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1. 发明申请

US20120171274A1 TRANSDERMAL PATCH 审中-公开
标题翻译：透明贴
公开(公告)号：US20120171274A1
公开(公告)日：2012-07-05
申请号：US13351724
申请日：2012-01-17
申请人： Hiroko Udagawa , Toshikazu Komoda , Masaru Hamabe , Yukihiko Noda , Sakiko Shibata , Masashi Yamada , Akihiro Kawashima , Hiroto Suzuki
发明人： Hiroko Udagawa , Toshikazu Komoda , Masaru Hamabe , Yukihiko Noda , Sakiko Shibata , Masashi Yamada , Akihiro Kawashima , Hiroto Suzuki
IPC分类号： A61K9/70 , A61P9/00 , A61K31/137
CPC分类号： A61K31/137 , A61K9/7061 , A61K47/14
摘要： The present invention provides a transdermal patch having excellent preservation stability and transdermal absorbency of DMAEs. The patch has a support and a plaster layer integrally laminated on one surface of the support, and the plaster layer includes: DMAEs; an acrylic adhesive prepared by copolymerizing monomers respectively containing 30 to 99% by weight of alkyl methacrylate having an alkyl group with a carbon number of 6 to 22 and 1 to 70% by weight of alkyl acrylate having an alkyl group with a carbon number of 2 to 20; and fatty acid ester prepared by dehydro-condensing saturated fatty acid having an alkyl group with a carbon number of 10 to 20 and saturated aliphatic monohydric alcohol having an alkyl group with a carbon number of 2 to 20, wherein solubility of the DMAEs is 0.05 to 5 g at 25° C. with respect to the fatty acid ester.
摘要翻译：本发明提供了具有优异的DMAE保存稳定性和透皮吸收性的透皮贴片。补片具有一体地层叠在支撑体的一个表面上的支撑体和石膏层，并且膏药层包括：DMAE; 通过共聚含有30〜99重量％的具有碳数为6〜22的烷基的甲基丙烯酸烷基酯和1〜70重量％的具有碳数为2的烷基的丙烯酸烷基酯的丙烯酸粘合剂到20 和通过使具有碳原子数为10〜20的烷基的饱和脂肪酸和碳数为2〜20的烷基的饱和脂肪族一元醇脱水缩合而制备的脂肪酸酯，其中DMAE的溶解度为0.05〜在25℃下相对于脂肪酸酯为5g。

2. 发明申请

US20090258063A1 Transdermal patch 审中-公开
标题翻译：透皮贴片
公开(公告)号：US20090258063A1
公开(公告)日：2009-10-15
申请号：US12310840
申请日：2007-09-11
申请人： Hiroko Udagawa , Toshikazu Komoda , Masaru Hamabe , Yukihiko Noda , Sakiko Shibata , Masashi Yamada , Akihiro Kawashima , Hiroto Suzuki
发明人： Hiroko Udagawa , Toshikazu Komoda , Masaru Hamabe , Yukihiko Noda , Sakiko Shibata , Masashi Yamada , Akihiro Kawashima , Hiroto Suzuki
IPC分类号： A61K9/70 , A61P9/12
CPC分类号： A61K31/137 , A61K9/7061 , A61K47/14
摘要： The present invention provides a transdermal patch having excellent preservation stability and transdermal absorbency of DMAEs. The patch has a support and a plaster layer integrally laminated on one surface of the support, and the plaster layer includes: DMAEs; an acrylic adhesive prepared by copolymerizing monomers respectively containing 30 to 99% by weight of alkyl methacrylate having an alkyl group with a carbon number of 6 to 22 and 1 to 70% by weight of alkyl acrylate having an alkyl group with a carbon number of 2 to 20; and fatty acid ester prepared by dehydro-condensing saturated fatty acid having an alkyl group with a carbon number of 10 to 20 and saturated aliphatic monohydric alcohol having an alkyl group with a carbon number of 2 to 20, wherein solubility of the DMAEs is 0.05 to 5 g at 25° C. with respect to the fatty acid ester.
摘要翻译：本发明提供了具有优异的DMAE保存稳定性和透皮吸收性的透皮贴片。补片具有一体地层叠在支撑体的一个表面上的支撑体和石膏层，并且膏药层包括：DMAE; 通过共聚含有30〜99重量％的具有碳数为6〜22的烷基的甲基丙烯酸烷基酯和1〜70重量％的具有碳原子数为2的烷基的丙烯酸烷基酯的丙烯酸粘合剂到20 和通过使具有碳原子数为10〜20的烷基的饱和脂肪酸和碳数为2〜20的烷基的饱和脂肪族一元醇脱水缩合而制备的脂肪酸酯，其中DMAE的溶解度为0.05〜在25℃下相对于脂肪酸酯为5g。

3. 发明申请

US20120114738A1 TRANSDERMAL PATCH 审中-公开
标题翻译：透明贴
公开(公告)号：US20120114738A1
公开(公告)日：2012-05-10
申请号：US13351750
申请日：2012-01-17
申请人： Toshikazu KOMODA , Hiroko Udagawa , Masaru Hamabe , Yukihiko Noda , Sakiko Shibata , Masashi Yamada , Akihiro Kawashima , Hiroto Suzuki
发明人： Toshikazu KOMODA , Hiroko Udagawa , Masaru Hamabe , Yukihiko Noda , Sakiko Shibata , Masashi Yamada , Akihiro Kawashima , Hiroto Suzuki
IPC分类号： A61K9/70 , A61K31/136
CPC分类号： A61K31/137 , A61K9/7061 , A61K47/10
摘要： The present invention provides a transdermal patch having excellent preservation stability and transdermal absorbency of DMAE or its pharmacologically acceptable salt. The patch has a support and a plaster layer integrally laminated on one surface of the support, and the plaster layer includes: 2-amino-1-(2′,5′-dimethoxyphenyl)ethanol or its pharmacologically acceptable salt; 40 to 98% by weight of acrylic adhesive prepared by copolymerizing monomers respectively containing 30 to 99% by weight of alkyl methacrylate having an alkyl group with a carbon number of 6 to 22 and 1 to 70% by weight of alkyl acrylate having an alkyl group with a carbon number of 2 to 20; and 1 to 30% by weight of saturated aliphatic monohydric alcohol having an alkyl group with a carbon number of 10 to 30.
摘要翻译：本发明提供了具有优异的DMAE或其药理学上可接受的盐的保存稳定性和透皮吸收性的透皮贴剂。贴剂在支撑体的一个表面上具有一体层压的支撑体和石膏层，石膏层包括：2-氨基-1-（2'，5'-二甲氧基苯基）乙醇或其药理学上可接受的盐; 通过共聚含有30〜99重量％的具有碳数为6〜22的烷基的甲基丙烯酸烷基酯和1〜70重量％的具有烷基的丙烯酸烷基酯的单体共聚而成的丙烯酸粘合剂为40〜98重量％碳数为2〜20; 和1〜30重量％的具有碳原子数为10〜30的烷基的饱和脂肪族一元醇。

4. 发明申请

US20090317452A1 Transdermal patch 审中-公开
标题翻译：透皮贴片
公开(公告)号：US20090317452A1
公开(公告)日：2009-12-24
申请号：US12310845
申请日：2007-09-11
申请人： Toshikazu Komoda , Hiroko Udagawa , Masaru Hamabe , Yukihiko Noda , Sakiko Shibata , Masashi Yamada , Akihiro Kawashima , Hiroto Suzuki
发明人： Toshikazu Komoda , Hiroko Udagawa , Masaru Hamabe , Yukihiko Noda , Sakiko Shibata , Masashi Yamada , Akihiro Kawashima , Hiroto Suzuki
IPC分类号： A61K9/70 , A61K31/136 , A61P9/02
CPC分类号： A61K31/137 , A61K9/7061 , A61K47/10
摘要： The present invention provides a transdermal patch having excellent preservation stability and transdermal absorbency of DMAE or its pharmacologically acceptable salt. The patch has a support and a plaster layer integrally laminated on one surface of the support, and the plaster layer includes: 2-amino-1-(2′,5′-dimethoxyphenyl)ethanol or its pharmacologically acceptable salt; 40 to 98% by weight of acrylic adhesive prepared by copolymerizing monomers respectively containing 30 to 99% by weight of alkyl methacrylate having an alkyl group with a carbon number of 6 to 22 and 1 to 70% by weight of alkyl acrylate having an alkyl group with a carbon number of 2 to 20; and 1 to 30% by weight of saturated aliphatic monohydric alcohol having an alkyl group with a carbon number of 10 to 30.
摘要翻译：本发明提供了具有优异的DMAE或其药理学上可接受的盐的保存稳定性和透皮吸收性的透皮贴剂。贴剂在支撑体的一个表面上具有一体层压的支撑体和石膏层，石膏层包括：2-氨基-1-（2'，5'-二甲氧基苯基）乙醇或其药理学上可接受的盐; 通过共聚含有30〜99重量％的具有碳数为6〜22的烷基的甲基丙烯酸烷基酯和1〜70重量％的具有烷基的丙烯酸烷基酯的单体共聚而成的丙烯酸粘合剂为40〜98重量％碳数为2〜20; 和1〜30重量％的具有碳原子数为10〜30的烷基的饱和脂肪族一元醇。

5. 发明申请

US20050214352A1 Patch and process for producing the same 审中-公开
标题翻译：补丁和生产过程相同
公开(公告)号：US20050214352A1
公开(公告)日：2005-09-29
申请号：US10511061
申请日：2003-04-11
申请人： Mitsuhiko Hori , Keiji Yamamoto , Kensuke Matsuoka , Yoshihisa Nakano , Kenjirou Mimomi , Masashi Yamada , Masaru Otsuka , Yasunori Suzuki , Akihiro Kawashima
发明人： Mitsuhiko Hori , Keiji Yamamoto , Kensuke Matsuoka , Yoshihisa Nakano , Kenjirou Mimomi , Masashi Yamada , Masaru Otsuka , Yasunori Suzuki , Akihiro Kawashima
IPC分类号： A61K9/70 , A61K31/137 , A61K47/10 , A61K47/14 , A61P9/02 , A61K31/138
CPC分类号： A61K9/7061 , A61K31/137
摘要： The present invention relates to a patch containing a substrate, a non-crosslinked adhesive layer (A) containing DMAE or a pharmacologically acceptable salt thereof laminated on one surface of the substrate and a crosslinked adhesive layer (B) laminated on the adhesive layer (A). According to the present invention, the percutaneous absorbability of DMAE or a pharmacologically acceptable salt thereof can be improved, and a patch free of problems such as adhesive residue and adhesive bleed can be provided.
摘要翻译：本发明涉及层叠在基材的一面上的含有基材，含有DMAE的非交联型粘合剂层（A）或其药理学上可接受的盐的贴剂和层叠在粘合剂层（A）上的交联粘合剂层）。根据本发明，可以提高DMAE或其药理学上可接受的盐的经皮吸收性，并且可以提供没有粘合剂残留和粘合剂渗色等问题的贴剂。

6. 发明授权

US5176787A Method and apparatus for measuring the diameter of a silicon single crystal 失效
标题翻译：用于测量硅单晶直径的方法和装置
公开(公告)号：US5176787A
公开(公告)日：1993-01-05
申请号：US691701
申请日：1991-04-26
申请人： Akihiro Kawashima , Tatsuo Sato , Toshio Okawa
发明人： Akihiro Kawashima , Tatsuo Sato , Toshio Okawa
IPC分类号： G01B11/10
CPC分类号： G01B11/105 , Y10T117/1004
摘要： A method of measuring the diameter of a silicon single crystal. At intervals of a given rotational period of a pulled single crystal being pulled by the CZ method, optical means samples the luminance distribution of a fusion ring to obtain measured diameter values of the pulled single crystal so that the measured diameter values are processed by a low-pass filter to generate filter output values converted to time series diameter data and the filter output values are subjected to moving averaging to calculate a diameter value. Also, an apparatus for measuring the diameter of a silicon single crystal includes optical means whereby at intervals of a given rotational period of a pulled single crystal being pulled by the CZ method the luminance distribution of a fusion ring is sampled and measured to generate measured diameter values of the pulled single crystal, a low-pass filter for filtering the low-frequency components of the measured diameter values to generate filter output values converted to time series data, and computing means for subjecting the filter output values to moving averaging to calculate a diameter value of the pulled single crystal.

7. 发明授权

US5200040A Method for rectification and apparatus therefor 失效
标题翻译：整改方法及其设备
公开(公告)号：US5200040A
公开(公告)日：1993-04-06
申请号：US668742
申请日：1991-03-13
申请人： Yuji Naka , Tatsuo Sato , Akihiro Kawashima
发明人： Yuji Naka , Tatsuo Sato , Akihiro Kawashima
IPC分类号： B01D3/38
CPC分类号： B01D3/38 , Y10S203/11
摘要： A method for rectification includes steps of supplying raw materials to a rectifying column from a raw material feed pipe; returning a refluent fluid from a refluxing pipe to the column; leading a hold-up liquid from a bottom tank having a higher surface to a bottom tank having a lower surface of a liquid in a bottom portion of the column; heating the hold-up in each of bottom tanks; exchanging heat by bringing a vapor produced by heating the bottoms into counter-current contact with the reluent liquid returned to the rectifying column on plates arranged in the rectifying column, taking out a vapor from the top of the rectifying column, and taking out bottoms from the bottom tank. An apparatus for rectification includes a rectifying column having a raw material feed pipe, an offtake pipe for taking out the vapor, a reflux pipe for returning the refluent liquid to the inside of the column in the upper portion of the rectifying column and plates for exchanging heat by bringing the vapor into contact with the refluent liquid. The bottom portion is divided into at least two bottom tanks having surfaces of liquid different in height, in the bottom portion of rectifying column. The bottoms in each of the bottom tanks are heated and an offtake pipe takes out the bottoms.
摘要翻译：精馏方法包括从原料供给管向精馏塔供给原料的工序; 将回流管返回到塔中; 将具有较高表面的底部罐的保持液引导到具有在塔的底部中的液体的下表面的底部罐; 加热每个底部储罐中的滞留物; 通过将通过加热底部产生的蒸汽与返回到精馏塔中的精馏塔的排出液反向接触，从精馏塔的顶部取出蒸气，并从塔顶馏出物底部坦克。一种整流装置，包括：具有原料供给管的精馏塔，取出蒸气的排出管，将排出液返回至精馏塔上部的塔内的回流管和交换用的板通过使蒸气与反应液体接触而产生热量。底部在精馏塔的底部被分成至少两个具有不同高度的液体表面的底部罐。每个底部罐中的底部被加热，并且出料管取出底部。

8. 发明授权

US5164039A Apparatus for controlling the diameter of silicon single crystal 失效
标题翻译：用于控制硅单晶直径的装置
公开(公告)号：US5164039A
公开(公告)日：1992-11-17
申请号：US755437
申请日：1991-09-05
申请人： Akihiro Kawashima , Tatsuo Sato , Toshio Okawa
发明人： Akihiro Kawashima , Tatsuo Sato , Toshio Okawa
IPC分类号： G01B11/08
CPC分类号： G01B11/08 , Y10T117/1008
摘要： A method of controlling the diameter of a silicon single crystal. In the course of manufacturing a silicon single crystal by pulling the silicon single crystal while rotating it relative to a crucible, a comparison between a measured diameter value of the pulled single crystal measured by optical means and a desired diameter value is made to determine a deviation so that the resulting deviation is subjected to an incomplete differential PID processing or the Smith method processing to calculate a pull rate and the pull rate is applied to a motor controller of a crystal pulling apparatus thereby performing the diameter control of the pulled single crystal through the manipulation of the pull rate. An apparatus for controlling the diameter of a silicon single crystal includes input means for receiving a measured diameter value of a pulled single crystal measured by optical means, incomplete differential PID computing means for making a comparison between a measured diameter value of the pulled single crystal and a desired diameter value a plurality of times at intervals of a unit rotational period to calculate a pull rate, and output means for applying the pull rate to a motor controller of a crystal pulling apparatus.

9. 发明申请

US20100308621A1 STRUCTURE OF MOUNTING IMPACT ABSORPTION MATERIAL FOR USE WITH VEHICLE 有权
标题翻译：安装冲击吸收材料的结构与车辆的使用
公开(公告)号：US20100308621A1
公开(公告)日：2010-12-09
申请号：US12791932
申请日：2010-06-02
申请人： Akihiro Kawashima , Masami Uratsu , Michinori Kawasumi , Eiji Fujii , Tomonari Masuda , Tadashi Nishimura , Mariko Wada , Mamoru Yamaguchi , Kenichi Uemori
发明人： Akihiro Kawashima , Masami Uratsu , Michinori Kawasumi , Eiji Fujii , Tomonari Masuda , Tadashi Nishimura , Mariko Wada , Mamoru Yamaguchi , Kenichi Uemori
IPC分类号： B62D25/00
CPC分类号： B60R21/04 , B60R21/0428 , B60R2021/0421
摘要： An aspect in accordance with the present invention is a structure of mounting an impact absorption material for use with a vehicle. The structure includes: a door trim 30, a holder, and an EA pad. The holder includes a base and a plurality of legs, the base of the holder being disposed on the compartment outer side surface of the EA pad. The plurality of legs are disposed at intervals around an outer peripheral edge of the base of the holder and extend from the base of the holder, along an outer peripheral side surface of the EA pad, and to the door trim, thereby fixing the base of the holder to the door trim.
摘要翻译：根据本发明的一个方面是安装用于车辆的冲击吸收材料的结构。该结构包括：门装饰件30，保持器和EA垫。保持器包括基部和多个腿，保持器的基部设置在EA垫的隔室外侧表面上。多个支腿围绕保持器的基部的外周边缘间隔设置，并且沿着EA垫的外周侧表面从保持器的基部延伸到门装饰件，从而将持有人到门饰。

10. 发明授权

US5246535A Method and apparatus for controlling the diameter of a silicon single crystal 失效
标题翻译：用于控制硅单晶直径的方法和装置
公开(公告)号：US5246535A
公开(公告)日：1993-09-21
申请号：US936071
申请日：1992-08-26
申请人： Akihiro Kawashima , Tatsuo Sato , Toshio Okawa
发明人： Akihiro Kawashima , Tatsuo Sato , Toshio Okawa
IPC分类号： G01B11/08
CPC分类号： G01B11/08
摘要： A method of controlling the diameter of a silicon single crystal. In the course of manufacturing a silicon single crystal by pulling the silicon single crystal while rotating it relative to a crucible, a comparison between a measured diameter value of the pulled single crystal measured by optical means and a desired diameter value is made to determine a deviation so that the resulting deviation is subjected to an incomplete differential PID processing or the Smith method processing to calculate a pull rate and the pull rate is applied to a motor controller of a crystal pulling apparatus thereby performing the diameter control of the pulled single crystal through the manipulation of the pull rate. An apparatus for controlling the diameter of a silicon single crystal includes input means for receiving a measured diameter value of a pulled single crystal measured by optical means, incomplete differential PID computing means for making a comparison between a measured diameter value of the pulled single crystal and a desired diameter value a plurality of times at intervals of a unit rotational period to calculate a pull rate, and output means for applying the pull rate to a motor controller of a crystal pulling apparatus.
摘要翻译：一种控制硅单晶直径的方法。在通过在相对于坩埚旋转的同时拉动硅单晶而制造硅单晶的过程中，通过光学装置测量的拉伸单晶的测量直径值与期望的直径值进行比较，以确定偏差使得所得到的偏差受到不完全差分PID处理或史密斯方法处理以计算拉动率，并且拉伸速率被施加到晶体拉制装置的电动机控制器，由此通过所述拉伸单晶的直径控制操纵拉力。一种用于控制硅单晶直径的装置包括：输入装置，用于接收通过光学装置测量的拉伸单晶的测量直径值;不完全差分PID计算装置，用于比较被测单体的测量直径值与以单位旋转周期的间隔多次进行期望的直径值，以计算牵引速度;以及输出装置，用于将牵引速率施加到晶体牵引装置的电动机控制器。

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