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1. 发明授权

US09314041B2 Immune function modulating agents 有权
标题翻译：免疫功能调节剂
公开(公告)号：US09314041B2
公开(公告)日：2016-04-19
申请号：US11817617
申请日：2006-02-23
申请人： Toshihiro Sashihara , Makoto Yamaguchi , Yoshitaka Nakamura , Shuji Ikegami , Seiko Narushima , Katsunori Kimura , Shinya Nagafuchi , Masaki Terahara
发明人： Toshihiro Sashihara , Makoto Yamaguchi , Yoshitaka Nakamura , Shuji Ikegami , Seiko Narushima , Katsunori Kimura , Shinya Nagafuchi , Masaki Terahara
IPC分类号： C12N1/20 , A23C19/032 , A23C9/123 , A23L1/30 , A61K35/747 , C12R1/225
CPC分类号： A23C19/0323 , A23C9/1234 , A23L33/135 , A61K35/747 , C12R1/225
摘要： A probiotic lactobacillus was discovered from lactobacilli of the Lactobacillus genus independently isolated from human adult feces. The probiotic lactobacillus was selected from other bacterial strains for: (1) being highly resistant to gastric acid/bile acid; (2) having a high promoting activity on IL-12 production from mouse derived spleen cells and a high Th1/Th2 balance-improving effect; (3) having a high ability to inhibit the production of antigen-specific IgE induced by intraperitoneally administering ovalbumin to BALB/c mice; (4) having a high ability to inhibit the production of antigen-specific IgE induced by orally administering a food antigen to C57BL/6N mice; (5) having a high Natural Killer cell-activating ability; (6) having a high IL-12 production-promoting activity on spleen cells and mesenteric lymph node cells derived from mice immunized with ovalbumin and a high Th1/Th2 balance-improving effect; and (7) having a high ability to suppress eosinophilia induced by a cedar pollen-extracted antigen. This discovery led to the completion of the present invention.
摘要翻译：从人类成年粪便独立分离的乳杆菌属的乳杆菌中发现益生菌乳杆菌。选自其他细菌菌株的益生菌乳杆菌：（1）对胃酸/胆汁酸具有高度抗性; （2）对小鼠来源的脾细胞的IL-12产生促进活性高，Th1 / Th2平衡提高效果好; （3）具有抑制通过向BALB / c小鼠腹膜内给予卵白蛋白诱导的抗原特异性IgE产生的高能力; （4）通过口服给C57BL / 6N小鼠口服给予抗原而诱导抗原特异性IgE产生的能力较强; （5）具有高自然杀伤细胞活化能力; （6）对来自用卵白蛋白免疫的小鼠脾细胞和肠系膜淋巴结细胞具有高IL-12产生促进活性和高Th1 / Th2平衡改善效果; 和（7）具有高的抑制由雪松花粉提取的抗原诱导的嗜酸性粒细胞增多的能力。这一发现导致了本发明的完成。

2. 发明申请

US20090269321A1 Immune Function Modulating Agents 有权
标题翻译：免疫功能调节剂
公开(公告)号：US20090269321A1
公开(公告)日：2009-10-29
申请号：US11817617
申请日：2006-02-23
申请人： Toshihiro Sashihara , Makoto Yamaguchi , Yoshitaka Nakamura , Shuji Ikegami , Seiko Narushima , Katsunori Kimura , Shinya Nagafuchi , Masaki Terahara
发明人： Toshihiro Sashihara , Makoto Yamaguchi , Yoshitaka Nakamura , Shuji Ikegami , Seiko Narushima , Katsunori Kimura , Shinya Nagafuchi , Masaki Terahara
IPC分类号： A61K45/00 , A61K35/74 , A61P37/08
CPC分类号： A23C19/0323 , A23C9/1234 , A23L33/135 , A61K35/747 , C12R1/225
摘要： A probiotic lactobacillus was discovered from lactobacilli of the Lactobacillus genus independently isolated from human adult feces. The probiotic lactobacillus was selected from other bacterial strains for: (1) being highly resistant to gastric acid/bile acid; (2) having a high promoting activity on IL-12 production from mouse derived spleen cells and a high Th1/Th2 balance-improving effect; (3) having a high ability to inhibit the production of antigen-specific IgE induced by intraperitoneally administering ovalbumin to BALB/c mice; (4) having a high ability to inhibit the production of antigen-specific IgE induced by orally administering a food antigen to C57BL/6N mice; (5) having a high Natural Killer cell-activating ability; (6) having a high IL-12 production-promoting activity on spleen cells and mesenteric lymph node cells derived from mice immunized with ovalbumin and a high Th1/Th2 balance-improving effect; and (7) having a high ability to suppress eosinophilia induced by a cedar pollen-extracted antigen. This discovery led to the completion of the present invention.
摘要翻译：从人类成年粪便独立分离的乳杆菌属的乳杆菌中发现益生菌乳杆菌。选自其他细菌菌株的益生菌乳杆菌：（1）对胃酸/胆汁酸具有高度抗性; （2）对小鼠来源的脾细胞的IL-12产生促进活性高，Th1 / Th2平衡提高效果好; （3）具有抑制通过向BALB / c小鼠腹膜内给予卵白蛋白诱导的抗原特异性IgE产生的高能力; （4）通过口服给C57BL / 6N小鼠口服给予抗原而诱导抗原特异性IgE产生的能力较强; （5）具有高自然杀伤细胞活化能力; （6）对来自用卵白蛋白免疫的小鼠脾细胞和肠系膜淋巴结细胞具有高IL-12产生促进活性和高Th1 / Th2平衡改善效果; 和（7）具有高的抑制由雪松花粉提取的抗原诱导的嗜酸性粒细胞增多的能力。这一发现导致了本发明的完成。

3. 发明授权

US08440233B2 Compositions against rotavirus infection and processes for producing the same 有权
标题翻译：针对轮状病毒感染的组合物及其制备方法
公开(公告)号：US08440233B2
公开(公告)日：2013-05-14
申请号：US13339019
申请日：2011-12-28
申请人： Yoshihiro Kanamaru , Yoshitaka Nakamura , Takeshi Takahashi , Shinya Nagafuchi , Makoto Yamaguchi , Hideo Ohtomo , Kenichi Nakazawa
发明人： Yoshihiro Kanamaru , Yoshitaka Nakamura , Takeshi Takahashi , Shinya Nagafuchi , Makoto Yamaguchi , Hideo Ohtomo , Kenichi Nakazawa
IPC分类号： A61K35/20
CPC分类号： A23C21/00 , A23L33/19
摘要： The present inventors discovered that microfiltration retentates of whey, and products obtained by treating whey using centrifugation and/or ammonium sulfate precipitation, have the activity of inhibiting rotavirus infection. In one embodiment, the present invention provides a method of preventing rotavirus infection, comprising administering to a subject a composition that comprises a whey cream serum obtained by treating whey by centrifugation, or a dehydrated product thereof, wherein the antiviral activity of said composition is retained after heat treatment.
摘要翻译：本发明人发现，通过使用离心分离和/或硫酸铵沉淀处理乳清得到的乳清微滤保留物和产物具有抑制轮状病毒感染的活性。在一个实施方案中，本发明提供了一种预防轮状病毒感染的方法，包括向受试者施用包含通过离心处理乳清得到的乳清奶油血清或其脱水产物的组合物，其中所述组合物的抗病毒活性被保留热处理后。

4. 发明申请

US20120100224A1 Compositions Against Rotavirus Infection and Processes For Producing The Same 有权
标题翻译：抗轮状病毒感染组合物及其制备方法
公开(公告)号：US20120100224A1
公开(公告)日：2012-04-26
申请号：US13339019
申请日：2011-12-28
申请人： Yoshihiro KANAMARU , Yoshitaka Nakamura , Takeshi Takahashi , Shinya Nagafuchi , Makoto Yamaguchi , Hideo Ohtomo , Kenichi Nakazawa
发明人： Yoshihiro KANAMARU , Yoshitaka Nakamura , Takeshi Takahashi , Shinya Nagafuchi , Makoto Yamaguchi , Hideo Ohtomo , Kenichi Nakazawa
IPC分类号： A61K35/20 , A61P31/14
CPC分类号： A23C21/00 , A23L33/19
摘要： The present inventors discovered that microfiltration retentates of whey, and products obtained by treating whey using centrifugation and/or ammonium sulfate precipitation, have the activity of inhibiting rotavirus infection.
摘要翻译：本发明人发现，通过使用离心分离和/或硫酸铵沉淀处理乳清得到的乳清微滤保留物和产物具有抑制轮状病毒感染的活性。

5. 发明授权

US08211476B2 Compositions against rotavirus infection and processes for producing the same 有权
标题翻译：针对轮状病毒感染的组合物及其制备方法
公开(公告)号：US08211476B2
公开(公告)日：2012-07-03
申请号：US10548906
申请日：2004-03-11
申请人： Yoshihiro Kanamaru , Yoshitaka Nakamura , Takeshi Takahashi , Shinya Nagafuchi , Makoto Yamaguchi , Hideo Ohtomo , Kenichi Nakazawa
发明人： Yoshihiro Kanamaru , Yoshitaka Nakamura , Takeshi Takahashi , Shinya Nagafuchi , Makoto Yamaguchi , Hideo Ohtomo , Kenichi Nakazawa
IPC分类号： A61K35/20
CPC分类号： A23C21/00 , A23L33/19
摘要： The present inventors discovered that microfiltration retentates of whey, and products obtained by treating whey using centrifugation and/or ammonium sulfate precipitation, have the activity of inhibiting rotavirus infection.
摘要翻译：本发明人发现，通过使用离心分离和/或硫酸铵沉淀处理乳清得到的乳清微滤保留物和产物具有抑制轮状病毒感染的活性。

6. 发明申请

US20060240115A1 Composition against injection with and process for producting the same 有权
标题翻译：用于注射的组合物及其制备方法
公开(公告)号：US20060240115A1
公开(公告)日：2006-10-26
申请号：US10548906
申请日：2004-03-11
申请人： Yoshihiro Kanamaru , Yoshitaka Nakamura , Takeshi Takahashi , Shinya Nagafuchi , Makoto Yamaguchi , Hideo Ohtomo , Kenichi Nakazawa
发明人： Yoshihiro Kanamaru , Yoshitaka Nakamura , Takeshi Takahashi , Shinya Nagafuchi , Makoto Yamaguchi , Hideo Ohtomo , Kenichi Nakazawa
IPC分类号： A61K35/20 , A23K1/00
CPC分类号： A23C21/00 , A23L33/19
摘要： The present inventors discovered that microfiltration retentates of whey, and products obtained by treating whey using centrifugation and/or ammonium sulfate precipitation, have the activity of inhibiting rotavirus infection.
摘要翻译：本发明人发现，通过使用离心分离和/或硫酸铵沉淀处理乳清得到的乳清微滤保留物和产物具有抑制轮状病毒感染的活性。

7. 发明申请

US20110107588A1 METHOD OF MANUFACTURING A SPARK PLUG 有权
标题翻译：制造火花塞的方法
公开(公告)号：US20110107588A1
公开(公告)日：2011-05-12
申请号：US12944827
申请日：2010-11-12
申请人： Kazuhiko Mori , Makoto Yamaguchi
发明人： Kazuhiko Mori , Makoto Yamaguchi
IPC分类号： H01S4/00
CPC分类号： H01T21/02 , Y10T29/49002
摘要： A process of manufacturing the spark plug that includes a step in which a receiving die having an insertion hole and a taper portion is used, wherein a thread portion of the spark plug is inserted into the insertion hole and a seat portion of the spark plug is brought into contact with the taper portion, and a pressing force is applied to a rear end portion of a metallic shell of the spark plug so as to bend a rear end opening portion of the metallic shell, and to thereby form a crimped portion, whereby an insulator and the metallic shell are fixed together.
摘要翻译：一种制造火花塞的方法，包括使用具有插入孔和锥形部的接收模具的步骤，其中火花塞的螺纹部分插入到插入孔中，并且火花塞的座部分是与锥形部接触，并且对火花塞的金属壳的后端部施加按压力，以弯曲金属壳的后端开口部，从而形成卷曲部，由此绝缘体和金属壳固定在一起。

8. 发明授权

US07914353B2 Spark plug and method for manufacturing the same 有权
标题翻译：火花塞及其制造方法
公开(公告)号：US07914353B2
公开(公告)日：2011-03-29
申请号：US12038045
申请日：2008-02-27
申请人： Kenji Kobayashi , Makoto Yamaguchi
发明人： Kenji Kobayashi , Makoto Yamaguchi
IPC分类号： H01T21/02
CPC分类号： H01T13/08 , H01T21/02
摘要： A method for manufacturing a spark plug and a spark plug manufactured by the method in which a gasket used for securing the air-tightness when mounting the spark plug on an internal-combustion engine is prevented from falling out from the metal shell with a simple step.
摘要翻译：一种用于制造火花塞和火花塞的方法，其通过以下方法制造：通过简单的步骤防止在将火花塞安装在内燃机上时用于确保气密性的垫圈的方法。

9. 发明授权

US07563458B2 Nutritional compositions for nutritional management of patients with liver disease 有权
标题翻译：用于肝病患者营养管理的营养组合物
公开(公告)号：US07563458B2
公开(公告)日：2009-07-21
申请号：US10535585
申请日：2003-11-21
申请人： Hisae Kume , Makoto Yamaguchi , Kenji Mizumoto , Hajime Sasaki
发明人： Hisae Kume , Makoto Yamaguchi , Kenji Mizumoto , Hajime Sasaki
IPC分类号： A61K35/20
CPC分类号： A61K45/06 , A23C19/076 , A23C21/02 , A23L27/34 , A23L29/231 , A23L29/35 , A23L33/12 , A23L33/15 , A23L33/16 , A23L33/18 , A23L33/19 , A23L33/40 , A23V2002/00 , A61K31/7016 , A61K35/20 , A61K38/1709 , A61K2300/00 , A23V2250/54252 , A23V2250/1842 , A23V2250/18 , A23V2250/5114 , A23V2250/5072 , A23V2250/032 , A23V2250/62 , A23V2250/70 , A23V2250/5424 , A23V2250/156 , A23V2250/1874 , A23V2250/188 , A23V2250/161
摘要： The present inventors discovered that the onset of galactosamine hepatopathy is suppressed by nutritional compositions comprising as essential ingredients: whey protein hydrolysates; lecithin and oils and fats high in oleic acid, which are able to improve the lipid metabolism; and palatinose having an insulin-sparing effect. Furthermore, the whey protein hydrolysate included in the nutritional compositions was found to suppress endotoxin-induced TNF-a and interleukin 6 (IL-6) production in macrophages.
摘要翻译：本发明人发现半乳糖胺肝病的发作由包含作为必需成分的营养组合物抑制：乳清蛋白水解物; 卵磷脂和高油酸的油脂，能够改善脂质代谢; 和具有胰岛素节约作用的帕拉金糖。此外，发现包含在营养组合物中的乳清蛋白水解物抑制巨噬细胞中内毒素诱导的TNF-α和白介素6（IL-6）产生。

10. 发明申请

US20080250901A1 Method of High-Melting-Point Metal Separation and Recovery 审中-公开
标题翻译：高熔点金属分离和回收方法
公开(公告)号：US20080250901A1
公开(公告)日：2008-10-16
申请号：US11886323
申请日：2006-03-08
申请人： Tadashi Ogasawara , Makoto Yamaguchi , Katsunori Dakeshita , Masahiko Hori
发明人： Tadashi Ogasawara , Makoto Yamaguchi , Katsunori Dakeshita , Masahiko Hori
IPC分类号： C22B34/12 , C22B9/02
CPC分类号： C25C3/02 , C22B9/02 , C22B34/1272 , C22B34/1295 , Y02P10/234
摘要： A TiCl4 gas is supplied to a molten CaCl2 liquid held in a reactor vessel 6 through a raw material feed pipe 11, TiCl4 is reduced to produce granular metallic Ti by Ca melted in the CaCl2 liquid. The molten CaCl2 liquid in which Ti granules taken out downward from the reactor vessel 6 is mixed is delivered to a separation process 12, the molten CaCl2 liquid is heated in a heating vessel 15, and separation is generated by a difference in specific gravity, whereby the molten CaCl2 liquid 16 is located in an upper layer while a metallic Ti 17 is located in a lower layer. The metallic Ti 17 in the lower layer is taken out from a high-melting-point metal discharge port 18, and the metallic Ti 17 is solidified to yield an ingot. The molten CaCl2 liquid 16 in the upper layer is delivered to an electrolysis process 13 along with the molten CaCl2 liquid taken out from the reactor vessel 6, and Ca generated by the electrolysis and CaCl2 are returned into the reactor vessel 6. A separation and recovery method of the invention is applied to the separation process 12 in the above production process, and high-quality Ti or Ti alloy is efficiently separated and recovered from the CaCl2-containing molten salt with a small amount of energies.
摘要翻译：将TiCl 4气体通过原料供给管11供给到保持在反应器容器6中的熔融CaCl 2 2液体，TiCl 4 通过在CaCl 2液体中熔化的Ca还原以产生颗粒状金属Ti。将其中从反应器6向下取出的Ti颗粒混合的熔融的CaCl 2 H 2液体被输送到分离过程12中，将熔融的CaCl 2液体加热到加热容器15，并且通过比重差产生分离，由此熔融的CaCl 2液体16位于上层，而金属Ti 17位于下层。下层的金属Ti 17从高熔点金属排出口18取出，使金属Ti 17固化，得到锭。上层的熔融CaCl 2液体16与从反应容器6取出的熔融CaCl 2液体一起被输送到电解过程13，由将电解和CaCl 2 2返回到反应容器6中。本发明的分离和回收方法在上述生产过程中应用于分离过程12，并且从包含CaCl 2的熔融盐中有效地分离和回收高品质的Ti或Ti合金，少量的能量。

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