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1. 发明授权

US5637318A Dermatological agent for assisting the transport of oxygen in the skin 失效
标题翻译：用于辅助皮肤中氧气运输的皮肤病药
公开(公告)号：US5637318A
公开(公告)日：1997-06-10
申请号：US674850
申请日：1996-07-03
申请人： Udo Gross , Joachim Roding , Klaus Stanzl , Leonhard Zastrow
发明人： Udo Gross , Joachim Roding , Klaus Stanzl , Leonhard Zastrow
IPC分类号： A61K9/06 , A61K8/00 , A61K8/11 , A61K8/14 , A61K8/55 , A61K8/58 , A61K9/08 , A61K9/107 , A61K9/127 , A61K9/14 , A61K9/70 , A61K31/02 , A61K31/025 , A61K31/08 , A61K31/13 , A61K31/34 , A61K31/535 , A61K31/66 , A61K38/16 , A61K47/24 , A61P3/00 , A61Q19/00 , A61K7/00
CPC分类号： A61K9/127 , A61K31/02 , A61K31/025 , A61K31/08 , A61K31/13 , A61K31/34 , A61K31/535 , Y10S514/964 , Y10S514/969
摘要： The invention relates to a dermatological agent for assisting the transport of oxygen in the skin, a process for its preparation and the use thereof. The problem with the known dermatological agents is the inadequate supply of oxygen to the skin and the adjoining tissue. The object of the invention is therefore to get through the horny layer of the skin and the epidermis by penetration processes in order to increase the oxygen concentration in the dermal area and adjoining tissue and to activate metabolic processes. According to the invention, this is effected by means of a dermatological agent containing asymmetric lamellar aggregates, consisting of phospholipids and oxygen-laden fluorocarbon or fluorocarbon mixture, the amount of fluorocarbon being in the range from 0.2 to 100% weight/volume, in a carrier which is suitable for dermatological use. Preparation is effected by emulsification of the corresponding constituents, and use in ointments, creams, lotions, waters, alcoholic extracts, pastes, powders, gels, tinctures or on dressings and plasters or in a spray.
摘要翻译： PCT No.PCT / DE93 / 00572 Sec。 371日期1994年12月22日第 102（e）日期1994年12月22日PCT提交1993年6月24日PCT公布。公开号WO94 / 00109 日期1994年1月6日本发明涉及一种用于辅助皮肤中氧气输送的皮肤病药，其制备方法及其用途。已知皮肤病学药剂的问题是氧气供应不足于皮肤和邻接的组织。因此，本发明的目的是通过渗透过程渗透皮肤和表皮的角质层，以增加皮肤区域和毗邻组织中的氧浓度并激活代谢过程。根据本发明，这通过含有由磷脂和含氧碳氟化合物或碳氟化合物混合物组成的不对称层状聚集体的皮肤病学试剂来实现，碳氟化合物的量在0.2至100重量/体积的范围内，适用于皮肤病学用途的载体。制剂通过乳化相应的成分进行，并用于软膏，霜剂，洗剂，水，酒精提取物，糊剂，粉末，凝胶，酊剂，敷料和膏药或喷雾剂中。

2. 发明授权

US5686102A Pharmacological composition for topical administration 失效
标题翻译：用于局部给药的药理组合物
公开(公告)号：US5686102A
公开(公告)日：1997-11-11
申请号：US674851
申请日：1996-07-03
申请人： Udo Gross , Joachim Roding , Klaus Stanzl , Leonhard Zastrow
发明人： Udo Gross , Joachim Roding , Klaus Stanzl , Leonhard Zastrow
IPC分类号： A61K8/14 , A61K8/70 , A61K9/127 , A61Q19/00 , A61K7/00
CPC分类号： A61K8/14 , A61K8/70 , A61K9/0014 , A61K9/127 , A61Q19/00 , Y10S514/944 , Y10S514/969
摘要： The invention relates to pharmaceutical compositions which are incorporated into the skin with the aid of novel microaggregates as carriers. The object of the invention is to make available pharmacological active compounds in a biologically and chemically inert carrier for therapeutic and diagnostic administration to the skin or for systemic administration, and in this way to make deeper penetration into the skin or transdermal transport possible. According to the invention, this is effected by means of a pharmaceutical composition for topical administration, which contains asymmetric lamellar aggregates, consisting of phospholipids, pharmacological active compounds and fluorocarbons or fluorocarbon mixtures, the proportion of fluorocarbon being in the range from 1 to 100% weight/volume, in a pharmaceutical excipient which is suitable for topical administration. Preparation is effected by emulsification of the appropriate constituents and use in ointments, creams, lotions, pastes, gels, powders or on a dressing or plaster or by means of a spray.
摘要翻译：本发明涉及借助于新的微团聚体作为载体并入皮肤中的药物组合物。本发明的目的是在生物和化学惰性的载体中制备可用的药理学活性化合物，用于治疗和诊断给予皮肤或全身给药，并且以这种方式使得能够更深入地渗入皮肤或透皮传递。根据本发明，这是通过用于局部给药的药物组合物实现的，其包含由磷脂，药理活性化合物和碳氟化合物或碳氟化合物混合物组成的不对称层状聚集体，碳氟化合物的比例在1至100％重量/体积，适用于局部给药的药物赋形剂。制备通过乳化适当的组分并用于软膏，乳膏，洗剂，糊剂，凝胶，粉末或敷料或膏药或通过喷雾剂进行。

3. 发明授权

US5641509A Preparation for topical use 失效
标题翻译：局部使用准备
公开(公告)号：US5641509A
公开(公告)日：1997-06-24
申请号：US640116
申请日：1996-04-30
申请人： Udo Gross , Joachim Roding , Klaus Stanzl , Leonhard Zastrow
发明人： Udo Gross , Joachim Roding , Klaus Stanzl , Leonhard Zastrow
IPC分类号： A61K8/14 , A61K8/70 , A61K8/72 , A61Q1/10 , A61Q17/04 , A61K9/127 , A61K7/00
CPC分类号： B82Y5/00 , A61K8/14 , A61K8/70 , A61K8/72 , A61Q1/10 , A61Q17/04 , Y10S514/944 , Y10S514/969
摘要： The invention relates to a preparation for topical use, having light protection properties and in a special application form. In the known light protection agents containing the naturally occurring active compound melanin, the problem is inadequate transport of the melanin to its site of action. According to the invention, this problem is solved by a preparation for topical use which is characterised in that it contains melanin, dissolved or dispersed in one or more fluorocarbons, which are present as asymmetric lamellar phospholipid aggregates in an aqueous system together with a phospholipid, with a particle size of the aggregates in the range from 200 to 3000 nm.
摘要翻译：本发明涉及局部使用的制剂，具有防光性能和特殊应用形式。在已知的含有天然存在的活性化合物黑色素的防晒剂中，问题是黑色素运送到其作用部位的问题。根据本发明，这个问题是通过局部使用的制剂来解决的，其特征在于它含有溶解或分散在一种或多种碳氟化合物中的黑色素，它们与磷脂一起在水性体系中作为不对称层状磷脂聚集体存在，聚集体的粒度在200〜3000nm的范围内。

4. 发明授权

US5643601A Phospholipid-and fluorocarbon-containing cosmetic 失效
标题翻译：含磷脂和含碳氟化合物的化妆品
公开(公告)号：US5643601A
公开(公告)日：1997-07-01
申请号：US674849
申请日：1996-07-03
申请人： Udo Gross , Joachim Roding , Klaus Stanzl , Leonhard Zastrow
发明人： Udo Gross , Joachim Roding , Klaus Stanzl , Leonhard Zastrow
IPC分类号： A61K8/14 , A61K8/70 , A61Q1/10 , A61Q5/00 , A61Q19/00 , A61K9/127 , A61K7/00
CPC分类号： A61Q19/00 , A61K8/0212 , A61K8/14 , A61K8/22 , A61K8/70 , A61Q1/02 , A61Q1/10 , A61Q15/00 , A61Q17/04 , A61Q19/002 , A61Q19/10 , A61Q5/00 , A61Q5/02 , Y10S514/944 , Y10S514/969
摘要： The invention relates to a cosmetic for assisting the transport of oxygen in the skin, a process for its preparation and the use thereof. The problem with the known cosmetics is the inadequate oxygen supply to the skin and the adjoining tissue. The object of the invention is therefore to get through the horny layer of the skin and the epidermis by penetration processes in order to increase the oxygen concentration in the dermal area and adjoining tissue and to activate metabolic processes. According to the invention, this is effected by a cosmetic containing asymmetric lamellar aggregates, consisting of phospholipids and oxygen-laden fluorocarbon or fluorocarbon mixture, the amount of fluorocarbon being in the range from 0.2 to 100% weight/volume, in a carrier suitable for dermatological use. Preparation is effected by emulsification of the corresponding constituents, and use in ointments, creams, lotions, waters, alcoholic extracts, pastes, powders, gels, tinctures or on dressings and plasters or in a spray.
摘要翻译：本发明涉及一种用于辅助皮肤中氧气输送的化妆品，其制备方法及其用途。已知化妆品的问题是对皮肤和相邻组织的氧气供应不足。因此，本发明的目的是通过渗透过程渗透皮肤和表皮的角质层，以增加皮肤区域和毗邻组织中的氧浓度并激活代谢过程。根据本发明，这是通过包含不对称层状聚集体的化妆品来实现的，该组合物由磷脂和含氧碳氟化合物或氟碳混合物组成，碳氟化合物的量在0.2至100重量/体积的范围内，适用于皮肤用药。制剂通过乳化相应的成分进行，并用于软膏，霜剂，洗剂，水，酒精提取物，糊剂，粉末，凝胶，酊剂，敷料和膏药或喷雾剂中。

5. 发明申请

US20060052649A1 Method for the preparation of high surface area metal fluorides 有权
标题翻译：高表面积金属氟化物的制备方法
公开(公告)号：US20060052649A1
公开(公告)日：2006-03-09
申请号：US10541612
申请日：2004-01-07
申请人： Erhard Kemnitz , Udo Gross , Stephan Ruediger
发明人： Erhard Kemnitz , Udo Gross , Stephan Ruediger
IPC分类号： C07C17/07 , B01J27/06
CPC分类号： C07C17/37 , B01J27/12 , B01J27/125 , B01J27/128 , B01J27/138 , B01J35/002 , B01J35/0033 , B01J35/1019 , B01J35/108 , B01J37/26 , C01B9/08 , C01F5/28 , C01F7/50 , C01P2002/02 , C01P2002/54 , C01P2002/82 , C01P2002/86 , C01P2004/52 , C01P2004/54 , C01P2006/12 , C01P2006/14 , C01P2006/16 , C07C2/68 , C07C17/087 , C07C17/21 , C07C17/358 , C07C45/46 , C07C2527/125 , C07C19/12 , C07C19/14 , C07C19/10 , C07C49/84
摘要： The present invention is related to a method for preparing an amorphous metal fluoride of the formula MX+FX-δ comprising the steps of a) providing a precursor, whereby the precursor comprises a structure having a formula of Mx+F(x-δ)-yBy; and b) reacting the precursor with a fluorinating agent generating the amorphous metal flouride having a formula of Mx+Fx-δ, whereby M is selected from the group comprising metals of the second, third and fourth main group and any subgroup of the periodic table, B is a coordinately bound group; x is any integer of 2 or 3; y is any integer between 1 and 3; δ is 0 to 0.1; and x−δ>y.
摘要翻译：本发明涉及一种制备式M X-X X-δ的无定形金属氟化物的方法，包括步骤

6. 发明授权

US4225404A Perfluoroolefin and perfluoroparaffin mixture and process for making same 失效
标题翻译：全氟烯烃和全氟烷烃混合物及其制备方法
公开(公告)号：US4225404A
公开(公告)日：1980-09-30
申请号：US912038
申请日：1978-08-24
申请人： Peter Dietrich , Gunter Engler , Armin Ferse , Harald Grimm, deceased , Udo Gross , Dietmar Handte , Klaus Lunkwitz , Ulrich Muller , Dietrich Prescher , Jurgen Schulze
发明人： Peter Dietrich , Gunter Engler , Armin Ferse , Harald Grimm, deceased , Udo Gross , Dietmar Handte , Klaus Lunkwitz , Ulrich Muller , Dietrich Prescher , Jurgen Schulze
IPC分类号： B01J19/08 , C07C17/367 , C07C21/18 , B01J1/10
CPC分类号： C07C21/18 , B01J19/085 , C07C17/367
摘要： Straight chain perfluoroolefins compounds of medium length with terminal or double bonds and a minor proportion of trifluoromethyl side chains or mixtures of such perfluoroolefins with perfluoro paraffins of equal chain length and corresponding structure, the perfluoroolefins being present in the mixture in an amount of 40 to 70%. The compounds are valuable as highly reactive intermediate products in the production of surface active agents. The compounds are made by subjecting a highly fluorinated organic compound to degradation by means of a high energy radiation of a density of 0.3 to 3.0 W/cm.sup.2 effected in a radiation chamber which has been subjected to a preceding rinsing with an inert gas or with a monomeric highly fluorinated organic compound.
摘要翻译：具有中等长度的具有末端或双键的直链全氟烯烃化合物和少量比例的三氟甲基侧链或这种全氟烯烃的混合物与具有相等链长和相应结构的全氟链烷烃的混合物中，全氟烯烃以40至70的量存在于混合物中％。这些化合物在表面活性剂生产中作为高反应性中间产物是有价值的。化合物是通过使高度氟化的有机化合物通过在用惰性气体进行先前漂洗的辐射室中进行的，在0.3至3.0W / cm 2的密度的高能量辐射下进行降解而制成的，单体高氟化有机化合物。

7. 发明授权

US07026359B1 Utilization of a highly fluorinated oligomeric alkane in ophthalmology 失效
标题翻译：高度氟化的低聚烷烃在眼科学中的应用
公开(公告)号：US07026359B1
公开(公告)日：2006-04-11
申请号：US10018398
申请日：2000-04-27
申请人： Udo Gross , Dirk-Henning Menz , Erhard Kemnitz , Hans Hoerauf , Karin Kobuch
发明人： Udo Gross , Dirk-Henning Menz , Erhard Kemnitz , Hans Hoerauf , Karin Kobuch
IPC分类号： A01N29/00
CPC分类号： A61K9/0048 , A61K31/025 , Y10S514/912
摘要： The invention relates to the utilization of a highly fluorinated oligomeric alkane as a therapeutic agent in ophthalmology, the alkane having the general formula [—RF(CH2)nCR1—CR2—]x, wherein RF is a linear or branched perfluorinated alkyl chain C2F5 to C12F23, R1 and R2 are independently selected from the group consisting of H, CH3, C2H5 and C3H7, n is selected from the numbers 0, 1 and 2, and x is a number between 2 and 6, with a molar mass of at least 750. According to the invention, a pharmacological agent is provided that is used in ophthalmology and that causes little or no damage to the retina even when used over a long period.
摘要翻译：本发明涉及高度氟化的低聚烷烃作为眼科治疗剂的用途，具有通式[-R“ 其中R 1是直链或支链的，其中R 1是直链或支链的全氟化烷基链C 2 F 5到C 12 F 23，R 1，和R 2 2独立地选自H，CH 3，C 2 H 5和C 3是选自数字0,1和2，x是2和6之间的数字，摩尔质量至少为750。根据对于本发明，提供了用于眼科学的药理学试剂，即使在长时间使用时也对视网膜几乎没有或没有损伤。

8. 发明授权

US4049681A Processes for the separation of potassium salts of perfluoroalkanoic acids from aqueous solutions thereof 失效
标题翻译：从其水溶液中分离全氟链烷酸钾盐的方法
公开(公告)号：US4049681A
公开(公告)日：1977-09-20
申请号：US641919
申请日：1975-12-18
申请人： Peter Dietrich , Gunter Engler , Armin Ferse , Harald Grimm , Udo Gross , Klaus Lunkwitz , Dietrich Prescher , Jurgen Schulze , Astrid Wallbraun
发明人： Peter Dietrich , Gunter Engler , Armin Ferse , Harald Grimm , Udo Gross , Klaus Lunkwitz , Dietrich Prescher , Jurgen Schulze , Astrid Wallbraun
IPC分类号： C07C51/48 , C09F7/00 , C11C3/00
CPC分类号： C07C51/48
摘要： Processes for the separation of a potassium salt of a perfluoroalkanoic acid having at least 1 and at most 12 carbon atoms per molecule or a mixture of potassium salts of a homologous mixture of the said perfluoroalkanoic acids from an aqueous solution that also contains a substantial proportion of one or more watersoluble salts of inorganic acids which process comprises extracting at room temperature the said aqueous solution with an organic solvent which is at least partially miscible with water and in which potassium salts of the said perfluoroalkanoic acids are soluble, the said organic solvent being selected from the group consisting of alkanols having at least 3 and at most 5 carbon atoms per molecule, ketones having at least 3 and at most 7 carbon atoms per molecule, N,N-dimethylformamide and dimethyl sulfoxide, and subsequently recovering the potassium salt of the perfluoroalkanoic acid or mixture of potassium salts of the homologous mixture of perfluoroalkanoic acids.
摘要翻译：每分子具有至少1个和最多12个碳原子的全氟链烷酸钾盐的分离方法或所述全氟链烷酸的同源混合物的钾盐水溶液的混合物的方法，所述水溶液还含有相当大比例的一种或多种无机酸的水溶性盐，其处理方法包括在室温下用有机溶剂萃取所述水溶液，所述有机溶剂至少部分地与水混溶，其中所述全氟链烷酸钾盐可溶，选择所述有机溶剂从每分子具有至少3个且至多5个碳原子的链烷醇组成的组，每分子具有至少3个且至多7个碳原子的酮，N，N-二甲基甲酰胺和二甲基亚砜，然后回收全氟链烷酸或全氟链烷酸的同源混合物的钾盐的混合物。

9. 发明授权

US07592287B2 Method for the preparation of high surface area metal fluorides 有权
标题翻译：高表面积金属氟化物的制备方法
公开(公告)号：US07592287B2
公开(公告)日：2009-09-22
申请号：US10541612
申请日：2004-01-07
申请人： Erhard Kemnitz , Udo Gross , Stephan Ruediger
发明人： Erhard Kemnitz , Udo Gross , Stephan Ruediger
IPC分类号： B01J27/06 , B01J27/122 , B01J27/138 , B01J27/132 , B01J27/135 , C01B9/08 , C01B9/00 , C01G23/02 , C01G19/08 , C01G49/10 , C01G15/00 , C01F3/00 , C01F7/48
CPC分类号： C07C17/37 , B01J27/12 , B01J27/125 , B01J27/128 , B01J27/138 , B01J35/002 , B01J35/0033 , B01J35/1019 , B01J35/108 , B01J37/26 , C01B9/08 , C01F5/28 , C01F7/50 , C01P2002/02 , C01P2002/54 , C01P2002/82 , C01P2002/86 , C01P2004/52 , C01P2004/54 , C01P2006/12 , C01P2006/14 , C01P2006/16 , C07C2/68 , C07C17/087 , C07C17/21 , C07C17/358 , C07C45/46 , C07C2527/125 , C07C19/12 , C07C19/14 , C07C19/10 , C07C49/84
摘要： The present invention is related to a method for preparing an amorphous metal fluoride of the formula MX+FX−δ comprising the steps of a) providing a precursor, whereby the precursor comprises a structure having a formula of Mx+F(x−δ)−yBy; and b) reacting the precursor with a fluorinating agent generating the amorphous metal flouride having a formula of Mx+Fx−δ, whereby M is selected from the group comprising metals of the second, third and fourth main group and any subgroup of the periodic table, B is a coordinately bound group; x is any integer of 2 or 3; y is any integer between 1 and 3; δ is 0 to 0.1; and x−δ>y.
摘要翻译：本发明涉及一种制备式MX + FX-δ的无定形金属氟化物的方法，包括以下步骤：a）提供前体，其中前体包含具有式M x + F（x-δ） -yBy; 和b）使前体与产生具有式Mx + Fx-δ的无定形金属氟化物的氟化剂反应，其中M选自第二，第三和第四主族金属和周期表的任何亚组 B是一个协调绑定的组; x是2或3的整数; y是1到3之间的整数; δ为0至0.1; 和x-delta> y。

10. 发明申请

US20080274037A1 Method For The Preparation Of X-Ray Amorphous Or Weakly Crystalline Metal Oxide Fluorides And New Uses Thereof 审中-公开
标题翻译：用于制备X射线非晶态或弱结晶金属氧化物氟化物的方法及其新用途
公开(公告)号：US20080274037A1
公开(公告)日：2008-11-06
申请号：US11720796
申请日：2005-12-05
申请人： Udo Gross , Erhard Kemnitz , Stephan Ruediger
发明人： Udo Gross , Erhard Kemnitz , Stephan Ruediger
IPC分类号： C01F7/50 , C01B11/24
CPC分类号： C01F5/28 , B01J27/12 , B01J27/125 , B01J27/138 , B01J35/002 , B01J35/1019 , C01B9/08 , C01F7/50 , C01P2002/02 , C01P2006/12 , C01P2006/14 , C03C17/22 , C03C2217/285
摘要： The present invention is related to a method for preparing an X-ray amorphous or weakly crystalline metal oxide fluoride of a composition represented by the formula Ma+ObFc comprising the steps of b) providing a precursor, whereby the precursor is a fluorinated metal compound having a composition which is represented by the formula Ma+F(a−d)BdLxb) converting the precursor into an metal oxide/hydroxide fluoride; and c) calcinating the metal oxide/hydroxide fluoride having the formula Ma+OcHfFc to generate the X-ray amorphous or weakly crystalline metal oxide fluoride of the formula Ma+ObFc, whereby M is selected from the group comprising metals of the first, second, third and fourth main group and any subgroup of the periodic table; B is a group or an anion which is selected from the group comprising alkoxide, enolates, alkyl, chloride, bromide, iodide, nitrate, and organic acid anions; B is preferably an alkoxy group; L is a solvent other than water; a is any integer of 1, 2, 3, 4, 5 or 6, preferably 2 or 3; and b and c are any numbers obeying the formula b/2+c=a, and c is 0.1b to 10b; d is a number between 0 and 0.8a, preferable between 0.1 and 0.3a; e is (a−c+f)/2; f is a number between 0 and (a−c); and x is between 0 and 6.
摘要翻译：本发明涉及一种制备由下式表示的组合物的X射线无定形或弱结晶金属氧化物氟化物的方法： c）包括以下步骤：b）提供前体，由此所述前体是具有由下式表示的组成的氟化金属化合物：（a） b）将前体转化为金属氧化物/氢氧化物氟化物; 和c）将具有下式的金属氧化物/氢氧化物氟化物煅烧：将式M a -O + 产生式M a O b O b C c C的X射线无定形或弱结晶金属氧化物氟化物，其中M选自包括第一，第二，第三和第四主族的金属和周期表的任何亚组; B是选自醇盐，烯醇化物，烷基，氯化物，溴化物，碘化物，硝酸盐和有机酸阴离子的基团或阴离子; B优选为烷氧基; L是水以外的溶剂; a是1,2,3,4,5或6，优选2或3的整数; b和c是符合公式b / 2 + c = a的任何数字，c是0.1b〜10b; d是0和0.8a之间的数，优选在0.1和0.3a之间; e为（a-c + f）/ 2; f是0和（a-c）之间的数字; x在0和6之间。

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