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1. 发明申请

US20080242734A1 Use of Biocistronic DNA Constructs for Identifying Compounds that Inhibit IRES-Dependent Translation 审中-公开
标题翻译：使用生物顺反子DNA构建体鉴定抑制IRES依赖性翻译的化合物
公开(公告)号：US20080242734A1
公开(公告)日：2008-10-02
申请号：US11781564
申请日：2007-07-23
申请人： Tzong-Yuan Wu , Shin-Jhan Zeng , Ying-Ju Chen , Tsu-An Hsu , Shin-Ru Shih , Suey-Sheng Kao , Tzyy-Rong Jinn
发明人： Tzong-Yuan Wu , Shin-Jhan Zeng , Ying-Ju Chen , Tsu-An Hsu , Shin-Ru Shih , Suey-Sheng Kao , Tzyy-Rong Jinn
IPC分类号： A61K31/13 , A61P25/24
CPC分类号： C12Q1/6897 , C12N15/67
摘要： The present invention relates to use of bicistronic DNA constructs for identifying compounds that inhibits IRES-dependent translation activity of an infectious enterovirus (EV) or encephalomyocarditis virus (EMCV) without affecting CAP-dependent translation activity of a host subject. The compounds thus identified are useful in preparation of a medicament for treating EV or EMCV infection.
摘要翻译：本发明涉及双顺反子DNA构建体用于鉴定抑制感染性肠病毒（EV）或脑心肌炎病毒（EMCV）的IRES依赖性翻译活性而不影响宿主受试者的依赖于CAP的翻译活性的化合物的用途。所鉴定的化合物可用于制备用于治疗EV或EMCV感染的药物。

2. 发明申请

US20080241922A1 Use of Biocistronic DNA Constructs for Identifying Compounds that Inhibit IRES-Dependent Translation 失效
公开(公告)号：US20080241922A1
公开(公告)日：2008-10-02
申请号：US11781596
申请日：2007-07-23
申请人： Tzong-Yuan Wu , Shin-Jhan Zeng , Ying-Ju Chen , Tsu-An Hsu , Shin-Ru Shih , Suey-Sheng Kao , Tzyy-Rong Jinn
发明人： Tzong-Yuan Wu , Shin-Jhan Zeng , Ying-Ju Chen , Tsu-An Hsu , Shin-Ru Shih , Suey-Sheng Kao , Tzyy-Rong Jinn
IPC分类号： C12N5/10
CPC分类号： C12Q1/6897 , C12N15/67
摘要： The present invention relates to use of bicistronic DNA constructs for identifying compounds that inhibits IRES-dependent translation activity of an infectious enterovirus (EV) or encephalomyocarditis virus (EMCV) without affecting CAP-dependent translation activity of a host subject. The compounds thus identified are useful in preparation of a medicament for treating EV or EMCV infection.

3. 发明授权

US07588885B2 Use of biocistronic DNA constructs for identifying compounds that inhibit IRES-dependent translation 失效
标题翻译：使用生物顺反子DNA构建体来鉴定抑制IRES依赖性翻译的化合物
公开(公告)号：US07588885B2
公开(公告)日：2009-09-15
申请号：US11781596
申请日：2007-07-23
申请人： Tzong-Yuan Wu , Shin-Jhan Zeng , Ying-Ju Chen , Tsu-An Hsu , Shin-Ru Shih , Suey-Sheng Kao , Tzyy-Rong Jinn
发明人： Tzong-Yuan Wu , Shin-Jhan Zeng , Ying-Ju Chen , Tsu-An Hsu , Shin-Ru Shih , Suey-Sheng Kao , Tzyy-Rong Jinn
IPC分类号： C12N15/63 , C12Q1/68 , C12P21/00
CPC分类号： C12Q1/6897 , C12N15/67
摘要： The present invention relates to use of bicistronic DNA constructs for identifying compounds that inhibits IRES-dependent translation activity of an infectious enterovirus (EV) or encephalomyocarditis virus (EMCV) without affecting CAP-dependent translation activity of a host subject. The compounds thus identified are useful in preparation of a medicament for treating EV or EMCV infection.
摘要翻译：本发明涉及双顺反子DNA构建体用于鉴定抑制感染性肠病毒（EV）或脑心肌炎病毒（EMCV）的IRES依赖性翻译活性而不影响宿主受试者的依赖于CAP的翻译活性的化合物的用途。所鉴定的化合物可用于制备用于治疗EV或EMCV感染的药物。

4. 发明授权

US07262051B2 Use of biscistronic DNA constructs for identifying compounds that inhibit IRES-dependent translation 失效
标题翻译：使用双顺反子DNA构建体来鉴定抑制IRES依赖性翻译的化合物
公开(公告)号：US07262051B2
公开(公告)日：2007-08-28
申请号：US10913269
申请日：2004-08-06
申请人： Tzong-Yuan Wu , Tsu-An Hsu , Shin-Ru Shih , Suey-Sheng Kao , Tzyy-Rong Jinn , Shin-Jhan Zeng , Ying-Ju Chen
发明人： Tzong-Yuan Wu , Tsu-An Hsu , Shin-Ru Shih , Suey-Sheng Kao , Tzyy-Rong Jinn , Shin-Jhan Zeng , Ying-Ju Chen
IPC分类号： C12N15/63 , C12Q1/68 , C12P21/00
CPC分类号： C12Q1/6897
摘要： The present invention relates to use of bicistronic DNA constructs for identifying compounds that inhibits IRES-dependent translation activity of an infectious enterovirus (EV) or encephalomyocarditis virus (EMCV) without affecting CAP-dependent translation activity of a host subject. The compounds thus identified are useful in preparation of a medicament for treating EV or EMCV infection.
摘要翻译：本发明涉及双顺反子DNA构建体用于鉴定抑制感染性肠病毒（EV）或脑心肌炎病毒（EMCV）的IRES依赖性翻译活性而不影响宿主受试者的依赖于CAP的翻译活性的化合物的用途。所鉴定的化合物可用于制备用于治疗EV或EMCV感染的药物。

5. 发明申请

US20060024680A1 Use of biscistronic DNA constructs for identifying compounds that inhibit IRES-dependent translation 失效
标题翻译：使用双顺反子DNA构建体来鉴定抑制IRES依赖性翻译的化合物
公开(公告)号：US20060024680A1
公开(公告)日：2006-02-02
申请号：US10913269
申请日：2004-08-06
申请人： Tzong-Yuan Wu , Tsu-An Hsu , Shin-Ru Shih , Suey-Sheng Kao , Tzyy-Rong Jinn , Shin-Jhan Zeng , Ying-Ju Chen
发明人： Tzong-Yuan Wu , Tsu-An Hsu , Shin-Ru Shih , Suey-Sheng Kao , Tzyy-Rong Jinn , Shin-Jhan Zeng , Ying-Ju Chen
IPC分类号： C12Q1/68 , C12P21/06
CPC分类号： C12Q1/6897
摘要： The present invention relates to use of bicistronic DNA constructs for identifying compounds that inhibits IRES-dependent translation activity of an infectious enterovirus (EV) or encephalomyocarditis virus (EMCV) without affecting CAP-dependent translation activity of a host subject. The compounds thus identified are useful in preparation of a medicament for treating EV or EMCV infection.
摘要翻译：本发明涉及双顺反子DNA构建体用于鉴定抑制感染性肠病毒（EV）或脑心肌炎病毒（EMCV）的IRES依赖性翻译活性而不影响宿主受试者的依赖于CAP的翻译活性的化合物的用途。所鉴定的化合物可用于制备用于治疗EV或EMCV感染的药物。

6. 发明授权

US06815444B2 Anti-enterovirus compounds 失效
标题翻译：抗肠道病毒化合物
公开(公告)号：US06815444B2
公开(公告)日：2004-11-09
申请号：US10444747
申请日：2003-05-23
申请人： Jyh-Haur Chern , Kak-Shan Shia , Shin-Ru Shih , Tsu-An Hsu , Chia-Liang Tai
发明人： Jyh-Haur Chern , Kak-Shan Shia , Shin-Ru Shih , Tsu-An Hsu , Chia-Liang Tai
IPC分类号： C07D48704
CPC分类号： C07D487/04
摘要： This invention features, among others, a pyrazolopyrimidine compound of formula (A): A is (CH2)q—CHRaRb; each of R1 and R2, independently, is hydrogen, halogen, cyano, nitro, or alkyl; or R1 and R2 taken together is (CH2)r; each of R3 and R4, independently, is hydrogen, halogen, cyano, nitro, or alkyl; each of R5, Ra, and Rb, independently, is aryl, aralkyl, or heteroaryl, optionally substituted with halogen, cyano, nitro, alkyl, aryl, aralkyl, heteroaryl, OR, O(O)CR, C(O)R, C(O)OR, C(O)NRR′, SR, S(O)R, S(O)OR, NRR′, NR(O)CR′, NRC(O)OR′, or NRC(O)NR′R″; each of m, n, o, p, and r, independently, is 0 or 1, and q is 0, 1, or 2; in which each of R, R′, and R″, independently, is hydrogen or alkyl, provided that the sum of m, n, o, and p is 1, 2, 3, or 4.
摘要翻译：本发明特别地包括式（A）的吡唑并嘧啶化合物：A是（CH 2）q-CHR a R b; R 1和R 2各自独立地是氢，卤素，氰基，硝基或烷基; 或者R 1和R 2一起是（CH 2）r; R 3和R 4各自独立地是氢，卤素，氰基，硝基或烷基; 氰基，硝基，烷基，芳基，芳烷基，杂芳基，OR，O（O）CR，R 3，R 3和R 4各自独立地是芳基，芳烷基或杂芳基， C（O）OR，NR（O）OR，C（O）NRR'，SR，S（O）R，S（O）OR，NRR' 或NRC（O）NR'R“; m，n，o，p和r各自独立地为0或1，q为0,1或2; 其中R，R'和R“各自独立地是氢或烷基，条件是m，n，o和p的和为1,2,3或4。

7. 发明申请

US20120046238A1 COUMARIN COMPOUNDS AND THEIR USE FOR TREATING VIRAL INFECTION 审中-公开
标题翻译：欧马林化合物及其用于治疗病毒感染的用途
公开(公告)号：US20120046238A1
公开(公告)日：2012-02-23
申请号：US13293181
申请日：2011-11-10
申请人： Hsing-Pang Hsieh , Tsu-An Hsu , Jiann-Yih Yeh , Jim-Tong Horng , Shin-Ru Shih , Sui-yuan Chang , Yu-Sheng Chao
发明人： Hsing-Pang Hsieh , Tsu-An Hsu , Jiann-Yih Yeh , Jim-Tong Horng , Shin-Ru Shih , Sui-yuan Chang , Yu-Sheng Chao
IPC分类号： A61K31/7048 , A61K31/536 , A61K31/5377 , A61K31/453 , A61K31/497 , A61K31/381 , A61K31/4025 , A61K31/4155 , A61K31/422 , A61K31/4433 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/18 , A61P31/20 , A61P31/22 , A61K31/35
CPC分类号： A61K31/352 , A61K31/357 , A61K31/381 , A61K31/4025 , A61K31/404 , A61K31/4155 , A61K31/422 , A61K31/427 , A61K31/4433 , A61K31/453 , A61K31/4725 , A61K31/497 , A61K31/5377 , A61K31/538 , A61K31/7048
摘要： A method for treating an infection with a virus. The method includes administering to a subject in need thereof an effective amount of one or more coumarin compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, and X are defined herein. Also disclosed is a pharmaceutical composition including a coumarin compound.
摘要翻译：用于治疗病毒感染的方法。该方法包括向有需要的受试者施用有效量的一种或多种式（I）的香豆素化合物：其中R1，R2，R3，R4，R5，R6和X如本文所定义。还公开了包含香豆素化合物的药物组合物。

8. 发明申请

US20090312406A1 COUMARIN COMPOUNDS AND THEIR USE FOR TREATING VIRAL INFECTION 审中-公开
标题翻译：欧马尼康化合物及其用于治疗病毒感染的用途
公开(公告)号：US20090312406A1
公开(公告)日：2009-12-17
申请号：US12481789
申请日：2009-06-10
申请人： Hsing-Pang Hsieh , Tsu-An Hsu , Jiann-Yih Yeh , Jim-Tong Horng , Shin-Ru Shih , Sui-yuan Chang , Yu-Sheng Chao
发明人： Hsing-Pang Hsieh , Tsu-An Hsu , Jiann-Yih Yeh , Jim-Tong Horng , Shin-Ru Shih , Sui-yuan Chang , Yu-Sheng Chao
IPC分类号： A61K31/352 , A61P31/12
CPC分类号： A61K31/352 , A61K31/357 , A61K31/381 , A61K31/4025 , A61K31/404 , A61K31/4155 , A61K31/422 , A61K31/427 , A61K31/4433 , A61K31/453 , A61K31/4725 , A61K31/497 , A61K31/5377 , A61K31/538 , A61K31/7048
摘要： A method for treating an infection with a virus. The method includes administering to a subject in need thereof an effective amount of one or more coumarin compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, and X are defined herein. Also disclosed is a pharmaceutical composition including a coumarin compound.
摘要翻译：用于治疗病毒感染的方法。该方法包括向有需要的受试者施用有效量的一种或多种式（I）的香豆素化合物：其中R1，R2，R3，R4，R5，R6和X如本文所定义。还公开了包含香豆素化合物的药物组合物。

9. 发明授权

US09657263B2 Pharmaceutical composition for inhibiting infection and replication of influenza A and B virus, and the manufacture thereof 有权
公开(公告)号：US09657263B2
公开(公告)日：2017-05-23
申请号：US13167453
申请日：2011-06-23
申请人： Chuang-Chun Chiuh , Shin-Ru Shih , Shau-Feng Chang , Yi-Hsiang Chen , I-Chen Hu
发明人： Chuang-Chun Chiuh , Shin-Ru Shih , Shau-Feng Chang , Yi-Hsiang Chen , I-Chen Hu
IPC分类号： A61K35/74 , C12N1/12 , A61K35/748 , C12N1/04
CPC分类号： C12N1/12 , A61K35/748 , C12N1/04
摘要： Disclosed is a pharmaceutical composition for inhibiting infection and replication of influenza A and B virus, and the manufacture thereof. The pharmaceutical composition is produced by a manufacture of low-temperature disintegrating cyanobacteria, comprising the steps of: (a) mixing cyanobacteria and non-organic solvent to form a suspension containing cyanobacteria; (b) freezing the suspension with a temperature below 0° C. to form a ice block and the ice block being melted at a low temperature, the whole step being repeated at least twice; (c) separating the cyanobacterial residues and extract solution of the suspension; and (d) collecting the isolated cyanobacterial extract solution; wherein the cyanobacterial extract solution is a solution containing cyanobacterial bioactive substances. The pharmaceutical composition is able to effectively inhibit binding of sialic acid and hemagglutinin of influenza A and/or B virus, so as to inhibit infection and replication of influenza virus. Further, this pharmaceutical composition is able to inhibit infection of influenza virus resistant to neuraminidase inhibitors.

10. 发明申请

US20070049623A1 Imidazolidinone compounds 有权
标题翻译：咪唑啉酮化合物
公开(公告)号：US20070049623A1
公开(公告)日：2007-03-01
申请号：US11590280
申请日：2006-10-30
申请人： Jyh-Haur Chern , Shin-Ru Shih , Chiung-Tong Chen , Chih-Shiang Chang , Chung-Chi Lee , Yen-Chun Lee , Chia-Liang Tai
发明人： Jyh-Haur Chern , Shin-Ru Shih , Chiung-Tong Chen , Chih-Shiang Chang , Chung-Chi Lee , Yen-Chun Lee , Chia-Liang Tai
IPC分类号： A61K31/4439 , C07D403/14 , C07D403/04
CPC分类号： C07D233/32 , C07D401/04 , C07D401/14 , C07D403/14 , C07D405/12 , C07D409/14 , C07D413/14 , C07D417/12
摘要： This invention relates to compounds of the following formula: in which R1, R2, A1, A2, X, Y, m, n, p, x and y are as defined herein, pharmaceutical compositions comprising the compounds and use of the compounds in treating enterovirus infection.
摘要翻译：本发明涉及下式的化合物：其中R 1，R 2，A 1，A 2， >，X，Y，m，n，p，x和y如本文所定义，包含该化合物的药物组合物和该化合物在治疗肠道病毒感染中的用途。

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