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    • 4. 发明授权
    • Anti-enterovirus compounds
    • 抗肠道病毒化合物
    • US06815444B2
    • 2004-11-09
    • US10444747
    • 2003-05-23
    • Jyh-Haur ChernKak-Shan ShiaShin-Ru ShihTsu-An HsuChia-Liang Tai
    • Jyh-Haur ChernKak-Shan ShiaShin-Ru ShihTsu-An HsuChia-Liang Tai
    • C07D48704
    • C07D487/04
    • This invention features, among others, a pyrazolopyrimidine compound of formula (A): A is (CH2)q—CHRaRb; each of R1 and R2, independently, is hydrogen, halogen, cyano, nitro, or alkyl; or R1 and R2 taken together is (CH2)r; each of R3 and R4, independently, is hydrogen, halogen, cyano, nitro, or alkyl; each of R5, Ra, and Rb, independently, is aryl, aralkyl, or heteroaryl, optionally substituted with halogen, cyano, nitro, alkyl, aryl, aralkyl, heteroaryl, OR, O(O)CR, C(O)R, C(O)OR, C(O)NRR′, SR, S(O)R, S(O)OR, NRR′, NR(O)CR′, NRC(O)OR′, or NRC(O)NR′R″; each of m, n, o, p, and r, independently, is 0 or 1, and q is 0, 1, or 2; in which each of R, R′, and R″, independently, is hydrogen or alkyl, provided that the sum of m, n, o, and p is 1, 2, 3, or 4.
    • 本发明特别地包括式(A)的吡唑并嘧啶化合物:A是(CH 2)q-CHR a R b; R 1和R 2各自独立地是氢,卤素,氰基,硝基或烷基; 或者R 1和R 2一起是(CH 2)r; R 3和R 4各自独立地是氢,卤素,氰基,硝基或烷基; 氰基,硝基,烷基,芳基,芳烷基,杂芳基,OR,O(O)CR,R 3,R 3和R 4各自独立地是芳基,芳烷基或杂芳基, C(O)OR,NR(O)OR,C(O)NRR',SR,S(O)R,S(O)OR,NRR' 或NRC(O)NR'R“; m,n,o,p和r各自独立地为0或1,q为0,1或2; 其中R,R'和R“各自独立地是氢或烷基,条件是m,n,o和p的和为1,2,3或4。