专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09657263B2 Pharmaceutical composition for inhibiting infection and replication of influenza A and B virus, and the manufacture thereof 有权
公开(公告)号：US09657263B2
公开(公告)日：2017-05-23
申请号：US13167453
申请日：2011-06-23
申请人： Chuang-Chun Chiuh , Shin-Ru Shih , Shau-Feng Chang , Yi-Hsiang Chen , I-Chen Hu
发明人： Chuang-Chun Chiuh , Shin-Ru Shih , Shau-Feng Chang , Yi-Hsiang Chen , I-Chen Hu
IPC分类号： A61K35/74 , C12N1/12 , A61K35/748 , C12N1/04
CPC分类号： C12N1/12 , A61K35/748 , C12N1/04
摘要： Disclosed is a pharmaceutical composition for inhibiting infection and replication of influenza A and B virus, and the manufacture thereof. The pharmaceutical composition is produced by a manufacture of low-temperature disintegrating cyanobacteria, comprising the steps of: (a) mixing cyanobacteria and non-organic solvent to form a suspension containing cyanobacteria; (b) freezing the suspension with a temperature below 0° C. to form a ice block and the ice block being melted at a low temperature, the whole step being repeated at least twice; (c) separating the cyanobacterial residues and extract solution of the suspension; and (d) collecting the isolated cyanobacterial extract solution; wherein the cyanobacterial extract solution is a solution containing cyanobacterial bioactive substances. The pharmaceutical composition is able to effectively inhibit binding of sialic acid and hemagglutinin of influenza A and/or B virus, so as to inhibit infection and replication of influenza virus. Further, this pharmaceutical composition is able to inhibit infection of influenza virus resistant to neuraminidase inhibitors.

2. 发明申请

US20120121744A1 PHARMACEUTICAL COMPOSITION FOR INHIBITING INFECTION AND REPLICATION OF INFLUENZA A AND B VIRUS, AND THE MANUFACTURE THEREOF 有权
标题翻译：用于抑制感染和复制流感病毒A和B病毒的药物组合物及其制造方法
公开(公告)号：US20120121744A1
公开(公告)日：2012-05-17
申请号：US13167453
申请日：2011-06-23
申请人： Chuang-Chun CHIUH , Shin-Ru SHIH , Shau-Feng CHANG , Yi-Hsiang CHEN , I-Chen HU
发明人： Chuang-Chun CHIUH , Shin-Ru SHIH , Shau-Feng CHANG , Yi-Hsiang CHEN , I-Chen HU
IPC分类号： A61K35/74 , A61P31/16 , C12N1/20
CPC分类号： C12N1/12 , A61K35/748 , C12N1/04
摘要： Disclosed is a pharmaceutical composition for inhibiting infection and replication of influenza A and B virus, and the manufacture thereof. The pharmaceutical composition is produced by a manufacture of low-temperature disintegrating cyanobacteria, comprising the steps of: (a) mixing cyanobacteria and non-organic solvent to form a suspension containing cyanobacteria; (b) freezing the suspension with a temperature below 0° C. to form a ice block and the ice block being melted at a low temperature, the whole step being repeated at least twice; (c) separating the cyanobacterial residues and extract solution of the suspension; and (d) collecting the isolated cyanobacterial extract solution; wherein the cyanobacterial extract solution is a solution containing cyanobacterial bioactive substances. The pharmaceutical composition is able to effectively inhibit binding of sialic acid and hemagglutinin of influenza A and/or B virus, so as to inhibit infection and replication of influenza virus. Further, this pharmaceutical composition is able to inhibit infection of influenza virus resistant to neuraminidase inhibitors.
摘要翻译：公开了用于抑制A型和B型流感病毒感染和复制的药物组合物及其制造方法。药物组合物是通过低温崩解蓝细菌的制造而制造的，包括以下步骤：（a）将蓝细菌和非有机溶剂混合以形成含有蓝细菌的悬浮液; （b）将温度低于0℃的悬浮液冷冻，形成冰块，冰块在低温下熔化，整个步骤重复至少两次; （c）分离悬浮液中的蓝藻残渣并提取溶液; 和（d）收集孤立的蓝藻提取物溶液; 其中蓝藻提取物溶液是含有蓝藻生物活性物质的溶液。药物组合物能够有效抑制唾液酸和甲型流感病毒和/或B型病毒血凝素的结合，从而抑制流感病毒的感染和复制。此外，该药物组合物能够抑制对神经氨酸酶抑制剂有抗性的流感病毒感染。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式