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1. 发明申请

US20050214352A1 Patch and process for producing the same 审中-公开
标题翻译：补丁和生产过程相同
公开(公告)号：US20050214352A1
公开(公告)日：2005-09-29
申请号：US10511061
申请日：2003-04-11
申请人： Mitsuhiko Hori , Keiji Yamamoto , Kensuke Matsuoka , Yoshihisa Nakano , Kenjirou Mimomi , Masashi Yamada , Masaru Otsuka , Yasunori Suzuki , Akihiro Kawashima
发明人： Mitsuhiko Hori , Keiji Yamamoto , Kensuke Matsuoka , Yoshihisa Nakano , Kenjirou Mimomi , Masashi Yamada , Masaru Otsuka , Yasunori Suzuki , Akihiro Kawashima
IPC分类号： A61K9/70 , A61K31/137 , A61K47/10 , A61K47/14 , A61P9/02 , A61K31/138
CPC分类号： A61K9/7061 , A61K31/137
摘要： The present invention relates to a patch containing a substrate, a non-crosslinked adhesive layer (A) containing DMAE or a pharmacologically acceptable salt thereof laminated on one surface of the substrate and a crosslinked adhesive layer (B) laminated on the adhesive layer (A). According to the present invention, the percutaneous absorbability of DMAE or a pharmacologically acceptable salt thereof can be improved, and a patch free of problems such as adhesive residue and adhesive bleed can be provided.
摘要翻译：本发明涉及层叠在基材的一面上的含有基材，含有DMAE的非交联型粘合剂层（A）或其药理学上可接受的盐的贴剂和层叠在粘合剂层（A）上的交联粘合剂层）。根据本发明，可以提高DMAE或其药理学上可接受的盐的经皮吸收性，并且可以提供没有粘合剂残留和粘合剂渗色等问题的贴剂。

2. 发明授权

US07964213B2 Patch and production method thereof 失效
标题翻译：补片及其制作方法
公开(公告)号：US07964213B2
公开(公告)日：2011-06-21
申请号：US10411822
申请日：2003-04-11
申请人： Mitsuhiko Hori , Keiji Yamamoto , Kensuke Matsuoka , Yoshihisa Nakano
发明人： Mitsuhiko Hori , Keiji Yamamoto , Kensuke Matsuoka , Yoshihisa Nakano
IPC分类号： A61F13/00
CPC分类号： A61K9/7061 , Y10T442/2738 , Y10T442/674
摘要： The present invention relates to a patch containing a substrate, a non-crosslinked adhesive layer (A) containing a drug laminated on one surface of the substrate and a crosslinked adhesive layer (B) laminated on the adhesive layer (A). According to the present invention, the percutaneous absorbability of the drug can be improved, and a patch free of problems such as adhesive residue and adhesive bleed can be provided.
摘要翻译：本发明涉及含有基材，含有层叠在基材的一个表面上的药物的非交联粘合剂层（A）和层压在粘合剂层（A）上的交联粘合剂层（B））的贴剂。根据本发明，可以提高药物的经皮吸收性，并且可以提供没有诸如粘合剂残留和粘合剂渗色的问题的贴剂。

3. 发明授权

US07029693B2 Percutaneously absorptive preparation 失效
公开(公告)号：US07029693B2
公开(公告)日：2006-04-18
申请号：US09946889
申请日：2001-09-05
申请人： Mitsuhiko Hori , Kensuke Matsuoka , Kenjiro Minomi , Yoshihisa Nakano
发明人： Mitsuhiko Hori , Kensuke Matsuoka , Kenjiro Minomi , Yoshihisa Nakano
IPC分类号： A61K9/70 , A01N25/34
CPC分类号： A61K9/7061
摘要： A percutaneously absorptive preparation is provided, which preparation having a support and an adhesive layer having a release-controlling layer, which is formed at least on one side of the support, wherein the adhesive layer contains an adhesive and 0.5–60 wt % of a drug except 1,2-ethanediol derivatives.

4. 发明授权

US6117447A Percutaneous absorption type preparation 有权
标题翻译：经皮吸收型制剂
公开(公告)号：US6117447A
公开(公告)日：2000-09-12
申请号：US203749
申请日：1998-12-02
申请人： Yoshihisa Nakano , Mitsuhiko Hori , Keiji Yamamoto , Saburo Otsuka
发明人： Yoshihisa Nakano , Mitsuhiko Hori , Keiji Yamamoto , Saburo Otsuka
IPC分类号： A61K9/70 , A61K31/00 , A61K31/045 , A61K31/135 , A61P11/00 , A61P11/08
CPC分类号： A61K9/7053 , A61K31/135 , A61K9/7061 , Y10S514/946 , Y10S514/947
摘要： A percutaneous absorption type preparation comprising a support and a plaster layer laminated thereon, which composes tulobuterol in a proportion of not less than 5 wt % in a dissolution state and an adhesive. The preparation of the present invention retains the active ingredient, tulobuterol, at a high concentration in a complete dissolution state in the plaster layer. Therefore, it is free of time-course changes in drug releasing property and adhesive property caused by precipitation of drug crystals with the lapse of time. The inventive preparation is superior in percutaneous absorption of the drug, particularly percutaneous absorption rate at the initial stage of the administration; shows superior duration of efficacy by maintaining effective blood concentration for a long time; and is associated with less changes with the lapse of time in adhesive property such as adhesion to the skin.
摘要翻译：一种经皮吸收型制剂，其包含层压在其上的支持体和石膏层，其在溶解状态下组成不小于5重量％的比例的丁非特罗和粘合剂。本发明的制剂在石膏层中以完全溶解状态保持高浓度的活性成分，特鲁替罗。因此，随着时间的流逝，药物释放性质和药物晶体析出引起的粘合性无时间变化。本发明的制剂在药物的经皮吸收方面优异，特别是在给药的初始阶段的经皮吸收速率; 通过长期维持有效的血液浓度显示出优异的疗效持续时间; 并且随着粘合性（如粘附于皮肤）随着时间的推移而变化较小。

5. 发明授权

US08591939B2 Adhesive preparation containing fentanyl 有权
标题翻译：含芬太尼的粘合剂
公开(公告)号：US08591939B2
公开(公告)日：2013-11-26
申请号：US11196935
申请日：2005-08-04
申请人： Yuji Saeki , Masato Nishimura , Kensuke Matsuoka , Takateru Muraoka , Yoshifumi Hosaka , Mitsuhiko Hori , Kazuhisa Ninomiya , Hitoshi Akemi , Hidetoshi Kuroda
发明人： Yuji Saeki , Masato Nishimura , Kensuke Matsuoka , Takateru Muraoka , Yoshifumi Hosaka , Mitsuhiko Hori , Kazuhisa Ninomiya , Hitoshi Akemi , Hidetoshi Kuroda
IPC分类号： A61K31/445 , A61F13/02
CPC分类号： A61K9/7053 , A61K31/4468
摘要： The present invention provides a Fentanyl-containing percutaneously absorbable adhesive preparation, which is obtained from economic starting materials, has a constitution simpler than that of conventional ones, has sufficient skin permeability, and which permits control of skin permeability by changing the mixing ratio of two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid. Specifically, the present invention provides a percutaneously absorbable adhesive preparation comprising a support and an adhesive layer laminated on one surface thereof, wherein the adhesive layer comprises Fentanyl, two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid compatible with the aforementioned two kinds of polyisobutylene and the aforementioned tackifier.
摘要翻译：本发明提供了一种经济起始材料得到的含有芬太尼的经皮吸收性粘合剂制剂，其结构比以往更简单，具有足够的皮肤渗透性，并且通过改变两者的混合比可以控制皮肤渗透性种类具有不同分子量的聚异丁烯，增粘剂和有机液体。具体地说，本发明提供了一种经皮吸收性粘合剂制剂，其包含在其一个表面上层叠的载体和粘合剂层，其中所述粘合剂层包括芬太尼，两种具有不同分子量的聚异丁烯，增粘剂和与上述相容的有机液体两种聚异丁烯和上述增粘剂。

6. 发明申请

US20060034900A1 Adhesive preparation containing fentanyl 有权
公开(公告)号：US20060034900A1
公开(公告)日：2006-02-16
申请号：US11196935
申请日：2005-08-04
申请人： Yuji Saeki , Masato Nishimura , Kensuke Matsuoka , Takateru Muraoka , Yoshifumi Hosaka , Mitsuhiko Hori , Kazuhisa Ninomiya , Hitoshi Akemi , Hidetoshi Kuroda
发明人： Yuji Saeki , Masato Nishimura , Kensuke Matsuoka , Takateru Muraoka , Yoshifumi Hosaka , Mitsuhiko Hori , Kazuhisa Ninomiya , Hitoshi Akemi , Hidetoshi Kuroda
IPC分类号： A61K31/445 , A61F13/02
CPC分类号： A61K9/7053 , A61K31/4468
摘要： The present invention provides a Fentanyl-containing percutaneously absorbable adhesive preparation, which is obtained from economic starting materials, has a constitution simpler than that of conventional ones, has sufficient skin permeability, and which permits control of skin permeability by changing the mixing ratio of two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid. Specifically, the present invention provides a percutaneously absorbable adhesive preparation comprising a support and an adhesive layer laminated on one surface thereof, wherein the adhesive layer comprises Fentanyl, two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid compatible with the aforementioned two kinds of polyisobutylene and the aforementioned tackifier.

7. 发明授权

US6146656A Percutaneous absorption preparation 失效
标题翻译：经皮吸收制剂
公开(公告)号：US6146656A
公开(公告)日：2000-11-14
申请号：US232684
申请日：1999-01-19
申请人： Mitsuhiko Hori , Kenjiro Minomi , Yoshihisa Nakano
发明人： Mitsuhiko Hori , Kenjiro Minomi , Yoshihisa Nakano
IPC分类号： A61K9/70 , A61F13/02 , A61K31/445
CPC分类号： A61K9/7053 , A61K9/7061
摘要： The present invention provides a percutaneous absorption preparation which comprises a skin contact base containing therein at least one active ingredient selected from the group consisting of biperiden, trihexyphenidyl and pharmacologically acceptable salts thereof in an amount of from 0.5 to 60% by weight. The percutaneous absorption preparation makes it possible to permit the percutaneous absorption of biperiden, trihexyphenidyl or pharmacologically acceptable salt thereof as an active ingredient so that the medicament can be used effectively and at the same time, pharmacological effects can be sustained long and administration can be carried out conveniently. In addition, the active ingredient contained in it can be maintained stably.
摘要翻译：本发明提供了一种经皮吸收制剂，其包含皮肤接触基质，其中含有至少一种活性成分，所述至少一种活性成分选自双倍哌啶，三己烯基及其药理学上可接受的盐，其量为0.5至60重量％。经皮吸收制剂使得双倍哌啶，三己苯醌或其药理学上可接受的盐的经皮吸收作为活性成分成为可能，可以有效地使用药物，同时可以持续长时间的药理作用，可以进行给药方便的此外，其中包含的活性成分可以稳定地保持。

8. 发明授权

US09289386B2 Oral film-form base and oral film-form preparation 有权
标题翻译：口服薄膜形式基础和口服膜形式制备
公开(公告)号：US09289386B2
公开(公告)日：2016-03-22
申请号：US13146829
申请日：2009-03-06
申请人： Daisuke Asari , Mitsuhiko Hori , Keiko Ogawa
发明人： Daisuke Asari , Mitsuhiko Hori , Keiko Ogawa
IPC分类号： A61K9/00 , A61K9/70 , A61K47/26 , A61K47/38
CPC分类号： A61K9/0056 , A61K9/7007 , A61K47/26 , A61K47/38
摘要： The present invention provides a film-form base having one or more sugars or sugar alcohols dispersed as fine particles therein, and also provides a film-form preparation containing the base and a drug. The base is produced by dispersing, in an organic solvent having a solubility parameter of 9.7 or higher, an edible polymer soluble in water and the organic solvent, and particles of one or two or more compounds selected from the group consisting of mono- to hexasaccharide sugars and sugar alcohols thereof which have an average particle size of 0.1 μm to 60 μm and are insoluble in an organic solvent. The present invention can therefore provide oral film-form base and preparation which have a rapid dissolution profile in the mouth and sufficient film strength, and provide a reduced sticky sensation attributed to the water-soluble polymer in the mouth and an improved feel when handled with the fingers.
摘要翻译：本发明提供一种具有分散为细颗粒的一种或多种糖或糖醇的薄膜形式的底物，并且还提供含有该基质和药物的薄膜形式的制剂。该碱是通过在溶解度参数为9.7以上的有机溶剂中分散可溶于水和有机溶剂的可食性聚合物，以及一种或两种以上选自单 - 六糖和糖醇，其平均粒度为0.1〜60μm，不溶于有机溶剂。因此，本发明可以提供在口腔中具有快速溶出曲线并具有足够的膜强度的口腔膜形式的基质和制剂，并且在口腔中提供归因于水溶性聚合物的降低的粘稠感和当用手指。

9. 发明授权

US5814032A Percutaneous administration tape preparation 失效
标题翻译：经皮给药胶带制剂
公开(公告)号：US5814032A
公开(公告)日：1998-09-29
申请号：US855897
申请日：1997-05-12
申请人： Mitsuhiko Hori , Katsuhiro Yamamoto , Tetsuo Watanabe
发明人： Mitsuhiko Hori , Katsuhiro Yamamoto , Tetsuo Watanabe
IPC分类号： A61K9/70 , A61K45/00 , A61K47/36 , A61K47/38 , A61K47/42 , A61F13/02 , B32B9/04
CPC分类号： A61K9/7053 , A61K9/7061
摘要： There provided a percutaneous administration tape preparation which can attach well to the skin surface even in the case of the permeation of water after attaching and can be easily detached from the skin surface without giving the skin simulation such as peeling off and the injury of the horny layer. The percutaneous administration tape preparation comprises a sheet-form support, a drug-containing pressure-sensitive adhesive layer, and a separator, wherein the drug-containing pressure-sensitive adhesive layer comprises a uniform dispersed state containing from 50 to 95% by weight one or more kinds of elastomers, from 5 to 50% by weight a hygroscopic material, and a percutaneous absorption drug so that a part of the hygroscopic material contained therein remains on the applied surface at detaching the tape preparation from the applied surface.
摘要翻译：提供了经皮给药胶带制剂，即使在附着后水渗透的情况下也能很好地附着于皮肤表面，并且可以容易地从皮肤表面脱离，而不会产生皮肤模拟，例如剥离和角质的损伤层。经皮给药带制剂包括片状载体，含药物的压敏粘合剂层和隔膜，其中含药物的压敏粘合剂层包含均匀的分散状态，其含有50至95重量％的一种或更多种类的弹性体，5至50重量％的吸湿材料和经皮吸收药物，使得其中包含的部分吸湿材料残留在施用的表面上，以将带制剂从施用的表面上分离。

10. 发明授权

US5368860A Preparation for transdermal drug administration 失效
标题翻译：透皮给药制剂
公开(公告)号：US5368860A
公开(公告)日：1994-11-29
申请号：US798149
申请日：1991-11-26
申请人： Masaki Sunami , Koji Maruyama , Mitsuhiko Hori , Shoichi Tokuda , Kenichiro Saito , Ikuo Kishi
发明人： Masaki Sunami , Koji Maruyama , Mitsuhiko Hori , Shoichi Tokuda , Kenichiro Saito , Ikuo Kishi
IPC分类号： A61K9/70 , A61K31/165 , A61K31/245 , A61K31/46 , A61K31/47 , A61K45/00 , A61P23/02 , A61P25/02 , A61P25/04 , A61F13/02
CPC分类号： A61K9/7061 , A61K31/165
摘要： A preparation for transdermal drug administration comprising a flexible backing layer and a pressure-sensitive adhesive layer containing a local anesthetic in a proportion of 40-65 weight %. Since the ratio of the amount of the undissolved local anesthetic (Ac) to that of the dissolved local anesthetic (As), Ac/As, in the pressure-sensitive adhesive layer is determined to be in the range of 0.1-1.8, the preparation for transdermal drug administration of the present invention is superior in self-adhesiveness and leaves no adhesive material upon removal from the skin. In addition, burst-like release of the undissolved drug from the pressure-sensitive adhesive layer immediately after application to the skin permits rapid appearance of the anesthetic effect, which enables wide clinical application of the preparations of the present invention.
摘要翻译：用于经皮给药的制剂包括柔性背衬层和含有40-65重量％比例的局部麻醉剂的压敏粘合剂层。由于粘合剂层中未溶解的局部麻醉剂（Ac）与溶解的局部麻醉剂（As）Ac / As的比例确定为0.1-1.8，所以制剂对于本发明的透皮给药，自身粘合性优异，从皮肤上除去时没有粘合剂。此外，在施用于皮肤之后立即从压敏粘合剂层中爆发出的未溶解药物的释放允许快速出现麻醉效果，这使得本发明的制剂能够广泛的临床应用。

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