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1. 发明申请

US20050047973A1 Device for holding a substance library carrier 审中-公开
标题翻译：持有物质库载体的装置
公开(公告)号：US20050047973A1
公开(公告)日：2005-03-03
申请号：US10820269
申请日：2004-04-08
申请人： Torsten Schulz , Eugen Ermantraut , Thomas Ullrich , Thomas Ellinger , Joachim Fischer , Thomas Kaiser , Klaus-Peter Mobius , Siegfried Poser , Jens Tuchscheerer , Martin Zieren
发明人： Torsten Schulz , Eugen Ermantraut , Thomas Ullrich , Thomas Ellinger , Joachim Fischer , Thomas Kaiser , Klaus-Peter Mobius , Siegfried Poser , Jens Tuchscheerer , Martin Zieren
IPC分类号： G01N33/53 , B01J19/00 , B01L3/00 , B01L7/00 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N33/566 , G01N37/00 , B01L9/00
CPC分类号： B01L7/52 , B01J2219/00527 , B01J2219/00531 , B01J2219/00596 , B01J2219/00605 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , B01L3/502715 , B01L2200/025 , B01L2200/027 , B01L2200/10 , B01L2200/141 , B01L2200/147 , B01L2300/044 , B01L2300/0636 , B01L2300/0877 , B01L2300/1805
摘要： Disclosed are devices for holding a substance library carrier, and which are useful in conducting reactions in which binding between complementary molecules is measured qualitatively or quantitatively. Also disclosed are methods for conducting such reactions in the device.
摘要翻译：公开了用于保存物质文库载体的装置，其可用于进行定性或定量测量互补分子之间的结合的反应。还公开了在该装置中进行这种反应的方法。

2. 发明申请

US20060147996A1 Device for holding and detecting substance libraries 审中-公开
标题翻译：用于保存和检测物质库的设备
公开(公告)号：US20060147996A1
公开(公告)日：2006-07-06
申请号：US11284469
申请日：2005-11-22
申请人： Thomas Ullrich , Torsten Schulz , Thomas Ellinger , Siegfried Poser , Eugen Ermantraut , Ralf Ehricht
发明人： Thomas Ullrich , Torsten Schulz , Thomas Ellinger , Siegfried Poser , Eugen Ermantraut , Ralf Ehricht
IPC分类号： C40B40/10 , C40B50/02
CPC分类号： C12Q1/686 , B01J19/0046 , B01J2219/00457 , B01J2219/00529 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00662 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01L3/5082 , B01L9/52 , B01L2200/025 , B01L2300/0609 , B01L2300/0636 , C12Q1/6837 , C40B40/06 , C40B40/10 , C12Q2537/162 , C12Q2537/161 , C12Q2531/107 , C12Q2525/186
摘要： The invention relates to a holding device for substance libraries which can be used, more particularly, for the detection of target molecules with the aid of substance libraries. Said device comprises: (i) a holder for a substance library carrier; (ii) a substance library carrier, which can be fixed to the holder; and (iii) a detection area applied to the substance library carrier, whereon a substance library is immobilized; and wherein at least one substance library carrier can be introduced into a laboratory reaction vessel.
摘要翻译：本发明涉及用于物质文库的保持装置，更具体地说，可用于借助物质文库检测靶分子。所述装置包括：（i）用于物质库载体的保持器; （ii）可以固定在保持器上的物质库载体; 和（iii）应用于物质文库载体的检测区域，其中固定有物质文库; 并且其中可以将至少一种物质文库载体引入实验室反应容器中。

3. 发明申请

US20050064469A1 Reaction vessel for carrying out array processes 有权
标题翻译：用于进行阵列处理的反应容器
公开(公告)号：US20050064469A1
公开(公告)日：2005-03-24
申请号：US10892743
申请日：2004-07-16
申请人： Torsten Schulz , Eugen Ermantraut , Ralf Ehricht , Klaus-Peter Mobius , Gerd Wagner , Joachim Fischer , Thomas Ellinger
发明人： Torsten Schulz , Eugen Ermantraut , Ralf Ehricht , Klaus-Peter Mobius , Gerd Wagner , Joachim Fischer , Thomas Ellinger
IPC分类号： B01J19/00 , B01L3/00 , B01L3/14 , B01L7/00 , C12M1/00 , C12N15/09 , C12Q1/68 , C40B40/02 , C40B40/06 , C40B50/06 , C40B60/12 , C40B60/14 , C40B70/00 , G01N21/17 , G01N33/53 , G01N33/543 , G01N37/00 , C12M1/34
CPC分类号： C12Q1/6837 , B01J2219/00283 , B01J2219/00529 , B01J2219/0054 , B01J2219/00585 , B01J2219/00596 , B01J2219/00707 , B01J2219/00722 , B01L3/50 , B01L3/5082 , B01L7/52 , B01L2300/0636 , B01L2300/0851 , C40B40/06 , C40B60/14 , C40B70/00 , G01N21/253 , G01N33/54366 , C12Q2547/101
摘要： The invention relates to a reaction vessel, a device and a method for detecting specific interactions between molecular target and probe molecules. The present invention especially relates to a reaction vessel which has a shape and size typical of a laboratory reaction vessel and in which a supporting element with probe molecules immobilised thereon on predetermined regions is arranged on its base surfaces.
摘要翻译：本发明涉及一种用于检测分子靶和探针分子之间的特异性相互作用的反应容器，装置和方法。本发明特别涉及一种反应容器，其具有典型的实验室反应容器的形状和尺寸，其中在预定区域上固定有探针分子的支撑元件布置在其基面上。

4. 发明申请

US20060078929A1 Device for the amplification and detection of nucleic acids 审中-公开
标题翻译：用于扩增和检测核酸的装置
公开(公告)号：US20060078929A1
公开(公告)日：2006-04-13
申请号：US11241671
申请日：2005-09-30
申请人： Ralf Bickel , Thomas Ellinger , Eugen Ermantraut , Thomas Kaiser , Torsten Schulz , Thomas Ullrich
发明人： Ralf Bickel , Thomas Ellinger , Eugen Ermantraut , Thomas Kaiser , Torsten Schulz , Thomas Ullrich
IPC分类号： C40B40/08 , G06F19/00 , C12M1/34
CPC分类号： B01L7/52 , B01L3/5027 , B01L2200/147 , B01L2300/0636 , B01L2300/0654 , B01L2300/0877 , G01N21/4738 , G01N21/59
摘要： The present invention relates to a device for the amplification and for the detection of nucleic acids comprising a temperature controlling and/or regulating unit; a reaction chamber containing a support with a detection area, on which a compound library is immobilized, wherein the temperature in the reaction chamber can be controlled and/or regulated by means of the temperature controlling and regulating unit; and an optical system, by means of which the time-dependent behavior of precipitate formations on the detection area is detectable. Methods of using the device are also disclosed.
摘要翻译：本发明涉及用于扩增和检测包含温度控制和/或调节单元的核酸的装置; 包含具有检测区域的载体的反应室，其上固定有化合物文库，其中可以通过温度控制和调节单元来控制和/或调节反应室中的温度; 以及光学系统，通过该光学系统可以检测出沉积物在检测区域上的时间依赖性。还公开了使用该装置的方法。

5. 发明申请

US20080108512A1 Method For The Site-Specific Synthesis Of Biopolymers On Solid Supports 审中-公开
标题翻译：固体载体上生物聚合物位点特异性合成方法
公开(公告)号：US20080108512A1
公开(公告)日：2008-05-08
申请号：US11667116
申请日：2005-11-25
申请人： Thomas Ellinger , Eugen Ermantraut , Nancy Hoizhey , Frank Plenz , Torsten Schulz , Jens Tuchscheerer , Daniel Weicherding
发明人： Thomas Ellinger , Eugen Ermantraut , Nancy Hoizhey , Frank Plenz , Torsten Schulz , Jens Tuchscheerer , Daniel Weicherding
IPC分类号： C40B40/06 , C40B50/14 , C40B40/10
CPC分类号： B01J19/0046 , B01J2219/0043 , B01J2219/00659 , B01J2219/00662 , B01J2219/00675 , B01J2219/00722 , B01J2219/00725 , B82Y30/00 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14
摘要： The present invention relates to methods for the site-specific synthesis of biopolymers such as nucleic acids or peptides and their respective derivatives on solid supports, wherein the local discrimination of the synthesis is performed by using masks that guide aqueous activating reagents for cleaving off protecting groups to predetermined regions on the support.
摘要翻译：本发明涉及用于固体支持物上的生物聚合物如核酸或肽及其各自衍生物的位点特异性合成的方法，其中合成的局部区别通过使用引导用于裂解保护基的水活化试剂的掩模进行到支撑体上的预定区域。

6. 发明授权

US07888074B2 Microchip matrix device for duplicating and characterizing nucleic acids 有权
标题翻译：用于复制和表征核酸的Microchip矩阵器件
公开(公告)号：US07888074B2
公开(公告)日：2011-02-15
申请号：US10038284
申请日：2002-01-02
申请人： Ralf Ehricht , Thomas Ellinger , Jens Tuchscherer , Eugen Ermantraut , Siegfried Poser , Torsten Schulz
发明人： Ralf Ehricht , Thomas Ellinger , Jens Tuchscherer , Eugen Ermantraut , Siegfried Poser , Torsten Schulz
IPC分类号： C12P19/34 , C12M1/36 , G01N15/06
CPC分类号： B01F13/0076 , B01L3/5027 , B01L3/508 , B01L2200/142 , B01L2300/0636 , B01L2300/0809 , B01L2400/0406 , B01L2400/0418
摘要： The aim of the invention is to provide a device for duplicating and characterizing nucleic acids almost simultaneously and with a high sample throughput rate. The device consists of a chamber body with a recess whose edge sealingly holds an optically transparent chip. Said chip holds nucleic acids in individual spots on a detection surface. The chamber body is placed on an optically transparent chamber support with a bearing surface, in such a way that a capillary gap, which can be filled with a liquid sample, is formed between the detection surface of the chip facing towards the chamber support and said chamber support. The chamber body is provided with an inlet and an outlet, which are spatially separate from each other, and has a space, which laterally encompasses the chip and which has a gas reservoir. The chamber support is provided with heating elements.
摘要翻译：本发明的目的是提供一种用于几乎同时复制和表征核酸并具有高样品通过率的装置。该装置包括具有凹口的腔体，其边缘密封地保持光学透明的芯片。所述芯片将核酸保留在检测表面上的各个斑点中。室体被放置在具有支承表面的光学透明室支撑件上，使得可以在面向腔室支撑件的芯片的检测表面之间形成可填充有液体样品的毛细管间隙，并且所述室支持。腔体设置有在空间上彼此分离的入口和出口，并且具有横向包围芯片并且具有气体储存器的空间。腔室支撑件设有加热元件。

7. 发明授权

US08906303B2 Assays 有权
标题翻译：测定
公开(公告)号：US08906303B2
公开(公告)日：2014-12-09
申请号：US12922383
申请日：2009-03-16
申请人： Eugen Ermantraut , Thomas Kaiser , Jens Tuchscheerer , Vico Baier , Torsten Schulz , Anke Wöstemeyer
发明人： Eugen Ermantraut , Thomas Kaiser , Jens Tuchscheerer , Vico Baier , Torsten Schulz , Anke Wöstemeyer
IPC分类号： G01N21/00 , B01L3/00
CPC分类号： G01N33/58 , B01L3/50273 , B01L2200/025 , B01L2200/0684 , B01L2300/0816 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , Y10T436/25
摘要： A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence of each analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction at each test zone is indicative of the presence in the sample of a target analyte. Capillary structures of the devices or used in the methods may comprise a matrix and the devices may comprise control elements and methods for assaying of sample may use corresponding controlling activities.
摘要翻译：描述了用于分析多种分析物中的每一种的样品的方法。该方法包括使间隔开的测试区域的阵列与液体样品（例如全血）接触。测试区域设置在微流体装置的通道内。通道由至少一个柔性壁和可以是柔性的第二壁限定。每个测试区域包含对各个目标分析物特异的探针化合物。微流体装置被压缩以减小通道的厚度，其是通道内的壁的内表面之间的距离。每个分析物的存在通过光学检测在相应位置处的内表面之间的距离减小的多个测试区域中的每一个处的相互作用来确定。每个测试区域的相互作用表明样品中目标分析物的存在。装置的毛细结构或方法中使用的毛细管结构可以包括基质，并且装置可以包括控制元件和用于测定样品的方法可以使用相应的控制活动。

8. 发明申请

US20120088252A1 Device and Method for the Detection of Particles 有权
标题翻译：用于检测颗粒的装置和方法
公开(公告)号：US20120088252A1
公开(公告)日：2012-04-12
申请号：US13274175
申请日：2011-10-14
申请人： Eugen Ermantraut , Ralf Bickel , Torsten Schulz , Thomas Ullrich , Jens Tuchscheerer
发明人： Eugen Ermantraut , Ralf Bickel , Torsten Schulz , Thomas Ullrich , Jens Tuchscheerer
IPC分类号： G01N21/75
CPC分类号： G01N33/56966 , B01F11/0045 , B01F11/0266 , B01F13/0059 , B01L3/50273 , B01L3/502746 , B01L2200/027 , B01L2300/0636 , B01L2300/0822 , B01L2300/0825 , B01L2400/0481 , G01N21/03 , G01N35/0099 , G01N2021/0346 , G01N2035/00346
摘要： The present invention relates to devices and methods for the qualitative and/or quantitative detection of particles. In particular, the invention relates to devices for the detection of particles, comprising a reaction chamber formed within a chamber body between a first surface and a second surface, wherein the second surface is located opposite to the first surface, and one or more displacers, wherein the distance between the first surface and the second surface is variable via the one or more displacers at least in one or more parts of the surface area of the first surface and/or second surface. The invention also relates to corresponding methods for the detection of particles.
摘要翻译：本发明涉及用于定性和/或定量检测颗粒的装置和方法。特别地，本发明涉及用于检测颗粒的装置，其包括形成在第一表面和第二表面之间的室主体内的反应室，其中第二表面位于与第一表面相对的位置，以及一个或多个位移器，其中所述第一表面和所述第二表面之间的距离可经由所述一个或多个置换器在所述第一表面和/或第二表面的表面区域的至少一个或多个部分中是可变的。本发明还涉及用于检测颗粒的相应方法。

9. 发明授权

US08467039B2 Device and method for the detection of particles 有权
标题翻译：用于检测颗粒的装置和方法
公开(公告)号：US08467039B2
公开(公告)日：2013-06-18
申请号：US13274175
申请日：2011-10-14
申请人： Eugen Ermantraut , Ralf Bickel , Torsten Schulz , Thomas Ullrich , Jens Tuchscheerer
发明人： Eugen Ermantraut , Ralf Bickel , Torsten Schulz , Thomas Ullrich , Jens Tuchscheerer
IPC分类号： G06K9/74
CPC分类号： G01N33/56966 , B01F11/0045 , B01F11/0266 , B01F13/0059 , B01L3/50273 , B01L3/502746 , B01L2200/027 , B01L2300/0636 , B01L2300/0822 , B01L2300/0825 , B01L2400/0481 , G01N21/03 , G01N35/0099 , G01N2021/0346 , G01N2035/00346
摘要： The present invention relates to devices and methods for the qualitative and/or quantitative detection of particles. In particular, the invention relates to devices for the detection of particles, comprising a reaction chamber formed within a chamber body between a first surface and a second surface, wherein the second surface is located opposite to the first surface, and one or more displacers, wherein the distance between the first surface and the second surface is variable via the one or more displacers at least in one or more parts of the surface area of the first surface and/or second surface. The invention also relates to corresponding methods for the detection of particles.
摘要翻译：本发明涉及用于定性和/或定量检测颗粒的装置和方法。特别地，本发明涉及用于检测颗粒的装置，其包括形成在第一表面和第二表面之间的室主体内的反应室，其中第二表面位于与第一表面相对的位置，以及一个或多个位移器，其中所述第一表面和所述第二表面之间的距离可以经由所述一个或多个位移器在所述第一表面和/或第二表面的表面区域的至少一个或多个部分中是可变的。本发明还涉及用于检测颗粒的相应方法。

10. 发明授权

US09891226B2 Assays 有权
公开(公告)号：US09891226B2
公开(公告)日：2018-02-13
申请号：US14564067
申请日：2014-12-08
申请人： Eugen Ermantraut , Thomas Kaiser , Jens Tuchscheerer , Vico Baier , Torsten Schulz , Anke Wostemeyer
发明人： Eugen Ermantraut , Thomas Kaiser , Jens Tuchscheerer , Vico Baier , Torsten Schulz , Anke Wostemeyer
IPC分类号： G01N21/00 , G01N33/58 , B01L3/00
CPC分类号： G01N33/58 , B01L3/50273 , B01L2200/025 , B01L2200/0684 , B01L2300/0816 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , Y10T436/25
摘要： A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence of each analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction at each test zone is indicative of the presence in the sample of a target analyte. Capillary structures of the devices or used in the methods may comprise a matrix and the devices may comprise control elements and methods for assaying of sample may use corresponding controlling activities.

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