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1. 发明授权

US4996979A Soft-goods type, formable orthopaedic cast 失效
标题翻译：软货物类型，成形矫形器
公开(公告)号：US4996979A
公开(公告)日：1991-03-05
申请号：US420920
申请日：1989-10-13
申请人： Tracy E. Grim , Vincent McGinniss , Kenneth E. Hughes , David A. Easter , Robert S. Whitmore, Jr. , Timothy J. Carpenter , David E. Guza
发明人： Tracy E. Grim , Vincent McGinniss , Kenneth E. Hughes , David A. Easter , Robert S. Whitmore, Jr. , Timothy J. Carpenter , David E. Guza
IPC分类号： A61F5/058 , A61F13/04
CPC分类号： A61F13/04 , A61F5/05841
摘要： A soft goods type foldable, wrappable sleeve orthopedic cast immobilizes and conforms to the shape and configuration of a limb, or other part of the anatomy. The soft-goods type cast assembly is initially specially formed or configured to specifically fit a selected portion of the anatomy of a patient. The cast conforms to the anatomy through the use of airtight and moisture-proof pouches which encapsulate either (1) open cell or fiberglass matrices impregnated with a water-activated hardenable pre-polymer, or (2) the entire assembly. After the tightening of the cast around the limb, the application of water activates the urethane polymer which conforms to the configuration of the limb encased. Supplemental bendable ribs may be employed to splint the limb prior to activation of the hardenable material. The soft goods type cast is held in place by straps, and may be removed or adjusted by releasing or tightening the straps. The splinting elements may be removed and replaced. An inlet duct may have a capsule in it with some of the chemical material which aids in polymerization of the urethane. A venting duct may also be provided to permit the escape of air or gases. The water activated pre-polymer material may include two isocyanate pre-polymers of significantly different viscosities and equivalent weights.
摘要翻译：柔软的货物类型可折叠，可包装的袖口矫形器固定并符合肢体或解剖结构的其他部分的形状和构型。软货物铸造组件最初被特别地形成或构造成特别地适合患者的解剖结构的选定部分。铸件通过使用气密和防潮袋，符合解剖学，其中包括（1）用水激活的可硬化预聚物浸渍的开孔或玻璃纤维基体，或（2）整个组件。在围绕肢体收紧铸件之后，水的使用激活了符合肢体包裹构型的聚氨酯聚合物。可补充的可弯曲肋条可在活化可硬化材料之前夹住肢体。软质铸件通过带子固定在适当位置，可以通过松开或拉紧带子来移除或调整。可以去除和更换夹板元件。入口管道可以在其中具有胶囊，其中一些化学材料有助于聚氨酯的聚合。还可以设置排气管以允许空气或气体逸出。水活化的预聚物材料可以包括具有显着不同粘度和当量重量的两种异氰酸酯预聚物。

2. 发明授权

US5830186A Method of dispensing medications by use of mucous membrane infusor 失效
标题翻译：使用粘膜注射液分配药物的方法
公开(公告)号：US5830186A
公开(公告)日：1998-11-03
申请号：US895791
申请日：1997-07-17
申请人： Gilbert Gonzales , David A. Easter , Douglas E. Boyd , Kenneth E. Hughes
发明人： Gilbert Gonzales , David A. Easter , Douglas E. Boyd , Kenneth E. Hughes
IPC分类号： A61M25/00 , A61M31/00 , A61M5/00
CPC分类号： A61M31/00 , A61M2025/0057 , A61M2210/1064 , A61M2210/1067
摘要： An infusor system for administering medications to a patient comprises a delivery tube with one of the ends couplable to a supply of liquid medication. A dispenser head is coupled to the other end of the delivery tube and medication is directed through the tube to the dispenser head. The dispenser head includes a contact surface and is configured to be placed within a body cavity of a patient such that the contact surface contacts a portion of a mucous membrane in the body. The dispenser head is operable for directing medication from the delivery tube to the contact surface and on to the mucous membrane to be absorbed by the mucous membrane and distributed in a body of a patient. In a preferred embodiment of the invention, the dispenser head includes a portion of compressible foam which is configured to fit within the rectal cavity of a patient. The dispenser head channels, wicks or otherwise directs medication to the rectal mucous membrane to be absorbed thereby. Unique methods of utilizing the infusor system to administer medication to a patient are set forth herein.
摘要翻译：用于向患者施用药物的输注系统包括其中一个端部可连接到液体药物供应的输送管。分配头联接到输送管的另一端并且药物被引导通过管到分配头。分配器头包括接触表面，并且构造成被放置在患者的体腔内，使得接触表面接触体内粘膜的一部分。分配头可操作用于将药物从输送管引导到接触表面，并且在粘膜上被粘膜吸收并分布在患者体内。在本发明的一个优选实施例中，分配器头部包括一部分可压缩泡沫体，其被配置成装配在患者的直肠腔内。分配器头部通道，灯芯或以其他方式将药物引导至直肠粘膜以被吸收。本文阐述了利用输注系统向患者施用药物的独特方法。

3. 发明授权

US5846216A Mucous membrane infusor and method of use for dispensing medications 失效
标题翻译：粘膜渗透液和用于分配药物的方法
公开(公告)号：US5846216A
公开(公告)日：1998-12-08
申请号：US418580
申请日：1995-04-06
申请人： Gilbert Gonzales , David A. Easter , Douglas E. Boyd , Kenneth E. Hughes
发明人： Gilbert Gonzales , David A. Easter , Douglas E. Boyd , Kenneth E. Hughes
IPC分类号： A61M25/00 , A61M31/00 , A61M35/00
CPC分类号： A61M31/00 , A61M2025/0057 , A61M2210/1064 , A61M2210/1067
摘要： An infusor system for administering medications to a patient comprises a delivery tube with one of the ends couplable to a supply of liquid medication. A dispenser head is coupled to the other end of the delivery tube and medication is directed through the tube to the dispenser head. The dispenser head includes a contact surface and is configured to be placed within a body cavity of a patient such that the contact surface contacts a portion of a mucous membrane in the body. The dispenser head is operable for directing medication from the delivery tube to the contact surface and on to the mucous membrane to be absorbed by the mucous membrane and distributed in a body of a patient. In a preferred embodiment of the invention, the dispenser head includes a portion of compressible foam which is configured to fit within the rectal cavity of a patient. The dispenser head channels, wicks or otherwise directs medication to the rectal mucous membrane to be absorbed thereby. Unique methods of utilizing the infusor system to administer medication to a patient are set forth herein.
摘要翻译：用于向患者施用药物的输注系统包括其中一个端部可连接到液体药物供应的输送管。分配头联接到输送管的另一端并且药物被引导通过管到分配头。分配器头包括接触表面，并且构造成被放置在患者的体腔内，使得接触表面接触体内粘膜的一部分。分配头可操作用于将药物从输送管引导到接触表面，并且在粘膜上被粘膜吸收并分布在患者体内。在本发明的一个优选实施例中，分配器头部包括一部分可压缩泡沫体，其被配置成装配在患者的直肠腔内。分配器头部通道，灯芯或以其他方式将药物引导至直肠粘膜以被吸收。本文阐述了利用输注系统向患者施用药物的独特方法。

4. 发明授权

US6053877A Movable sample tube multiple biopsy sampling device 有权
标题翻译：活动样品管多次活检取样装置
公开(公告)号：US6053877A
公开(公告)日：2000-04-25
申请号：US193723
申请日：1998-11-17
申请人： Michael S. Banik , Joseph E. Young , Scott E. Swaffar , Michael B. Mosholder , Kenneth E. Hughes , Jan B. Yates , Norman J. Hedman , Jeremy M. Harris , Alan A. Alten
发明人： Michael S. Banik , Joseph E. Young , Scott E. Swaffar , Michael B. Mosholder , Kenneth E. Hughes , Jan B. Yates , Norman J. Hedman , Jeremy M. Harris , Alan A. Alten
IPC分类号： A61B10/00 , A61B10/02 , A61B10/04 , A61B10/06 , A61B17/28 , A61B17/34 , A61B5/00
CPC分类号： A61B10/0266 , A61B10/04 , A61B10/06 , A61B2010/0225 , A61B2017/2936 , A61B2017/2939 , A61B2017/2944 , A61B2017/3488
摘要： An instrument for obtaining tissue samples from a site deep within the body. The instrument has an elongated proximal portion that is constructed to follow a long, torturous path to the site and has a distal end constructed to sever and remove a tissue sample from the body, including tissue specimens, polyps or the like. The instrument is constructed to take multiple biopsy samples without being withdrawn from the body. The instrument includes a tissue sample retractor. The retractor is axially movable between an extended tissue-engaging position and a retracted position. There is an open passage into which the retractor moves when moving from the extended to the retracted position. The retractor has a distal end portion constructed to engage tissue and apply axial transporting force thereto while moving from the extended to the retracted position. The retractor is constructed to be advanced and retracted repeatedly to accumulate a series of samples in the instrument.
摘要翻译：用于从身体深处的部位获取组织样本的仪器。该仪器具有细长的近端部分，该近端部分被构造成遵循到该部位的长而弯曲的路径，并且具有构造成从身体切断和移除组织样本的远端，包括组织标本，息肉等。该仪器被构造成采取多个活检样本，而不会从体内撤出。仪器包括组织样本牵开器。牵开器可以在延伸的组织接合位置和缩回位置之间轴向移动。当从缩短位置移动时，有一个打开的通道，牵开器可移动。牵开器具有远端部分，该远端部分被构造成在从延伸到缩回位置的同时从组织接合并向其施加轴向传送力。牵引器被构造成反复进退并在仪器中积累一系列样品。

5. 发明授权

US07708759B2 Apparatus and methods for securing tendons or ligaments to bone 失效
标题翻译：将腱或韧带固定在骨上的装置和方法
公开(公告)号：US07708759B2
公开(公告)日：2010-05-04
申请号：US10620932
申请日：2003-07-16
申请人： Lawrence M. Lubbers , Kenneth E. Hughes , Carl R. Coleman , Warren P. Williamson, IV , Craig B. Berky , Thomas J. Ward
发明人： Lawrence M. Lubbers , Kenneth E. Hughes , Carl R. Coleman , Warren P. Williamson, IV , Craig B. Berky , Thomas J. Ward
IPC分类号： A61B17/04
CPC分类号： A61B17/0401 , A61B17/0487 , A61B17/064 , A61B17/1146 , A61B17/1686 , A61B17/683 , A61B17/685 , A61B2017/0404 , A61B2017/0406 , A61B2017/0408 , A61B2017/0409 , A61B2017/0412 , A61B2017/0414 , A61B2017/0427 , A61B2017/0437 , A61B2017/044 , A61B2017/0441 , A61B2017/0445 , A61B2017/0454 , A61B2017/0456 , A61B2017/0458 , A61B2017/0461 , A61B2017/0462 , A61B2017/0464 , A61B2017/0488 , A61B2017/0496 , A61B2017/06028 , A61B2017/06057 , A61B2017/0641 , A61B2017/0646 , A61B2017/0648 , A61B2017/0649 , A61B2090/0801 , A61F2/0805 , A61F2/0811 , A61F2002/0829 , A61F2002/0835 , A61F2002/0858 , A61F2002/0888
摘要： Apparatus and methods for repairing damaged tendons or ligaments. Various repair apparatus include an elongate tensile member and a pair of anchor structures connected for movement along the tensile member on either side of a repair site, such as a tear or laceration. The anchor structures may take many forms, and may include barbed, helical, and crimp-type anchors. In the preferred embodiments, at least one anchor structure is movable along the elongate tensile member to assist with adjusting a tendon segment to an appropriate repair position and the anchor structure or structures are then lockable onto the elongate tensile member to assist with affixing the tendon at the repair position. Tendon-to-bone repair apparatus and methods are also disclosed employing similar concepts. Tendon retrieval devices include helical members for rotating into a tendon end and subsequently moving the tendon to an appropriate operating position.
摘要翻译：用于修复损伤的腱或韧带的装置和方法。各种修理装置包括细长的拉伸构件和一对锚结构，其连接用于沿着维修部位的任一侧上的拉伸构件移动，例如撕裂或撕裂。锚结构可以具有许多形式，并且可以包括倒刺，螺旋和压接型锚。在优选实施例中，至少一个锚结构可以沿着细长的拉伸构件移动以帮助将腱段调整到适当的修复位置，并且锚定结构或结构然后可锁定到细长的拉伸构件上以辅助将腱固定在修理位置。还公开了类似的概念的肌腱对骨修复装置和方法。肌腱取出装置包括用于旋转到腱端部并随后将腱移动到适当的操作位置的螺旋构件。

6. 发明授权

US06984241B2 Apparatus and methods for tendon or ligament repair 失效
公开(公告)号：US06984241B2
公开(公告)日：2006-01-10
申请号：US09969947
申请日：2001-10-03
申请人： Lawrence M. Lubbers , Kenneth E. Hughes , Carl R. Coleman , Warren P. Williamson, IV , Craig B. Berky , Matthew J. Huddleston , Thomas J. Ward , Mark A. Goldin , Jeremy Jarrett , Joseph E. Young
发明人： Lawrence M. Lubbers , Kenneth E. Hughes , Carl R. Coleman , Warren P. Williamson, IV , Craig B. Berky , Matthew J. Huddleston , Thomas J. Ward , Mark A. Goldin , Jeremy Jarrett , Joseph E. Young
IPC分类号： A61B17/04
CPC分类号： A61B17/0401 , A61B17/0487 , A61B17/064 , A61B17/1146 , A61B17/1686 , A61B17/683 , A61B17/685 , A61B2017/0404 , A61B2017/0406 , A61B2017/0408 , A61B2017/0409 , A61B2017/0412 , A61B2017/0414 , A61B2017/0427 , A61B2017/0437 , A61B2017/044 , A61B2017/0441 , A61B2017/0445 , A61B2017/0454 , A61B2017/0456 , A61B2017/0458 , A61B2017/0461 , A61B2017/0462 , A61B2017/0464 , A61B2017/0488 , A61B2017/0496 , A61B2017/06028 , A61B2017/06057 , A61B2017/0641 , A61B2017/0646 , A61B2017/0648 , A61B2017/0649 , A61B2090/0801 , A61F2/0805 , A61F2/0811 , A61F2002/0829 , A61F2002/0835 , A61F2002/0858 , A61F2002/0888
摘要： Apparatus and methods for repairing damaged tendons or ligaments. Various repair apparatus include an elongate tensile member and a pair of anchor structures connected for movement along the tensile member on either side of a repair site, such as a tear or laceration. The anchor structures may take many forms, and may include barbed, helical, and crimp-type anchors. In the preferred embodiments, at least one anchor structure is movable along the elongate tensile member to assist with adjusting a tendon segment to an appropriate repair position and the anchor structure or structures are then lockable onto the elongate tensile member to assist with affixing the tendon at the repair position. The invention further provides tendon-to-bone repair apparatus and methods employing similar concepts. Tendon retrieval devices of the invention include helical members for rotating into a tendon end and subsequently moving the tendon to an appropriate operating position.

7. 发明授权

US4544516A Collagen orientation 失效
标题翻译：胶原方向
公开(公告)号：US4544516A
公开(公告)日：1985-10-01
申请号：US509423
申请日：1983-06-30
申请人： Kenneth E. Hughes , Timothy B. Hutson , David J. Fink
发明人： Kenneth E. Hughes , Timothy B. Hutson , David J. Fink
IPC分类号： A61F2/00 , A61L27/24 , C08L89/06 , D01D1/02
CPC分类号： C08L89/06 , A61L27/24 , A61F2310/00365 , Y10S128/08
摘要： Monomeric collagen is oriented in solution and the orientation is retained in the resulting gel by setting up convective flow paths in the solution during gelation. The convection is induced by uniform peripheral heating of the cold, collagen solution in a small-diameter cylinder. Oriented collagen produced in this manner has excellent wet strength for use in implants for natural reconstruction of body collagen.
摘要翻译：单体胶原蛋白在溶液中取向，并且通过在凝胶化期间在溶液中设置对流流动路径将所得凝胶保留在所得凝胶中。通过在小直径圆筒中的冷的胶原溶液的均匀的外围加热引起对流。以这种方式产生的定向胶原蛋白具有优异的湿强度，用于植入物中用于人体胶原蛋白的自然重建。

8. 发明授权

US5714042A Paper strengthened with solubilized collagen and method 失效
标题翻译：用增溶的胶原和方法增强纸张
公开(公告)号：US5714042A
公开(公告)日：1998-02-03
申请号：US483720
申请日：1995-06-07
申请人： Kenneth E. Hughes , David C. Masterson , David J. Fink , Barbara A. Metz , Gordon E. Pickett , Paul M. Gemmer , Richard S. Brody
发明人： Kenneth E. Hughes , David C. Masterson , David J. Fink , Barbara A. Metz , Gordon E. Pickett , Paul M. Gemmer , Richard S. Brody
IPC分类号： A61K38/00 , C07K14/78 , D21H11/14 , D21H17/22 , D21H21/18 , D21H17/00
CPC分类号： C07K14/78 , D21H17/22 , A61K38/00 , D21H11/14 , D21H21/18
摘要： A method for making a collagen strengthened cellulosic sheet by providing a cellulosic pulp slurry; adding solubilized collagen to the pulp slurry, and mixing for a time effective for interaction of the cellulosic pulp slurry and solubilized collagen; forming the interacted cellulosic pulp slurry and solubilized collagen into a sheet; and drying the sheet; also, a method for using solubilized collagen for strengthening paper by mixing the solubilized collagen with a cellulosic pulp slurry; and making a cellulosic pulp product from the mixture and drying.
摘要翻译：一种通过提供纤维素浆浆制备胶原增强的纤维素片的方法; 将溶解的胶原蛋白加入到纸浆中，并混合一段有效的纤维素浆浆和溶解胶原的相互作用的时间; 将相互作用的纤维素浆浆和溶解的胶原蛋白形成片; 并干燥片材; 还有，通过将溶解的胶原与纤维素浆浆混合来使用溶解的胶原来增强纸的方法; 并从混合物中制备纤维素纸浆产物并干燥。

9. 发明授权

US5700353A Paper strengthened with solubilized collagen and method 失效
标题翻译：用增溶的胶原和方法增强纸张
公开(公告)号：US5700353A
公开(公告)日：1997-12-23
申请号：US477856
申请日：1995-06-07
申请人： Kenneth E. Hughes , David C. Masterson , David J. Fink , Barbara A. Metz , Gordon E. Pickett , Paul M. Gemmer , Richard S. Brody
发明人： Kenneth E. Hughes , David C. Masterson , David J. Fink , Barbara A. Metz , Gordon E. Pickett , Paul M. Gemmer , Richard S. Brody
IPC分类号： A61K38/00 , C07K14/78 , D21H11/14 , D21H17/22 , D21H21/18 , D21H17/00
CPC分类号： C07K14/78 , D21H17/22 , A61K38/00 , D21H11/14 , D21H21/18
摘要： A method for making a collagen strengthened cellulosic sheet by providing a cellulosic pulp slurry; adding solubilized collagen to the pulp slurry, and mixing for a time effective for interaction of the cellulosic pulp slurry and solubilized collagen; forming the interacted cellulosic pulp slurry and solubilized collagen into a sheet; and drying the sheet; also, a method for using solubilized collagen for strengthening paper by mixing the solubilized collagen with a cellulosic pulp slurry; and making a cellulosic pulp product from the mixture and drying.
摘要翻译：一种通过提供纤维素浆浆制备胶原增强的纤维素片的方法; 将溶解的胶原蛋白加入到纸浆中，并混合一段有效的纤维素浆浆和溶解胶原的相互作用的时间; 将相互作用的纤维素浆浆和溶解的胶原蛋白形成片; 并干燥片材; 还有，通过将溶解的胶原与纤维素浆浆混合来使用溶解的胶原来增强纸的方法; 并从混合物中制备纤维素纸浆产物并干燥。

10. 发明授权

US4469101A Suture device 失效
标题翻译：缝合装置
公开(公告)号：US4469101A
公开(公告)日：1984-09-04
申请号：US385699
申请日：1982-06-07
申请人： Carl R. Coleman , Kenneth E. Hughes
发明人： Carl R. Coleman , Kenneth E. Hughes
IPC分类号： A61B17/00 , A61B17/11 , A61F2/08 , A61B17/04 , A61F1/00
CPC分类号： A61B17/1146 , A61F2/08 , A61B2017/00004
摘要： A suture device for use in tendon repair which comprises an open network constructed of nontoxic tissue-receptive intersecting members extending between opposite ends and formed to receive and fit tightly over opposing and approximated ends of a lacerated tendon.
摘要翻译：一种用于肌腱修复的缝合装置，其包括由相对端之间延伸的无毒组织接受交叉构件构成的开放网络，并形成为紧密地接合并紧贴在撕裂腱的相对和近似末端上。

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