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1. 发明授权

US5800390A Equipment for intracerebral administration of preparations 失效
标题翻译：大脑内给药制剂的设备
公开(公告)号：US5800390A
公开(公告)日：1998-09-01
申请号：US900135
申请日：1997-07-25
申请人： Toru Hayakawa , Toshiki Yoshimine , Hiromu Yamamoto , Akira Sato , Tsunemasa Irie , Keiji Fujioka , Yoshihiro Takada , Yoshio Sasaki
发明人： Toru Hayakawa , Toshiki Yoshimine , Hiromu Yamamoto , Akira Sato , Tsunemasa Irie , Keiji Fujioka , Yoshihiro Takada , Yoshio Sasaki
IPC分类号： A61M37/00 , A61M39/02 , A61M11/00
CPC分类号： A61M37/00 , A61M39/0208 , A61M2210/0693
摘要： Equipment for intracerebral administration of preparations is composed of a preparation-administering device (1) holding a preparation (2), and a plunger (4) removably arranged in the preparation-administering device adapted to push the preparation held therein toward one end of the preparation-administering device. The intracerebral preparation-administration equipment is inserted into a preparation-introducing guide (5) previously implanted in the head of a patient to introduce the preparation into its guide hole (26). The preparation is then guided to a site of administration through a flexible guide tube (23) communicated with the guide hole of the preparation-introducing guide. The equipment for intracerebral administration of preparations may be composed of a tubular preparation-retaining member (30) having a preparation contained therein, and a holder (32) for holding the tubular preparation-retaining member along with a push rod (31) inserted thereinto as an integral part thereof. In this case, the administration equipment itself is inserted into and held in the preparation-introducing guide (5).
摘要翻译： PCT No.PCT / JP92 / 00658 Sec。 371日期：1993年11月24日 102（e）日期1993年11月24日PCT提交1992年5月22日PCT公布。第WO92 / 20400号公报日期：1992年11月26日制剂的脑内给药设备由保持制剂（2）的制剂给药装置（1）和可移除地布置在准备投与装置中的柱塞（4）组成，其适于推动保持在其中的制剂朝向准备给药装置的一端。将脑内准备给药装置插入预先植入患者头部的制剂引入导向件（5）中，以将制剂引入其引导孔（26）。然后将制剂通过与制剂引入导向件的引导孔连通的柔性引导管（23）引导到给药部位。脑内给药制剂的装置可以由其中容纳有制剂的管状制剂保持构件（30）和用于将管状制剂保持构件与插入其中的推杆（31）保持的保持器（32）组成。作为其组成部分。在这种情况下，管理设备本身被插入并保持在准备导入引导件（5）中。

2. 发明授权

US4900304A Solid preparation administering instrument 失效
标题翻译：固体制剂给药仪器
公开(公告)号：US4900304A
公开(公告)日：1990-02-13
申请号：US79429
申请日：1987-07-30
申请人： Keiji Fujioka , Shigeji Sato , Nobuhiko Tamura , Yoshihiro Takada , Yoshio Sasaki
发明人： Keiji Fujioka , Shigeji Sato , Nobuhiko Tamura , Yoshihiro Takada , Yoshio Sasaki
IPC分类号： A61M5/00 , A61M36/00 , A61M36/12 , A61M37/00
CPC分类号： A61M37/0069
摘要： A device for administering solid or semisolid preparations under the skin, which comprises a solid needle member with an acute tip end, and a cylindrical member slidably mounted on the needle member. The solid needle member having a recess at its front part to form a preparation chamber between the needle member and cylindrical member, and the chamber being opened or closed by moving the cylindrical member in the direction parallel to the axis of the needle member. The device may comprises a cylindrical member with a capsule chamber, a hollow needle member removable mounted on the front end of the cylindrical member, and a plunger slidably arranged in the capsule chamber of the cylindrical member, all of which have a common axis so that the plunger enters into the hollow needle member through the capsule chamber.

3. 发明授权

US5011692A Sustained pulsewise release pharmaceutical preparation 失效
标题翻译：持续脉搏释放药物制剂
公开(公告)号：US5011692A
公开(公告)日：1991-04-30
申请号：US946158
申请日：1986-12-23
申请人： Keiji Fujioka , Shigeji Sato , Yoshihiro Takada , Yoshio Sasaki , Nobuhiko Tamura
发明人： Keiji Fujioka , Shigeji Sato , Yoshihiro Takada , Yoshio Sasaki , Nobuhiko Tamura
IPC分类号： A61K9/00 , A61K9/20 , A61K9/22 , A61K9/24 , A61K9/70
CPC分类号： A61K9/2072 , A61K9/209
摘要： The invention relates to sustained pulsewise release pharmaceutical preparation which comprices drug-containing polymeric material layers (layers A) and polymeric material layers containing the drug in question only in a slight amount or free of the drug (layers B) disposed alternatingly, with the whole surface extending in the direction perpendicular to the layer plane being coated with a polymeric material which is insoluble in water or scarcely soluble in water (polymeric material C).This pharmaceutical preparation of this invention is designed so that active ingredients which should desirably be released pulsewise can be released therefrom in a pulse-like and clinically significant manner and thereby the pharmacological effects of said active ingredients can be maintained for a prolonged period of time.
摘要翻译：本发明涉及持续的脉搏释放药物制剂，其将含药物的聚合物材料层（层A）和含有所述药物的聚合物材料层仅含有少量或不含交替设置的药物（B层）与整体表面沿垂直于层平面的方向延伸，涂覆有不溶于水或几乎不溶于水的聚合材料（聚合物C）。本发明的这种药物制剂被设计成使得脉动式的理想释放的活性成分能以脉冲状和临床显着的方式从其中释放出来，从而可以延长所述活性成分的药理作用。

4. 发明授权

US5236704A Controlled release formulation 失效
标题翻译：控制释放公式
公开(公告)号：US5236704A
公开(公告)日：1993-08-17
申请号：US302476
申请日：1989-01-27
申请人： Keiji Fujioka , Shigeji Sato , Nobuhiko Tamura , Yoshihiro Takada , Yoshio Sasaki , Miho Maeda
发明人： Keiji Fujioka , Shigeji Sato , Nobuhiko Tamura , Yoshihiro Takada , Yoshio Sasaki , Miho Maeda
IPC分类号： A61K9/20 , A61K9/22 , A61K47/12 , A61K47/18 , A61K47/42
CPC分类号： A61K9/2063 , A61K47/12 , A61K47/183 , A61K47/42 , A61K9/2013 , Y10S514/801 , Y10S514/964
摘要： A controlled release formulation which comprises a compound selected from the group consisting of organic acidic compounds and acid anhydrides or esters capable of generating one of the organic acidic compounds through hydrolysis together with an active ingredient and collagen as a carrier, said formulation being capable of exhibiting a predetermined release profile of the active ingredient. A process for producing said formulation is also provided.

5. 发明授权

US4774091A Long-term sustained-release preparation 失效
标题翻译：长期缓释制剂
公开(公告)号：US4774091A
公开(公告)日：1988-09-27
申请号：US846193
申请日：1986-03-31
申请人： Yoshiya Yamahira , Keiji Fujioka , Shiegeji Sato , Yoshihiro Takada
发明人： Yoshiya Yamahira , Keiji Fujioka , Shiegeji Sato , Yoshihiro Takada
IPC分类号： A61K9/00 , A61K9/20 , A61K31/405 , A61K31/415 , A61K38/21 , A61K37/24
CPC分类号： A61K9/0024 , A61K31/405 , A61K31/415 , A61K38/212 , A61K9/2063 , Y10S514/801 , Y10S514/944 , Y10S514/953 , Y10S514/965
摘要： A solid sustained-release preparation in the form of a needle-like or bar-like shape, which consists essentially of an active ingredient and a pharmaceutically acceptable biodegradable carrier (e.g. proteins, preferably collagen, gelatin, and a mixture thereof). The sustained-release preparation can be administered to the body or implanted into the body by injection or an injection-like method and can release the active ingredient at an effective level for a long period of time when administered.
摘要翻译：呈针状或棒状形式的固体缓释制剂，其基本上由活性成分和药学上可接受的生物可降解载体（例如蛋白质，优选胶原，明胶及其混合物）组成。持续释放制剂可以通过注射或注射样方法施用于身体或植入体内，并且可以在施用时长时间释放有效成分。

6. 发明授权

US5171219A Pharmaceutical preparation administrator 失效
标题翻译：药物制剂管理员
公开(公告)号：US5171219A
公开(公告)日：1992-12-15
申请号：US534874
申请日：1990-06-08
申请人： Keiji Fujioka , Yoshihiro Takada , Ayumi Aisaka
发明人： Keiji Fujioka , Yoshihiro Takada , Ayumi Aisaka
IPC分类号： A61M3/00 , A61M11/00 , A61M35/00 , B05B11/00 , B05B11/02
CPC分类号： B05B11/02 , A61M35/003
摘要： A preparation administrator has an administrator body including a solid preparation and having at its one end an inflow channel for solvent and at the other end an outflow channel for liquid preparation, a solvent container containing a solvent to dissolve, disperse or suspend the preparation and being connected to the inflow channel of the administrator body, and an ejector for ejecting the solvent together with the solid preparation in the body through the outflow channel of the body. A solid preparation in the administrator body is dissolved, or suspended or dispersed in the solvent fed from the solvent container and ejected as a liquid preparation through the outflow channel of the body.

7. 发明授权

US5021241A Long-term sustained-release preparation 失效
标题翻译：长期缓释制剂
公开(公告)号：US5021241A
公开(公告)日：1991-06-04
申请号：US187443
申请日：1988-04-28
申请人： Yoshiya Yamahira , Keiji Fujioka , Shigeji Sato , Yoshihiro Takada
发明人： Yoshiya Yamahira , Keiji Fujioka , Shigeji Sato , Yoshihiro Takada
IPC分类号： A61K9/00 , A61K9/20 , A61K31/405 , A61K31/415 , A61K38/21
CPC分类号： A61K9/0024 , A61K31/405 , A61K31/415 , A61K38/212 , A61K9/2063 , Y10S514/801 , Y10S514/944 , Y10S514/953 , Y10S514/965
摘要： A solid sustained-release preparation in the form of a needle-like or bar-like shape, which consists essentially of an active ingredient and a pharmaceutically acceptable biodegradable carrier (e.g. proteins, preferably collagen, gelatin, and a mixture thereof). The sustained release preparation can be administered to the body or implanted into the body by injection or an injection-like method and can release the active ingredient at an effective level for a long period of time when administered.

8. 发明授权

US4950234A Device for administering solid preparations 失效
标题翻译：用于施用固体制剂的装置
公开(公告)号：US4950234A
公开(公告)日：1990-08-21
申请号：US198290
申请日：1988-05-25
申请人： Keiji Fujioka , Nobuhiko Tamura , Yoshihiro Takada , Kenji Himeshima
发明人： Keiji Fujioka , Nobuhiko Tamura , Yoshihiro Takada , Kenji Himeshima
IPC分类号： A61M5/178 , A61M31/00 , A61M36/00 , A61M37/00
CPC分类号： A61M37/0069
摘要： A device for administering solid or semisolid preparations in an organism subcutaneously. The equipment comprises a barrel having a nozzle for attachment of a hollow needle, a plunger slidably arranged in the barrel and is used in combination with a guide member adapted to be snugly accommodated within the lumen of the barrel. The solid preparations are generally housed in the guide member and/or needle and forced into the body subcutaneously through the needle.

9. 发明授权

US5385738A Sustained-release injection 失效
标题翻译：缓释注射液
公开(公告)号：US5385738A
公开(公告)日：1995-01-31
申请号：US844929
申请日：1992-03-04
申请人： Yoshiya Yamahira , Keiji Fujioka , Shigeji Sato , Yoshihiro Takada
发明人： Yoshiya Yamahira , Keiji Fujioka , Shigeji Sato , Yoshihiro Takada
IPC分类号： A61K9/00 , A61K9/10 , A61K9/16 , A61K9/20 , A61K31/405 , A61K31/415 , A61K38/21 , A61K9/14 , A61F2/02 , A61K9/50 , B01J13/02
CPC分类号： A61K9/0024 , A61K31/405 , A61K31/415 , A61K38/212 , A61K9/10 , A61K9/1658 , A61K9/2063 , Y10S514/801 , Y10S514/953 , Y10S514/963 , Y10S514/964 , Y10S514/965 , Y10T428/2984 , Y10T428/2989
摘要： The present invention relates to a sustained-release injection, which comprises a suspension of a powder comprising an active ingredient and a pharmaceutically acceptable biodegradable carrier (e.g. proteins, polysaccharides and synthetic high molecular compounds, preferably collagen, atelocollagen, gelatin, and a mixture thereof) in a viscous solvent for injection (e.g. vegetable oils, polyethylene glycol, propylene glycol, silicone oil, and medium-chain fatty acid triglycerides). The sustained-release injection can release the active ingredient at an effective level for a long period of time when injected.
摘要翻译：本发明涉及一种缓释注射液，其包含由活性成分和药学上可接受的生物可降解载体（例如蛋白质，多糖和合成高分子化合物，优选胶原，阿胶囊，明胶及其混合物）组成的粉末的悬浮液）（例如植物油，聚乙二醇，丙二醇，硅油和中链脂肪酸甘油三酸酯）中。持续释放注射剂可以在注射时长时间释放有效成分。

10. 发明授权

US4963529A Stable growth hormone releasing factor preparation 失效
标题翻译：稳定的生长激素释放因子制剂
公开(公告)号：US4963529A
公开(公告)日：1990-10-16
申请号：US168617
申请日：1988-03-08
申请人： Keiji Fujioka , Shigeji Sato , Yoshihiro Takada
发明人： Keiji Fujioka , Shigeji Sato , Yoshihiro Takada
IPC分类号： A61K38/25
CPC分类号： A61K38/25 , Y10S514/97
摘要： Growth hormone releasing factor (GRF) preparation which is excellent in stablity by having human serum albumin or glycine incorporated therein, with or without buffer. An amount of human serum albumin or glycine contained is usually 100 .mu.g to 30 mg per 100 .mu.g GRF. The preparation may be in the solid or solution form, preferably in the lyophilized form. An amount of buffer, if added, is preferably enough so that pH of the preparation is kept at 2-7. More preference is that the preparation is kept in nitrogen gas atmosphere. The lyophilized preparation is readily usable for, for example, injection.
摘要翻译：生长激素释放因子（GRF）制剂，其中含有或不含有缓冲液的人血清白蛋白或甘氨酸是稳定的。人血清白蛋白或甘氨酸含量通常为100μg至30mg / 100g GRF。制剂可以是固体或溶液形式，优选为冻干形式。缓冲液的量如果加入，则优选足以使制剂的pH保持在2-7。更优选的是将制剂保持在氮气气氛中。冻干制剂容易用于例如注射。

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