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1. 发明授权

US10201305B2 Apparatus for data retention in an implantable medical device 有权
公开(公告)号：US10201305B2
公开(公告)日：2019-02-12
申请号：US11264887
申请日：2005-11-02
申请人： Touby A. Drew , Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , David L. Carlson
发明人： Touby A. Drew , Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , David L. Carlson
IPC分类号： A61B5/04 , A61B5/00 , A61N1/372 , G06F19/00 , G06F17/30 , A61B5/0205 , A61B5/0402 , A61B5/0476 , A61B5/11 , A61B5/16 , G16H10/60 , A61N1/36 , A61N1/365 , A61N1/37 , A61B5/021 , A61B5/024 , A61B5/03 , A61B5/08 , G16H40/63
摘要： An apparatus for storing data records associated with a medical monitoring event in a data structure. An implanted device obtains data and stores the data in the data record in a first data structure that is age-based. Before an oldest data record is lost, the oldest data record may be stored in a second data structure that is priority index-based. The priority index may be determined by a severity level and may be further determined by associated factors. The implanted device may organize, off-load, report, and/or display a plurality of data records based on an associated priority index. Additionally, the implanted device may select a subset or composite of physiologic channels from the available physiologic channels based on a selection criterion.

2. 发明授权

US09743878B2 Event-based lead impedance monitoring 有权
公开(公告)号：US09743878B2
公开(公告)日：2017-08-29
申请号：US11413072
申请日：2006-04-27
申请人： Touby A. Drew
发明人： Touby A. Drew
IPC分类号： A61N1/00 , A61B5/00 , A61B5/048 , A61B5/053 , A61N1/36 , A61N1/05
CPC分类号： A61B5/4094 , A61B5/048 , A61B5/053 , A61N1/0529 , A61N1/36082
摘要： A medical device senses electrical activity within a patient and, in some embodiments, delivers stimulation to the patient via a plurality electrical paths, which include electrodes and associated conductors of one or more leads. The medical device determines whether a symptomatic event, such as a seizure, is detected based on the sensed electrical activity, and measures the impedance of one or more of the paths in response to the determination. If the medical device identifies a dysfunctional electrical path based on the measured impedance, the device may, as examples, disable the dysfunctional electrical path, or modify a stimulation or sensing program to not use the dysfunctional electrical path. In this manner, the medical device may identify inaccurate symptomatic event detection and, where the device delivers a therapy in response to such detection, such as stimulation via the electrical paths, avoid inappropriate therapy delivery.

3. 发明授权

US07885712B2 Medical device programming safety 有权
标题翻译：医疗器械编程安全
公开(公告)号：US07885712B2
公开(公告)日：2011-02-08
申请号：US11940604
申请日：2007-11-15
申请人： Steven M. Goetz , Donald R. Johnson , Touby A. Drew , Andrew H. Houchins , Jeffrey T. Keacher , Theodore J. Stone , Earle T. Roberts
发明人： Steven M. Goetz , Donald R. Johnson , Touby A. Drew , Andrew H. Houchins , Jeffrey T. Keacher , Theodore J. Stone , Earle T. Roberts
IPC分类号： A61N1/08
CPC分类号： G06F19/3481 , G06F19/00 , G06F19/3418
摘要： Techniques for increasing the safety of medical device programming using general purpose hardware, such as a general purpose personal computer, are described. In some embodiments, a system includes an intermediate computing device comprising an applications module. Information from the applications module, such as instructions for an implantable medical device (IMD), may be presented to a user via a user input terminal that is separate from the intermediate computing device. A user may interact with the user input terminal to select an instruction from the applications module, and the intermediate computing device may transmit the selected instruction to the IMD. In some embodiments, the intermediate computing device comprises a web server and the user input terminal comprises a web browser configured to access the web server. In other embodiments, the intermediate computing device comprises a client server and the user input terminal comprises a client.
摘要翻译：描述用于增加使用通用硬件（例如通用个人计算机）的医疗设备编程安全性的技术。在一些实施例中，系统包括包括应用模块的中间计算设备。可以经由与中间计算设备分离的用户输入终端向用户呈现来自应用模块的信息，诸如可植入医疗设备（IMD）的指令。用户可以与用户输入终端交互以从应用模块选择指令，并且中间计算设备可以将所选择的指令发送到IMD。在一些实施例中，中间计算设备包括web服务器，并且用户输入终端包括被配置为访问web服务器的web浏览器。在其他实施例中，中间计算设备包括客户端服务器，并且用户输入终端包括客户端。

4. 发明申请

US20100274322A1 TRACKING OF COMMUNICATION SESSIONS WITH AN IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：用可植入医疗设备跟踪通信会议
公开(公告)号：US20100274322A1
公开(公告)日：2010-10-28
申请号：US12428019
申请日：2009-04-22
申请人： Touby A. Drew
发明人： Touby A. Drew
IPC分类号： A61N1/08
CPC分类号： A61N1/37235 , A61N1/37247 , G16H40/40
摘要： Communication sessions between external devices and implantable medical devices are tracked using a session value that is incremented for each new session and that is stored within the implantable medical device. Session logs that are created for each session may include the session value that is obtained for that session. The session value allows available session logs to be considered in the proper sequence and allows for an awareness of missing session logs. The incrementing of the session value may occur at the external device according to one convention, or at the implantable medical device according to another. The session value to be used for a given session may be the value accessed from the implantable medical device according to one convention or may be the session value that results from incrementing the session value that is accessed from the implantable medical device according to another.
摘要翻译：在外部设备和可植入医疗设备之间的通信会话使用对于每个新会话递增并存储在可植入医疗设备内的会话值来跟踪。为每个会话创建的会话日志可能包括为该会话获取的会话值。会话值允许以适当的顺序考虑可用的会话日志，并允许意识到缺少的会话日志。会话值的增加可以根据一个惯例在外部设备处发生，或者根据另一个惯例在可植入医疗设备处发生。用于给定会话的会话值可以是根据一个约定从可植入医疗设备访问的值，或者可以是从根据另一个可植入医疗设备访问的会话值增加导致的会话值。

5. 发明申请

US20080235469A1 Peak Data Retention of Signal Data In An Implantable Medical Device 有权
标题翻译：可植入医疗器械中信号数据的峰值数据保留
公开(公告)号：US20080235469A1
公开(公告)日：2008-09-25
申请号：US12037694
申请日：2008-02-26
申请人： Touby A. Drew
发明人： Touby A. Drew
IPC分类号： G06F12/08
CPC分类号： A61B5/02055 , A61B5/4094 , A61B5/7232 , A61N1/08 , A61N1/3601 , A61N1/36082
摘要： Methods and apparatus for storing data records associated with an extreme value are disclosed. Signal data is stored in a first buffer of a set of buffers. If a local extreme value for the first buffer exceeds a global extreme value, signal data is stored in a second buffer of the set of buffers. This process is repeated, wrapping around and overwriting buffers until the signal data in a current buffer does not have a local extreme value that exceeds the global extreme value. When this happens, signal data may be stored in a subsequent buffer and if a local extreme value of the subsequent buffer does not exceed the global extreme value, further signal data may be stored in the subsequent buffer in a circular manner until either an instantaneous extreme value exceeds the global extreme value or the recording period ends. In an embodiment, the extreme value may be a peak value.
摘要翻译：公开了存储与极值相关联的数据记录的方法和装置。信号数据存储在一组缓冲器的第一缓冲器中。如果第一缓冲区的局部极值超过全局极值，则信号数据被存储在该组缓冲器的第二缓冲器中。重复此过程，环绕并覆盖缓冲区，直到当前缓冲区中的信号数据不具有超过全局极值的局部极值。当这种情况发生时，信号数据可以存储在随后的缓冲器中，并且如果后续缓冲器的局部极值不超过全局极限值，则可以以循环方式将另外的信号数据存储在随后的缓冲器中，直到瞬时极限值超过全局极值或记录周期结束。在一个实施例中，极值可以是峰值。

6. 发明申请

US20080140161A1 MEDICAL DEVICE PROGRAMMING SAFETY 有权
标题翻译：医疗设备编程安全
公开(公告)号：US20080140161A1
公开(公告)日：2008-06-12
申请号：US11940573
申请日：2007-11-15
申请人： Steven M. Goetz , Donald R. Johnson , Touby A. Drew , Andrew H. Houchins , Jeffrey T. Keacher , Theodore J. Stone , Earle T. Roberts
发明人： Steven M. Goetz , Donald R. Johnson , Touby A. Drew , Andrew H. Houchins , Jeffrey T. Keacher , Theodore J. Stone , Earle T. Roberts
IPC分类号： A61N1/00
CPC分类号： G06F19/3481 , G06F19/00 , G06F19/3418
摘要： Techniques for increasing the safety of medical device programming using general purpose hardware, such as a general purpose personal computer, are described. Some embodiments include a watchdog module that is serviced by the general purpose hardware, a mediator module that monitors programming instructions from the general purpose hardware, and/or a safe mode input that may be activated by a user. In some embodiments, a system comprises an implantable medical device, an intermediate device, a computing device that communicates with the implantable medical device via the intermediate device. The intermediate device may provide any one or more of the safety measures described above. In some embodiments, the intermediate device is dedicated hardware, and critical programming functions are provided by the intermediate device, rather than the general purpose hardware. In some embodiments, an implantable medical device provides one or more of the above-discussed safety features, rather than a separate intermediate device.
摘要翻译：描述用于增加使用通用硬件（例如通用个人计算机）的医疗设备编程安全性的技术。一些实施例包括由通用硬件服务的看门狗模块，监视来自通用硬件的编程指令的调解器模块和/或可由用户激活的安全模式输入。在一些实施例中，系统包括可植入医疗装置，中间装置，经由中间装置与可植入医疗装置通信的计算装置。中间装置可以提供上述任何一种或多种安全措施。在一些实施例中，中间设备是专用硬件，并且关键编程功能由中间设备而不是通用硬件提供。在一些实施例中，可植入医疗装置提供一个或多个上述安全特征，而不是单独的中间装置。

7. 发明授权

US09471752B2 Operating environment monitor for medical device programming 有权
标题翻译：医疗器械编程操作环境监控
公开(公告)号：US09471752B2
公开(公告)日：2016-10-18
申请号：US11949347
申请日：2007-12-03
申请人： Steven M. Goetz , Touby A. Drew , Andrew H. Houchins
发明人： Steven M. Goetz , Touby A. Drew , Andrew H. Houchins
IPC分类号： G06F19/00 , G06F9/445 , G06F9/48 , A61N1/372
CPC分类号： G06F19/3418 , A61B2560/0271 , A61N1/37235 , A61N1/37282 , G06F9/44505 , G06F9/4843 , G06F19/00 , G16H40/40 , G16H40/63
摘要： A programming system for an electronic medical device (EMD) is described. The programming system, as described in this disclosure, comprises a host computer, such as a general purpose computer in an in-clinic computer network, executing a software platform that provides an operating environment with which a user can interact to program an EMD. The software platform invokes monitoring software that ensures that the host computer satisfies criteria for safe operation of the operating environment, e.g., ensures that the host computer meets the minimum operating conditions required for reliable operation of the operating environment. In particular, the monitoring software may monitor system faults that occur during operation, as well as ensure that criteria for safe operation are satisfied prior to initiating the operating environment.
摘要翻译：描述了用于电子医疗装置（EMD）的编程系统。如本公开中所描述的，编程系统包括主计算机，例如临床内计算机网络中的通用计算机，执行提供用户可以与之交互以编程EMD的操作环境的软件平台。软件平台调用监视软件，确保主计算机满足操作环境的安全操作的标准，例如确保主计算机满足操作环境可靠运行所需的最低操作条件。特别地，监视软件可以监视在操作期间发生的系统故障，并且在启动操作环境之前确保满足安全操作的标准。

8. 发明授权

US08795260B2 Refill of implantable fluid delivery devices based on therapeutic fluid expiration 有权
标题翻译：基于治疗性液体呼气的可植入液体输送装置的补充
公开(公告)号：US08795260B2
公开(公告)日：2014-08-05
申请号：US12641372
申请日：2009-12-18
申请人： Touby A. Drew
发明人： Touby A. Drew
IPC分类号： A61M5/168
CPC分类号： A61M5/14276 , A61M5/14244 , A61M5/1684 , A61M2205/18 , A61M2205/52 , G06F19/00 , G06F19/3418 , G06F19/3462
摘要： An expiration time of a therapeutic fluid delivered by an implantable fluid delivery device is employed to calculate a fill volume and determine a refill interval for the fluid. The expiration time of the therapeutic fluid may be based on or dictated by a stability time set by the manufacturer of the therapeutic fluid, a clinician treating a patient to whom the fluid is to be delivered, the manufacturer of the device delivering the fluid, or combinations thereof.
摘要翻译：由可植入流体输送装置输送的治疗液的终止时间用于计算填充体积并确定流体的再填充间隔。治疗性流体的终止时间可以基于由治疗流体的制造者设定的稳定性时间，临床医生治疗要输送流体的患者，输送流体的装置的制造商，或者其组合。

9. 发明授权

US08478417B2 Techniques for data reporting in an implantable medical device 有权
标题翻译：可植入医疗器械数据报告技术
公开(公告)号：US08478417B2
公开(公告)日：2013-07-02
申请号：US11264860
申请日：2005-11-02
申请人： Touby A. Drew , Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , David L. Carlson
发明人： Touby A. Drew , Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , David L. Carlson
IPC分类号： A61N1/08
CPC分类号： A61B5/4094 , A61B5/0006 , A61B5/0031 , A61B5/02055 , A61B5/021 , A61B5/024 , A61B5/031 , A61B5/04001 , A61B5/04012 , A61B5/0402 , A61B5/0476 , A61B5/0816 , A61B5/1118 , A61B5/165 , A61B5/4082 , A61B5/686 , A61B5/7232 , A61B5/7282 , A61N1/36132 , A61N1/36135 , A61N1/36521 , A61N1/36585 , A61N1/3702 , A61N1/37252 , A61N1/37282 , G06F17/30336 , G06F19/00 , G06F19/3418 , G16H10/60 , G16H40/63
摘要： Methods and apparatus for storing data records associated with a medical monitoring event in a data structure. An implanted device obtains data and stores the data in the data record in a first data structure that is age-based. Before an oldest data record is lost, the oldest data record may be stored in a second data structure that is priority index-based. The priority index may be determined by a severity level and may be further determined by associated factors. The implanted device may organize, off-load, report, and/or display a plurality of data records based on an associated priority index. Additionally, the implanted device may select a subset or composite of physiologic channels from the available physiologic channels based on a selection criterion.
摘要翻译：用于存储与数据结构中的医疗监视事件相关联的数据记录的方法和装置。植入装置获取数据并将数据存储在基于年龄的第一数据结构中的数据记录中。在最旧的数据记录丢失之前，最早的数据记录可以存储在基于优先级索引的第二数据结构中。优先权索引可以由严重性级别确定，并且可以由相关因素进一步确定。植入的装置可以基于相关联的优先级索引来组织，卸载，报告和/或显示多个数据记录。另外，植入装置可以基于选择标准从可用生理通道中选择生理通道的子集或复合物。

10. 发明授权

US08165683B2 Method and apparatus for detection of nervous system disorders 有权
标题翻译：用于检测神经系统疾病的方法和装置
公开(公告)号：US08165683B2
公开(公告)日：2012-04-24
申请号：US11609465
申请日：2006-12-12
申请人： David L. Carlson , Eric J. Panken , Touby A. Drew , Jonathan C. Werder
发明人： David L. Carlson , Eric J. Panken , Touby A. Drew , Jonathan C. Werder
IPC分类号： A61N1/36
CPC分类号： A61B5/02405 , A61B5/0456 , A61B5/0476 , A61B5/0482 , A61B5/4094 , A61B5/7221 , A61B5/7275 , A61N1/36082 , A61N2/006 , G06F19/00 , G06K9/00543
摘要： Systems and methods for detecting and/or treating nervous system disorders, such as seizures. Certain embodiments of the invention relate generally to implantable medical devices (IMDs) adapted to detect and treat nervous system disorders in patients with an IMD. Certain embodiments of the invention include detection of seizures based upon comparisons of long-term and short-term representations of physiological signals. Other embodiments include prediction of seizure activity based upon analysis of physiological signal levels. An embodiment of the invention monitors the quality of physiological signals, and may be able to compensate for signals of low signal quality. A further embodiment of the invention includes detection of seizure activity following the delivery of therapy.
摘要翻译：用于检测和/或治疗神经系统疾病例如癫痫发作的系统和方法。本发明的某些实施方案一般涉及适于检测和治疗患有IMD的患者的神经系统疾病的可植入医疗装置（IMD）。本发明的某些实施方案包括基于生理信号的长期和短期表示的比较来检测癫痫发作。其他实施方案包括基于生理信号水平的分析预测癫痫发作活动。本发明的实施例监测生理信号的质量，并且可能能够补偿低信号质量的信号。本发明的另一个实施方案包括在递送治疗后检测发作活动。

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