一流动室和第二流动室的第二流动室和第二流动室。可以通过在主阀上形成压差来打开主阀。提供静电控制的先导阀，用于控制主阀上的压差用于“on-ff”操作。静电控制先导阀还可以被操作以沿着一定范围的压力差来“调制”主阀上的压力差。

3. 发明申请

US20060137749A1 Electrostatically actuated gas valve 失效
标题翻译：静电致动气阀
公开(公告)号：US20060137749A1
公开(公告)日：2006-06-29
申请号：US11025758
申请日：2004-12-29
申请人： Ulrich Bonne , Cleopatra Cabuz , Eugen Cabuz , Stephen Kemp , John Adams , Tzu-Yu Wang , Sybrandus Munsterhuis , Gerrit Baarda
发明人： Ulrich Bonne , Cleopatra Cabuz , Eugen Cabuz , Stephen Kemp , John Adams , Tzu-Yu Wang , Sybrandus Munsterhuis , Gerrit Baarda
IPC分类号： G05D16/06
CPC分类号： F16K31/402 , F16K31/02 , F16K31/385 , F23N1/005 , F23N2035/18 , F23N2035/20 , F23N2035/24 , Y10T137/7761 , Y10T137/87917
摘要： A gas valve body with a first flow chamber and, a second flow chamber including and a main valve positioned in line and between the first flow chamber and the second flow chamber. The main valve can be opened by creating a pressure differential across the main valve. An electrostatically controlled pilot valve is provided for controlling the pressure differential across the main valve for “on-ff” operation. The electrostatically controlled pilot valve may also be operated to “modulate” the pressure differential across the main valve along a range of pressure differential values.
摘要翻译：一种具有第一流动室的气体阀体，以及包括第一流动室和第二流动室的第二流动室和第二流动室。可以通过在主阀上形成压差来打开主阀。提供静电控制的先导阀，用于控制主阀上的压差用于“on-ff”操作。静电控制先导阀还可以被操作以沿着一定范围的压力差来“调制”主阀上的压力差。

4. 发明授权

US06597438B1 Portable flow cytometry 有权
标题翻译：便携式流式细胞仪
公开(公告)号：US06597438B1
公开(公告)日：2003-07-22
申请号：US09630924
申请日：2000-08-02
申请人： Cleopatra Cabuz , J. David Zook , James Allen Cox , Thomas Raymond Ohnstein , Ulrich Bonne , Eugen Loan Cabuz , Ernest Allen Satren , Aravind Padmanabhan , Teresa M. Marta
发明人： Cleopatra Cabuz , J. David Zook , James Allen Cox , Thomas Raymond Ohnstein , Ulrich Bonne , Eugen Loan Cabuz , Ernest Allen Satren , Aravind Padmanabhan , Teresa M. Marta
IPC分类号： G01N3349
CPC分类号： G01N15/1404 , A61B5/150022 , A61B5/15003 , A61B5/150221 , A61B5/150343 , A61B5/150351 , A61B5/150809 , A61B5/150824 , A61B5/157 , B01L3/5027 , G01N2015/1486 , Y10T436/101666
摘要： A portable or wearable cytometer that can be used at remote locations, such as in the field or at home. The flow cytometer of the present invention may help improve the healthcare of many weak, sick or elderly people by providing early detection of infection. By detecting the infection early, the infection may be more readily treatable. In military applications, the portable cytometer of the present invention may help save lives by providing early detection of infection due to biological agents.
摘要翻译：便携式或可穿戴式的血细胞计数仪，可在远程位置使用，如在野外或家中使用。本发明的流式细胞仪可以通过提供早期检测感染来帮助改善许多弱者，病人或老年人的医疗保健。通过早期检测感染，感染可能更容易治疗。在军事应用中，本发明的便携式血细胞计数器可以通过提供由于生物制剂引起的感染的早期检测来帮助挽救生命。

5. 发明授权

US06382228B1 Fluid driving system for flow cytometry 有权
标题翻译：用于流式细胞仪的流体驱动系统
公开(公告)号：US06382228B1
公开(公告)日：2002-05-07
申请号：US09630923
申请日：2000-08-02
申请人： Cleopatra Cabuz , J. David Zook , Thomas Raymond Ohnstein , Ulrich Bonne , Eugen Loan Cabuz , Ernest Allen Satren
发明人： Cleopatra Cabuz , J. David Zook , Thomas Raymond Ohnstein , Ulrich Bonne , Eugen Loan Cabuz , Ernest Allen Satren
IPC分类号： G05D706
CPC分类号： G05D7/0694 , G01N15/1404 , Y10T137/0368 , Y10T137/0396 , Y10T137/7759 , Y10T137/7761 , Y10T137/87265
摘要： A fluid driving system for portable flow cytometers or other portable devices that accepts a less precise and less stable pressure source, and then adjusts the pressure in a closed-loop manner to maintain a constant, desired flow velocity. The fluid driving system may be used in portable or wearable cytometers for use in remote locations, such as at home or in the field.
摘要翻译：用于便携式流式细胞仪或其他便携式装置的流体驱动系统，其接受不太精确和不太稳定的压力源，然后以闭环方式调节压力以保持恒定的所需流速。流体驱动系统可以用于便携式或可穿戴式细胞仪中，用于远程位置，例如在家中或在现场。

6. 发明申请

US20130038446A1 LOCATOR SYSTEM USING DISPARATE LOCATOR SIGNALS 有权
标题翻译：定位器系统使用不同的定位器信号
公开(公告)号：US20130038446A1
公开(公告)日：2013-02-14
申请号：US13207247
申请日：2011-08-10
申请人： Steve Huseth , Cleopatra Cabuz
发明人： Steve Huseth , Cleopatra Cabuz
IPC分类号： G08B1/08
CPC分类号： G08B21/0202 , G08B29/183
摘要： The present disclosure relates generally to locating systems, and more particularly, to handheld locator systems for locating personnel or other objects in buildings or other environments. In one illustrative embodiment, a tag is attached to an object to be located (e.g. firefighter). The tag may be configured to emit a first signal and a second signal, where the first signal and the second signal having disparate propagation characteristics in the environment. In some cases, the first signal may be an acoustic signal and the second signal may be an RF signal, but this is not required in all embodiments. By using a first signal or set of signals, and then automatically switching to another signal or set of signal(s) when the first signal or set of signals are not received clearly, the tag/receiver system may help mitigate the failure modes/weaknesses of any single technology, and may provide advantages over use of any of the technologies used singly.
摘要翻译：本公开一般涉及定位系统，更具体地，涉及用于在人造建筑物或其他环境中定位人员或其他物体的手持定位器系统。在一个说明性实施例中，标签附接到要定位的对象（例如消防员）。标签可以被配置为发射第一信号和第二信号，其中第一信号和第二信号在环境中具有不同的传播特性。在一些情况下，第一信号可以是声信号，第二信号可以是RF信号，但是在所有实施例中不是必需的。通过使用第一信号或一组信号，然后当第一信号或一组信号没有被清楚地接收时，自动切换到另一个信号或一组信号，标签/接收机系统可以帮助减轻故障模式/弱点任何单一技术，并且可以提供优于使用单独使用的任何技术的优点。

7. 发明授权

US08361410B2 Flow metered analyzer 有权
标题翻译：流量计分析仪
公开(公告)号：US08361410B2
公开(公告)日：2013-01-29
申请号：US11428332
申请日：2006-06-30
申请人： Aravind Padmanabhan , Cleopatra Cabuz
发明人： Aravind Padmanabhan , Cleopatra Cabuz
IPC分类号： G01N21/00
CPC分类号： B01L3/502746 , B01L3/50273 , B01L9/527 , B01L2200/14 , B01L2200/146 , B01L2200/147 , B01L2300/14 , B01L2300/1838 , B01L2400/0487 , B01L2400/082 , G01N15/1484 , G01N2015/0073 , G01N2015/008 , G01N2015/0084 , G01N2015/1486
摘要： A hematology analyzer or cytometer cartridge system having flow metering. It may have on- or off-cartridge flow metering and control. The system may have local and direct flow measurement to provide accurate counts per unit volume. There may be numerous arrangements for fluidic circuit checks of the cartridge. Examples may include checks pertaining to zero flow, interface, pressure, flow rate, fluid type and quality, backflow, dry qualification, temperature exposure limits, and so on, of the circuits and cartridge associated items.
摘要翻译：具有流量计量的血液分析仪或血细胞计数器系统。它可以具有开/关流量计量和控制。该系统可以具有本地和直接流量测量，以提供每单位体积的精确计数。可能存在许多针对盒的流体回路检查的布置。示例可以包括关于电路和盒相关物品的零流量，界面，压力，流速，流体类型和质量，回流，干质量鉴定，温度暴露限制等的检查。

8. 发明授权

US08097225B2 Microfluidic cartridge with reservoirs for increased shelf life of installed reagents 有权
标题翻译：具有储存器的微流控筒，以提高安装试剂的保质期
公开(公告)号：US08097225B2
公开(公告)日：2012-01-17
申请号：US10900887
申请日：2004-07-28
申请人： Aravind Padmanabhan , Cleopatra Cabuz , Kenneth O. MacFadden
发明人： Aravind Padmanabhan , Cleopatra Cabuz , Kenneth O. MacFadden
IPC分类号： G01N21/00
CPC分类号： B41J2/17513 , B01L3/502707 , B01L2200/16 , B01L2300/0816 , B01L2300/0887 , B01L2300/12 , B01L2300/165 , B01L2400/06
摘要： A microfluidic cartridge that includes at least one reservoir for storing a reagent or the like for an extended period of time. In one illustrative embodiment, at least part of a wall of a reservoir includes a hydrophobic material, such as a polymonochlorotrifluoroethylene (PCTFE) homopolymer and/or copolymer. The hydrophobic material may help reduce leaching, evaporation, diffusion and/or other transfer of the reagent or one of its components from the reservoir. When the reagent or the like is lyophilized, the hydrophobic material may help keep water, water vapor and/or other gases or liquids from entering the reservoir prior to use of the microfluidic cartridge.
摘要翻译：一种微流体盒，其包括用于长时间存储试剂等的至少一个贮存器。在一个示例性实施方案中，储存器的壁的至少一部分包括疏水性材料，例如聚单氯三氟乙烯（PCTFE）均聚物和/或共聚物。疏水性材料可以帮助减少试剂或其一种组分从贮存器的浸出，蒸发，扩散和/或其它转移。当试剂等被冻干时，在使用微流控盒之前，疏水材料可以帮助保持水，水蒸气和/或其它气体或液体不会进入储存器。

9. 发明申请

US20120003730A1 PORTABLE SAMPLE ANALYZER CARTRIDGE 有权
标题翻译：便携式样品分析仪盒
公开(公告)号：US20120003730A1
公开(公告)日：2012-01-05
申请号：US13220449
申请日：2011-08-29
申请人： Aravind Padmanabhan , James A. Cox , Cleopatra Cabuz
发明人： Aravind Padmanabhan , James A. Cox , Cleopatra Cabuz
IPC分类号： C12M1/34
CPC分类号： B01L3/502715 , B01L9/527 , B01L2200/027 , B01L2200/04 , B01L2200/0636 , B01L2200/146 , B01L2300/0672 , B01L2300/0816 , B01L2300/0877 , B01L2300/14 , B01L2400/0487 , G01N15/1484 , G01N35/00722 , G01N2015/0073 , G01N2015/0084 , G01N2015/0088 , G01N2015/1413 , G01N2015/1486 , G01N2035/00891
摘要： A sample analyzer cartridge for use at a point of care of a patient such as in a doctor's office, in the home, or elsewhere in the field. By providing a removable and/or disposable cartridge with all of the needed reagents and/or fluids, the sample analyzer can be reliably used outside of the laboratory environment, with little or no specialized training.
摘要翻译：在患者的护理点使用的样品分析器盒，例如在医生的办公室，家庭或现场的其他地方。通过提供具有所有需要的试剂和/或流体的可拆卸和/或一次性的筒，样品分析仪可以在实验室环境之外被可靠地使用，很少或没有专门的培训。

10. 发明授权

US07641856B2 Portable sample analyzer with removable cartridge 有权
标题翻译：带可移动墨盒的便携式样品分析仪
公开(公告)号：US07641856B2
公开(公告)日：2010-01-05
申请号：US10908461
申请日：2005-05-12
申请人： Aravind Padmanabhan , James A. Cox , Bernard S. Fritz , Cleopatra Cabuz
发明人： Aravind Padmanabhan , James A. Cox , Bernard S. Fritz , Cleopatra Cabuz
IPC分类号： G01N33/00 , G01N33/48 , G01N31/00 , G01N15/00 , B01L3/02
CPC分类号： G01N15/1404 , G01N2015/1413 , G01N2015/1486 , Y10T436/101666
摘要： A sample analyzer with a removable and/or disposable cartridge for use at the point of care of a patient such as in a doctor's office, in the home, or elsewhere in the field. By providing a removable and/or disposable cartridge with all of the needed reagents and/or fluids, the sample analyzer can be reliably used outside of the laboratory environment, with little or no specialized training.
摘要翻译：具有可拆卸和/或一次性药筒的样品分析器，用于患者的护理点，例如在医生的办公室，家庭或现场的其他地方。通过提供具有所有需要的试剂和/或流体的可拆卸和/或一次性的筒，样品分析仪可以在实验室环境之外被可靠地使用，很少或没有专门的培训。

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