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1. 发明申请

US20120046292A1 DIACYLETHYLENEDIAMINE COMPOUND 审中-公开
标题翻译：二乙烯基胺化合物
公开(公告)号：US20120046292A1
公开(公告)日：2012-02-23
申请号：US13263258
申请日：2010-04-19
申请人： Tomoaki Kawano , Yasuhiro Yonetoku , Takeshi Hanazawa , Takahiro Nigawara , Hiroki Fukudome , Hiroshi Moritani
发明人： Tomoaki Kawano , Yasuhiro Yonetoku , Takeshi Hanazawa , Takahiro Nigawara , Hiroki Fukudome , Hiroshi Moritani
IPC分类号： A61K31/197 , C07D307/79 , A61K31/343 , A61P3/04 , A61K31/495 , C07D239/42 , A61K31/498 , A61K31/5375 , C07C229/38 , C07D295/155
CPC分类号： C07D207/06 , C07B2200/05 , C07C233/62 , C07C235/46 , C07C235/50 , C07C235/84 , C07C237/34 , C07C255/46 , C07C271/20 , C07C275/26 , C07C275/28 , C07C307/06 , C07C311/51 , C07C317/44 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/18 , C07C2602/42 , C07C2602/44 , C07D209/08 , C07D209/42 , C07D209/44 , C07D211/16 , C07D211/18 , C07D211/32 , C07D211/34 , C07D211/38 , C07D211/44 , C07D211/46 , C07D211/52 , C07D211/60 , C07D211/62 , C07D213/64 , C07D213/81 , C07D213/82 , C07D215/48 , C07D215/54 , C07D217/02 , C07D217/06 , C07D217/26 , C07D231/14 , C07D231/22 , C07D239/28 , C07D239/42 , C07D241/04 , C07D241/42 , C07D257/04 , C07D263/32 , C07D263/34 , C07D263/48 , C07D271/06 , C07D271/10 , C07D275/02 , C07D277/20 , C07D277/56 , C07D277/68 , C07D295/14 , C07D295/155 , C07D295/18 , C07D295/20 , C07D295/205 , C07D307/79 , C07D309/06 , C07D317/46 , C07D317/72 , C07D319/18 , C07D333/38 , C07D333/54 , C07D333/68 , C07D333/70 , C07D409/12 , C07D451/02 , C07D495/04
摘要： [Problem]A compound which is useful as an anti-obesity agent is provided.[Means for Solution]The present inventors have investigated a compound having a DGAT1 inhibitory action, which is promising as an active ingredient of a pharmaceutical composition for treating obesity, type II diabetes mellitus, fatty liver, and diseases associated with these diseases, and as a result, they have found that the diacylethylenediamine compound of the present invention has an excellent DGAT1 inhibitory action, thereby completing the present invention. That is, the diacylethylenediamine compound of the present invention has a DGAT1 inhibitory action, and can be therefore used as an agent for preventing and/or treating obesity, type II diabetes mellitus, fatty liver, and diseases associated with these diseases.
摘要翻译： [问题]提供了可用作抗肥胖剂的化合物。 [解决方案]本发明人研究了具有DGAT1抑制作用的化合物，其有希望作为用于治疗肥胖，II型糖尿病，脂肪肝和与这些疾病相关的疾病的药物组合物的活性成分，以及作为结果发现本发明的二酰亚乙基二胺化合物具有优异的DGAT1抑制作用，从而完成了本发明。也就是说，本发明的二酰亚胺二胺化合物具有DGAT1抑制作用，因此可以用作预防和/或治疗肥胖，II型糖尿病，脂肪肝和与这些疾病相关的疾病的药剂。

2. 发明申请

US20110105460A1 TRIAZOLE DERIVATIVE OR SALT THEREOF 有权
标题翻译：三唑衍生物或其盐
公开(公告)号：US20110105460A1
公开(公告)日：2011-05-05
申请号：US13002373
申请日：2009-07-02
申请人： Seiji Yoshimura , Noriyuki Kawano , Tomoaki Kawano , Daisuke Sasuga , Takanori Koike , Hideyuki Watanabe , Hiroki Fukudome , Nobuyuki Shiraishi , Ryosuke Munakata , Hiroaki Hoshii , Kayoko Mihara
发明人： Seiji Yoshimura , Noriyuki Kawano , Tomoaki Kawano , Daisuke Sasuga , Takanori Koike , Hideyuki Watanabe , Hiroki Fukudome , Nobuyuki Shiraishi , Ryosuke Munakata , Hiroaki Hoshii , Kayoko Mihara
IPC分类号： A61K31/4196 , C07D401/12 , A61K31/4439 , C07D249/08 , C07D403/12 , A61K31/506 , C07D413/12 , A61K31/422 , A61K31/4245 , A61K31/5377 , C07D417/12 , A61K31/541 , C07D405/12 , A61K31/427 , C07D413/14 , C07D409/04 , C07D403/10 , C07D471/04 , A61K31/437 , A61P3/10 , A61P25/24 , A61P25/18 , A61P25/28
CPC分类号： C07D249/08 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/10 , C07D417/12
摘要： [Problem] A compound, which can be used for preventing or treating diseases, in which 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is concerned, in particular, diabetes, insulin resistance, dementia, schizophrenia and depression, is provided.[Means for Solution] It was found that a triazole derivative, in which one of the 3- and 5-positions of the triazole ring has (di)alkylmethyl or cycloalkyl, each of which is substituted with —O— (aryl or a heterocyclic group, each of which may be substituted, or lower alkylene-cycloalkyl), and the other thereof has aryl, a heterocyclic group or cycloalkyl, each of which may be substituted, or a pharmaceutically acceptable salt thereof exhibits potent 11β-HSD1 inhibitory action. From the above, the triazole derivative of the present invention can be used for preventing or treating diabetes, insulin resistance, dementia, schizophrenia and depression.
摘要翻译： [问题]提供了一种可用于预防或治疗疾病的化合物，其中涉及11种β-羟基类固醇脱氢酶（11＆bgr-HSD1），特别是糖尿病，胰岛素抵抗，痴呆，精神分裂症和抑郁症。 [解决方案]发现三唑环的3-和5-位之一具有（二）烷基甲基或环烷基的三唑衍生物，其各自被-O-（芳基或杂环）基团，其各自可以被取代，或低级亚烷基 - 环烷基），另一个具有可以被取代的芳基，杂环基或环烷基，或其药学上可接受的盐显示出有效的11β-HSD1抑制作用。由上可知，本发明的三唑衍生物可用于预防或治疗糖尿病，胰岛素抵抗，痴呆，精神分裂症和抑郁症。

3. 发明授权

US08377923B2 Triazole derivative or salt thereof 有权
标题翻译：三唑衍生物或其盐
公开(公告)号：US08377923B2
公开(公告)日：2013-02-19
申请号：US13002373
申请日：2009-07-02
申请人： Seiji Yoshimura , Noriyuki Kawano , Tomoaki Kawano , Daisuke Sasuga , Takanori Koike , Hideyuki Watanabe , Hiroki Fukudome , Nobuyuki Shiraishi , Ryosuke Munakata , Hiroaki Hoshii , Kayoko Mihara
发明人： Seiji Yoshimura , Noriyuki Kawano , Tomoaki Kawano , Daisuke Sasuga , Takanori Koike , Hideyuki Watanabe , Hiroki Fukudome , Nobuyuki Shiraishi , Ryosuke Munakata , Hiroaki Hoshii , Kayoko Mihara
IPC分类号： A01N43/00 , A01N43/58 , A61K31/55 , C07D241/36 , C07D249/08 , C07D249/14
CPC分类号： C07D249/08 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/10 , C07D417/12
摘要： [Problem] A compound, which can be used for preventing or treating diseases, in which 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is concerned, in particular, diabetes, insulin resistance, dementia, schizophrenia and depression, is provided.[Means for Solution] It was found that a triazole derivative, in which one of the 3- and 5-positions of the triazole ring has (di)alkylmethyl or cycloalkyl, each of which is substituted with —O— (aryl or a heterocyclic group, each of which may be substituted, or lower alkylene-cycloalkyl), and the other thereof has aryl, a heterocyclic group or cycloalkyl, each of which may be substituted, or a pharmaceutically acceptable salt thereof exhibits potent 11β-HSD1 inhibitory action. From the above, the triazole derivative of the present invention can be used for preventing or treating diabetes, insulin resistance, dementia, schizophrenia and depression.
摘要翻译： [问题]提供了一种可用于预防或治疗疾病的化合物，其中涉及11种β-羟基类固醇脱氢酶（11＆bgr-HSD1），特别是糖尿病，胰岛素抵抗，痴呆，精神分裂症和抑郁症。 [解决方案]发现三唑环的3-和5-位之一具有（二）烷基甲基或环烷基的三唑衍生物，其各自被-O-（芳基或杂环）基团，其各自可以被取代，或低级亚烷基 - 环烷基），另一个具有可以被取代的芳基，杂环基或环烷基，或其药学上可接受的盐显示出有效的11β-HSD1抑制作用。由上可知，本发明的三唑衍生物可用于预防或治疗糖尿病，胰岛素抵抗，痴呆，精神分裂症和抑郁症。

4. 发明申请

US20070259854A1 Triazole Derivative or Salt Thereof 有权
标题翻译：三唑衍生物或其盐
公开(公告)号：US20070259854A1
公开(公告)日：2007-11-08
申请号：US11663089
申请日：2005-09-14
申请人： Takeshi Murakami , Tomoaki Kawano , Ryota Shiraki , Hirofumi Ishii , Seiji Yoshimura , Takehiko Ohkawa , Mitsuru Hosaka , Hiroki Fukudome , Yutaka Inoki
发明人： Takeshi Murakami , Tomoaki Kawano , Ryota Shiraki , Hirofumi Ishii , Seiji Yoshimura , Takehiko Ohkawa , Mitsuru Hosaka , Hiroki Fukudome , Yutaka Inoki
IPC分类号： A61K31/4196 , A61K31/55 , A61P7/12 , C07D223/00 , C07D249/08
CPC分类号： C07D409/14 , C07D249/08 , C07D401/04 , C07D401/08 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/06 , C07D409/08 , C07D417/12 , C07D471/04 , C07D487/04
摘要： [Problem] There is provided a compound which can be used for therapy of diseases in which 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) participates, in particular diabetes, insulin resistance. [Means for Solution] It has been found that a triazole derivative wherein the triazole ring is substituted with a trisubstituted methyl group in the 2-position or a pharmaceutically acceptable salt thereof has a strong 11β-HSD1 inhibitory activity. Moreover, the triazole derivative of the invention exhibits an excellent blood-glucose level-lowering action and hence can be used for therapy of diabetes, insulin resistance.
摘要翻译： [问题]提供了可用于治疗其中参与了11β-羟类固醇脱氢酶1型（11beta-HSD1）的疾病的化合物，特别是糖尿病，胰岛素抵抗。 [解决方案]已经发现，其中三唑环被2-位上的三取代甲基或其药学上可接受的盐取代的三唑衍生物具有强的11beta-HSD1抑制活性。此外，本发明的三唑衍生物显示出优异的血糖降低作用，因此可用于治疗糖尿病，胰岛素抵抗。

5. 发明授权

US07776897B2 Triazole derivative or salt thereof 有权
标题翻译：三唑衍生物或其盐
公开(公告)号：US07776897B2
公开(公告)日：2010-08-17
申请号：US11663089
申请日：2005-09-14
申请人： Takeshi Murakami , Tomoaki Kawano , Ryota Shiraki , Hirofumi Ishii , Seiji Yoshimura , Takehiko Ohkawa , Mitsuru Hosaka , Hiroki Fukudome , Yutaka Inoki
发明人： Takeshi Murakami , Tomoaki Kawano , Ryota Shiraki , Hirofumi Ishii , Seiji Yoshimura , Takehiko Ohkawa , Mitsuru Hosaka , Hiroki Fukudome , Yutaka Inoki
IPC分类号： A61K31/41 , C07D249/08
CPC分类号： C07D409/14 , C07D249/08 , C07D401/04 , C07D401/08 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/06 , C07D409/08 , C07D417/12 , C07D471/04 , C07D487/04
摘要： There is provided a compound which can be used for therapy of diseases in which 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) participates, in particular diabetes, insulin resistance.It has been found that a triazole derivative wherein the triazole ring is substituted with a trisubstituted methyl group in the 2-position or a pharmaceutically acceptable salt thereof has a strong 11β-HSD1 inhibitory activity. Moreover, the triazole derivative of the invention exhibits an excellent blood-glucose level-lowering action and hence can be used for therapy of diabetes, insulin resistance.
摘要翻译：提供了一种化合物，其可以用于治疗其中参与的11β-羟基类固醇脱氢酶（11＆bgr--HSD1）的疾病，特别是糖尿病，胰岛素抵抗。已经发现，其中三唑环被2-位上的三取代的甲基或其药学上可接受的盐取代的三唑衍生物具有强的11β-HSD1抑制活性。此外，本发明的三唑衍生物显示出优异的血糖降低作用，因此可用于治疗糖尿病，胰岛素抵抗。

6. 发明申请

US20090082367A1 TRIAZOLE DERIVATIVE OR A SALT THEREOF 审中-公开
标题翻译：三唑衍生物或其盐
公开(公告)号：US20090082367A1
公开(公告)日：2009-03-26
申请号：US12293214
申请日：2007-03-14
申请人： Seiji Yoshimura , Ryota Shiraki , Tomoaki Kawano , Daisuke Sasuga , Mitsuru Hosaka , Hiroki Fukudome , Kazuo Kurosawa , Hirofumi Ishii , Takanori Koike
发明人： Seiji Yoshimura , Ryota Shiraki , Tomoaki Kawano , Daisuke Sasuga , Mitsuru Hosaka , Hiroki Fukudome , Kazuo Kurosawa , Hirofumi Ishii , Takanori Koike
IPC分类号： A61K31/4196 , C07D401/06 , A61K31/4439 , A61K31/497 , A61P3/10 , A61K31/4709 , C07D403/06
CPC分类号： C07D249/08 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/08 , C07D409/06 , C07D409/08 , C07D409/12 , C07D413/06 , C07D417/06
摘要： [Problem] To provide a compound which may be used in treating diseases in which 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is concerned, especially diabetes and insulin resistance.[Means for Solution] It was found that a triazole derivative or a pharmaceutically acceptable salt thereof, in which the 3-position of triazole ring is substituted with a trisubstituted methyl group and the 5-position is substituted with a lower alkyl, cycloalkyl or the like, has a strong 11β-HSD1-inhibitory activity. In addition, since the triazole derivative of the present invention shows excellent blood glucose-lowering action, it may be used in the treatment of diabetes and insulin resistance.
摘要翻译： [问题]提供可用于治疗其中涉及11β-羟类固醇脱氢酶1型（11beta-HSD1）的疾病的化合物，特别是糖尿病和胰岛素抵抗。 [解决方法]发现三唑环的3-位被三取代甲基取代的三唑衍生物或其药学上可接受的盐，并且5位被低级烷基，环烷基或具有强的11beta-HSD1抑制活性。此外，由于本发明的三唑衍生物显示出优异的降血糖作用，因此可用于治疗糖尿病和胰岛素抵抗。

7. 发明申请

US20070243052A1 Loader work apparatus 有权
标题翻译：装载机工作装置
公开(公告)号：US20070243052A1
公开(公告)日：2007-10-18
申请号：US11726377
申请日：2007-03-21
申请人： Hiroki Fukudome , Masataka Takagi , Koji Saito , Eiji Miyazaki , Shuichi Takeshita
发明人： Hiroki Fukudome , Masataka Takagi , Koji Saito , Eiji Miyazaki , Shuichi Takeshita
IPC分类号： B66C23/00
CPC分类号： E02F3/382 , E02F3/627
摘要： A work apparatus to be mounted to a work vehicle includes: a pair of cylindrical masts 35 disposed erect on right and left sides of a vehicle body having a control valve; a boom 91 pivotally supported to the masts; an implement pivotally supported to the boom; a boom cylinder 60 for pivoting the boom; an implement cylinder 61 for operating the implement; a boom piping system communicating the control valve with the boom cylinder; and an implement piping system communicating the control valve with the implement cylinder; wherein a channel constituting member 84 constituting the boom piping system extends vertically within each mast; one end of the channel constituting member 84 extends to the outside at a lower portion of the mast to be connected with the control valve; and the other end of the channel constituting member 84 extends to the outside at an upper portion of the mast 35 to be connected with boom cylinder 60.
摘要翻译：要安装到作业车辆上的作业装置包括：一对直立在具有控制阀的车身的右侧和左侧的圆柱形桅杆35; 枢轴支撑在桅杆上的吊杆91; 可枢转地支撑在起重臂上的工具; 用于枢转吊杆的动臂缸60; 用于操作工具的工具缸61; 将控制阀与动臂缸连通的吊杆管道系统; 以及将控制阀与工具缸连通的工具管道系统; 其中构成动臂管道系统的通道构成构件84在每个桅杆内垂直延伸; 通道构成构件84的一端在与控制阀连接的桅杆的下部延伸到外部; 并且通道构成构件84的另一端在桅杆35的上部延伸到外部，以与动臂缸60连接。

8. 外观设计

USD533883S1 Boom assembly for a loader bucket 有权
标题翻译：装载机铲斗的起重机组装
公开(公告)号：USD533883S1
公开(公告)日：2006-12-19
申请号：US29233915
申请日：2005-07-11
申请人： Yoshitaka Higashikawa , Hiroki Fukudome
设计人： Yoshitaka Higashikawa , Hiroki Fukudome

9. 发明授权

US07922204B2 Vibration-isolating device for steering wheel of traveling working vehicle with wheel steering mechanism 有权
标题翻译：具有车轮转向机构的行驶车辆方向盘隔振装置
公开(公告)号：US07922204B2
公开(公告)日：2011-04-12
申请号：US12212232
申请日：2008-09-17
申请人： Nobuyuki Yoshii , Kiyoshige Maezawa , Tadashi Nakamura , Hiroki Fukudome
发明人： Nobuyuki Yoshii , Kiyoshige Maezawa , Tadashi Nakamura , Hiroki Fukudome
IPC分类号： B62D1/16
CPC分类号： F16D3/68 , B62D7/224 , F16D3/70 , F16F15/124
摘要： A vibration-isolating device for a steering wheel of a travelling working vehicle equipped with a wheel steering mechanism includes a first steering shaft (32) that transmits rotational displacement, the first steering shaft being operatively connected to the steering wheel (7); a second steering shaft (33) that transmits rotational displacement, the second steering shaft being operatively connected to the wheel steering mechanism (P, 23); and a vibration-isolating connecting mechanism (31) that operatively connects the first steering shaft (32) and the second steering shaft (33) to each other so that rotational displacement can be transmitted. When the angles of rotational displacement of the first steering shaft (32) and the second steering shaft (33) are within ranges of rotation angles for linearly driving the vehicle, rotational displacement cannot be transmitted between the first steering shaft (32) and the second steering shaft (33).
摘要翻译：一种配备有车轮转向机构的行驶工作车辆的方向盘的防振装置，包括：第一转向轴（32），其传递旋转位移，所述第一转向轴与所述方向盘（7）可操作地连接; 第二转向轴（33），其传递旋转位移，所述第二转向轴可操作地连接到所述车轮转向机构（P，23）; 以及将第一转向轴（32）和第二转向轴（33）可操作地连接的振动隔离连接机构（31），从而能够传递旋转位移。当第一转向轴（32）和第二转向轴（33）的旋转位移角度在用于线性驱动车辆的旋转角度的范围内时，旋转位移不能在第一转向轴（32）和第二转向轴转向轴（33）。

10. 发明申请

US20060073003A1 Front loader attachment construction and work vehicle having the attachment construction 有权
标题翻译：前装载机附件结构和具有附接结构的工作车辆
公开(公告)号：US20060073003A1
公开(公告)日：2006-04-06
申请号：US11069913
申请日：2005-03-01
申请人： Hiroki Fukudome , Koichi Kawaguchi , Kiyokazu Nakanishi
发明人： Hiroki Fukudome , Koichi Kawaguchi , Kiyokazu Nakanishi
IPC分类号： B66C23/00
CPC分类号： E02F3/627
摘要： An attachment construction for attaching a front loader having booms to a front of a tractor vehicle body is disclosed. The construction includes a pair of support tables projecting from the front portion of the tractor body to the right and left outer sides thereof, an engine constituting the vehicle body being disposed forwardly of the support tables, a front axle frame being secured to right and left sides of the engine, a pair of main frames disposed erect on the respective support tables for supporting the booms, and a pair of attaching brackets secured to right/left inner ends of the respective support tables for attaching the support tables to the vehicle body. Each attaching bracket includes a front attaching portion secured to the front axle frame and a rear attaching portion projecting rearwardly of the support table associated therewith and secured to a fore-and-aft intermediate portion of the vehicle body.
摘要翻译：公开了一种用于将具有吊臂的前部装载机附接到拖拉机车体的前部的附接结构。该结构包括从拖拉机主体的前部向其左右外侧突出的一对支撑台，构成车身的发动机设置在支撑台的前方，前轴框架左右固定发动机的侧面，一对直立设置在用于支撑吊杆的支撑台上的一对主框架，以及一对固定在相应的支撑台的左右内端的附接支架，用于将支撑台附接到车体。每个附接支架包括固定到前轴框架的前附接部分和从其相关联的支撑台的后方突出并固定到车身的前后中间部分的后连接部分。

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