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    • 6. 发明授权
    • Pyridine derivative
    • 吡啶衍生物
    • US5922743A
    • 1999-07-13
    • US849148
    • 1997-08-07
    • Hirofusa ShiraiKenji HanabusaYuki TakahashiFumio MizobeKazunori Hanada
    • Hirofusa ShiraiKenji HanabusaYuki TakahashiFumio MizobeKazunori Hanada
    • C07D213/38C07D213/40C07D213/55C07D213/56C07D213/02A61K31/44
    • C07D213/40C07D213/38C07D213/55C07D213/56
    • A pyridine derivative represented by the following formula: ##STR1## where R.sup.1 and R.sup.2 are as defined in the specification, or a salt thereof. These compounds directly or indirectly act on neuronal cells in vivo and are effective in the amelioration and curing of nerve disorders due to neuronal degeneration, such as, for example, traumatic symptoms and maladies, disorders induced by drugs such as alcohol and antineoplastic agents, inflammatory disorders, metabolic disorders observed in diabetes, and disorders due to idiopathic degeneration of peripheral nerves. These compounds are also effective for ameliorating and curing symptoms and maladies due to degeneration of central nerves, for example, Alzheimer's disease and cerebrovascular ischemia, Down's syndrome, Parkinson's disease, Huntington's chorea, diseases secondary to cerebral ischemia, cerebral infarction, intracerebral bleeding, head injuries, amnesia, and spinal neuropathy.
    • PCT No.PCT / JP95 / 02399 Sec。 371日期1997年8月7日 102(e)日期1997年8月7日PCT 1995年11月27日PCT公布。 第WO96 / 16942号公报 日期:1996年6月6日由下式表示的吡啶衍生物:其中R1和R2如说明书中所定义,或其盐。 这些化合物在体内直接或间接作用于神经元细胞,并且由于神经元变性(例如创伤性症状和疾病),药物如酒精和抗肿瘤剂引起的疾病,炎性反应,有助于改善和治疗神经障碍 疾病,糖尿病中观察到的代谢紊乱以及由于周围神经特发性退化引起的疾病。 这些化合物对于改善和治疗由于中枢神经变性引起的症状和疾病也是有效的,例如阿尔茨海默病和脑血管缺血,唐氏综合征,帕金森病,亨廷顿舞蹈病,脑缺血继发性疾病,脑梗死,脑内出血,头部 损伤,遗忘和脊髓神经病变。
    • 9. 发明授权
    • Liquid crystal composition, liquid crystal display device and liquid crystal displaying method
    • 液晶组合物,液晶显示装置和液晶显示方法
    • US06682787B2
    • 2004-01-27
    • US10077885
    • 2002-02-20
    • Takashi KatoNorihiro MizoshitaKenji Hanabusa
    • Takashi KatoNorihiro MizoshitaKenji Hanabusa
    • C09K1952
    • C09K19/52C09K19/02Y10S516/90Y10T428/10Y10T428/1005Y10T428/1059
    • Disclosed is a liquid crystal composition by which the state of molecular orientation of a liquid crystalline compound can be stably maintained even when no electric field is caused to effect on, and moreover the state of molecular orientation of the liquid crystalline compound can be changed, and a liquid crystal display device and a liquid crystal displaying method by which a displayed state can be stably retained even after the action of an electric field is ceased, and moreover the displayed state can be dissolved with ease. The liquid crystal composition contains a liquid crystalline compound and a liquid crystal orientation state-regulating agent for regulating the orientated state of the liquid crystalline compound by gelling, wherein a phase transition temperature between an isotropic liquid phase and a liquid crystal phase in the liquid crystalline compound is higher than a gelling temperature by the liquid crystal orientation state-regulating agent. The liquid crystal display device has a liquid crystal layer formed of the liquid crystal composition.
    • 公开了一种液晶组合物,即使在没有电场发生作用的情况下也可以稳定地保持液晶化合物的分子取向状态,而且可以改变液晶化合物的分子取向状态, 液晶显示装置和液晶显示方法,即使在电场的动作停止之后也能够稳定地保持显示状态,并且还可以容易地溶解显示状态。 液晶组合物含有液晶化合物和用于通过胶凝调节液晶化合物的取向状态的液晶取向状态调节剂,其中在液晶中各向同性液相和液晶相之间的相转变温度 化合物比液晶取向状态调节剂高于胶凝温度。 液晶显示装置具有由液晶组合物形成的液晶层。